N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline hydrochloride--water (1/1) (BioDeep_00001044672)

   


代谢物信息卡片


N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline hydrochloride--water (1/1)

化学式: C24H37ClN2O2 (420.2543)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: [H+].CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3.O.[Cl-]
InChI: 1H



数据库引用编号

2 个数据库交叉引用编号

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相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Erol C Vatansever, Kai S Yang, Aleksandra K Drelich, Kaci C Kratch, Chia-Chuan Cho, Kempaiah Rayavara Kempaiah, Jason C Hsu, Drake M Mellott, Shiqing Xu, Chien-Te K Tseng, Wenshe Ray Liu. Bepridil is potent against SARS-CoV-2 in vitro. Proceedings of the National Academy of Sciences of the United States of America. 2021 03; 118(10):. doi: 10.1073/pnas.2012201118. [PMID: 33597253]
  • Kazuki Matsui, Yutaro Mukai, Kota Sakakura, Kyoichi Wada, Tsutomu Nakamura, Atsufumi Kawabata, Nobue Terakawa, Naoki Hayakawa, Kengo Kusano, Kouichi Hosomi, Satoshi Yokoyama, Mitsutaka Takada. Relationship between serum bepridil concentration and corrected QT interval. International journal of clinical pharmacology and therapeutics. 2021 Jan; 59(1):63-70. doi: 10.5414/cp203843. [PMID: 33026317]
  • Bhavesh D Patel, Nageswararao Palakundam, Rajesh Alamanda, Ajit R Gadekar, Amol A Raje, Rakshit Ameta. A simple and sensitive LC-MS/MS method for quantification of Bepridil in rat plasma and its application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2019 Aug; 172(?):113-119. doi: 10.1016/j.jpba.2019.04.038. [PMID: 31029800]
  • Chikako Shimizu, Yutaka Mitani, Youichi Tsuchiya, Toshitaka Nabeshima. Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice. Biological & pharmaceutical bulletin. 2018 Jul; 41(7):1049-1061. doi: 10.1248/bpb.b18-00093. [PMID: 29769465]
  • Pradeep Sherkhane, Josef P Kapfhammer. Chronic pharmacological blockade of the Na+ /Ca2+ exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures. The European journal of neuroscience. 2017 Sep; 46(5):2108-2120. doi: 10.1111/ejn.13649. [PMID: 28715135]
  • Kosuke Doki, Yukio Sekiguchi, Keisuke Kuga, Kazutaka Aonuma, Masato Homma. Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity. Drug metabolism and pharmacokinetics. 2015 Aug; 30(4):257-62. doi: 10.1016/j.dmpk.2015.04.001. [PMID: 26195225]
  • Tsuyoshi Shiga, Masayuki Hashiguchi, Miyoko Naganuma, Atsushi Suzuki, Nobuhisa Hagiwara. Contributing factors to the apparent clearance of bepridil in patients with paroxysmal or persistent atrial fibrillation: analysis using population pharmacokinetics. Therapeutic drug monitoring. 2013 Jun; 35(3):367-73. doi: 10.1097/ftd.0b013e318286ec33. [PMID: 23666576]
  • Wei Cui, Jie Zhang, Chuan-Xin Zhang, Guang-Zhong Jiao, Min Zhang, Tian-Yang Wang, Ming-Jiu Luo, Jing-He Tan. Control of spontaneous activation of rat oocytes by regulating plasma membrane Na+/Ca2+ exchanger activities. Biology of reproduction. 2013 Jun; 88(6):160. doi: 10.1095/biolreprod.113.108266. [PMID: 23677981]
  • Kumiko Noda, Yoshikazu Gotoh, Satoru Tanioka, Yasuhiro Narayama, Michiya Kobayashi, Shinji Iwai, Noriyoshi Katoh, Koji Tadano. The relationship between the plasma concentration of bepridil and its efficacy in the treatment of atrial fibrillation in Japanese patients. Biological & pharmaceutical bulletin. 2012; 35(5):672-6. doi: 10.1248/bpb.35.672. [PMID: 22687400]
  • Kumiko Noda, Yasuhiro Narayama, Yoshikazu Goto, Michiya Kobayashi, Hiroshi Kuronuma, Shinji Iwai, Katsumi Itoh, Noriyoshi Katoh, Koji Tadano. An LC method for quantifying bepridil in human plasma using 1-naphthol as the internal standard. Journal of chromatographic science. 2011 Aug; 49(7):519-23. doi: 10.1093/chrsci/49.7.519. [PMID: 21801483]
  • Tsuyoshi Shiga, Atsushi Suzuki, Miyoko Naganuma, Fumitaka Hosaka, Morio Shoda, Nobuhisa Hagiwara. Clinical outcome in patients with paroxysmal or persistent atrial fibrillation receiving bepridil. Circulation journal : official journal of the Japanese Circulation Society. 2011; 75(6):1334-42. doi: 10.1253/circj.cj-10-1084. [PMID: 21483159]
  • Mitsuharu Kawamura, Hiroyuki Ito, Tatsuya Onuki, Fumito Miyoshi, Norikazu Watanabe, Taku Asano, Kaoru Tanno, Youichi Kobayashi. Candesartan decreases type III procollagen-N-peptide levels and inflammatory marker levels and maintains sinus rhythm in patients with atrial fibrillation. Journal of cardiovascular pharmacology. 2010 May; 55(5):511-7. doi: 10.1097/fjc.0b013e3181d70690. [PMID: 20164787]
  • Eva Toronyi. [Role of apoptosis in the kidney after reperfusion]. Orvosi hetilap. 2008 Feb; 149(7):305-15. doi: 10.1556/oh.2008.28212. [PMID: 18258561]
  • Akira Fujiki, Tamotsu Sakamoto, Kunihiro Nishida, Koichi Mizumaki, Hiroshi Inoue. Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation. Journal of cardiovascular pharmacology. 2007 Sep; 50(3):264-6. doi: 10.1097/fjc.0b013e318074f952. [PMID: 17878753]
  • Masato Taguchi, Akira Fujiki, Jotaro Iwamoto, Hiroshi Inoue, Katsutoshi Tahara, Katsuya Saigusa, Isao Horiuchi, Yukari Oshima, Yukiya Hashimoto. Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias. Biological & pharmaceutical bulletin. 2006 Mar; 29(3):517-21. doi: 10.1248/bpb.29.517. [PMID: 16508157]
  • Toshiaki Sato, Alexandre D T Costa, Tomoaki Saito, Takehiko Ogura, Hideyuki Ishida, Keith D Garlid, Haruaki Nakaya. Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. The Journal of pharmacology and experimental therapeutics. 2006 Jan; 316(1):182-8. doi: 10.1124/jpet.105.094029. [PMID: 16174795]
  • Motohiro Shiotani, Takuma Harada, Junko Abe, Yasufusa Sawada, Keitaro Hashimoto, Yoshimasa Hamada, Ikuo Horii. Practical application of guinea pig telemetry system for QT evaluation. The Journal of toxicological sciences. 2005 Aug; 30(3):239-47. doi: 10.2131/jts.30.239. [PMID: 16141657]
  • Tomoko Uchino, Tae-Seong Lee, Toshihiko Kaku, Noboru Yamashita, Takayuki Noguchi, Katsushige Ono. Voltage-dependent and frequency-independent inhibition of recombinant Cav3.2 T-type Ca2+ channel by bepridil. Pharmacology. 2005 Jul; 74(4):174-81. doi: 10.1159/000085329. [PMID: 15855830]
  • Masaki Ohsawa, Fumitaka Tanaka, Fusanori Kunugita, Hidenori Saito, Motoyuki Nakamura, Takahiro Shiroto, Kazuhiko Hotta, Naoki Chiba, Katsuhiko Hiramori. A case of sick sinus syndrome that developed torsades de pointes, pacing failure and sensing failure during administration of bepridil. Japanese heart journal. 2003 Sep; 44(5):783-8. doi: 10.1536/jhj.44.783. [PMID: 14587660]
  • Zoltán Macháty, Jagdeece J Ramsoondar, Aaron J Bonk, Randall S Prather, Kenneth R Bondioli. Na(+)/Ca(2+) exchanger in porcine oocytes. Biology of reproduction. 2002 Oct; 67(4):1133-9. doi: 10.1095/biolreprod67.4.1133. [PMID: 12297528]
  • Ieva Stupans, Amra Kirlich, Kellie L Tuck, Peter J Hayball. Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants. Journal of agricultural and food chemistry. 2002 Apr; 50(8):2464-9. doi: 10.1021/jf0112320. [PMID: 11929315]
  • S Kobayashi, Y Reien, T Ogura, T Saito, Y Masuda, H Nakaya. Inhibitory effect of bepridil on hKv1.5 channel current: comparison with amiodarone and E-4031. European journal of pharmacology. 2001 Nov; 430(2-3):149-57. doi: 10.1016/s0014-2999(01)01381-4. [PMID: 11711026]
  • W N Wu, G W Caldwell, J A Masucci. Evaluation of the absorption, excretion, and metabolism of the antihypertensive agent RWJ-26899 in male and female CR Wistar rats and Beagle dogs. European journal of drug metabolism and pharmacokinetics. 2001 Jul; 26(3):155-66. doi: 10.1007/bf03190391. [PMID: 11695715]
  • H Lou, H Yuan, Y Yamazaki, T Sasaki, S Oka. Alkaloids and flavonoids from peanut skins. Planta medica. 2001 Jun; 67(4):345-9. doi: 10.1055/s-2001-14319. [PMID: 11458452]
  • R Søgaard, T Ljungstrøm, K A Pedersen, S P Olesen, B S Jensen. KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology. American journal of physiology. Cell physiology. 2001 Apr; 280(4):C859-66. doi: 10.1152/ajpcell.2001.280.4.c859. [PMID: 11245603]
  • Y Watanabe, J Kimura. Blocking effect of bepridil on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes. Japanese journal of pharmacology. 2001 Apr; 85(4):370-5. doi: 10.1254/jjp.85.370. [PMID: 11388640]
  • T Mukoda, B Sun, A Ishiguro. Antioxidant activities of buckwheat hull extract toward various oxidative stress in vitro and in vivo. Biological & pharmaceutical bulletin. 2001 Mar; 24(3):209-13. doi: 10.1248/bpb.24.209. [PMID: 11256471]
  • Y Rikitake, S Kawashima, S Takeshita, T Yamashita, H Azumi, M Yasuhara, H Nishi, N Inoue, M Yokoyama. Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits. Atherosclerosis. 2001 Jan; 154(1):87-96. doi: 10.1016/s0021-9150(00)00468-8. [PMID: 11137086]
  • T Yasuda, A Inaba, M Ohmori, T Endo, S Kubo, K Ohsawa. Urinary metabolites of gallic acid in rats and their radical-scavenging effects on 1,1-diphenyl-2-picrylhydrazyl radical. Journal of natural products. 2000 Oct; 63(10):1444-6. doi: 10.1021/np0000421. [PMID: 11076575]
  • A Viallon, S Laporte-Simitsidis, V Pouzet, C Venet, B Tardy, F Zéni, J C Bertrand. [Bepridil: importance of serum level in treatment surveillance]. Presse medicale (Paris, France : 1983). 2000 Apr; 29(12):645-7. doi: NULL. [PMID: 10780196]
  • C R Jan, C J Tseng. A novel action of the antianginal drug bepredil: induction of internal Ca(2+) release and external Ca(2+) influx in Madin-Darby canine kidney (MDCK) epithelial cells. Biochemical pharmacology. 2000 Mar; 59(6):639-46. doi: 10.1016/s0006-2952(99)00361-5. [PMID: 10677580]
  • F Yamaguchi, T Ariga, Y Yoshimura, H Nakazawa. Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind. Journal of agricultural and food chemistry. 2000 Feb; 48(2):180-5. doi: 10.1021/jf990845y. [PMID: 10691613]
  • N Yamamoto, J H Moon, T Tsushida, A Nagao, J Terao. Inhibitory effect of quercetin metabolites and their related derivatives on copper ion-induced lipid peroxidation in human low-density lipoprotein. Archives of biochemistry and biophysics. 1999 Dec; 372(2):347-54. doi: 10.1006/abbi.1999.1516. [PMID: 10600174]
  • T Egashira, F Takayama, Y Yamanaka, Y Komatsu. Monitoring of radical scavenging activity of peroral administration of the Kampo medicine Sho-saiko-to in rats. Japanese journal of pharmacology. 1999 Aug; 80(4):379-82. doi: 10.1254/jjp.80.379. [PMID: 10496340]
  • I R Brude, C A Drevon, K Viken, J E Arnstad, K N Valnes, M S Nenseter. Doxazosin treatment and peroxidation of low-density lipoprotein among male hypertensive subjects: in vitro and ex vivo studies. Biochemical pharmacology. 1999 Jul; 58(1):183-91. doi: 10.1016/s0006-2952(99)00057-x. [PMID: 10403533]
  • M A Gyamfi, M Yonamine, Y Aniya. Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally-induced liver injuries. General pharmacology. 1999 Jun; 32(6):661-7. doi: 10.1016/s0306-3623(98)00238-9. [PMID: 10401991]
  • J R Pepperell, K Kommineni, S Buradagunta, P J Smith, D L Keefe. Transmembrane regulation of intracellular calcium by a plasma membrane sodium/calcium exchanger in mouse ova. Biology of reproduction. 1999 May; 60(5):1137-43. doi: 10.1095/biolreprod60.5.1137. [PMID: 10208975]
  • E Toronyi, J Hamar, F Perner, B Szende. Prevention of apoptosis reperfusion renal injury by calcium channel blockers. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 1999 May; 51(3):209-12. doi: 10.1016/s0940-2993(99)80098-0. [PMID: 10334460]
  • B Burlando, B Marchi, T Krüppel, M Orunesu, A Viarengo. Occurrence of Na(+)-Ca2+ exchange in the ciliate Euplotes crassus and its role in Ca2+ homeostasis. Cell calcium. 1999 Feb; 25(2):153-60. doi: 10.1054/ceca.1998.0014. [PMID: 10326682]
  • T Atsumi, I Iwakura, Y Kashiwagi, S Fujisawa, T Ueha. Free radical scavenging activity in the nonenzymatic fraction of human saliva: a simple DPPH assay showing the effect of physical exercise. Antioxidants & redox signaling. 1999; 1(4):537-46. doi: 10.1089/ars.1999.1.4-537. [PMID: 11233150]
  • A Jussofie, M Kirsch, H de Groot. Ca2+-dependent cytotoxicity of H2O2 in L929 cells: the role of H2O2-induced Na+-influx. Free radical biology & medicine. 1998 Oct; 25(6):712-9. doi: 10.1016/s0891-5849(98)00159-2. [PMID: 9801072]
  • Y J Wu, C Y Hong, S J Lin, P Wu, M S Shiao. Increase of vitamin E content in LDL and reduction of atherosclerosis in cholesterol-fed rabbits by a water-soluble antioxidant-rich fraction of Salvia miltiorrhiza. Arteriosclerosis, thrombosis, and vascular biology. 1998 Mar; 18(3):481-6. doi: 10.1161/01.atv.18.3.481. [PMID: 9514418]
  • P M Abuja, P Liebmann, M Hayn, K Schauenstein, H Esterbauer. Antioxidant role of melatonin in lipid peroxidation of human LDL. FEBS letters. 1997 Aug; 413(2):289-93. doi: 10.1016/s0014-5793(97)00918-6. [PMID: 9280299]
  • T Seifert, O Zschörnig, J Arnhold, K Arnold. Beta-blockers inhibit the modification of low-density lipoproteins by sodium hypochlorite in vitro. Chemistry and physics of lipids. 1997 Jan; 85(1):13-21. doi: 10.1016/s0009-3084(96)02637-0. [PMID: 9032944]
  • B Halvorsen, I Brude, C A Drevon, J Nysom, L Ose, E N Christiansen, M S Nenseter. Effect of homocysteine on copper ion-catalyzed, azo compound-initiated, and mononuclear cell-mediated oxidative modification of low density lipoprotein. Journal of lipid research. 1996 Jul; 37(7):1591-600. doi: NULL. [PMID: 8827529]
  • P T Pollak. A systematic review and critical comparison of internal standards for the routine liquid chromatographic assay of amiodarone and desethylamiodarone. Therapeutic drug monitoring. 1996 Apr; 18(2):168-78. doi: 10.1097/00007691-199604000-00011. [PMID: 8721281]
  • S D Lee, G H Hsiue, C Y Kao, P C Chang. Artificial cornea: surface modification of silicone rubber membrane by graft polymerization of pHEMA via glow discharge. Biomaterials. 1996 Mar; 17(6):587-95. doi: 10.1016/0142-9612(96)88709-6. [PMID: 8652777]
  • H Luurila, K T Olkkola, P J Neuvonen. Interaction between erythromycin and the benzodiazepines diazepam and flunitrazepam. Pharmacology & toxicology. 1996 Feb; 78(2):117-22. doi: 10.1111/j.1600-0773.1996.tb00191.x. [PMID: 8822046]
  • W M Awni, C E Halstenson, R K Nayak, J A Opsahl, R K Desiraju, F L Minn, G R Matzke. Pharmacokinetics of bepridil and two of its metabolites in patients with end-stage renal disease. Journal of clinical pharmacology. 1995 Apr; 35(4):379-83. doi: 10.1002/j.1552-4604.1995.tb04077.x. [PMID: 7650227]
  • J F Pritchard, G R Matzke, J A Opsahl, C E Halstenson, R K Nayak. Effects of hemodialysis on plasma protein binding of bepridil. Journal of clinical pharmacology. 1995 Feb; 35(2):137-41. doi: 10.1002/j.1552-4604.1995.tb05001.x. [PMID: 7751422]
  • Y S Lee, M M Sayeed, R D Wurster. Intracellular Ca2+ mediates the cytotoxicity induced by bepridil and benzamil in human brain tumor cells. Cancer letters. 1995 Jan; 88(1):87-91. doi: 10.1016/0304-3835(94)03619-t. [PMID: 7850778]
  • A Wu, R A Colvin. Characterization of exchange inhibitory peptide effects on Na+/Ca2+ exchange in rat and human brain plasma membrane vesicles. Journal of neurochemistry. 1994 Dec; 63(6):2136-43. doi: 10.1046/j.1471-4159.1994.63062136.x. [PMID: 7964733]
  • B Takase, A Kurita, H Hikita, A Uehata, T Nishioka, T Maruyama, K Mizuno, H Nakamura, Y Kanda. Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. The American journal of cardiology. 1994 Jun; 73(15):1063-8. doi: 10.1016/0002-9149(94)90284-4. [PMID: 8198031]
  • S C Linn, C K van Kalken, O van Tellingen, P van der Valk, C J van Groeningen, C M Kuiper, H M Pinedo, G Giaccone. Clinical and pharmacologic study of multidrug resistance reversal with vinblastine and bepridil. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1994 Apr; 12(4):812-9. doi: 10.1200/jco.1994.12.4.812. [PMID: 7908691]
  • T Tsuda, A Sugaya, Y Z Liu, K Katoh, H Tanaka, H Kawazura, E Sugaya, M Kusai, M Kohno. Radical scavenger effect of Boschniakia rossica. Journal of ethnopharmacology. 1994 Jan; 41(1-2):85-90. doi: 10.1016/0378-8741(94)90062-0. [PMID: 8170164]
  • L M Hollingshead, D Faulds, A Fitton. Bepridil. A review of its pharmacological properties and therapeutic use in stable angina pectoris. Drugs. 1992 Nov; 44(5):835-57. doi: 10.2165/00003495-199244050-00009. [PMID: 1280569]
  • H Kovacic, P Gallice, A Crevat. Inhibition of sodium pump by bepridil. An in vitro and microcalorimetric study. Biochemical pharmacology. 1992 Oct; 44(8):1529-34. doi: 10.1016/0006-2952(92)90468-x. [PMID: 1329768]
  • B N Singh. Safety profile of bepridil determined from clinical trials in chronic stable angina in the United States. The American journal of cardiology. 1992 Apr; 69(11):68D-74D. doi: 10.1016/0002-9149(92)90962-x. [PMID: 1532469]
  • R DiBianco. Bepridil treatment of chronic stable angina: a review of comparative studies versus placebo, nifedipine, and diltiazem. The American journal of cardiology. 1992 Apr; 69(11):56D-62D. doi: 10.1016/0002-9149(92)90960-7. [PMID: 1532468]
  • B Brembilla-Perrot, E Aliot, J Clementy, P Cosnay, P Djiane, J P Fauchier, S Kacet, D Lellouche, P Mabo, M Richard. Evaluation of bepridil efficacy by electrophysiologic testing in patients with recurrent ventricular tachycardia: comparison of two regimens. Cardiovascular drugs and therapy. 1992 Apr; 6(2):187-93. doi: 10.1007/bf00054570. [PMID: 1390333]
  • R J Bindels, P L Ramakers, J A Dempster, A Hartog, C H van Os. Role of Na+/Ca2+ exchange in transcellular Ca2+ transport across primary cultures of rabbit kidney collecting system. Pflugers Archiv : European journal of physiology. 1992 Apr; 420(5-6):566-72. doi: 10.1007/bf00374634. [PMID: 1614831]
  • W N Wu, J F Pritchard, K T Ng, J F Hills, J A Uetz, K A Yorgey, L A McKown, P J O'Neill. Disposition of bepridil in laboratory animals and man. Xenobiotica; the fate of foreign compounds in biological systems. 1992 Feb; 22(2):153-69. doi: 10.3109/00498259209046614. [PMID: 1632105]
  • C K van Kalken, J J van der Hoeven, J de Jong, G Giaccone, G J Schuurhuis, P A Maessen, W M Blokhuis, W J van der Vijgh, H M Pinedo. Bepridil in combination with anthracyclines to reverse anthracycline resistance in cancer patients. European journal of cancer (Oxford, England : 1990). 1991; 27(6):739-44. doi: 10.1016/0277-5379(91)90178-g. [PMID: 1829915]
  • G Flik, T J Schoenmakers, J A Groot, C H van Os, S E Wendelaar Bonga. Calcium absorption by fish intestine: the involvement of ATP- and sodium-dependent calcium extrusion mechanisms. The Journal of membrane biology. 1990 Jan; 113(1):13-22. doi: 10.1007/bf01869601. [PMID: 2137539]
  • L O Larson, C B Hantler, J J Lynch, S N Landau, J A Buben, B R Lucchesi, P R Knight. Cardiac electrophysiologic interactions of bepridil, a new calcium antagonist, with enflurane, halothane, and isoflurane. Journal of cardiothoracic anesthesia. 1988 Jun; 2(3):346-55. doi: 10.1016/0888-6296(88)90316-x. [PMID: 17171871]
  • N Ogawa, S Yokota, H Ono. Different interaction of bepridil and diltiazem with BAY K 8644 in the abolition of autoregulation of renal blood flow. Journal of cardiovascular pharmacology. 1988 Feb; 11(2):147-50. doi: . [PMID: 2452307]
  • G R Hasegawa. Nicardipine, nitrendipine, and bepridil: new calcium antagonists for cardiovascular disorders. Clinical pharmacy. 1988 Feb; 7(2):97-108. doi: . [PMID: 3280222]
  • S E Husted, C Pedersen, H K Nielsen, E Apoil, O H Nielsen, K Lindvig, L R Krusell, A Høegholm. Effect of bepridil on metabolic control and insulin secretion in diabetics. European journal of clinical pharmacology. 1988; 34(3):221-6. doi: 10.1007/bf00540947. [PMID: 3294020]
  • W N Wu, J F Hills, S Y Chang, K T Ng. Metabolism of bepridil in laboratory animals and humans. Drug metabolism and disposition: the biological fate of chemicals. 1988 Jan; 16(1):69-77. doi: NULL. [PMID: 2894958]
  • P L Jacobs, L P Delbressine, F M Kaspersen, G J Schmeits. A mass spectrometric approach to the identification of conjugated drug metabolites. Biomedical & environmental mass spectrometry. 1987 Nov; 14(11):689-97. doi: 10.1002/bms.1200141121. [PMID: 2962678]
  • M P Dube, F B Davis, P J Davis, S D Blas. Bepridil and cetiedil reversibly inhibit thyroid hormone stimulation in vitro of human red cell Ca2+-ATPase activity. Molecular endocrinology (Baltimore, Md.). 1987 Feb; 1(2):168-71. doi: 10.1210/mend-1-2-168. [PMID: 2970587]
  • G J Schuurhuis, H J Broxterman, J J van der Hoeven, H M Pinedo, J Lankelma. Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and -sensitive cell lines. A comparison with verapamil. Cancer chemotherapy and pharmacology. 1987; 20(4):285-90. doi: 10.1007/bf00262578. [PMID: 3500807]
  • E Winslow, J K Campbell, R J Marshall. Comparative electrophysiological effects of disopyramide and bepridil on rabbit atrial, papillary, and Purkinje tissue: modification by reduced extracellular potassium. Journal of cardiovascular pharmacology. 1986 Nov; 8(6):1208-16. doi: 10.1097/00005344-198611000-00017. [PMID: 2434748]
  • L J Lesko, J R Benotti, J S Alpert, P M Brady, J E McCue, B H Weiner, I S Ockene. Pharmacokinetics of intravenous bepridil in patients with coronary disease. Journal of pharmaceutical sciences. 1986 Oct; 75(10):952-4. doi: 10.1002/jps.2600751008. [PMID: 3491897]
  • M L Holland, K T Ng. Automated capillary gas chromatographic assay using nitrogen-phosphorus ionization detection for the determination of bepridil in human plasma. Journal of chromatography. 1986 Jan; 374(1):87-93. doi: 10.1016/s0378-4347(00)83255-7. [PMID: 3485109]
  • G G Belz, S Wistuba, J H Matthews. Digoxin and bepridil: pharmacokinetic and pharmacodynamic interactions. Clinical pharmacology and therapeutics. 1986 Jan; 39(1):65-71. doi: 10.1038/clpt.1986.12. [PMID: 3484691]
  • E Singlas, H Martre, A M Taburet. [Clinical pharmacology of calcium inhibitors]. Archives des maladies du coeur et des vaisseaux. 1985 Nov; 78 Spec No(?):15-22. doi: . [PMID: 3937500]
  • J L Medvedowsky, C Barnay, C Arnaud, P Bonet, F Quittet, L F Lam. [Bepridil in the treatment of supraventricular paroxysmal tachycardias]. Archives des maladies du coeur et des vaisseaux. 1985 Oct; 78 Spec No(?):67-74. doi: . [PMID: 3938262]
  • J F Pritchard, L A McKown, B H Dvorchik, P J O'Neill. Plasma protein binding of bepridil. Journal of clinical pharmacology. 1985 Jul; 25(5):347-53. doi: 10.1002/j.1552-4604.1985.tb02853.x. [PMID: 3875635]
  • W Schneider, C Mehlhorn, M Kaltenbach, W D Bussmann. [Anti-angina effect of the calcium antagonist bepridil in stable angina pectoris]. Zeitschrift fur Kardiologie. 1985 Jun; 74(6):341-7. doi: NULL. [PMID: 3895761]
  • W H Frishman, S Charlap, D J Farnham, H S Sawin, E L Michelson, M H Crawford, R DiBianco, J B Kostis, S R Zellner, D D Michie. Combination propranolol and bepridil therapy in stable angina pectoris. The American journal of cardiology. 1985 Mar; 55(7):43C-49C. doi: 10.1016/0002-9149(85)90805-7. [PMID: 3883741]
  • L Z Benet. Pharmacokinetics and metabolism of bepridil. The American journal of cardiology. 1985 Mar; 55(7):8C-13C. doi: 10.1016/0002-9149(85)90799-4. [PMID: 3872057]
  • K T Ng, J A Plutte, L J Galante. Determination of bepridil in biological fluids by high-performance liquid chromatography. Journal of chromatography. 1984 Jul; 309(1):125-31. doi: 10.1016/0378-4347(84)80012-2. [PMID: 6332822]
  • C Froment, J Husson. [Bepridil and hyperkalemia. Discussion of a case]. Annales de cardiologie et d'angeiologie. 1984 Jul; 33(5):323-4. doi: NULL. [PMID: 6332570]
  • H Montluc, P Jaillon, M Biour, G Cheymol. [Effects of bepridil on heart rate and arterial pressure at rest and during exercise in the healthy subject. Study of relations between effects and plasma concentration]. Therapie. 1984 May; 39(3):221-9. doi: NULL. [PMID: 6611603]
  • R DiBianco, J Alpert, R J Katz, J Spann, E Chesler, D P Ferri, L J Larca, R B Costello, J M Gore, M J Eisenman. Bepridil for chronic stable angina pectoris: results of a prospective multicenter, placebo-controlled, dose-ranging study in 77 patients. The American journal of cardiology. 1984 Jan; 53(1):35-41. doi: 10.1016/0002-9149(84)90680-5. [PMID: 6362386]
  • E Albengres, S Urien, J F Pognat, J P Tillement. Multiple binding of bepridil in human blood. Pharmacology. 1984; 28(3):139-49. doi: 10.1159/000137955. [PMID: 6201931]
  • H P Wijnand, C J Timmer. Mini-computer programs for bioequivalence testing of pharmaceutical drug formulations in two-way cross-over studies. Including a survey of current parametric evaluation techniques. Computer programs in biomedicine. 1983 Aug; 17(1-2):73-88. doi: 10.1016/0010-468x(83)90027-2. [PMID: 6607152]
  • G Forche, H Kopera, H J Marsoner. The effect of Bepridil on respiratory and cardiovascular function: a placebo-controlled study. International journal of clinical pharmacology, therapy, and toxicology. 1983 May; 21(5):234-40. doi: . [PMID: 6602783]
  • P Duchêne-Marullaz, J P Kantelip, J F Trolèse. Effects of bepridil, a new antianginal agent, on ambulatory electrocardiography in human volunteers. Journal of cardiovascular pharmacology. 1983 May; 5(3):506-10. doi: 10.1097/00005344-198305000-00024. [PMID: 6191153]
  • J P Kantelip, P Duchène-Marullaz, J F Trolèse, J F Pognat. [Effect of bepridil on the heart rate of the healthy subject. Correlation with plasma levels]. Archives des maladies du coeur et des vaisseaux. 1983 Feb; 76(2):221-6. doi: NULL. [PMID: 6407430]
  • J Vink, J H van Hal, J F Pognat, J L Bouquet des Chaut. Determination of the anti-ischaemic drug bepridil in human plasma using gas chromatography with nitrogen-sensitive detection. Journal of chromatography. 1983 Jan; 272(1):87-94. doi: 10.1016/s0378-4347(00)86105-8. [PMID: 6601664]
  • J Ponsonnaille, B Citron, F Threil, D Heiligenstein, H Gras. [The electrophysiologic effects of intravenously administered bepridil]. Archives des maladies du coeur et des vaisseaux. 1982 Dec; 75(12):1415-23. doi: NULL. [PMID: 6820263]
  • S Lotersztajn, P Mavier, J Clergue, D Dhumeaux, F Pecker. Human liver plasma membrane Ca-ATPase: identification and sensitivity to calcium antagonists. Hepatology (Baltimore, Md.). 1982 Nov; 2(6):843-8. doi: 10.1002/hep.1840020618. [PMID: 6216195]
  • M Constantin, M Beaughard, P Piris, C Labrid. [Bepridil, a functional antagonist of beta1-adrenergic stimulation. Dissociated effects on cardiostimulation and lipolysis. (author's transl)]. Journal de pharmacologie. 1981 Jul; 12(3):239-54. doi: . [PMID: 6116833]