Lyngbyatoxin (BioDeep_00000010864)
Marine Natural Products
代谢物信息卡片
Lyngbyatoxin A
化学式: C27H39N3O2 (437.3042114)
中文名称: 鞘丝藻毒素 a
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=CC(C)(CCC=C(C)C)c1ccc2c3c(c[nH]c13)CC(CO)NC(=O)C(C(C)C)N2C
InChI: InChI=1S/C27H39N3O2/c1-8-27(6,13-9-10-17(2)3)21-11-12-22-23-19(15-28-24(21)23)14-20(16-31)29-26(32)25(18(4)5)30(22)7/h8,10-12,15,18,20,25,28,31H,1,9,13-14,16H2,2-7H3,(H,29,32)
描述信息
D009676 - Noxae > D011042 - Poisons > D008235 - Lyngbya Toxins
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins
同义名列表
3 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:80050
- KEGG: C15720
- PubChem: 3979
- Metlin: METLIN71051
- ChEMBL: CHEMBL581451
- MeSH: Lyngbya Toxins
- CAS: 70497-14-2
- PMhub: MS000024762
- PubChem: 47205046
- NIKKAJI: J147.589D
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sicheng Shen, Weiping Wang, Zijun Chen, Huihui Zhang, Yuchun Yang, Xiaoliang Wang, Peng Fu, Bingnan Han. Absolute Structure Determination and Kv1.5 Ion Channel Inhibition Activities of New Debromoaplysiatoxin Analogues.
Marine drugs.
2021 Nov; 19(11):. doi:
10.3390/md19110630. [PMID: 34822501] - Min-Kyoung Kang, Min-Hee Kim, Min-Jiao Liu, Chun Zhi Jin, So Hee Park, Jong Min Lee, Junheon Kim, Dong-Jin Park, Hae-Ryong Park, Young Ho Kim, Chang-Jin Kim. Nematicidal activity of teleocidin B4 isolated from Streptomyces sp. against pine wood nematode, Bursaphelenchus xylophilus.
Pest management science.
2021 Apr; 77(4):1607-1615. doi:
10.1002/ps.6095. [PMID: 32954637] - Yusuke Hanaki, Masayuki Kikumori, Harukuni Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C Yanagita, Kazuhiro Irie. Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.
Molecules (Basel, Switzerland).
2017 Apr; 22(4):. doi:
10.3390/molecules22040631. [PMID: 28406454] - Xiaoji Wang, Chanshan Lv, Junmin Feng, Linjun Tang, Zhuo Wang, Yuqing Liu, Yi Meng, Tao Ye, Zhengshuang Xu. Studies toward the total synthesis of Itralamide B and biological evaluation of its structural analogs.
Marine drugs.
2015 Apr; 13(4):2085-104. doi:
10.3390/md13042085. [PMID: 25871289] - Kenjiro Suzuki, Ryuichi Mizuno, Kiyotake Suenaga, Toshiaki Teruya, Nobuyuki Tanaka, Takeo Kosaka, Mototsugu Oya. Bisebromoamide, an extract from Lyngbya species, induces apoptosis through ERK and mTOR inhibitions in renal cancer cells.
Cancer medicine.
2013 Feb; 2(1):32-9. doi:
10.1002/cam4.53. [PMID: 24133625] - Koichi Nakae, Nobuo Hosokawa, Ryuichi Sawa, Yumiko Kubota, Tohru Masuda, Syunichi Ohba, Masayuki Igarashi, Naoko Nakagawa, Yoshio Nishimura, Yuzuru Akamatsu. A new teleocidin analog from Streptomyces sp. MM216-87F4 induces substance P release from rat dorsal root ganglion neurons.
The Journal of antibiotics.
2006 Jan; 59(1):11-7. doi:
10.1038/ja.2006.3. [PMID: 16568714] - Angela Capper, Ian R Tibbetts, Judith M O'Neil, Glendon R Shaw. The fate of Lyngbya majuscula toxins in three potential consumers.
Journal of chemical ecology.
2005 Jul; 31(7):1595-606. doi:
10.1007/s10886-005-5800-5. [PMID: 16222795] - K L Marshall, R L Vogt. Illness associated with eating seaweed, Hawaii, 1994.
The Western journal of medicine.
1998 Nov; 169(5):293-5. doi:
". [PMID: 9830364] - A P Kozikowski, S Wang, D Ma, J Yao, S Ahmad, R I Glazer, K Bogi, P Acs, S Modarres, N E Lewin, P M Blumberg. Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity.
Journal of medicinal chemistry.
1997 Apr; 40(9):1316-26. doi:
10.1021/jm960875h. [PMID: 9135029] - H Ueyama, I Sasaki, K Shimomura, M Suganuma. Specific protein interacting with a tumor promoter, debromoaplysiatoxin, in bovine serum is alpha 1-acid glycoprotein.
Journal of cancer research and clinical oncology.
1995; 121(4):211-8. doi:
10.1007/bf01366964. [PMID: 7751319] - A Komori, J Yatsunami, S Okabe, S Abe, K Hara, M Suganuma, S J Kim, H Fujiki. Anticarcinogenic activity of green tea polyphenols.
Japanese journal of clinical oncology.
1993 Jun; 23(3):186-90. doi:
10.1093/oxfordjournals.jjco.a039631. [PMID: 8350491] - H Ohigashi, Y Sakai, K Yamaguchi, I Umezaki, K Koshimizu. Possible anti-tumor promoting properties of marine algae and in vivo activity of Wakame seaweed extract.
Bioscience, biotechnology, and biochemistry.
1992 Jun; 56(6):994-5. doi:
10.1271/bbb.56.994. [PMID: 1369377] - A Murakami, S Tanaka, H Ohigashi, M Hirota, R Irie, N Takeda, A Tatematsu, K Koshimizu. Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters.
Bioscience, biotechnology, and biochemistry.
1992 May; 56(5):769-72. doi:
10.1271/bbb.56.769. [PMID: 1369383] - J M Mullin, K V Snock, M T McGinn. Effects of apical vs. basolateral palytoxin on LLC-PK1 renal epithelia.
The American journal of physiology.
1991 Jun; 260(6 Pt 1):C1201-11. doi:
10.1152/ajpcell.1991.260.6.c1201. [PMID: 1676241] - L Levine. Actions of vanadate on arachidonic acid metabolism by cells in culture.
Prostaglandins.
1991 Jan; 41(1):7-19. doi:
10.1016/0090-6980(91)90100-t. [PMID: 2020748] - K Nam, S Kimura, H Fujiki, Y Imanishi. Effects of phorbol ester and teleocidin on Ca2+-induced fusion of liposomes.
Biochemical and biophysical research communications.
1989 Dec; 165(3):1256-61. doi:
10.1016/0006-291x(89)92737-x. [PMID: 2610691] - K Y Nam, S Kimura, Y Imanishi, H Fujiki. Distribution of tumor promoters in lipid membranes and changes in membrane structure.
Biophysical chemistry.
1989 Sep; 34(1):43-53. doi:
10.1016/0301-4622(89)80040-7. [PMID: 2611340] - H Kawakami, M Higashihara, S Kume, M Yamanaka, H Hirano. Localization of granular components in ADP- and/or teleocidin-stimulated human blood platelets as revealed by immunocytochemical methods.
Acta haematologica.
1989; 82(2):75-80. doi:
10.1159/000205287. [PMID: 2508398] - K Ohuchi, T Sugawara, M Watanabe, N Hirasawa, S Tsurufuji, H Fujiki, S B Christensen, T Sugimura. Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages.
British journal of pharmacology.
1988 Jul; 94(3):917-23. doi:
10.1111/j.1476-5381.1988.tb11604.x. [PMID: 3140994] - S Kano, T Iizuka, Y Ishimura, H Fujiki, T Sugimura. Stimulation of superoxide anion formation by the non-TPA type tumor promoters palytoxin and thapsigargin in porcine and human neutrophils.
Biochemical and biophysical research communications.
1987 Mar; 143(2):672-7. doi:
10.1016/0006-291x(87)91406-9. [PMID: 2882751] - T Terasaki, Y Shimosato, T Nakajima, M Tsumuraya, S Morinaga, S Hirohashi, K Yamaguchi, K Kato, H Ichinose, T Nagatsu. Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Japanese journal of clinical oncology.
1986 Sep; 16(3):203-12. doi:
. [PMID: 3022030] - H Brockerhoff. Membrane protein-lipid hydrogen bonding: evidence from protein kinase C, diglyceride, and tumor promotors.
FEBS letters.
1986 May; 201(1):1-4. doi:
10.1016/0014-5793(86)80559-2. [PMID: 3086122] - H Fujiki. [The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion].
Gan to kagaku ryoho. Cancer & chemotherapy.
1986 Mar; 13(3 Pt 2):758-65. doi:
. [PMID: 2870684] - S Gamou, N Shimizu. Adipocyte differentiation of 3T3-L1 cells in serum-free hormone-supplemented media: effects of insulin and dihydroteleocidin B.
Cell structure and function.
1986 Mar; 11(1):21-30. doi:
10.1247/csf.11.21. [PMID: 2420477] - H Ohigashi, H Takamura, K Koshimizu, H Tokuda, Y Ito. Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L.
Cancer letters.
1986 Feb; 30(2):143-51. doi:
10.1016/0304-3835(86)90082-0. [PMID: 3006912] - Y Keisari, I Geva, E Flescher, H Goldin, G Lavie. Stimulation of human monocyte oxidative burst and related cytotoxicity by tumor-promoting and non-tumor-promoting diterpene esters, indole alkaloids and polyacetate-type agents.
International journal of cancer.
1985 Oct; 36(4):467-72. doi:
10.1002/ijc.2910360409. [PMID: 3930412] - K J Leister, C E Wenner, L D Tomei. Correlation of ouabain-sensitive ion movements with cell-cycle activation.
Proceedings of the National Academy of Sciences of the United States of America.
1985 Mar; 82(6):1599-603. doi:
10.1073/pnas.82.6.1599. [PMID: 2984662] - R N Mascardo, P Sherline. Tumor promoters stimulate hyperplasia of microtubule organizing center and inhibit DNA synthesis in cultured cells.
The Journal of clinical investigation.
1984 Oct; 74(4):1186-92. doi:
10.1172/jci111527. [PMID: 6480823] - E G Fey, S Penman. Tumor promoters induce a specific morphological signature in the nuclear matrix-intermediate filament scaffold of Madin-Darby canine kidney (MDCK) cell colonies.
Proceedings of the National Academy of Sciences of the United States of America.
1984 Jul; 81(14):4409-13. doi:
10.1073/pnas.81.14.4409. [PMID: 6431407] - E Friedman, C Urmacher, S Winawer. A model for human colon carcinoma evolution based on the differential response of cultured preneoplastic, premalignant, and malignant cells to 12-O-tetradecanoylphorbol-13-acetate.
Cancer research.
1984 Apr; 44(4):1568-78. doi:
NULL. [PMID: 6423277] - P Kanter, K J Leister, L D Tomei, P A Wenner, C E Wenner. Epidermal growth factor and tumor promoters prevent DNA fragmentation by different mechanisms.
Biochemical and biophysical research communications.
1984 Jan; 118(2):392-9. doi:
10.1016/0006-291x(84)91315-9. [PMID: 6608349] - V Wunderlich, G Sydow, L Baumbach. Enhancement of primate retrovirus synthesis by tumour promoters.
IARC scientific publications.
1984; ?(56):299-304. doi:
NULL. [PMID: 6443105] - A D Horowitz, H Fujiki, I B Weinstein, A Jeffrey, E Okin, R E Moore, T Sugimura. Comparative effects of aplysiatoxin, debromoaplysiatoxin, and teleocidin on receptor binding and phospholipid metabolism.
Cancer research.
1983 Apr; 43(4):1529-35. doi:
. [PMID: 6299522] - Y Kaneko. Epidermal growth factor enhances acetylation of nuclear proteins in cultured human liver cells.
Biochimica et biophysica acta.
1983 Feb; 762(1):111-8. doi:
10.1016/0167-4889(83)90123-4. [PMID: 6403049] - H Nishino, H Fujiki, M Terada, S Sato. Enhanced incorporation of radioactive inorganic phosphate into phospholipids of HeLa cells by tumor promoters.
Carcinogenesis.
1983; 4(1):107-10. doi:
10.1093/carcin/4.1.107. [PMID: 6401600] - Y Nakao, S Matsuda, H Kimoto, T Matsui, N Kobayashi, M Kishihara, T Fujita, S Watanabe, K Ueda, Y Ito. Paradoxical anti-leukemic effects of plant-derived tumor promoters on a human thymic lymphoblast cell line.
International journal of cancer.
1982 Dec; 30(6):687-95. doi:
10.1002/ijc.2910300603. [PMID: 6819241] - M Kawanishi, Y Ito. Similarity of Epstein-Barr virus early polypeptides induced by various tumor promoters.
Cancer letters.
1982 May; 16(1):19-23. doi:
10.1016/0304-3835(82)90086-6. [PMID: 6288232] - Y Kaneko. Antagonistic action of retinoic acid and teleocidin on the proliferation and epidermal growth factor binding of rat hepatoma cells.
International journal of cancer.
1981 Jun; 27(6):841-6. doi:
10.1002/ijc.2910270617. [PMID: 6793526]