TTNPB (BioDeep_00000010804)

   


代谢物信息卡片


4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid

化学式: C24H28O2 (348.2089)
中文名称: 芳维甲酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CC1=CC=C(C=C1)C(=O)O)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
InChI: InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+

描述信息

D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids
D000970 - Antineoplastic Agents

同义名列表

5 个代谢物同义名

arotinoid acid; Ro 13-7410; TTNPB; 4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid; Arotinoid acid



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • José Córdoba-Caballero, Pedro Seoane, Fernando M Jabato, James R Perkins, Manuel Manchado, M Gonzalo Claros. An improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae. Scientific reports. 2020 11; 10(1):20654. doi: 10.1038/s41598-020-77201-z. [PMID: 33244091]
  • Manabu Kawata, Daisuke Mori, Kosuke Kanke, Hironori Hojo, Shinsuke Ohba, Ung-Il Chung, Fumiko Yano, Hideki Masaki, Makoto Otsu, Hiromitsu Nakauchi, Sakae Tanaka, Taku Saito. Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds. Stem cell reports. 2019 09; 13(3):530-544. doi: 10.1016/j.stemcr.2019.07.012. [PMID: 31402337]
  • Shiho Oeda, Yohei Hayashi, Techuan Chan, Minoru Takasato, Yuko Aihara, Koji Okabayashi, Kiyoshi Ohnuma, Makoto Asashima. Induction of intermediate mesoderm by retinoic acid receptor signaling from differentiating mouse embryonic stem cells. The International journal of developmental biology. 2013; 57(5):383-9. doi: 10.1387/ijdb.130058ma. [PMID: 23873370]
  • Salvatore Modica, Raffaella M Gadaleta, Antonio Moschetta. Deciphering the nuclear bile acid receptor FXR paradigm. Nuclear receptor signaling. 2010 Nov; 8(?):e005. doi: 10.1621/nrs.08005. [PMID: 21383957]
  • Ju Hye Lee, Mutsumi Kishikawa, Motofumi Kumazoe, Koji Yamada, Hirofumi Tachibana. Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor. PloS one. 2010 Jun; 5(6):e11051. doi: 10.1371/journal.pone.0011051. [PMID: 20548792]
  • Pan Deng, Xiaoyan Chen, Yunbiao Tang, Yongqing Wang, Hongwen Zhang, Dafang Zhong. Determination of arotinoid acid in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Oct; 877(27):2983-8. doi: 10.1016/j.jchromb.2009.07.017. [PMID: 19632163]
  • Iria Nieto-Vazquez, Sonia Fernández-Veledo, Cristina de Alvaro, Margarita Lorenzo. Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. Diabetes. 2008 Dec; 57(12):3211-21. doi: 10.2337/db07-1062. [PMID: 18796617]
  • Shi-Ying Cai, Liangshi Xiong, Charles G Wray, Nazzareno Ballatori, James L Boyer. The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Sep; 293(3):R1400-9. doi: 10.1152/ajpregu.00781.2006. [PMID: 17567710]
  • Yuichi Inoue, Hiroharu Kawahara, Sanetaka Shirahata, Yasushi Sugimoto. Retinoic acid improves a hybridoma culture in a fructose-based medium by up-regulation of fructose incorporation via retinoid nuclear receptors. Bioscience, biotechnology, and biochemistry. 2006 Sep; 70(9):2248-53. doi: 10.1271/bbb.60178. [PMID: 16960373]
  • S Joshi, R Guleria, J Pan, D DiPette, U S Singh. Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene. 2006 Jan; 25(2):240-7. doi: 10.1038/sj.onc.1209027. [PMID: 16158052]
  • T D Brandebourg, C Y Hu. Regulation of differentiating pig preadipocytes by retinoic acid. Journal of animal science. 2005 Jan; 83(1):98-107. doi: 10.2527/2005.83198x. [PMID: 15583048]
  • Walter Royal, Michelle Leander, Yuqing E Chen, Eugene O Major, Reid P Bissonnette. Nuclear receptor activation and interaction with morphine. Journal of neuroimmunology. 2004 Dec; 157(1-2):61-5. doi: 10.1016/j.jneuroim.2004.08.023. [PMID: 15579281]
  • Akira Abe, Heather K Poucher, Miki Hiraoka, James A Shayman. Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells. Journal of lipid research. 2004 Apr; 45(4):667-73. doi: 10.1194/jlr.m300342-jlr200. [PMID: 14754907]
  • Karine Hellemans, Krista Rombouts, Erik Quartier, Andrea S Dittié, Andreas Knorr, Liliane Michalik, Vera Rogiers, Frans Schuit, Walter Wahli, Andrea Geerts. PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. Journal of lipid research. 2003 Feb; 44(2):280-95. doi: 10.1194/jlr.m200376-jlr200. [PMID: 12576510]
  • Roberto Montesano, Priscilla Soulié. Retinoids induce lumen morphogenesis in mammary epithelial cells. Journal of cell science. 2002 Dec; 115(Pt 23):4419-31. doi: 10.1242/jcs.00164. [PMID: 12414989]
  • D Alsop, S Brown, G Van Der Kraak. Development of a retinoic acid receptor-binding assay with rainbow trout tissue: characterization of retinoic acid binding, receptor tissue distribution, and developmental changes. General and comparative endocrinology. 2001 Sep; 123(3):254-67. doi: 10.1006/gcen.2001.7659. [PMID: 11589627]
  • L A Hammond, C H Van Krinks, J Durham, S E Tomkins, R D Burnett, E L Jones, R A Chandraratna, G Brown. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. British journal of cancer. 2001 Aug; 85(3):453-62. doi: 10.1054/bjoc.2001.1939. [PMID: 11487280]
  • R Pakala, C R Benedict. RAR gamma agonists inhibit proliferation of vascular smooth muscle cells. Journal of cardiovascular pharmacology. 2000 Feb; 35(2):302-8. doi: 10.1097/00005344-200002000-00019. [PMID: 10672865]
  • N Vu-Dac, P Gervois, I P Torra, J C Fruchart, V Kosykh, T Kooistra, H M Princen, J Dallongeville, B Staels. Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids. The Journal of clinical investigation. 1998 Aug; 102(3):625-32. doi: 10.1172/jci1581. [PMID: 9691099]
  • T Sun, Y Zhao, D J Mangelsdorf, E R Simpson. Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells. Endocrinology. 1998 Apr; 139(4):1684-91. doi: 10.1210/endo.139.4.5959. [PMID: 9528950]
  • A Kaptein, D M Neele, J Twisk, H F Hendriks, T Kooistra, H M Princen. Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: involvement of retinoic acid and retinoid X receptors. Journal of lipid research. 1997 Nov; 38(11):2273-80. doi: 10.1016/s0022-2275(20)34941-5. [PMID: 9392425]
  • J Corbeil, E Rapaport, D D Richman, D J Looney. Antiproliferative effect of retinoid compounds on Kaposi's sarcoma cells. The Journal of clinical investigation. 1994 May; 93(5):1981-6. doi: 10.1172/jci117190. [PMID: 8182129]
  • T M elAttar, H S Lin. In vitro inhibition of prostaglandin biosynthesis in squamous cell carcinoma by retinoids. Eicosanoids. 1990; 3(2):95-8. doi: . [PMID: 2144980]
  • H J Egger, U B Ranalder, E U Koelle, M Klaus. Determination of the new aromatic retinoic acid Ro 13-7410 in plasma by two-dimensional gas chromatography negative ion chemical ionization mass spectrometry with selected-ion monitoring. Biomedical & environmental mass spectrometry. 1989 Jul; 18(7):453-63. doi: 10.1002/bms.1200180703. [PMID: 2775901]
  • W B Howard, C C Willhite, R P Sharma, S T Omaye, A Hatori. Pharmacokinetics, tissue distribution and placental permeability of tetrahydro-tetramethyl-naphthalenyl-propenyl benzoic acid (a retinoidal benzoic acid derivative) in hamsters. European journal of drug metabolism and pharmacokinetics. 1989 Apr; 14(2):153-9. doi: 10.1007/bf03190856. [PMID: 2591420]
  • U M Ney, I J Ball, R P Hill, D Westmacott, D P Bloxham. Anti-inflammatory effects of synthetic retinoids may be related to their immunomodulatory action. Dermatologica. 1987; 175 Suppl 1(?):93-9. doi: 10.1159/000248865. [PMID: 3500881]