(2S,3S,4S,5R)-6-[3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazin-2-ium-2-yl]-3,4,5-trihydroxyoxane-2-carboxylic acid (BioDeep_00001099176)
代谢物信息卡片
化学式: C15H16Cl2N5O6+ (432.0478)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C([N+](=N2)C3C(C(C(C(O3)C(=O)O)O)O)O)N)N
InChI: InChI=1S/C15H15Cl2N5O6/c16-5-3-1-2-4(6(5)17)7-12(18)20-15(19)22(21-7)13-10(25)8(23)9(24)11(28-13)14(26)27/h1-3,8-11,13,23-25H,(H4,18,19,20,26,27)/p+1/t8-,9-,10+,11-,13?/m0/s1
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Daniela Milosheska, Bogdan Lorber, Tomaž Vovk, Matej Kastelic, Vita Dolžan, Iztok Grabnar. Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters.
British journal of clinical pharmacology.
2016 08; 82(2):399-411. doi:
10.1111/bcp.12984. [PMID: 27096250] - Bozo Zonja, Sandra Pérez, Damià Barceló. Human Metabolite Lamotrigine-N(2)-glucuronide Is the Principal Source of Lamotrigine-Derived Compounds in Wastewater Treatment Plants and Surface Water.
Environmental science & technology.
2016 Jan; 50(1):154-64. doi:
10.1021/acs.est.5b03691. [PMID: 26606642] - Arne Reimers, Grethe Helde, Geir Bråthen, Eylert Brodtkorb. Lamotrigine and its N2-glucuronide during pregnancy: the significance of renal clearance and estradiol.
Epilepsy research.
2011 May; 94(3):198-205. doi:
10.1016/j.eplepsyres.2011.02.002. [PMID: 21356585] - Inger Ohman, Olof Beck, Sigurd Vitols, Torbjörn Tomson. Plasma concentrations of lamotrigine and its 2-N-glucuronide metabolite during pregnancy in women with epilepsy.
Epilepsia.
2008 Jun; 49(6):1075-80. doi:
10.1111/j.1528-1167.2007.01471.x. [PMID: 18076642] - Maria Addolorata Saracino, Francesca Bugamelli, Matteo Conti, Mario Amore, Maria Augusta Raggi. Rapid HPLC analysis of the antiepileptic lamotrigine and its metabolites in human plasma.
Journal of separation science.
2007 Sep; 30(14):2249-55. doi:
10.1002/jssc.200700110. [PMID: 17683041] - Andrew Rowland, David J Elliot, J Andrew Williams, Peter I Mackenzie, Ronald G Dickinson, John O Miners. In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Jun; 34(6):1055-62. doi:
10.1124/dmd.106.009340. [PMID: 16565174] - M W Sinz, R P Remmel. Analysis of lamotrigine and lamotrigine 2-N-glucuronide in guinea pig blood and urine by reserved-phase ion-pairing liquid chromatography.
Journal of chromatography.
1991 Nov; 571(1-2):217-30. doi:
10.1016/0378-4347(91)80448-l. [PMID: 1810949]
