Amrubicinol (BioDeep_00001049191)
代谢物信息卡片
化学式: C25H27NO9 (485.1685732000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1(CC(C2=C(C1)C(=C3C(=C2O)C(=O)C4=CC=CC=C4C3=O)O)OC5CC(C(CO5)O)O)N)O
InChI: InChI=1S/C25H27NO9/c1-10(27)25(26)7-13-18(16(8-25)35-17-6-14(28)15(29)9-34-17)24(33)20-19(23(13)32)21(30)11-4-2-3-5-12(11)22(20)31/h2-5,10,14-17,27-29,32-33H,6-9,26H2,1H3/t10?,14-,15+,16-,17-,25-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yoshinori Makino, Reiko Makihara-Ando, Takanori Ogawa, Hitoshi Sato, Yasushi Goto, Shintaro Kanda, Hidehito Horinouchi, Yutaka Fujiwara, Yuichiro Ohe, Noboru Yamamoto. Individual optimal dose of amrubicin to prevent severe neutropenia in Japanese patients with lung cancer.
Cancer science.
2019 Nov; 110(11):3573-3583. doi:
10.1111/cas.14194. [PMID: 31505087] - Yoshinori Makino, Michiko Watanabe, Reiko Ando Makihara, Hiroshi Nokihara, Noboru Yamamoto, Yuichiro Ohe, Erika Sugiyama, Hitoshi Sato, Yoshikazu Hayashi. Simultaneous optimization of limited sampling points for pharmacokinetic analysis of amrubicin and amrubicinol in cancer patients.
Asia-Pacific journal of clinical oncology.
2016 Sep; 12(3):259-64. doi:
10.1111/ajco.12485. [PMID: 26948073] - Nianhang Chen, Sant P Chawla, Elena Gabriela Chiorean, William L Read, Mayer Gorbaty, Alain C Mita, Lotus Yung, Peter Bryan, Richard McNally, Markus F Renschler, Sunil Sharma. Phase I study to assess the pharmacokinetics and the effect on cardiac repolarization of amrubicin and amrubicinol in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology.
2013 Apr; 71(4):1083-94. doi:
10.1007/s00280-013-2093-1. [PMID: 23400695] - Yoshinori Makino, Noboru Yamamoto, Hitoshi Sato, Reiko Ando, Yasushi Goto, Chiharu Tanai, Hajime Asahina, Hiroshi Nokihara, Ikuo Sekine, Hideo Kunitoh, Yuichiro Ohe, Erika Sugiyama, Nobuaki Yokote, Tomohide Tamura, Hiroshi Yamamoto. Pharmacokinetic and pharmacodynamic study on amrubicin and amrubicinol in Japanese patients with lung cancer.
Cancer chemotherapy and pharmacology.
2012 Apr; 69(4):861-9. doi:
10.1007/s00280-011-1768-8. [PMID: 22042514] - Yukiko Maeda, Akinobu Hamada, Emiko Sanematsu, Ji-ichro Sasaki, Koji Yokoo, Asumi Hira, Hideyuki Saito. Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats.
Cancer chemotherapy and pharmacology.
2010 Apr; 65(5):953-9. doi:
10.1007/s00280-009-1102-x. [PMID: 19697031] - Reiko Ando, Yoshinori Makino, Tomohide Tamura, Noboru Yamamoto, Rena Nishigaki, Takehiro Kimura, Nobuaki Yokote, Hiroshi Yamamoto. Simple and sensitive HPLC method for determination of amrubicin and amrubicinol in human plasma: application to a clinical pharmacokinetic study.
Biomedical chromatography : BMC.
2010 Mar; 24(3):301-6. doi:
10.1002/bmc.1289. [PMID: 19634123] - Machiko Ohsawa, Mutsuko Demizu, Satomi Chihara, Hiroshi Ueda, Tsutomu Igarashi, Naoki Tomiyama, Yuko Nakashima, Keita Hosoi, Kyonyobi Min. [Pharmacokinetic study of amrubicin in a case of small lung cancer on hemodialysis].
Gan to kagaku ryoho. Cancer & chemotherapy.
2009 Aug; 36(8):1311-4. doi:
NULL. [PMID: 19692770] - Tatsuo Kimura, Shinzoh Kudoh, Shigeki Mitsuoka, Naruo Yoshimura, Hidenori Tanaka, Kazuhisa Asai, Shigenori Kyoh, Yoshihiro Tochino, Kanako Umekawa, Kazuto Hirata. Plasma concentration of amrubicinol in plateau phase in patients treated for 3 days with amrubicin is correlated with hematological toxicities.
Anti-cancer drugs.
2009 Jul; 20(6):513-8. doi:
10.1097/cad.0b013e32832b0585. [PMID: 19352172] - Isamu Okamoto, Akinobu Hamada, Yusuke Matsunaga, Ji-ichiro Sasaki, Shinji Fujii, Hideshi Uramoto, Haruhiko Yamagata, Ichiro Mori, Hiroto Kishi, Hiroshi Semba, Hideyuki Saito. Phase I and pharmacokinetic study of amrubicin, a synthetic 9-aminoanthracycline, in patients with refractory or relapsed lung cancer.
Cancer chemotherapy and pharmacology.
2006 Feb; 57(3):282-8. doi:
10.1007/s00280-005-0051-2. [PMID: 16028099] - Yusuke Matsunaga, Akinobu Hamada, Isamu Okamoto, Ji-ichiro Sasaki, Eiji Moriyama, Hiroto Kishi, Mitsuhiro Matsumoto, Asumi Hira, Hiroshi Watanabe, Hideyuki Saito. Pharmacokinetics of amrubicin and its active metabolite amrubicinol in lung cancer patients.
Therapeutic drug monitoring.
2006 Feb; 28(1):76-82. doi:
10.1097/01.ftd.0000185771.82620.ee. [PMID: 16418698] - T Yamaoka, M Hanada, S Ichii, S Morisada, T Noguchi, Y Yanagi. Cytotoxicity of amrubicin, a novel 9-aminoanthracycline, and its active metabolite amrubicinol on human tumor cells.
Japanese journal of cancer research : Gann.
1998 Oct; 89(10):1067-73. doi:
10.1111/j.1349-7006.1998.tb00498.x. [PMID: 9849587] - J Avruch, G R Leone, D B Martin. Effects of epinephrine and insulin on phosphopeptide metabolism in adipocytes.
The Journal of biological chemistry.
1976 Mar; 251(5):1511-5. doi:
NULL. [PMID: 176155]