3-O-[3-O-(5-Cytidylyl)-5-cytidylyl]-5-cytidylic acid (BioDeep_00001058422)
代谢物信息卡片
化学式: C27H38N9O22P3 (933.1344198)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OC3C(OC(C3O)N4C=CC(=NC4=O)N)COP(=O)(O)OC5C(OC(C5O)N6C=CC(=NC6=O)N)COP(=O)(O)O)O)O
InChI: InChI=1S/C27H38N9O22P3/c28-13-1-4-34(25(41)31-13)22-17(38)16(37)10(54-22)7-52-60(47,48)58-21-12(56-24(19(21)40)36-6-3-15(30)33-27(36)43)9-53-61(49,50)57-20-11(8-51-59(44,45)46)55-23(18(20)39)35-5-2-14(29)32-26(35)42/h1-6,10-12,16-24,37-40H,7-9H2,(H,47,48)(H,49,50)(H2,28,31,41)(H2,29,32,42)(H2,30,33,43)(H2,44,45,46)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,22-,23-,24-/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Soo Jin Oh, Ok Sarah Shin. SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response.
Cells.
2021 03; 10(3):. doi:
10.3390/cells10030530
. [PMID: 33801464] - Mingshu Xiao, Arun Richard Chandrasekaran, Wei Ji, Fan Li, Tiantian Man, Changfeng Zhu, Xizhong Shen, Hao Pei, Qian Li, Li Li. Affinity-Modulated Molecular Beacons on MoS2 Nanosheets for MicroRNA Detection.
ACS applied materials & interfaces.
2018 Oct; 10(42):35794-35800. doi:
10.1021/acsami.8b14035
. [PMID: 30277380] - Jianqi Yang, Colleen M Croniger, Julie Lekstrom-Himes, Pu Zhang, Maris Fenyus, Daniel G Tenen, Gretchen J Darlington, Richard W Hanson. Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha.
The Journal of biological chemistry.
2005 Nov; 280(46):38689-99. doi:
10.1074/jbc.m503486200
. [PMID: 16166091] - Yukinobu Uchiyama, Junko Tagami, Shinji Kamisuki, Nobuyuki Kasai, Masahiko Oshige, Hiroyuki Chiku, Siroh Ibe, Osamu Koiwai, Fumio Sugawara, Kengo Sakaguchi. Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin.
Biochimica et biophysica acta.
2005 Oct; 1725(3):298-304. doi:
10.1016/j.bbagen.2005.06.017
. [PMID: 16099107] - Zhongjun Dong, Haiming Wei, Rui Sun, Zhiqing Hu, Bin Gao, Zhigang Tian. Involvement of natural killer cells in PolyI:C-induced liver injury.
Journal of hepatology.
2004 Dec; 41(6):966-73. doi:
10.1016/j.jhep.2004.08.021
. [PMID: 15582130] - Beata Kuśnierz-Cabala, Jerzy W Naskalski, Boguslaw Kedra, Józefa Panek. Comparison of sensitivity and specificity of serum poly-C avid ribonuclease activity and C-reactive protein concentration in detection of mild and severe acute pancreatitis.
Clinical chemistry and laboratory medicine.
2004 May; 42(5):549-55. doi:
10.1515/cclm.2004.093
. [PMID: 15202793] - Kazuya Koumoto, Mariko Umeda, Munenori Numata, Takahiro Matsumoto, Kazuo Sakurai, Toyoki Kunitake, Seiji Shinkai. Low Mw sulfated curdlan with improved water solubility forms macromolecular complexes with polycytidylic acid.
Carbohydrate research.
2004 Jan; 339(1):161-7. doi:
10.1016/j.carres.2003.09.022
. [PMID: 14659684] - Irini D Leimoni, Diamantis C Sideris, Emmanuel G Fragoulis. Purification from normal human plasma and biochemical characterization of a ribonuclease specific for poly(C) and poly(U).
Archives of biochemistry and biophysics.
2003 May; 413(1):83-90. doi:
10.1016/s0003-9861(03)00082-1
. [PMID: 12706344] - Yasuomi Yamasaki, Kazuya Sumimoto, Makiya Nishikawa, Fumiyoshi Yamashita, Kiyoshi Yamaoka, Mitsuru Hashida, Yoshinobu Takakura. Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: importance of molecular size and negative charge density for in vivo recognition by receptors.
The Journal of pharmacology and experimental therapeutics.
2002 May; 301(2):467-77. doi:
10.1124/jpet.301.2.467
. [PMID: 11961045] - J Li, L Fernandez, K C O'Connor, T Imanishi-Kari, B D Stollar. The rearranged V(H) domain of a physiologically selected anti-single-stranded DNA antibody as a precursor for formation of IgM and IgG antibodies to diverse antigens.
Journal of immunology (Baltimore, Md. : 1950).
2001 Oct; 167(7):3746-55. doi:
10.4049/jimmunol.167.7.3746
. [PMID: 11564791] - H Ide, Y W Kow, B X Chen, B F Erlanger, S S Wallace. Antibodies to oxidative DNA damage: characterization of antibodies to 8-oxopurines.
Cell biology and toxicology.
1997 Oct; 13(6):405-17. doi:
10.1023/a:1007467726635
. [PMID: 9352119] - M Fujiwara, J D Baldeschwieler, R H Grubbs. Receptor-mediated endocytosis of poly(acrylic acid)-conjugated liposomes by macrophages.
Biochimica et biophysica acta.
1996 Jan; 1278(1):59-67. doi:
10.1016/0005-2736(95)00183-2
. [PMID: 8611608] - E Fernández, M J Fallon, M L Frazier, R de Llorens, C M Cuchillo. Expression of acinar and ductal products in Capan-1 cells growing in synthetic serum and serum-free media.
Cancer.
1994 May; 73(9):2285-95. doi:
10.1002/1097-0142(19940501)73:9<2285::aid-cncr2820730909>3.0.co;2-m
. [PMID: 7513248] - E Rieder, T Bunch, F Brown, P W Mason. Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice.
Journal of virology.
1993 Sep; 67(9):5139-45. doi:
10.1128/jvi.67.9.5139-5145.1993
. [PMID: 8394441] - S K Datta, J J Trentin. Genetic resistance to lymphoma-leukemia: role of natural killer cells in the rejection of lymphoma grafts.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
1993; 47(10):451-6. doi:
10.1016/0753-3322(93)90342-i
. [PMID: 8061245] - K Maruoka, M Yamanaka, M Misago, K Nakata, J Tsukada, K Nagata, T Sato, N Mori, S Oda, S Chiba. [Clinical significance of determination of serum RNase activities in patients with eosinophilia--II. Measurements using polyuridylic acid and polycytidylic acid as substrates].
Rinsho byori. The Japanese journal of clinical pathology.
1990 Oct; 38(10):1161-6. doi:
NULL
. [PMID: 2262974] - K Ohgi, A Sanda, Y Takizawa, M Irie. Purification of acid ribonucleases from bovine spleen.
Journal of biochemistry.
1988 Feb; 103(2):267-73. doi:
10.1093/oxfordjournals.jbchem.a122259
. [PMID: 3131316] - S S Grigorian, F I Ershov, A M Poverennyĭ, G A Popov, V K Podgorodnichenko. [Characteristics of interferon production from the enteral administration of inducers].
Voprosy virusologii.
1988 Jan; 33(1):67-70. doi:
NULL
. [PMID: 2453100] - S S Grigorian, F I Ershov, A M Poverennyĭ, V K Podgorodnichenko, G A Popov. [Interferon-inducing activity of liposome-incorporated double-stranded polynucleotides and the means for its enhancement].
Voprosy virusologii.
1987 May; 32(3):352-7. doi:
NULL
. [PMID: 2445111] - M Francesconi, S Meryn. Estimation of poly (C) avid serum ribonuclease in hepatoma patients.
Cancer detection and prevention.
1987; 10(5-6):379-81. doi:
NULL
. [PMID: 3032438] - L J Krueger, P J Andryuk, M J Borigini. Nucleic acid hybridization in plasma: method for the quantitation of poly(I).poly(C12, U) in plasma of cancer patients.
Journal of biological response modifiers.
1986 Dec; 5(6):539-47. doi:
NULL
. [PMID: 3794757] - S S Grigorian, F I Ershov, V K Podgorodnichenko, G A Popov, A M Poverennyĭ. [Interferon induction via peroral administration of high-molecular polynucleotides].
Voprosy virusologii.
1986 May; 31(3):338-42. doi:
NULL
. [PMID: 2429452] - K Jung. An optimized micromethod for determining the catalytic activity of serum ribonuclease.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1986 Apr; 24(4):243-50. doi:
10.1515/cclm.1986.24.4.243
. [PMID: 3701275] - E J Mellor, F Brown, T J Harris. Analysis of the secondary structure of the poly(C) tract in foot-and-mouth disease virus RNAs.
The Journal of general virology.
1985 Sep; 66 ( Pt 9)(?):1919-29. doi:
10.1099/0022-1317-66-9-1919
. [PMID: 2993483] - S Sakakibara, N Namba, K Shiomi, H Kagamiyama. Intensification of galactosamine hepatotoxicity by polyriboinosinic acid-polyribocytidylic acid.
Life sciences.
1985 Feb; 36(8):705-12. doi:
10.1016/0024-3205(85)90189-4
. [PMID: 3974407] - P F Torrence, E De Clercq. Preparation and biological properties of a highly active poly(G) X poly(C) inducer of interferon.
Antiviral research.
1984 Dec; 4(6):339-50. doi:
10.1016/0166-3542(84)90005-6
. [PMID: 6085233] - M P Kung, Y K Ho, D Lalka, T J Bardos. Plasma clearance and tissue distribution of partially thiolated polycytidylic acid and its degradation products in rodents.
Cancer research.
1984 Oct; 44(10):4602-6. doi:
NULL
. [PMID: 6467215] - G Delage, E Nahon, T Huynh, J Jeusset, F Lacour. A monoclonal antibody to the double-stranded polyribonucleotide complex poly(A) X poly(U).
Molecular immunology.
1984 Oct; 21(10):939-44. doi:
10.1016/0161-5890(84)90150-0
. [PMID: 6504052] - M P Costa Giomi, I E Bergmann, E A Scodeller, P Augé de Mello, I Gomez, J L La Torre. Heterogeneity of the polyribocytidylic acid tract in aphthovirus: biochemical and biological studies of viruses carrying polyribocytidylic acid tracts of different lengths.
Journal of virology.
1984 Sep; 51(3):799-805. doi:
10.1128/jvi.51.3.799-805.1984
. [PMID: 6088803] - S Honda, M Komori, M Soda, J Kabashima, S Funatsu, H Fukushima, F Akash, Y Tanaka, N Nakamura, K Makiyama. [The nature and clinical significance of human serum ribonuclease measured by using synthetic substrate].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
1984 Jul; 81(7):1598-606. doi:
NULL
. [PMID: 6492456] - L M Vil'ner, V A Lashkevich, N S Tikhomirova-Sidorova, E M Kogan, A L Timkovskiĭ. [Combined antiviral effect of synthetic polyribonucleotide interferonogens and specific antiviral antibodies in arbovirus infections].
Voprosy virusologii.
1984 May; 29(3):334-7. doi:
NULL
. [PMID: 6464427] - V K Podgorodnichenko, A M Poverennyĭ, D B Dzhumaev, S A Auelbekov, Kh A Aslanov. [DNA-binding proteins in human serum].
Voprosy meditsinskoi khimii.
1982 Sep; 28(5):63-7. doi:
NULL
. [PMID: 7179836] - Y K Ho, E Mayhew, H D Preisler, T J Bardos. Effects of partially thiolated polycytidylic acid and liposomes on in vitro colony-forming cells of leukemic mice.
Cancer research.
1982 May; 42(5):1740-3. doi:
NULL
. [PMID: 7066895] - L M Vil'ner, V A Lashkevich. [Effect of amphotericin B on the activity of synthetic polyribonucleotide interferon inducers].
Voprosy virusologii.
1982 Mar; 27(2):166-9. doi:
NULL
. [PMID: 6178217] - E Nahon, J F Delfraissy, M F Kahn, J Jeusset, P Galanaud, F Lacour. Anti-poly(G) . poly(C) antibodies in the serum of patients with systemic lupus erythematosus.
Clinical immunology and immunopathology.
1982 Mar; 22(3):349-62. doi:
10.1016/0090-1229(82)90052-6
. [PMID: 7105496] - E Z Rabin, B Tattrie. The isolation, purification, and properties of a ribonuclease (Mr 18 000) from human uremic serum, and its relation to the human urinary ribonuclease (Mr 33 000). II. Properties of the enzymes.
Biochimica et biophysica acta.
1982 Feb; 701(1):132-7. doi:
10.1016/0167-4838(82)90321-1
. [PMID: 7055583] - N Hölbling, J Funovics, J Euler, J Karner, G Zöch, G Sauermann. [The value of poly-C-specific serum ribonuclease and CEA in the diagnosis of pancreatic carcinoma (author's transl)].
Klinische Wochenschrift.
1981 Nov; 59(21):1201-7. doi:
10.1007/bf01721215
. [PMID: 7311390] - F I Ershov, A N Fomina, V F Krylov, N P Obrosova-Serova, S S Grigorian. [Trial of polyguacyl safety and tolerance].
Voprosy virusologii.
1981 Jul; ?(4):418-23. doi:
NULL
. [PMID: 6272492] - M Francesconi, S Meryn, K Moser, K Bauer. Evidence of age-dependent activity increase of poly(C)-avid-serum ribonuclease in man.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1981 Jan; 19(1):17-20. doi:
10.1515/cclm.1981.19.1.17
. [PMID: 7205154] - J W Cranston, F Perini, E R Crisp, C V Hixson. Purification and properties of ribonucleases from human urine.
Biochimica et biophysica acta.
1980 Dec; 616(2):239-58. doi:
10.1016/0005-2744(80)90142-4
. [PMID: 7213638] - N Stebbing, I J Lindley. Anti-viral effects of single-stranded polynucleotides against avirulent Semliki Forest virus infection of mice and avirulent infection of rats with encephalomyocarditis virus.
Archives of virology.
1980; 64(1):57-66. doi:
10.1007/bf01317391
. [PMID: 6246856] - M J Grubman, H L Bachrach. Isolation of foot-and-mouth disease virus messenger RNA from membrane-bound polyribosomes and characterization of its 5' and 3' termini.
Virology.
1979 Oct; 98(2):466-70. doi:
10.1016/0042-6822(79)90570-1
. [PMID: 228483] - Y K Ho, H D Preisler, T J Bardos. Effects of partially thiolated polycytidylic acid on the clonogenicity of murine leukemic stem cells.
Cancer research.
1979 Aug; 39(8):3163-6. doi:
NULL
. [PMID: 287552] - H Ikehara, D Yoshikawa, K Ishikawa, F Tamada, S Baba. [An establishment of assay for serum ribonuclease activity and its clinical significance (author's transl)].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
1979 May; 76(5):1129-34. doi:
NULL
. [PMID: 459142] - L M Vil'ner, A L Timkovskiĭ, E M Kogan, N G Naumovich, L M Brodskaia. [Hydrolysis and the inactivation of double-stranded polyribonucleotides by monkey blood serum].
Voprosy virusologii.
1979 Mar; ?(2):181-5. doi:
NULL
. [PMID: 107655] - L Cebecauer, J Rovenský, J Doskocil, J Pekárek, L Borecký, D Zitńan. Effect of different polyribonucleotides on the induction of antibodies to DNA and RNA and serum complement level in mice.
Acta biologica et medica Germanica.
1979; 38(5-6):843-6. doi:
NULL
. [PMID: 525155] - S V Skurkovich, N A Arkhipova, N V Olshanskaya, E I Eremkina, M A Krokhina, E G Klinova, L A Kolpikova, N S Sidorova, E M Kogan, N S Naumovich, S E Bresler, A L Timkovski, R I Salganik, A I Zakabunin, L A Makhonova, S A Majakova, E V Leschynskaya. Interferon-containing plasma: the preparation for treatment of viral infections.
Biomedicine / [publiee pour l'A.A.I.C.I.G.].
1978 Nov; 29(7):227-8. doi:
NULL
. [PMID: 747728] - K Akagi, M Yamanaka, K Murai, Y Niho, T Omae. Serum acid ribonuclease in myelogenous leukemia.
Cancer research.
1978 Jul; 38(7):2168-73. doi:
NULL
. [PMID: 26465] - O A Aksenov, S E Bresler, A I Zakabunin, E M Kogan, V K Raĭt. [Laboratory and clinical study of biological activity of poly G-poly C complex].
Voprosy virusologii.
1978 Jul; ?(4):466-70. doi:
NULL
. [PMID: 749342] - K Akagi, M Yamanaka, K Murai, T Omae. Purification and properties of acid ribonucleases in human serum and leukocytes.
Cancer research.
1978 Jul; 38(7):2163-7. doi:
NULL
. [PMID: 26464] - A Funakoshi, M Matsumoto, H Wakasugi, H Ibayashi. [Diagnostic significance of serum ribonuclease determination in the pancreatic cancer (author's transl)].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
1978 Jan; 75(1):59-63. doi:
NULL
. [PMID: 642218] - Y Kitagawa, T Matsumoto, E Okuhara, E Shikata. Immunogenicity of rice dwarf virus-ribonucleic acid.
The Tohoku journal of experimental medicine.
1977 Aug; 122(4):337-43. doi:
10.1620/tjem.122.337
. [PMID: 918970] - E Z Rabin, S L Jindal, G A Posen, B Tattrie, D Algom, D A Roncari, M Freedman, E F Saunders. Ribonuclease activity in renal failure: evidence for toxicity.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association.
1977; 14(?):528-34. doi:
NULL
. [PMID: 341143] - K K Reddi. Purification and properties of a ribonuclease in human urine that hydrolyses polycytidylic acid.
Preparative biochemistry.
1977; 7(3-4):283-99. doi:
10.1080/00327487708061644
. [PMID: 20615] - L M Brodskaia, L M Vil'ner. [Comparative antiviral and interferonogenic activity of synthetic polyribonucleotide complexes of poly(I).poly(C) and poly(G).poly(C) in different cell systems].
Voprosy virusologii.
1976 Nov; ?(6):685-9. doi:
NULL
. [PMID: 1035996] - E de Clercq, P F Torrence, T Fukui, M Ikehara. Role of purine N-3 in the biologic activities of poly(A) and poly(I).
Nucleic acids research.
1976 Jun; 3(6):1591-601. doi:
10.1093/nar/3.6.1591
. [PMID: 60741] - F M Hallinan, N Maclean. DNA polymerase activity in plasma from leukaemic guinea-pigs.
British journal of cancer.
1976 Apr; 33(4):419-26. doi:
10.1038/bjc.1976.67
. [PMID: 57790] - E De Clercq, P F Torrence, B Witkop. Polynucleotide displacement reactions: detection by interferon induction.
Biochemistry.
1976 Feb; 15(4):717-24. doi:
10.1021/bi00649a001
. [PMID: 942856] - W F Geber, S S Lefkowitz, C Y Hung. Action of naloxone on the interferon-lowering activity of morphine in the mouse.
Pharmacology.
1976; 14(4):322-9. doi:
10.1159/000136611
. [PMID: 935246] - N N Aronson, A Yannarell. Effects of membrane ribonuclease and 3'-nucleotidase on the digestion of polyuridylic acid by rat liver plasma membrane.
Biochimica et biophysica acta.
1975 Nov; 413(1):135-42. doi:
10.1016/0005-2736(75)90064-4
. [PMID: 89] - W P Drake, M Schmukler, W J Pendergrast, A S Davis, J L Lichtenfeld, M R Mardiney. Abnormal profile of human nucleolytic activity as a test for cancer.
Journal of the National Cancer Institute.
1975 Nov; 55(5):1055-9. doi:
10.1093/jnci/55.5.1055
. [PMID: 1206731] - E Z Rabin, V Weinberger. The isolation, purification, and properties of a ribonuclease from normal human urine.
Biochemical medicine.
1975 Sep; 14(1):1-11. doi:
10.1016/0006-2944(75)90014-9
. [PMID: 2164] - J L Bear, H B Gray, L Rainen, I M Chang, R Howard, G Serio, A P Kimball. Interaction of Rhodium(II) carboxylates with molecules of biologic importance.
Cancer chemotherapy reports.
1975 May; 59(3):611-20. doi:
NULL
. [PMID: 1106839]