N-(aminosulfonyl)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]propanimidamide hydrochloride (BioDeep_00001045218)
代谢物信息卡片
N-(aminosulfonyl)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]propanimidamide hydrochloride
化学式: C8H16ClN7O2S3 (373.02161060000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [H+].C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N.[Cl-]
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
同义名列表
相关代谢途径
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Rajalakshmi Munusamy, Sangeetha Shanmugasundharam. Improved gastric residence time of famotidine by raft-forming drug delivery system using DOE.
International journal of immunopathology and pharmacology.
2024 Jan; 38(?):3946320241249429. doi:
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The Science of the total environment.
2023 Nov; 900(?):165886. doi:
10.1016/j.scitotenv.2023.165886. [PMID: 37524191] - Mona F Mahmoud, Walied Abdo, Mohamed Nabil, Badreddine Drissi, Assem M El-Shazly, Mohamed A O Abdelfattah, Mansour Sobeh. Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 160(?):114331. doi:
10.1016/j.biopha.2023.114331. [PMID: 36736281] - Ahmed A Ishola, Tanuja Joshi, Suliat I Abdulai, Habibu Tijjani, Hemlata Pundir, Subhash Chandra. Molecular basis for the repurposing of histamine H2-receptor antagonist to treat COVID-19.
Journal of biomolecular structure & dynamics.
2022 08; 40(13):5785-5802. doi:
10.1080/07391102.2021.1873191. [PMID: 33491579] - Huan Yang, Sam J George, Dane A Thompson, Harold A Silverman, Téa Tsaava, Aisling Tynan, Valentin A Pavlov, Eric H Chang, Ulf Andersson, Michael Brines, Sangeeta S Chavan, Kevin J Tracey. Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm.
Molecular medicine (Cambridge, Mass.).
2022 05; 28(1):57. doi:
10.1186/s10020-022-00483-8. [PMID: 35578169] - Christina M Brennan, Sandeep Nadella, Xiang Zhao, Richard J Dima, Nicole Jordan-Martin, Breanna R Demestichas, Sam O Kleeman, Miriam Ferrer, Eva Carlotta von Gablenz, Nicholas Mourikis, Michael E Rubin, Harsha Adnani, Hassal Lee, Taehoon Ha, Soma Prum, Cheryl B Schleicher, Sharon S Fox, Michael G Ryan, Christina Pili, Gary Goldberg, James M Crawford, Sara Goodwin, Xiaoyue Zhang, Jonathan B Preall, Ana S H Costa, Joseph Conigliaro, Joseph R Masci, Jie Yang, David A Tuveson, Kevin J Tracey, Tobias Janowitz. Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial.
Gut.
2022 05; 71(5):879-888. doi:
10.1136/gutjnl-2022-326952. [PMID: 35144974] - Foad Rommasi, Mohammad Javad Nasiri, Mehdi Mirsaeidi. Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features.
Molecular and cellular biochemistry.
2022 Mar; 477(3):711-726. doi:
10.1007/s11010-021-04325-9. [PMID: 35013850] - Toshiki Kuno, Matsuo So, Mai Takahashi, Natalia N Egorova. The association between famotidine and in-hospital mortality of patients with COVID-19.
Journal of medical virology.
2022 03; 94(3):1186-1189. doi:
10.1002/jmv.27375. [PMID: 34609001] - Martine Gehin, Jolanta Wierdak, Giancarlo Sabattini, Patricia N Sidharta, Jasper Dingemanse. Effect of gastric pH and of a moderate CYP3A4 inducer on the pharmacokinetics of daridorexant, a dual orexin receptor antagonist.
British journal of clinical pharmacology.
2022 02; 88(2):810-819. doi:
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2022 02; 88(2):655-668. doi:
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Infectious disorders drug targets.
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2021 Sep; 39(14):5327-5333. doi:
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2021 Jul; 71(6):295-301. doi:
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The American journal of gastroenterology.
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2021 05; 96(5):1365-1367. doi:
10.1016/j.mayocp.2021.03.001. [PMID: 33958065] - Ka Shing Cheung, Ivan F N Hung, Wai K Leung. Association Between Famotidine Use and COVID-19 Severity in Hong Kong: A Territory-wide Study.
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2021 04; 160(5):1898-1899. doi:
10.1053/j.gastro.2020.05.098. [PMID: 32682763] - Vijay P Singh, Bara El-Kurdi, Christopher Rood. What Underlies the Benefit of Famotidine Formulations Used During COVID-19?.
Gastroenterology.
2021 04; 160(5):1899-1900. doi:
10.1053/j.gastro.2020.07.051. [PMID: 32777281] - Azza Shoaibi, Stephen Patrick Fortin, Rachel Weinstein, Jesse A Berlin, Patrick Ryan. Comparative Effectiveness of Famotidine in Hospitalized COVID-19 Patients.
The American journal of gastroenterology.
2021 04; 116(4):692-699. doi:
10.14309/ajg.0000000000001153. [PMID: 33982938] - Tianyi Ma, Meng Wu. Association Between Famotidine Use and Clinical Outcomes in Patients With COVID-19: Assessment of Available Evidence.
The American journal of gastroenterology.
2021 04; 116(4):848-849. doi:
10.14309/ajg.0000000000001008. [PMID: 33982973] - Jeffrey Mather. Response to Ma and Wu.
The American journal of gastroenterology.
2021 04; 116(4):849-850. doi:
10.14309/ajg.0000000000001068. [PMID: 33982974] - Madeline Loffredo, Hector Lucero, Da-Yuan Chen, Aoife O'Connell, Simon Bergqvist, Ahmad Munawar, Asanga Bandara, Steff De Graef, Stephen D Weeks, Florian Douam, Mohsan Saeed, Ali H Munawar. The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication.
Scientific reports.
2021 03; 11(1):5433. doi:
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2021 03; 126(3):217-218. doi:
10.1016/j.anai.2020.11.003. [PMID: 33161155] - Samrat Yeramaneni, Pratik Doshi, Kenneth Sands, Mandelin Cooper, Dax Kurbegov, Gregg Fromell. Famotidine Use Is Not Associated With 30-day Mortality: A Coarsened Exact Match Study in 7158 Hospitalized Patients With Coronavirus Disease 2019 From a Large Healthcare System.
Gastroenterology.
2021 02; 160(3):919-921.e3. doi:
10.1053/j.gastro.2020.10.011. [PMID: 33058865] - Leonard Chiu, Max Shen, Chun-Han Lo, Nicholas Chiu, Austin Chen, Hyun Joon Shin, Elizabeth Horn Prsic, Chin Hur, Ronald Chow, Benjamin Lebwohl. Effect of famotidine on hospitalized patients with COVID-19: A systematic review and meta-analysis.
PloS one.
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Gastroenterology.
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10.1111/jvim.12408. [PMID: 25056694] - Xuehua Zhu, Xiaole Qi, Zhenghong Wu, Ziwei Zhang, Jiayu Xing, Xiangbo Li. Preparation of multiple-unit floating-bioadhesive cooperative minitablets for improving the oral bioavailability of famotidine in rats.
Drug delivery.
2014 Sep; 21(6):459-66. doi:
10.3109/10717544.2013.879626. [PMID: 24456044] - K Asokkumar, Saikat Sen, M Umamaheswari, A T Sivashanmugam, V Subhadradevi. Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa.
Pharmacological reports : PR.
2014 Aug; 66(4):594-9. doi:
10.1016/j.pharep.2014.01.006. [PMID: 24948059] - Mariusz J Świąder, Stanisław J Czuczwar. Interaction of famotidine, an H2 histamine receptor antagonist, with conventional antiepileptic drugs in mice.
Pharmacological reports : PR.
2014 Jun; 66(3):485-91. doi:
10.1016/j.pharep.2013.11.006. [PMID: 24905528] - Walter D Y Quan, Francine Marie Quan. Activity of outpatient intravenous interleukin-2 and famotidine in metastatic clear cell kidney cancer.
Cancer biotherapy & radiopharmaceuticals.
2014 Mar; 29(2):58-61. doi:
10.1089/cbr.2013.1555. [PMID: 24251758] - Angela A Huertas-Ceballos, Stuart Logan, Cathy Bennett, Colin Macarthur, Alice E Martin. WITHDRAWN: Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood.
The Cochrane database of systematic reviews.
2014 Feb; ?(2):CD003017. doi:
10.1002/14651858.cd003017.pub3. [PMID: 24532249] - Vaibhav Agarwal, Mayank Bansal. Statistical optimization and fabrication of a press coated pulsatile dosage form to treat nocturnal acid breakthrough.
Current drug delivery.
2013 Aug; 10(4):444-52. doi:
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Biomedical chromatography : BMC.
2013 Jul; 27(7):866-73. doi:
10.1002/bmc.2873. [PMID: 23401067] - Christie E Ferrecchia, Theodore R Hobbs. Efficacy of oral fecal bacteriotherapy in rhesus macaques (Macaca mulatta) with chronic diarrhea.
Comparative medicine.
2013 Feb; 63(1):71-5. doi:
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Current drug delivery.
2012 Nov; 9(6):608-16. doi:
10.2174/156720112803529756. [PMID: 22935056] - Elise S Demitrack, Eitaro Aihara, Susan Kenny, Andrea Varro, Marshall H Montrose. Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage.
Gut.
2012 Jun; 61(6):804-11. doi:
10.1136/gutjnl-2011-300420. [PMID: 21997560] - Naoto Takahashi, Masatomo Miura, Takenori Niioka, Kenichi Sawada. Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients.
Cancer chemotherapy and pharmacology.
2012 Apr; 69(4):999-1004. doi:
10.1007/s00280-011-1797-3. [PMID: 22147077] - Souryvanh Nirasay, Yves Mouget, Isabelle Marcotte, Jerome P Claverie. Supported bilayer on a nanopatterned membrane as model PAMPA membranes.
International journal of pharmaceutics.
2011 Dec; 421(1):170-5. doi:
10.1016/j.ijpharm.2011.09.013. [PMID: 21959106] - A Mordecai, R K Sellon, K L Mealey. Normal dogs treated with famotidine for 14 days have only transient increases in serum gastrin concentrations.
Journal of veterinary internal medicine.
2011 Nov; 25(6):1248-52. doi:
10.1111/j.1939-1676.2011.00826.x. [PMID: 22092612] - Xiaodong Wang, Marta Boffito, Jenny Zhang, Ellen Chung, Li Zhu, Yaoshi Wu, Kristine Patterson, Angela Kashuba, Pablo Tebas, Michael Child, Lisa Mahnke, Richard Bertz. Effects of the H2-receptor antagonist famotidine on the pharmacokinetics of atazanavir-ritonavir with or without tenofovir in HIV-infected patients.
AIDS patient care and STDs.
2011 Sep; 25(9):509-15. doi:
10.1089/apc.2011.0113. [PMID: 21770762] - H Matsuo, H Sakamoto, K Arizono, R Shinohara. Behavior of pharmaceuticals in waste water treatment plant in Japan.
Bulletin of environmental contamination and toxicology.
2011 Jul; 87(1):31-5. doi:
10.1007/s00128-011-0299-7. [PMID: 21562834] - Amirhossein Ahmadi, Mohammad Ali Ebrahimzadeh, Saeb Ahmad-Ashrafi, Mohammad Karami, Mohammad Reza Mahdavi, Seyed Soheil Saeedi Saravi. Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists.
Fundamental & clinical pharmacology.
2011 Feb; 25(1):72-9. doi:
10.1111/j.1472-8206.2009.00810.x. [PMID: 20070855] - Walter D Y Quan, Gregory A Gagnon, Paul R Walker, Francine M Quan. Pulse interleukin-2 with famotidine induces CD56+ lymphocytes in the peripheral blood of patients with metastatic melanoma or kidney cancer.
Cancer biotherapy & radiopharmaceuticals.
2011 Feb; 26(1):65-7. doi:
10.1089/cbr.2010.0879. [PMID: 21348776] - Hisayoshi Kawahara, Hiroomi Okuyama, Keisuke Nose, Hiroshi Nakai, Akihiro Yoneda, Akio Kubota, Masahiro Fukuzawa. Physiological and clinical characteristics of gastroesophageal reflux after congenital diaphragmatic hernia repair.
Journal of pediatric surgery.
2010 Dec; 45(12):2346-50. doi:
10.1016/j.jpedsurg.2010.08.029. [PMID: 21129542] - M Saeed Arayne, Najma Sultana, M Hashim Zuberi, Farhan Ahmed Siddiqui. Simultaneous determination of metformin, cimetidine, famotidine, and ranitidine in human serum and dosage formulations using HPLC with UV detection.
Journal of chromatographic science.
2010 Oct; 48(9):721-5. doi:
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American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2010 Jul; 10(7):1556-68. doi:
10.1111/j.1600-6143.2010.03147.x. [PMID: 20642682] - Keiji Okada, Kazue Yajima, Takamichi Ohba, Tamako Miyazaki, Takenori Orihashi, Shigeru Sato, Jun Yasuda. The effect of experimental inhibition of gastric acid secretion on curd formation in abomasum and weight gain of calves.
Animal science journal = Nihon chikusan Gakkaiho.
2010 Feb; 81(1):89-93. doi:
10.1111/j.1740-0929.2009.00710.x. [PMID: 20163678] - Kimberly K Adkison, Soniya S Vaidya, Daniel Y Lee, Seok Hwee Koo, Linghui Li, Amar A Mehta, Annette S Gross, Joseph W Polli, Joan E Humphreys, Yu Lou, Edmund J D Lee. Oral sulfasalazine as a clinical BCRP probe substrate: pharmacokinetic effects of genetic variation (C421A) and pantoprazole coadministration.
Journal of pharmaceutical sciences.
2010 Feb; 99(2):1046-62. doi:
10.1002/jps.21860. [PMID: 19569219] - Xiuhong Sun, Yuan Tian, Zunjian Zhang, Yun Chen. A single LC-tandem mass spectrometry method for the simultaneous determination of four H2 antagonists in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Dec; 877(31):3953-9. doi:
10.1016/j.jchromb.2009.10.003. [PMID: 19853541] - Walter D Y Quan, Francine M Quan. High-dose intensity pulse interleukin-2 with famotidine in metastatic kidney cancer.
Cancer biotherapy & radiopharmaceuticals.
2009 Apr; 24(2):181-3. doi:
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Journal of fluorescence.
2009 Mar; 19(2):333-44. doi:
10.1007/s10895-008-0421-3. [PMID: 18956234] - Sonia Ananthakrishnan, Lewis E Braverman, Robert M Levin, Barbarajean Magnani, Elizabeth N Pearce. The effect of famotidine, esomeprazole, and ezetimibe on levothyroxine absorption.
Thyroid : official journal of the American Thyroid Association.
2008 May; 18(5):493-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Apr; 36(4):649-54. doi:
10.1124/dmd.107.019869. [PMID: 18180268] - Angela M Bettge, Gary N Gross. A serum sickness-like reaction to a commonly used acne drug.
JAAPA : official journal of the American Academy of Physician Assistants.
2008 Mar; 21(3):33-4. doi:
10.1097/01720610-200803000-00009. [PMID: 18432045] - Jackie J Gai, Stanley L Marks. Salmon poisoning disease in two Malayan sun bears.
Journal of the American Veterinary Medical Association.
2008 Feb; 232(4):586-8. doi:
10.2460/javma.232.4.586. [PMID: 18279100] - Walter D Y Quan, Francine M Quan, Linda A King, Paul R Walker. Low-dose cyclophosphamide and continuous-infusion interleukin-2 with famotidine in previously treated metastatic melanoma or kidney cancer.
Cancer biotherapy & radiopharmaceuticals.
2008 Feb; 23(1):108-13. doi:
10.1089/cbr.2007.0420. [PMID: 18298334] - A Huertas-Ceballos, S Logan, C Bennett, C Macarthur. Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood.
The Cochrane database of systematic reviews.
2008 Jan; ?(1):CD003017. doi:
10.1002/14651858.cd003017.pub2. [PMID: 18254013] - Qing Zhai, Jun Fu, Xia Huang, Bin Xu, Yao-Zong Yuan, Tao Jiang, Zheng-Xing Rong, Hong-Zhuan Chen. Clinical study on the influence of a fixed-dose combination of famotidine with calcium carbonate and magnesium hydroxide on the bioavailability of famotidine.
Arzneimittel-Forschung.
2008; 58(11):581-4. doi:
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