Na-CPT (BioDeep_00000001050)

   

PANOMIX_OTCML-2023


代谢物信息卡片


INDOLIZINO(1,2-B)QUINOLINE-7-ACETIC ACID, .ALPHA.-ETHYL-9,11-DIHYDRO-.ALPHA.-HYDROXY-8-(HYDROXYMETHYL)-9-OXO-, SODIUM SALT (1:1), (.ALPHA.S)-

化学式: C20H17N2NaO5 (388.1035112)
中文名称: 喜树碱钠盐, 喜树碱钠
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 14.58%

分子结构信息

SMILES: CCC(C1=C(C(=O)N2CC3=CC4=CC=CC=C4N=C3C2=C1)CO)(C(=O)[O-])O.[Na+]
InChI: /q

描述信息

Camptothecin Sodium is the sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The sodium salt of camptothecin is more water-soluble than the parent molecule. (NCI04)
Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA[1][2].

同义名列表

13 个代谢物同义名

INDOLIZINO(1,2-B)QUINOLINE-7-ACETIC ACID, .ALPHA.-ETHYL-9,11-DIHYDRO-.ALPHA.-HYDROXY-8-(HYDROXYMETHYL)-9-OXO-, SODIUM SALT (1:1), (.ALPHA.S)-; INDOLIZINO(1,2-B)QUINOLINE-7-ACETIC ACID, .ALPHA.-ETHYL-9,11-DIHYDRO-.ALPHA.-HYDROXY-8-(HYDROXYMETHYL)-9-OXO-, MONOSODIUM SALT, (.ALPHA.S)-; INDOLIZINO(1,2-B)QUINOLINE-7-ACETIC ACID, .ALPHA.-ETHYL-9,11-DIHYDRO-.ALPHA.-HYDROXY-8-(HYDROXYMETHYL)-9-OXO-, MONOSODIUM SALT, (S)-; sodium (S)-2-hydroxy-2-(8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)butanoate; sodium (2S)-2-hydroxy-2-[8-(hydroxymethyl)-9-oxo-9H,11H-indolizino[1,2-b]quinolin-7-yl]butanoate; sodium;(2S)-2-hydroxy-2-[8-(hydroxymethyl)-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]butanoate; sodium camptothecin, AldrichCPR; 20(S)-Camptothecin sodium salt; SODIUM CAMPTOTHECINATE; Camptothecine sodium; Camptothecin sodium; Sodium Camptothecin; Na-CPT



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M E Wall, M C Wani, A W Nicholas, G Manikumar, C Tele, L Moore, A Truesdale, P Leitner, J M Besterman. Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. Journal of medicinal chemistry. 1993 Sep; 36(18):2689-700. doi: 10.1021/jm00070a013. [PMID: 8410981]
  • M C Wani, A W Nicholas, M E Wall. Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin. Journal of medicinal chemistry. 1987 Dec; 30(12):2317-9. doi: 10.1021/jm00395a024. [PMID: 3681902]
  • M E Wall, M C Wani, S M Natschke, A W Nicholas. Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity. Journal of medicinal chemistry. 1986 Aug; 29(8):1553-5. doi: 10.1021/jm00158a044. [PMID: 3735324]
  • M C Wani, P E Ronman, J T Lindley, M E Wall. Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. Journal of medicinal chemistry. 1980 May; 23(5):554-60. doi: 10.1021/jm00179a016. [PMID: 7381856]