Monosialoganglioside-GM1 (BioDeep_00001045320)
代谢物信息卡片
Monosialoganglioside-GM1
化学式: C57H99N3O31 (1321.6262224)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCC=CC(C(COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)O)O)NC(=O)C)OC5(CC(C(C(O5)C(C(CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)NC(=O)C)O
InChI: InChI=1S/C57H99N3O31/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-30(69)29(58-26(2)66)25-82-53-45(78)43(76)47(35(23-64)85-53)87-55-46(79)51(91-57(56(80)81)19-31(70)37(59-27(3)67)50(90-57)39(72)32(71)20-61)48(36(24-65)86-55)88-52-38(60-28(4)68)49(41(74)34(22-63)83-52)89-54-44(77)42(75)40(73)33(21-62)84-54/h17-18,29-55,61-65,69-79H,5-16,19-25H2,1-4H3,(H,58,66)(H,59,67)(H,60,68)(H,80,81)/b18-17+/t29-,30+,31-,32+,33+,34+,35+,36+,37+,38+,39+,40-,41-,42-,43+,44+,45+,46+,47+,48-,49+,50+,51+,52-,53+,54-,55-,57-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Thierry Mallevaey, Andrew J Clarke, James P Scott-Browne, Mary H Young, Laila C Roisman, Daniel G Pellicci, Onisha Patel, Julian P Vivian, Jennifer L Matsuda, James McCluskey, Dale I Godfrey, Philippa Marrack, Jamie Rossjohn, Laurent Gapin. A molecular basis for NKT cell recognition of CD1d-self-antigen.
Immunity.
2011 Mar; 34(3):315-26. doi:
10.1016/j.immuni.2011.01.013. [PMID: 21376640] - Ricard Rojas-Garcia, Eduard Gallardo, Noemi De Luna, Candido Juarez, Eugenia Martinez-Hernandez, Alejandra Carvajal, Carlos Casasnovas, Eva Fages, Pablo Davila-González, Isabel Illa. Bulbar involvement in patients with antiganglioside antibodies against NeuNAc(alpha2-3)Gal.
Journal of neurology, neurosurgery, and psychiatry.
2010 Jun; 81(6):623-8. doi:
10.1136/jnnp.2009.183517. [PMID: 19726412] - Ricardo D Lardone, Nobuhiro Yuki, Masaaki Odaka, Jose L Daniotti, Fernando J Irazoqui, Gustavo A Nores. Anti-GM1 IgG antibodies in Guillain-Barré syndrome: fine specificity is associated with disease severity.
Journal of neurology, neurosurgery, and psychiatry.
2010 Jun; 81(6):629-33. doi:
10.1136/jnnp.2009.183665. [PMID: 19965859] - S Attarian, J Boucraut, A M Hubert, D Uzenot, E Delmont, A Verschueren, J Franques, J P Azulay, J Pouget. Chronic ataxic neuropathies associated with anti-GD1b IgM antibodies: response to IVIg therapy.
Journal of neurology, neurosurgery, and psychiatry.
2010 Jan; 81(1):61-4. doi:
10.1136/jnnp.2009.185736. [PMID: 19726417] - K Kaida, M Kanzaki, D Morita, K Kamakura, K Motoyoshi, M Hirakawa, S Kusunoki. Anti-ganglioside complex antibodies in Miller Fisher syndrome.
Journal of neurology, neurosurgery, and psychiatry.
2006 Sep; 77(9):1043-6. doi:
10.1136/jnnp.2006.087940. [PMID: 16614007] - Jennifer L Kanter, Sirisha Narayana, Peggy P Ho, Ingrid Catz, Kenneth G Warren, Raymond A Sobel, Lawrence Steinman, William H Robinson. Lipid microarrays identify key mediators of autoimmune brain inflammation.
Nature medicine.
2006 Jan; 12(1):138-43. doi:
10.1038/nm1344. [PMID: 16341241] - Seigo Usuki, Juan Sanchez, Toshio Ariga, Iku Utsunomiya, Kyoji Taguchi, Michael H Rivner, Robert K Yu. AIDP and CIDP having specific antibodies to the carbohydrate epitope (-NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glc-) of gangliosides.
Journal of the neurological sciences.
2005 May; 232(1-2):37-44. doi:
10.1016/j.jns.2005.01.007. [PMID: 15850580] - Minako Hirakawa, Daiji Morita, Shoji Tsuji, Susumu Kusunoki. Effects of phospholipids on antiganglioside antibody reactivity in GBS.
Journal of neuroimmunology.
2005 Feb; 159(1-2):129-32. doi:
10.1016/j.jneuroim.2004.09.018. [PMID: 15652411] - Ken-ichi Kaida, Daiji Morita, Mami Kanzaki, Keiko Kamakura, Kazuo Motoyoshi, Minako Hirakawa, Susumu Kusunoki. Ganglioside complexes as new target antigens in Guillain-Barré syndrome.
Annals of neurology.
2004 Oct; 56(4):567-71. doi:
10.1002/ana.20222. [PMID: 15389898] - R Press, S Matá, F Lolli, J Zhu, T Andersson, H Link. Temporal profile of anti-ganglioside antibodies and their relation to clinical parameters and treatment in Guillain-Barré syndrome.
Journal of the neurological sciences.
2001 Sep; 190(1-2):41-7. doi:
10.1016/s0022-510x(01)00580-9. [PMID: 11574105] - N Ortiz, R Rosa, E Gallardo, I Illa, J Tomas, J Aubry, M Sabater, M Santafé. IgM monoclonal antibody against terminal moiety of GM2, GalNAc-GD1a and GalNAc-GM1b from a pure motor chronic demyelinating polyneuropathy patient: effects on neurotransmitter release.
Journal of neuroimmunology.
2001 Sep; 119(1):114-23. doi:
10.1016/s0165-5728(01)00373-3. [PMID: 11525808] - B Cavanna, H Jiang, S Allaria, M Carpo, G Scarlato, E Nobile-Orazio. Anti-GM(2) IgM antibody-induced complement-mediated cytotoxicity in patients with dysimmune neuropathies.
Journal of neuroimmunology.
2001 Mar; 114(1-2):226-31. doi:
10.1016/s0165-5728(00)00461-6. [PMID: 11240036] - C W Ang, B C Jacobs, A H Brandenburg, J D Laman, F G van der Meché, A D Osterhaus, P A van Doorn. Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barré syndrome.
Neurology.
2000 Apr; 54(7):1453-8. doi:
10.1212/wnl.54.7.1453. [PMID: 10751257] - N Yuki, Y Tagawa, F Irie, Y Hirabayashi, S Handa. Close association of Guillain-Barré syndrome with antibodies to minor monosialogangliosides GM1b and GM1 alpha.
Journal of neuroimmunology.
1997 Apr; 74(1-2):30-4. doi:
10.1016/s0165-5728(96)00201-9. [PMID: 9119976] - N A Gregson, J H Rees, R A Hughes. Reactivity of serum IgG anti-GM1 ganglioside antibodies with the lipopolysaccharide fractions of Campylobacter jejuni isolates from patients with Guillain-Barre syndrome (GBS).
Journal of neuroimmunology.
1997 Mar; 73(1-2):28-36. doi:
10.1016/s0165-5728(96)00162-2. [PMID: 9058756] - B C Jacobs, M P Hazenberg, P A van Doorn, H P Endtz, F G van der Meché. Cross-reactive antibodies against gangliosides and Campylobacter jejuni lipopolysaccharides in patients with Guillain-Barré or Miller Fisher syndrome.
The Journal of infectious diseases.
1997 Mar; 175(3):729-33. doi:
10.1093/infdis/175.3.729. [PMID: 9041356] - T W Ho, S T Hsieh, I Nachamkin, H J Willison, K Sheikh, J Kiehlbauch, K Flanigan, J C McArthur, D R Cornblath, G M McKhann, J W Griffin. Motor nerve terminal degeneration provides a potential mechanism for rapid recovery in acute motor axonal neuropathy after Campylobacter infection.
Neurology.
1997 Mar; 48(3):717-24. doi:
10.1212/wnl.48.3.717. [PMID: 9065554] - N Yuki, T Taki, S Handa. Antibody to GalNAc-GD1a and GalNAc-GM1b in Guillain-Barré syndrome subsequent to Campylobacter jejuni enteritis.
Journal of neuroimmunology.
1996 Dec; 71(1-2):155-61. doi:
10.1016/s0165-5728(96)00142-7. [PMID: 8982115] - B V Taylor, L Gross, A J Windebank. The sensitivity and specificity of anti-GM1 antibody testing.
Neurology.
1996 Oct; 47(4):951-5. doi:
10.1212/wnl.47.4.951. [PMID: 8857725] - G Adler, T Pacuszka, M Strugalska, I Targońska, M Panasiewicz, A Lewartowska. Anti-fucosyl-GM1 ganglioside IgG and IgM autoantibodies in human serum: no link to pathology.
Immunology letters.
1996 Sep; 52(2-3):89-93. doi:
10.1016/0165-2478(96)02589-8. [PMID: 8905401] - G Paterson, G Wilson, P G Kennedy, H J Willison. Analysis of anti-GM1 ganglioside IgM antibodies cloned from motor neuropathy patients demonstrates diverse V region gene usage with extensive somatic mutation.
Journal of immunology (Baltimore, Md. : 1950).
1995 Sep; 155(6):3049-59. doi:
NULL. [PMID: 7673721] - I Illa, N Ortiz, E Gallard, C Juarez, J M Grau, M C Dalakas. Acute axonal Guillain-Barré syndrome with IgG antibodies against motor axons following parenteral gangliosides.
Annals of neurology.
1995 Aug; 38(2):218-24. doi:
10.1002/ana.410380214. [PMID: 7654069] - I Wirguin, L Suturkova-Milosevic, P Della-Latta, T Fisher, R H Brown, N Latov. Monoclonal IgM antibodies to GM1 and asialo-GM1 in chronic neuropathies cross-react with Campylobacter jejuni lipopolysaccharides.
Annals of neurology.
1994 Jun; 35(6):698-703. doi:
10.1002/ana.410350610. [PMID: 8210226] - R K Mizutamari, H Wiegandt, G A Nores. Characterization of anti-ganglioside antibodies present in normal human plasma.
Journal of neuroimmunology.
1994 Mar; 50(2):215-20. doi:
10.1016/0165-5728(94)90048-5. [PMID: 8120143] - T Nakao, K Kon, S Ando, T Miyatake, N Yuki, Y T Li, S Furuya, Y Hirabayashi. Novel lacto-ganglio type gangliosides with GM2-epitope in bovine brain which react with IgM from a patient of the amyotrophic lateral sclerosis-like disorder.
The Journal of biological chemistry.
1993 Oct; 268(28):21028-34. doi:
10.1016/s0021-9258(19)36889-9. [PMID: 7691804] - H Yoshino, N Miyatani, M Saito, T Ariga, A Lugaresi, N Latov, Y Kushi, T Kasama, R K Yu. Isolated bovine spinal motoneurons have specific ganglioside antigens recognized by sera from patients with motor neuron disease and motor neuropathy.
Journal of neurochemistry.
1992 Nov; 59(5):1684-91. doi:
10.1111/j.1471-4159.1992.tb10999.x. [PMID: 1383424] - A B Younes-Chennoufi, J M Léger, J J Hauw, J L Preud'homme, P Bouche, P Aucouturier, H Ratinahirana, C Lubetzki, O Lyon-Caen, N Baumann. Ganglioside GD1b is the target antigen for a biclonal IgM in a case of sensory-motor axonal polyneuropathy: involvement of N-acetylneuraminic acid in the epitope.
Annals of neurology.
1992 Jul; 32(1):18-23. doi:
10.1002/ana.410320105. [PMID: 1379422] - F Li, A Pestronk. Autoantibodies to GM1 ganglioside: different reactivity to GM1-liposomes in amyotrophic lateral sclerosis and lower motor neuron disorders.
Journal of the neurological sciences.
1991 Aug; 104(2):209-14. doi:
10.1016/0022-510x(91)90312-u. [PMID: 1940974] - A Pestronk, V Chaudhry, E L Feldman, J W Griffin, D R Cornblath, E H Denys, M Glasberg, R W Kuncl, R K Olney, W C Yee. Lower motor neuron syndromes defined by patterns of weakness, nerve conduction abnormalities, and high titers of antiglycolipid antibodies.
Annals of neurology.
1990 Mar; 27(3):316-26. doi:
10.1002/ana.410270314. [PMID: 2327739] - F P Thomas, J E Thomas, S A Sadiq, L H van den Berg, R I Roelofs, N Latov, A P Hays. Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons.
Journal of neuropathology and experimental neurology.
1990 Mar; 49(2):89-95. doi:
10.1097/00005072-199003000-00001. [PMID: 1689771] - H Baba, G C Daune, A A Ilyas, A Pestronk, D R Cornblath, V Chaudhry, J W Griffin, R H Quarles. Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy.
Journal of neuroimmunology.
1989 Dec; 25(2-3):143-50. doi:
10.1016/0165-5728(89)90131-8. [PMID: 2584393] - M E Shy, V A Evans, F D Lublin, R L Knobler, T Heiman-Patterson, A J Tahmoush, G Parry, P Schick, T G DeRyk. Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasia.
Annals of neurology.
1989 May; 25(5):511-3. doi:
10.1002/ana.410250517. [PMID: 2505666] - A A Ilyas, H J Willison, R H Quarles, F B Jungalwala, D R Cornblath, B D Trapp, D E Griffin, J W Griffin, G M McKhann. Serum antibodies to gangliosides in Guillain-Barré syndrome.
Annals of neurology.
1988 May; 23(5):440-7. doi:
10.1002/ana.410230503. [PMID: 3133978]
