GW-4064 (BioDeep_00000010805)
Volatile Flavor Compounds
代谢物信息卡片
3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
化学式: C28H22Cl3NO4 (541.0614342)
中文名称: 3-(2,6-二氯苯基)-4-(3-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)C=CC4=CC(=CC=C4)C(=O)O)Cl
InChI: InChI=1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:79997
- ChEBI: CHEBI:93125
- KEGG: C15635
- PubChem: 9893571
- PubChem: 44483281
- Metlin: METLIN70989
- ChEMBL: CHEMBL318457
- CAS: 1089660-72-9
- CAS: 278779-30-9
- CAS: 292047-56-4
- PMhub: MS000024701
- PubChem: 17396625
- PDB-CCD: 064
- NIKKAJI: J1.383.256K
- KNApSAcK: 79997
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hsuan-Miao Liu, Zi-Yu Chang, Ching-Wei Yang, Hen-Hong Chang, Tzung-Yan Lee. Farnesoid X Receptor Agonist GW4064 Protects Lipopolysaccharide-Induced Intestinal Epithelial Barrier Function and Colorectal Tumorigenesis Signaling through the αKlotho/βKlotho/FGFs Pathways in Mice.
International journal of molecular sciences.
2023 Nov; 24(23):. doi:
10.3390/ijms242316932. [PMID: 38069256] - Rulaiha Taylor, Laura Armstrong, Anisha Bhattacharya, Zakiyah Henry, Anita Brinker, Brian Buckley, Bo Kong, Grace Guo. Myclobutanil-mediated alteration of liver-gut FXR signaling in mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2023 Feb; 191(2):387-399. doi:
10.1093/toxsci/kfac129. [PMID: 36511616] - Juan Zou, Yuanyuan Li, Jingyi Cai, Xiaotian Peng, Lincong Zhang, Tian Tian, Tianming Wang, Rong Shi, Jiasheng Wu, Yueming Ma. Identification of Yinchenwuling fang's active components and hepatoprotective effects against cholestatic liver damage induced by alpha-naphthyl isothiocyanate in mice.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2023 Jan; 1215(?):123570. doi:
10.1016/j.jchromb.2022.123570. [PMID: 36542898] - Lu Lu, Yi-Xin Jiang, Xiao-Xia Liu, Jin-Mei Jin, Wen-Jie Gu, Xin Luan, Ying-Yun Guan, Li-Jun Zhang. FXR agonist GW4064 enhances anti-PD-L1 immunotherapy in colorectal cancer.
Oncoimmunology.
2023; 12(1):2217024. doi:
10.1080/2162402x.2023.2217024. [PMID: 37261088] - Petar D Petrov, Polina Soluyanova, Sonia Sánchez-Campos, José V Castell, Ramiro Jover. Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Dec; 158(?):112664. doi:
10.1016/j.fct.2021.112664. [PMID: 34767876] - Alex Zaufel, Sandra M W van de Wiel, Lu Yin, Günter Fauler, Daphne Chien, Xinzhong Dong, John F Gilmer, Jennifer K Truong, Paul A Dawson, Stan F J van de Graaf, Peter Fickert, Tarek Moustafa. Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.
Biochimica et biophysica acta. Molecular basis of disease.
2021 08; 1867(8):166153. doi:
10.1016/j.bbadis.2021.166153. [PMID: 33895309] - Fulin Liu, Jin Zhou, Juanjuan Guo, Wen Huang, Wei Zhang, Hui Wang. Prenatal ethanol exposure increases maternal bile acids through placental transport pathway.
Toxicology.
2021 06; 458(?):152848. doi:
10.1016/j.tox.2021.152848. [PMID: 34217791] - Lori W E van der Schoor, Henkjan J Verkade, Anna Bertolini, Sanne de Wit, Elvira Mennillo, Eva Rettenmeier, André A Weber, Rick Havinga, Petra Valášková, Jana Jašprová, Dicky Struik, Vincent W Bloks, Shujuan Chen, Andrea B Schreuder, Libor Vítek, Robert H Tukey, Johan W Jonker. Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia.
Scientific reports.
2021 05; 11(1):11107. doi:
10.1038/s41598-021-90687-5. [PMID: 34045606] - Xiaojiao Zheng, Tianlu Chen, Runqiu Jiang, Aihua Zhao, Qing Wu, Junliang Kuang, Dongnan Sun, Zhenxing Ren, Mengci Li, Mingliang Zhao, Shouli Wang, Yuqian Bao, Huating Li, Cheng Hu, Bing Dong, Defa Li, Jiayu Wu, Jialin Xia, Xuemei Wang, Ke Lan, Cynthia Rajani, Guoxiang Xie, Aiping Lu, Weiping Jia, Changtao Jiang, Wei Jia. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.
Cell metabolism.
2021 04; 33(4):791-803.e7. doi:
10.1016/j.cmet.2020.11.017. [PMID: 33338411] - Sang Youb Han, Hye Kyoung Song, Jin Joo Cha, Jee Young Han, Young Sun Kang, Dae Ryong Cha. Farnesoid X receptor (FXR) agonist ameliorates systemic insulin resistance, dysregulation of lipid metabolism, and alterations of various organs in a type 2 diabetic kidney animal model.
Acta diabetologica.
2021 Apr; 58(4):495-503. doi:
10.1007/s00592-020-01652-z. [PMID: 33399988] - Guoshun Luo, Xin Lin, Zhenbang Li, Maoxu Xiao, Xinyu Li, Dayong Zhang, Hua Xiang. Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator.
European journal of medicinal chemistry.
2021 Jan; 209(?):112910. doi:
10.1016/j.ejmech.2020.112910. [PMID: 33049605] - Xiaodong Wei, Yingxiong Ma, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Zhihua Liao, Min Chen. Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jan; 80(?):153378. doi:
10.1016/j.phymed.2020.153378. [PMID: 33113499] - Junyou Li, Mengqi Liu, Yazhou Li, Dan-Dan Sun, Zhihao Shu, Qian Tan, Shimeng Guo, Rongrong Xie, Lixin Gao, Hongbo Ru, Yi Zang, Hong Liu, Jia Li, Yu Zhou. Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis.
Journal of medicinal chemistry.
2020 11; 63(21):12748-12772. doi:
10.1021/acs.jmedchem.0c01065. [PMID: 32991173] - Teerasak Wongwan, Varanuj Chatsudthipong, Sunhapas Soodvilai. Farnesoid X Receptor Activation Stimulates Organic Cations Transport in Human Renal Proximal Tubular Cells.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21176078. [PMID: 32846898] - Arisa Masuda, Keigo Gohda, Yusuke Iguchi, Ko Fujimori, Yukiko Yamashita, Keisuke Oda, Mizuho Une, Naoki Teno. N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR).
Bioorganic & medicinal chemistry.
2020 07; 28(14):115512. doi:
10.1016/j.bmc.2020.115512. [PMID: 32616182] - Aihua Zhao, Shouli Wang, Wenlian Chen, Xiaojiao Zheng, Fengjie Huang, Xiaolong Han, Kun Ge, Cynthia Rajani, Yanxia Huang, Herbert Yu, Jinshui Zhu, Wei Jia. Increased levels of conjugated bile acids are associated with human bile reflux gastritis.
Scientific reports.
2020 07; 10(1):11601. doi:
10.1038/s41598-020-68393-5. [PMID: 32665615] - Yu Yang, Yu Zhao, Wenzhen Li, Yuyao Wu, Xin Wang, Yijie Wang, Tingmei Liu, Tinghong Ye, Yongmei Xie, Zhiqiang Cheng, Jun He, Peng Bai, Yiwen Zhang, Liang Ouyang. Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment.
European journal of medicinal chemistry.
2020 Jul; 197(?):112311. doi:
10.1016/j.ejmech.2020.112311. [PMID: 32339855] - F Anthony Romero, Christopher T Jones, Yingzi Xu, Martijn Fenaux, Randall L Halcomb. The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.
Journal of medicinal chemistry.
2020 05; 63(10):5031-5073. doi:
10.1021/acs.jmedchem.9b01701. [PMID: 31930920] - Sarah Farr, Bogdan Stankovic, Simon Hoffman, Hassan Masoudpoor, Chris Baker, Jennifer Taher, Angela E Dean, Sayeepriyadarshini Anakk, Khosrow Adeli. Bile acid treatment and FXR agonism lower postprandial lipemia in mice.
American journal of physiology. Gastrointestinal and liver physiology.
2020 04; 318(4):G682-G693. doi:
10.1152/ajpgi.00386.2018. [PMID: 32003602] - Tomofumi Fujino, Kouta Sugizaki, Rei Kato, Masaki Beppu, Satoshi Murakami, Hyunjung Lee, Toshiyuki Oshima, Makio Hayakawa. Farnesoid X receptor and liver X receptors regulate Oct3/4 expression by multiple feedback regulating system in normal renal-derived cells and renal adenocarcinoma cells.
The Journal of toxicological sciences.
2020; 45(1):25-35. doi:
10.2131/jts.45.25. [PMID: 31932555] - Dong-Hyun Kim, Hoon-In Choi, Jung Sun Park, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim. Src-mediated crosstalk between FXR and YAP protects against renal fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 10; 33(10):11109-11122. doi:
10.1096/fj.201900325r. [PMID: 31298930] - Yi Cao, Yongtao Xiao, KeJun Zhou, Junkai Yan, Panliang Wang, Weihui Yan, Wei Cai. FXR agonist GW4064 improves liver and intestinal pathology and alters bile acid metabolism in rats undergoing small intestinal resection.
American journal of physiology. Gastrointestinal and liver physiology.
2019 08; 317(2):G108-G115. doi:
10.1152/ajpgi.00356.2017. [PMID: 30920307] - Zhou-Yi Wu, Hu Li, Jian-Rui Li, Xiao-Qin Lv, Jian-Dong Jiang, Zong-Gen Peng. Farnesoid X receptor agonist GW4064 indirectly inhibits HCV entry into cells via down-regulating scavenger receptor class B type I.
European journal of pharmacology.
2019 Jun; 853(?):111-120. doi:
10.1016/j.ejphar.2019.03.033. [PMID: 30902657] - Sangwon Byun, Hyunkyung Jung, Jinjing Chen, Young-Chae Kim, Dong-Hyun Kim, Bo Kong, Grace Guo, Byron Kemper, Jongsook Kim Kemper. Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis.
The Journal of biological chemistry.
2019 05; 294(22):8732-8744. doi:
10.1074/jbc.ra119.008360. [PMID: 30996006] - Asmita Pant, Elizabeth A Rondini, Thomas A Kocarek. Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells.
Toxicology and applied pharmacology.
2019 02; 365(?):61-70. doi:
10.1016/j.taap.2019.01.003. [PMID: 30611723] - Leonore Wigger, Cristina Casals-Casas, Michaël Baruchet, Khanh B Trang, Sylvain Pradervand, Aurélien Naldi, Béatrice Desvergne. System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells.
PloS one.
2019; 14(8):e0220894. doi:
10.1371/journal.pone.0220894. [PMID: 31437187] - Rongmao Qiu, Guoshun Luo, Xuerong Cai, Linyi Liu, Mingqi Chen, Deying Chen, Qidong You, Hua Xiang. Structure-guided design and synthesis of isoflavone analogs of GW4064 with potent lipid accumulation inhibitory activities.
Bioorganic & medicinal chemistry letters.
2018 12; 28(23-24):3726-3730. doi:
10.1016/j.bmcl.2018.10.021. [PMID: 30342957] - Rongmao Qiu, Guoshun Luo, Xinyu Li, Fan Zheng, Haolin Li, Jin Zhang, Qidong You, Hua Xiang. Lipid accumulation inhibitory activities of novel isoxazole-based chenodeoxycholic acids: Design, synthesis and preliminary mechanism study.
Bioorganic & medicinal chemistry letters.
2018 09; 28(17):2879-2884. doi:
10.1016/j.bmcl.2018.07.026. [PMID: 30031618] - Yunlong Xia, Fuyang Zhang, Shihao Zhao, Yueyang Li, Xiyao Chen, Erhe Gao, Xinyue Xu, Zhenyu Xiong, Xiaomeng Zhang, Jinglong Zhang, Huishou Zhao, Wei Wang, Helin Wang, Yanjie Guo, Yi Liu, Congye Li, Shan Wang, Ling Zhang, Wenjun Yan, Ling Tao. Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction.
Cardiovascular research.
2018 08; 114(10):1335-1349. doi:
10.1093/cvr/cvy093. [PMID: 29668847] - Hsuan-Miao Liu, Tzung-Yan Lee, Jyh-Fei Liao. GW4064 attenuates lipopolysaccharide‑induced hepatic inflammation and apoptosis through inhibition of the Toll‑like receptor 4‑mediated p38 mitogen‑activated protein kinase signaling pathway in mice.
International journal of molecular medicine.
2018 Mar; 41(3):1455-1462. doi:
10.3892/ijmm.2018.3366. [PMID: 29328388] - Fan Yang, Yao Wang, Gang Li, Juan Xue, Zhi-Lin Chen, Feng Jin, Lei Luo, Xuan Zhou, Qian Ma, Xin Cai, Hua-Rong Li, Lei Zhao. Effects of corilagin on alleviating cholestasis via farnesoid X receptor-associated pathways in vitro and in vivo.
British journal of pharmacology.
2018 03; 175(5):810-829. doi:
10.1111/bph.14126. [PMID: 29235094] - Young-Chae Kim, Sunmi Seok, Sangwon Byun, Bo Kong, Yang Zhang, Grace Guo, Wen Xie, Jian Ma, Byron Kemper, Jongsook Kim Kemper. AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle.
Nature communications.
2018 02; 9(1):540. doi:
10.1038/s41467-018-03060-y. [PMID: 29416063] - Hsuan-Miao Liu, Jyh-Fei Liao, Tzung-Yan Lee. Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice.
Biochemical and biophysical research communications.
2017 08; 490(3):841-848. doi:
10.1016/j.bbrc.2017.06.129. [PMID: 28647362] - Daniel Flesch, Sun-Yee Cheung, Jurema Schmidt, Matthias Gabler, Pascal Heitel, Jan Kramer, Astrid Kaiser, Markus Hartmann, Mara Lindner, Kerstin Lüddens-Dämgen, Jan Heering, Christina Lamers, Hartmut Lüddens, Mario Wurglics, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk. Nonacidic Farnesoid X Receptor Modulators.
Journal of medicinal chemistry.
2017 08; 60(16):7199-7205. doi:
10.1021/acs.jmedchem.7b00903. [PMID: 28749691] - Monica D Chow, Yi-Horng Lee, Grace L Guo. The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Molecular aspects of medicine.
2017 08; 56(?):34-44. doi:
10.1016/j.mam.2017.04.004. [PMID: 28442273] - Haiping Hao, Lijuan Cao, Changtao Jiang, Yuan Che, Songyang Zhang, Shogo Takahashi, Guangji Wang, Frank J Gonzalez. Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis.
Cell metabolism.
2017 Apr; 25(4):856-867.e5. doi:
10.1016/j.cmet.2017.03.007. [PMID: 28380377] - Stefanie Albrecht, Ann-Katrin Fleck, Ina Kirchberg, Stephanie Hucke, Marie Liebmann, Luisa Klotz, Tanja Kuhlmann. Activation of FXR pathway does not alter glial cell function.
Journal of neuroinflammation.
2017 03; 14(1):66. doi:
10.1186/s12974-017-0833-6. [PMID: 28351411] - Tomofumi Fujino, Ryosuke Sakamaki, Haruka Ito, Yumiko Furusato, Nami Sakamoto, Toshiyuki Oshima, Makio Hayakawa. Farnesoid X receptor regulates the growth of renal adenocarcinoma cells without affecting that of a normal renal cell-derived cell line.
The Journal of toxicological sciences.
2017; 42(3):259-265. doi:
10.2131/jts.42.259. [PMID: 28496032] - Qingli Liu, Meng Yang, Xuekun Fu, Renzhong Liu, Caijun Sun, Haobo Pan, Chi-Wai Wong, Min Guan. Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression.
Molecular and cellular endocrinology.
2016 11; 436(?):93-101. doi:
10.1016/j.mce.2016.07.027. [PMID: 27471003] - Jamie E Moscovitz, Bo Kong, Kyle Buckley, Brian Buckley, Grace L Guo, Lauren M Aleksunes. Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064.
Toxicology and applied pharmacology.
2016 Nov; 310(?):60-67. doi:
10.1016/j.taap.2016.08.021. [PMID: 27609522] - Yanping Xu. Recent Progress on Bile Acid Receptor Modulators for Treatment of Metabolic Diseases.
Journal of medicinal chemistry.
2016 07; 59(14):6553-79. doi:
10.1021/acs.jmedchem.5b00342. [PMID: 26878262] - Zhibo Gai, Ting Gui, Christian Hiller, Gerd A Kullak-Ublick. Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice.
The Journal of biological chemistry.
2016 Jan; 291(5):2397-411. doi:
10.1074/jbc.m115.694323. [PMID: 26655953] - Noura Alasmael, Rati Mohan, Lisiane B Meira, Karen E Swales, Nick J Plant. Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential.
Cancer letters.
2016 Jan; 370(2):250-9. doi:
10.1016/j.canlet.2015.10.031. [PMID: 26545738] - Michael J Genin, Ana B Bueno, Javier Agejas Francisco, Peter R Manninen, Wayne P Bocchinfuso, Chahrzad Montrose-Rafizadeh, Ellen A Cannady, Timothy M Jones, John R Stille, Eyas Raddad, Charles Reidy, Amy Cox, M Dodson Michael, Laura F Michael. Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia.
Journal of medicinal chemistry.
2015 Dec; 58(24):9768-72. doi:
10.1021/acs.jmedchem.5b01161. [PMID: 26568144] - Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W Krausz, Jingmin Shi, Chad N Brocker, Dhimant Desai, Shantu G Amin, William H Bisson, Yulan Liu, Oksana Gavrilova, Andrew D Patterson, Frank J Gonzalez. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.
Nature communications.
2015 Dec; 6(?):10166. doi:
10.1038/ncomms10166. [PMID: 26670557] - Shu Li, Xin Chen, Lu Zhou, Bang-Mao Wang. Farnesoid X receptor signal is involved in deoxycholic acid-induced intestinal metaplasia of normal human gastric epithelial cells.
Oncology reports.
2015 Nov; 34(5):2674-82. doi:
10.3892/or.2015.4207. [PMID: 26324224] - Jing Jin, Xiaozhe Sun, Zhongxiang Zhao, Wenwen Wang, Yuwen Qiu, Xinlu Fu, Min Huang, Zhiying Huang. Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Sep; 22(10):894-901. doi:
10.1016/j.phymed.2015.06.007. [PMID: 26321738] - Shu Zhang, Xian Pan, Hyunyoung Jeong. GW4064, an agonist of farnesoid X receptor, represses CYP3A4 expression in human hepatocytes by inducing small heterodimer partner expression.
Drug metabolism and disposition: the biological fate of chemicals.
2015 May; 43(5):743-8. doi:
10.1124/dmd.114.062836. [PMID: 25725071] - Elizabeth J Tarling, Hannah Ahn, Thomas Q de Aguiar Vallim. The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2.
Arteriosclerosis, thrombosis, and vascular biology.
2015 Apr; 35(4):787-95. doi:
10.1161/atvbaha.114.304179. [PMID: 25593129] - Keiyu Oshida, Naresh Vasani, Russell S Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M Aleksunes, Curtis Klaassen, J Christopher Corton. Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.
PloS one.
2015; 10(2):e0112655. doi:
10.1371/journal.pone.0112655. [PMID: 25689681] - Domingo Barettino, Susana Masiá, Fermí Montó, Paloma Pérez, Pilar D'Ocon, Lucrecia Moreno, Vicente Muedra. Glucocorticoids as modulators of expression and activity of Antithrombin (At): potential clinical relevance.
Thrombosis research.
2015 Jan; 135(1):183-91. doi:
10.1016/j.thromres.2014.10.026. [PMID: 25466848] - Yi Pan, Hou-gang Zhou, Hui Zhou, Min Hu, Li-jun Tang. Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells.
Drug design, development and therapy.
2015; 9(?):2375-82. doi:
10.2147/dddt.s78496. [PMID: 25987835] - Jun Yao, Chun-Suo Zhou, Xiong Ma, Bai-Qing Fu, Li-Sheng Tao, Miao Chen, Ya-Ping Xu. FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation.
World journal of gastroenterology.
2014 Oct; 20(39):14430-41. doi:
10.3748/wjg.v20.i39.14430. [PMID: 25339829] - Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.
Scientific reports.
2014 Sep; 4(?):6437. doi:
10.1038/srep06437. [PMID: 25257666] - Liping Yang, David Broderick, Yuan Jiang, Victor Hsu, Claudia S Maier. Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.
Biochimica et biophysica acta.
2014 Sep; 1844(9):1684-93. doi:
10.1016/j.bbapap.2014.06.007. [PMID: 24953769] - Marcin Magierowski, Katarzyna Jasnos, Zbigniew Sliwowski, Marcin Surmiak, Gracjana Krzysiek-Maczka, Agata Ptak-Belowska, Slawomir Kwiecien, Tomasz Brzozowski. Exogenous asymmetric dimethylarginine (ADMA) in pathogenesis of ischemia-reperfusion-induced gastric lesions: interaction with protective nitric oxide (NO) and calcitonin gene-related peptide (CGRP).
International journal of molecular sciences.
2014 Mar; 15(3):4946-64. doi:
10.3390/ijms15034946. [PMID: 24658439] - Clemens Röhrl, Karin Eigner, Stefanie Fruhwürth, Herbert Stangl. Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells.
PloS one.
2014; 9(7):e102026. doi:
10.1371/journal.pone.0102026. [PMID: 25010412] - Liangpeng Li, Hong Liu, Jiahe Peng, Yongchao Wang, Yan Zhang, Jinyu Dong, Xiaohua Liu, Dongmei Guo, Yu Jiang. Farnesoid X receptor up-regulates expression of lipid transfer inhibitor protein in liver cells and mice.
Biochemical and biophysical research communications.
2013 Nov; 441(4):880-5. doi:
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Biochemical pharmacology.
2013 Oct; 86(7):926-39. doi:
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Journal of lipid research.
2013 Sep; 54(9):2475-84. doi:
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Circulation research.
2013 Jun; 112(12):1602-12. doi:
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Pharmaceutical research.
2013 May; 30(5):1447-57. doi:
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Endocrinology.
2013 May; 154(5):1794-801. doi:
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Nutrition, metabolism, and cardiovascular diseases : NMCD.
2013 Feb; 23(2):94-101. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2013 Feb; 41(2):529-35. doi:
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Hepatology (Baltimore, Md.).
2013 Feb; 57(2):716-26. doi:
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The Journal of pharmacology and experimental therapeutics.
2012 Dec; 343(3):556-67. doi:
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Molecular and cellular endocrinology.
2012 Oct; 362(1-2):69-75. doi:
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The Journal of steroid biochemistry and molecular biology.
2012 Oct; 132(1-2):41-7. doi:
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Biochemical pharmacology.
2012 Jun; 83(12):1674-81. doi:
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Cell metabolism.
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PloS one.
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American journal of physiology. Endocrinology and metabolism.
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PloS one.
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Bioorganic & medicinal chemistry letters.
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FEBS letters.
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Toxicology and applied pharmacology.
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The Journal of pharmacology and experimental therapeutics.
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Toxicological sciences : an official journal of the Society of Toxicology.
2009 Jul; 110(1):47-60. doi:
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American journal of physiology. Heart and circulatory physiology.
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Arteriosclerosis, thrombosis, and vascular biology.
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American journal of physiology. Regulatory, integrative and comparative physiology.
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Hepatology (Baltimore, Md.).
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Molecular endocrinology (Baltimore, Md.).
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The Journal of biological chemistry.
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Cancer research.
2006 Oct; 66(20):10120-6. doi:
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American journal of physiology. Heart and circulatory physiology.
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The Journal of biological chemistry.
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