11-dehydro-thromboxane B2(1-) (BioDeep_00001040310)
代谢物信息卡片
11-dehydro-thromboxane B2(1-)
化学式: C20H31O6- (367.2120526)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(C=CC1C(C(CC(=O)O1)O)CC=CCCCC(=O)[O-])O
InChI: InChI=1S/C20H32O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/p-1/b7-4-,13-12+/t15-,16-,17-,18+/m0/s1
描述信息
A thromboxane anion that is the conjugate base of 11-dehydro-thromboxane B2, obtained by deprotonation of the carboxy group; major species at pH 7.3.
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alexander A Boucher, Brenton J Francisco, Amanda Pfeiffer, Matthew Martin, Janine Martin, Amy Shova, Jaimie D Nathan, Gregory M Tiao, Lori Luchtman-Jones. Urinary 11-dehydrothromboxane B2 aspirin efficacy testing is sensitive to perioperative inflammation in pediatric solid-organ transplant patients.
Pediatric blood & cancer.
2022 02; 69(2):e29413. doi:
10.1002/pbc.29413. [PMID: 34676969] - Mingwen Yang, Zekang Ye, Lianlian Mei, Inam Ullah, Chuchu Tan, Guoyu Wang, Qian Gu, Yi Lu, Samee Abdus, Lu Shi, Xiaoxuan Gong, Jianling Bai, John W Eikelboom, Chunjian Li. Pharmacodynamic effects of indobufen compared with aspirin in patients with coronary atherosclerosis.
European journal of clinical pharmacology.
2021 Dec; 77(12):1815-1823. doi:
10.1007/s00228-021-03177-y. [PMID: 34331551] - Silvia Lee, Beate Eichelberger, Christoph W Kopp, Simon Panzer, Thomas Gremmel. Residual platelet reactivity in low-dose aspirin-treated patients with class 1 obesity.
Vascular pharmacology.
2021 02; 136(?):106819. doi:
10.1016/j.vph.2020.106819. [PMID: 33207279] - Pavel Chrbolka, Stefan Alusik, Dagmar Kalatova, Zoltan Paluch. Increased platelet activity in tinnitus patients.
Neuro endocrinology letters.
2020 Sep; 41(2):102-106. doi:
. [PMID: 33185996] - Vikas Kumar, A Aneesh Kumar, Vinod Joseph, Vipin Mohan Dan, Abdul Jaleel, T R Santhosh Kumar, Chandrasekharan C Kartha. Untargeted metabolomics reveals alterations in metabolites of lipid metabolism and immune pathways in the serum of rats after long-term oral administration of Amalaki rasayana.
Molecular and cellular biochemistry.
2020 Jan; 463(1-2):147-160. doi:
10.1007/s11010-019-03637-1. [PMID: 31595424] - Chikako Sakaguchi, Naoki Miura, Hiromi Ohara, Yasufumi Nagata. Effects of reduced exposure to cigarette smoking on changes in biomarkers of potential harm in adult smokers: results of combined analysis of two clinical studies.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2019 Jul; 24(5):457-468. doi:
10.1080/1354750x.2019.1609579. [PMID: 31084221] - Paola Simeone, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Maria Teresa Guagnano, Armando Tartaro, Riccardo C Bonadonna, Virginia Federico, Francesco Cipollone, Agostino Consoli, Francesca Santilli. Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss.
Nutrients.
2018 Dec; 10(12):. doi:
10.3390/nu10121872. [PMID: 30513818] - Paola Simeone, Andrea Boccatonda, Rossella Liani, Francesca Santilli. Significance of urinary 11-dehydro-thromboxane B2 in age-related diseases: Focus on atherothrombosis.
Ageing research reviews.
2018 12; 48(?):51-78. doi:
10.1016/j.arr.2018.09.004. [PMID: 30273676] - Anupama Vasudevan, Kristen M Tecson, Jeanna Bennett-Firmin, Teodoro Bottiglieri, Luis R Lopez, Margarita Peterson, Mohanakrishnan Sathyamoorthy, Raphael Schiffmann, Jeffrey M Schussler, Caren Swift, Carlos E Velasco, Peter A McCullough. Prognostic value of urinary 11-dehydro-thromboxane B2 for mortality: A cohort study of stable coronary artery disease patients treated with aspirin.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
2018 10; 92(4):653-658. doi:
10.1002/ccd.27437. [PMID: 29193683] - Stefania Tacconelli, Melania Dovizio, Luigia Di Francesco, Alessandra Meneguzzi, Ilaria D'Agostino, Virgilio Evangelista, Stefano Manarini, Marta L Capone, Linda Grossi, Ettore Porreca, Concetta Di Febbo, Annalisa Bruno, Patrizia Ballerini, Giacomo Levantesi, Cristiano Fava, Pietro Minuz, Paola Patrignani. Reduced Variability to Aspirin Antiplatelet Effect by the Coadministration of Statins in High-Risk Patients for Cardiovascular Disease.
Clinical pharmacology and therapeutics.
2018 07; 104(1):111-119. doi:
10.1002/cpt.1075. [PMID: 29574792] - John M Thomason, Todd M Archer, Robert W Wills, Andrew J Mackin. Effects of immunosuppressive agents on the hemostatic system in normal dogs.
Journal of veterinary internal medicine.
2018 Jul; 32(4):1325-1333. doi:
10.1111/jvim.15132. [PMID: 29749651] - Roberto Cangemi, Roberto Carnevale, Cristina Nocella, Camilla Calvieri, Vittoria Cammisotto, Marta Novo, Valentina Castellani, Alessandra D'Amico, Chiara Zerbinati, Lucia Stefanini, Francesco Violi. Glucocorticoids impair platelet thromboxane biosynthesis in community-acquired pneumonia.
Pharmacological research.
2018 05; 131(?):66-74. doi:
10.1016/j.phrs.2018.03.014. [PMID: 29577968] - Jane A Mitchell, Rebecca B Knowles, Nicholas S Kirkby, Daniel M Reed, Matthew L Edin, William E White, Melissa V Chan, Hilary Longhurst, Magdi M Yaqoob, Ginger L Milne, Darryl C Zeldin, Timothy D Warner. Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.
Circulation research.
2018 02; 122(4):555-559. doi:
10.1161/circresaha.117.312144. [PMID: 29298774] - Nina S McCarthy, Ciara Vangjeli, Praveen Surendran, Achim Treumann, Cathy Rooney, Emily Ho, Peter Sever, Simon Thom, Alun D Hughes, Patricia B Munroe, Philip Howard, Toby Johnson, Mark Caulfield, Denis C Shields, Eoin O'Brien, Desmond J Fitzgerald, Alice V Stanton. Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
Atherosclerosis.
2018 02; 269(?):42-49. doi:
10.1016/j.atherosclerosis.2017.12.013. [PMID: 29258006] - N McLewee, T Archer, R Wills, A Mackin, J Thomason. Effects of aspirin dose escalation on platelet function and urinary thromboxane and prostacyclin levels in normal dogs.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):60-67. doi:
10.1111/jvp.12432. [PMID: 28664658] - Nan Wang, Kimberly C Vendrov, Brian P Simmons, Robert N Schuck, George A Stouffer, Craig R Lee. Urinary 11-dehydro-thromboxane B2 levels are associated with vascular inflammation and prognosis in atherosclerotic cardiovascular disease.
Prostaglandins & other lipid mediators.
2018 01; 134(?):24-31. doi:
10.1016/j.prostaglandins.2017.11.003. [PMID: 29155368] - Lei Pi, Di Che, Haifeng Long, Zhenzhen Fang, Jiawen Li, Shuyi Lin, Yunfeng Liu, Meiai Li, Lijuan Bao, Wenli Li, Yuan Zhang, Qiulian Deng, Techang Liu, Li Zhang, Xiaoqiong Gu. Immature platelets and antiplatelet therapy response to aspirin in Kawasaki disease.
Drug design, development and therapy.
2018; 12(?):1353-1362. doi:
10.2147/dddt.s163705. [PMID: 29872260] - Nikolaos Kakouros, Tyler J Gluckman, John V Conte, Thomas S Kickler, Katherine Laws, Bruce A Barton, Jeffrey J Rade. Differential Impact of Serial Measurement of Nonplatelet Thromboxane Generation on Long-Term Outcome After Cardiac Surgery.
Journal of the American Heart Association.
2017 Nov; 6(11):. doi:
10.1161/jaha.117.007486. [PMID: 29097390] - Vincenzo Mollace, Giuseppe Rosano, Natalia Malara, Enzo Di Fabrizio, Cristiana Vitale, Marialaura Coluccio, Jessica Maiuolo, Ayesha Ali Wasti, Carolina Muscoli, Micaela Gliozzi, Rocco Mollace, Vincenzo Musolino, Cristina Carresi, Massimo Fini, Bruno Silvestrini. Aspirin wears smart.
European heart journal. Cardiovascular pharmacotherapy.
2017 10; 3(4):185-188. doi:
10.1093/ehjcvp/pvx017. [PMID: 28505311] - Nikola Hadzi-Petrushev, Dine Mitrov, Vladimir Kostovski, Mitko Mladenov. The impact of vitamin C on the relationship among inflammation, lipid peroxidation and platelet activation during analgesic nephropathy in rats.
Journal of basic and clinical physiology and pharmacology.
2017 Sep; 28(5):473-481. doi:
10.1515/jbcpp-2016-0150. [PMID: 28771433] - Daniele Pastori, Cristina Nocella, Alessio Farcomeni, Simona Bartimoccia, Maria Santulli, Fortunata Vasaturo, Roberto Carnevale, Danilo Menichelli, Francesco Violi, Pasquale Pignatelli. Relationship of PCSK9 and Urinary Thromboxane Excretion to Cardiovascular Events in Patients With Atrial Fibrillation.
Journal of the American College of Cardiology.
2017 Sep; 70(12):1455-1462. doi:
10.1016/j.jacc.2017.07.743. [PMID: 28911508] - Anupama Vasudevan, Teodoro Bottiglieri, Kristen M Tecson, Mohanakrishnan Sathyamoorthy, Jeffrey M Schussler, Carlos E Velasco, Luis R Lopez, Caren Swift, Margarita Peterson, Jeanna Bennett-Firmin, Raphael Schiffmann, Peter A McCullough. Residual thromboxane activity and oxidative stress: influence on mortality in patients with stable coronary artery disease.
Coronary artery disease.
2017 Jun; 28(4):287-293. doi:
10.1097/mca.0000000000000461. [PMID: 28005558] - Peter A McCullough, Anupama Vasudevan, Mohanakrishnan Sathyamoorthy, Jeffrey M Schussler, Carlos E Velasco, Luis R Lopez, Caren Swift, Margarita Peterson, Jenna Bennett-Firmin, Raphael Schiffmann, Teodoro Bottiglieri. Urinary 11-Dehydro-Thromboxane B2 and Mortality in Patients With Stable Coronary Artery Disease.
The American journal of cardiology.
2017 04; 119(7):972-977. doi:
10.1016/j.amjcard.2016.12.004. [PMID: 28139223] - Patrizia Ferroni, Francesca Santilli, Francesco Cavaliere, Paola Simeone, Leopoldo Costarelli, Rossella Liani, Romina Tripaldi, Silvia Riondino, Mario Roselli, Giovanni Davi, Fiorella Guadagni. Oxidant stress as a major determinant of platelet activation in invasive breast cancer.
International journal of cancer.
2017 Feb; 140(3):696-704. doi:
10.1002/ijc.30488. [PMID: 27784132] - Paul A Gurbel, Kevin P Bliden, Rahul Chaudhary, Jeff Patrick, Fang Liu, Gailing Chen, Christopher McLeod, Udaya S Tantry. Antiplatelet Effect Durability of a Novel, 24-Hour, Extended-Release Prescription Formulation of Acetylsalicylic Acid in Patients With Type 2 Diabetes Mellitus.
The American journal of cardiology.
2016 Dec; 118(12):1941-1947. doi:
10.1016/j.amjcard.2016.08.088. [PMID: 27769511] - Peter A McCullough, Anupama Vasudevan, Luis R Lopez, Caren Swift, Margarita Peterson, Jeanna Bennett-Firmin, Raphael Schiffmann, Teodoro Bottiglieri. Oxidative stress reflected by increased F2-isoprostanes is associated with increasing urinary 11-dehydro thromboxane B2 levels in patients with coronary artery disease.
Thrombosis research.
2016 Dec; 148(?):85-88. doi:
10.1016/j.thromres.2016.10.022. [PMID: 27815971] - Pasquale Pignatelli, Daniele Pastori, Simona Bartimoccia, Danilo Menichelli, Tommasa Vicario, Cristina Nocella, Roberto Carnevale, Francesco Violi. Anti Xa oral anticoagulants inhibit in vivo platelet activation by modulating glycoprotein VI shedding.
Pharmacological research.
2016 11; 113(Pt A):484-489. doi:
10.1016/j.phrs.2016.09.035. [PMID: 27693274] - Jason Patregnani, Darren Klugman, David Zurakowski, Pranava Sinha, Robert Freishtat, John Berger, Yaser Diab. High on Aspirin Platelet Reactivity in Pediatric Patients Undergoing the Fontan Procedure.
Circulation.
2016 10; 134(17):1303-1305. doi:
10.1161/circulationaha.116.023457. [PMID: 27777299] - Daniele Pastori, Pasquale Pignatelli, Alessio Farcomeni, Danilo Menichelli, Cristina Nocella, Roberto Carnevale, Francesco Violi. Aging-Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation.
Journal of the American Heart Association.
2016 09; 5(9):. doi:
10.1161/jaha.116.003682. [PMID: 27609361] - Rahul Chaudhary, Kevin P Bliden, Jalaj Garg, Nafees Mohammed, Udaya Tantry, Denny Mathew, Peter P Toth, Christopher Franzese, Martin Gesheff, Shachi Pandya, Paul Gurbel. Statin therapy and inflammation in patients with diabetes treated with high dose aspirin.
Journal of diabetes and its complications.
2016 Sep; 30(7):1365-70. doi:
10.1016/j.jdiacomp.2016.05.002. [PMID: 27237049] - Natale Vazzana, Francesca Santilli, Stefano Lattanzio, Mario Liani, Luciano Giacci, Goffredo Del Rosso, Filippo Salvati, Andrea Boccatonda, Patrizia Ferroni, Giovanni Davì. Determinants of thromboxane biosynthesis in patients with moderate to severe chronic kidney disease.
European journal of internal medicine.
2016 Sep; 33(?):74-80. doi:
10.1016/j.ejim.2016.06.016. [PMID: 27389698] - Kazuyuki Nagatsuka, Shigeki Miyata, Akiko Kada, Atsushi Kawamura, Jyoji Nakagawara, Eisuke Furui, Shin Takiuchi, Katsushi Taomoto, Kazuomi Kario, Shinichiro Uchiyama, Kozue Saito, Takehiko Nagao, Kazuo Kitagawa, Naohisa Hosomi, Keiji Tanaka, Koichi Kaikita, Yasuo Katayama, Takeo Abumiya, Hiroshi Nakane, Hideo Wada, Akira Hattori, Kazumi Kimura, Takaaki Isshiki, Masakatsu Nishikawa, Takemori Yamawaki, Naohiro Yonemoto, Hiromi Okada, Hisao Ogawa, Kazuo Minematsu, Toshiyuki Miyata. Cardiovascular events occur independently of high on-aspirin platelet reactivity and residual COX-1 activity in stable cardiovascular patients.
Thrombosis and haemostasis.
2016 08; 116(2):356-68. doi:
10.1160/th15-11-0864. [PMID: 27098431] - Wojciech Szczeklik, Edyta Stodółkiewicz, Marcin Rzeszutko, Marek Tomala, Anton Chrustowicz, Krzysztof Żmudka, Marek Sanak. Urinary 11-Dehydro-Thromboxane B2 as a Predictor of Acute Myocardial Infarction Outcomes: Results of Leukotrienes and Thromboxane In Myocardial Infarction (LTIMI) Study.
Journal of the American Heart Association.
2016 08; 5(8):. doi:
10.1161/jaha.116.003702. [PMID: 27481134] - P Maga, M Sanak, J Jawien, B Rewerska, M Maga, A Wachsmann, M Koziej, I Gregorczyk-Maga, R Nizankowski. 11-dehydro thromboxane B2 levels after percutaneous transluminal angioplasty in patients with peripheral arterial occlusive disease during a one year follow-up period.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2016 Jun; 67(3):377-83. doi:
. [PMID: 27511998] - Nikolaos Kakouros, Susanna M Nazarian, Patrizia B Stadler, Thomas S Kickler, Jeffrey J Rade. Risk Factors for Nonplatelet Thromboxane Generation After Coronary Artery Bypass Graft Surgery.
Journal of the American Heart Association.
2016 Mar; 5(3):e002615. doi:
10.1161/jaha.115.002615. [PMID: 27068626] - Andrea L Edel, Amanda F Patenaude, Melanie N Richard, Elena Dibrov, J Alejandro Austria, Harold M Aukema, Grant N Pierce, Michel Aliani. The effect of flaxseed dose on circulating concentrations of alpha-linolenic acid and secoisolariciresinol diglucoside derived enterolignans in young, healthy adults.
European journal of nutrition.
2016 Mar; 55(2):651-663. doi:
10.1007/s00394-015-0885-2. [PMID: 25808116] - Ya-xiong Wan, Bin Luo, Yan-rong Shi, Mei-chi Chen, Li-na Wang, Ren-hong Wang, Jing-ping Niu. [The effect of cold air and dust weather on the content of IL-6,8- iso-PGF2α and 11-DH-TXB2 in urine].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2016 Jan; 32(1):5-7, 12. doi:
NULL. [PMID: 27255031] - Ali Maleki, Mostafa Cheraghi, Scott Reza Jafarian Kerman, Mahdi Montazeri, Negin Rashidi, Reza Ghanavati, Saeid Foroughi, Farshid Alyari, Hassan Ahmadvand. Aspirin Resistance in Different Doses by Bleeding Time and Urinary 11-dehydro-thromboxane B2.
Indian journal of physiology and pharmacology.
2016 Jan; 60(1):30-7. doi:
. [PMID: 29953191] - Francesca Santilli, Maria Teresa Guagnano, Paolo Innocenti, Liberato Aceto, Natale Vazzana, Stefano Lattanzio, Rossella Liani, Romina Tripaldi, Valeria Creato, Mario Romano, Giovanni Davì. Pentraxin 3 and Platelet Activation in Obese Patients After Gastric Banding.
Circulation journal : official journal of the Japanese Circulation Society.
2016; 80(2):502-11. doi:
10.1253/circj.cj-15-0721. [PMID: 26632534] - Teng-fei Liu, Jing-wei Zhang, Xia-huan Chen, Xue-ru Feng, Zhong-sheng Bai, Mei-lin Liu. [Correlation between the level of the urinary 11-dehydrothromboxane B2 and the clinical efficacy of aspirin in patients with type 2 diabetes and coronary artery disease].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2015 Dec; 47(6):920-4. doi:
. [PMID: 26679651] - Haruyo Ujike-Omori, Yohei Maeshima, Masaru Kinomura, Katsuyuki Tanabe, Kiyoshi Mori, Hiroyuki Watatani, Norikazu Hinamoto, Hitoshi Sugiyama, Yoshiki Sakai, Hiroshi Morimatsu, Hirofumi Makino. The urinary levels of prostanoid metabolites predict acute kidney injury in heterogeneous adult Japanese ICU patients: a prospective observational study.
Clinical and experimental nephrology.
2015 Dec; 19(6):1024-36. doi:
10.1007/s10157-015-1092-4. [PMID: 25669623] - Tengfei Liu, Jingwei Zhang, Xiahuan Chen, Xueru Feng, Sidney W Fu, Timothy A McCaffrey, Meilin Liu. Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease.
Gene.
2015 Oct; 571(1):23-7. doi:
10.1016/j.gene.2015.06.045. [PMID: 26095809] - Pasquale Pignatelli, Daniele Pastori, Alessio Farcomeni, Cristina Nocella, Simona Bartimoccia, Tommasa Vicario, Tommaso Bucci, Roberto Carnevale, Francesco Violi. Mediterranean diet reduces thromboxane A2 production in atrial fibrillation patients.
Clinical nutrition (Edinburgh, Scotland).
2015 Oct; 34(5):899-903. doi:
10.1016/j.clnu.2014.09.011. [PMID: 25288566] - Daniele Pastori, Pasquale Pignatelli, Alessio Farcomeni, Roberto Cangemi, William R Hiatt, Simona Bartimoccia, Cristina Nocella, Tommasa Vicario, Tommaso Bucci, Roberto Carnevale, Gregory Y H Lip, Francesco Violi. Urinary 11-dehydro-thromboxane B2 is associated with cardiovascular events and mortality in patients with atrial fibrillation.
American heart journal.
2015 Sep; 170(3):490-7.e1. doi:
10.1016/j.ahj.2015.05.011. [PMID: 26385032] - Jules I Schwartz, Bret J Musser, Wesley K Tanaka, William V Taggart, Anish Mehta, Keith M Gottesdiener, Howard E Greenberg. Inhibition of prostacyclin and thromboxane biosynthesis in healthy volunteers by single and multiple doses of acetaminophen and indomethacin.
Clinical pharmacology in drug development.
2015 09; 4(5):337-45. doi:
10.1002/cpdd.194. [PMID: 27137142] - E Véricel, R Colas, C Calzada, Q H Lê, N Feugier, C Cugnet, H Vidal, M Laville, P Moulin, M Lagarde. Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients.
Thrombosis and haemostasis.
2015 Aug; 114(2):289-96. doi:
10.1160/th14-12-1003. [PMID: 25832443] - Markus Schmugge, Oliver Speer, Sabine Kroiss, Walter Knirsch, Oliver Kretschmar, Margaret L Rand, Manuela Albisetti. Monitoring aspirin therapy in children after interventional cardiac catheterization: laboratory measures, dose response, and clinical outcomes.
European journal of pediatrics.
2015 Jul; 174(7):933-41. doi:
10.1007/s00431-014-2485-1. [PMID: 25589198] - Christopher J Franzese, Kevin P Bliden, Martin G Gesheff, Shachi Pandya, Kirk E Guyer, Anand Singla, Udaya S Tantry, Peter P Toth, Paul A Gurbel. Relation of fish oil supplementation to markers of atherothrombotic risk in patients with cardiovascular disease not receiving lipid-lowering therapy.
The American journal of cardiology.
2015 May; 115(9):1204-11. doi:
10.1016/j.amjcard.2015.02.002. [PMID: 25759102] - Sonia Medina, Raúl Domínguez-Perles, Diego A Moreno, Cristina García-Viguera, Federico Ferreres, José Ignacio Gil, Ángel Gil-Izquierdo. The intake of broccoli sprouts modulates the inflammatory and vascular prostanoids but not the oxidative stress-related isoprostanes in healthy humans.
Food chemistry.
2015 Apr; 173(?):1187-94. doi:
10.1016/j.foodchem.2014.10.152. [PMID: 25466142] - Frank Lüdicke, John Magnette, Gizelle Baker, Rolf Weitkunat. A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2015; 20(6-7):411-21. doi:
10.3109/1354750x.2015.1096303. [PMID: 26616146] - Charles D Varnell, Stuart L Goldstein, Donald L Yee, Jun Teruya, Kirk E Guyer, Shakeel Siddiqui, John L Jefferies. Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: another example of developmental hemostasis?.
Pediatric blood & cancer.
2014 Nov; 61(11):2074-6. doi:
10.1002/pbc.25089. [PMID: 24803308] - Nikola Hadzi-Petrushev, Velimir Stojkovski, Dine Mitrov, Mitko Mladenov. D-galactose induced inflammation lipid peroxidation and platelet activation in rats.
Cytokine.
2014 Sep; 69(1):150-3. doi:
10.1016/j.cyto.2014.05.006. [PMID: 24907931] - Stephanie Ross, John Eikelboom, Sonia S Anand, Niclas Eriksson, Hertzel C Gerstein, Shamir Mehta, Stuart J Connolly, Lynda Rose, Paul M Ridker, Lars Wallentin, Daniel I Chasman, Salim Yusuf, Guillaume Paré. Association of cyclooxygenase-2 genetic variant with cardiovascular disease.
European heart journal.
2014 Sep; 35(33):2242-8a. doi:
10.1093/eurheartj/ehu168. [PMID: 24796340] - K P Bliden, A Singla, M G Gesheff, P P Toth, A Tabrizchi, G Ens, K Guyer, M Singh, C J Franzese, D Stapleton, U S Tantry, P A Gurbel. Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin.
Thrombosis and haemostasis.
2014 Aug; 112(2):323-31. doi:
10.1160/th14-01-0094. [PMID: 24763965] - Christopher N Floyd, Timothy Goodman, Silke Becker, Nan Chen, Agnesa Mustafa, Emma Schofield, James Campbell, Malcolm Ward, Pankaj Sharma, Albert Ferro. Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.
British journal of clinical pharmacology.
2014 Aug; 78(2):320-8. doi:
10.1111/bcp.12335. [PMID: 25099258] - Stefano Lattanzio, Francesca Santilli, Rossella Liani, Natale Vazzana, Thor Ueland, Patrizia Di Fulvio, Gloria Formoso, Agostino Consoli, Pål Aukrust, Giovanni Davì. Circulating dickkopf-1 in diabetes mellitus: association with platelet activation and effects of improved metabolic control and low-dose aspirin.
Journal of the American Heart Association.
2014 Jul; 3(4):. doi:
10.1161/jaha.114.001000. [PMID: 25037197] - Francesca Santilli, Leonardo Paloscia, Rossella Liani, Marta Di Nicola, Massimo Di Marco, Stefano Lattanzio, Sara La Barba, Silvia Pascale, Marco Mascellanti, Giovanni Davì. Circulating myeloid-related protein-8/14 is related to thromboxane-dependent platelet activation in patients with acute coronary syndrome, with and without ongoing low-dose aspirin treatment.
Journal of the American Heart Association.
2014 Jul; 3(4):. doi:
10.1161/jaha.114.000903. [PMID: 25037196] - D Mitrov, N Hadzi-Petrushev, V Stojkovski, E Gjorgievska, H Gagov, M Mladenov. Influence of chronic chromium exposition on the processes of lipid peroxidation inflammation and platelet activation in rats.
Journal of biological regulators and homeostatic agents.
2014 Jul; 28(3):531-5. doi:
. [PMID: 25316141] - Pornpatr A Dharmasaroja, Suvaraporn Sae-Lim. Comparison of aspirin response measured by urinary 11-dehydrothromboxane B2 and VerifyNow aspirin assay in patients with ischemic stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2014 May; 23(5):953-7. doi:
10.1016/j.jstrokecerebrovasdis.2013.08.001. [PMID: 24126290] - A P DeFilippis, S N Rai, A Cambon, R J Miles, A S Jaffe, A B Moser, R O Jones, R Bolli, S P Schulman. Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2014 Apr; 24(4):428-33. doi:
10.1016/j.numecd.2013.08.012. [PMID: 24370448] - Lillian Harboe Gonçalves, Marcos Vinícius Ferreira Silva, Rita Carolina Figueiredo Duarte, Luci Maria S Dusse, Ana Paula Fernandes, Adriana A Bosco, Karina Braga Gomes, Maria das Graças Carvalho. Acetylsalicylic acid therapy: influence of metformin use and other variables on urinary 11-dehydrothromboxane B2 levels.
Clinica chimica acta; international journal of clinical chemistry.
2014 Feb; 429(?):76-8. doi:
10.1016/j.cca.2013.11.028. [PMID: 24316050] - Francesca Santilli, Natale Vazzana, Pierpaolo Iodice, Stefano Lattanzio, Rossella Liani, Rosa Grazia Bellomo, Gianfranco Lessiani, Francesca Perego, Raoul Saggini, Giovanni Davì. Effects of high-amount-high-intensity exercise on in vivo platelet activation: modulation by lipid peroxidation and AGE/RAGE axis.
Thrombosis and haemostasis.
2013 Dec; 110(6):1232-40. doi:
10.1160/th13-04-0295. [PMID: 24030807] - Roberta d'Emmanuele di Villa Bianca, Emma Mitidieri, Matteo N D Di Minno, Nicholas S Kirkby, Timothy D Warner, Giovanni Di Minno, Giuseppe Cirino, Raffaella Sorrentino. Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia.
Proceedings of the National Academy of Sciences of the United States of America.
2013 Sep; 110(39):15812-7. doi:
10.1073/pnas.1309049110. [PMID: 24019484] - Elodie Gautier-Veyret, Claire Arnaud, Magnus Bäck, Jean-Louis Pépin, Marcelo H Petri, Jean-Philippe Baguet, Renaud Tamisier, Patrick Lévy, Françoise Stanke-Labesque. Intermittent hypoxia-activated cyclooxygenase pathway: role in atherosclerosis.
The European respiratory journal.
2013 Aug; 42(2):404-13. doi:
10.1183/09031936.00096512. [PMID: 23060635] - Pornpatr A Dharmasaroja, Sombat Muengtaweepongsa, Suvaraporn Sae-Lim. Aspirin nonresponders in patients with ischaemic stroke.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2013 Jun; 24(4):361-4. doi:
10.1097/mbc.0b013e32835cc157. [PMID: 23429255] - Natale Vazzana, Antonina Ganci, Angelo Baldassare Cefalù, Stefano Lattanzio, Davide Noto, Nicole Santoro, Raoul Saggini, Luca Puccetti, Maurizio Averna, Giovanni Davì. Enhanced lipid peroxidation and platelet activation as potential contributors to increased cardiovascular risk in the low-HDL phenotype.
Journal of the American Heart Association.
2013 Apr; 2(2):e000063. doi:
10.1161/jaha.113.000063. [PMID: 23557750] - Roger C Carroll, Robert M Craft, Carolyn C Snider, Venkata R Aligeti, Dale C Wortham. A comparison of VerifyNowR with PlateletMappingR--detected aspirin resistance and correlation with urinary thromboxane.
Anesthesia and analgesia.
2013 Feb; 116(2):282-6. doi:
10.1213/ane.0b013e318277de06. [PMID: 23302970] - L Sadilkova, Z Paluch, J Mottlova, F Bednar, S Alusik. The effect of selected pre-analytical phase variables on plasma thromboxane A₂ measurements in humans.
International journal of laboratory hematology.
2013 Feb; 35(1):92-100. doi:
10.1111/j.1751-553x.2012.01458.x. [PMID: 22908995] - Atsuhiro Nakamura, Noritoshi Nagaya, Hiroaki Obata, Katsuya Sakai, Yoshiki Sakai, Masanori Yoshikawa, Kaoru Hamada, Kunio Matsumoto, Hiroshi Kimura. Oral administration of a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity for pulmonary arterial hypertension.
Circulation journal : official journal of the Japanese Circulation Society.
2013; 77(8):2127-33. doi:
10.1253/circj.cj-13-0107. [PMID: 23676973] - A Dudley, J Thomason, S Fritz, J Grady, J Stokes, R Wills, L Pinchuk, A Mackin, K Lunsford. Cyclooxygenase expression and platelet function in healthy dogs receiving low-dose aspirin.
Journal of veterinary internal medicine.
2013 Jan; 27(1):141-9. doi:
10.1111/jvim.12022. [PMID: 23278865] - Thomas Gremmel, Thomas Perkmann, Daniela Seidinger, Renate Koppensteiner, Simon Panzer, Christoph W Kopp, Sabine Steiner. Differential impact of inflammation on six laboratory assays measuring residual arachidonic acid-inducible platelet reactivity during dual antiplatelet therapy.
Journal of atherosclerosis and thrombosis.
2013; 20(7):630-45. doi:
10.5551/jat.17665. [PMID: 23739624] - Xingyang Yi, Qiang Zhou, Jing Lin, Lifen Chi, Zhao Han. Platelet response to aspirin in Chinese stroke patients is independent of genetic polymorphisms of COX-1 C50T and COX-2 G765C.
Journal of atherosclerosis and thrombosis.
2013; 20(1):65-72. doi:
10.5551/jat.14092. [PMID: 22972377] - Agnieszka Kapłon-Cieślicka, Marek Rosiak, Marek Postuła, Agnieszka Serafin, Agnieszka Kondracka, Grzegorz Opolski, Krzysztof J Filipiak. Predictors of high platelet reactivity during aspirin treatment in patients with type 2 diabetes.
Kardiologia polska.
2013; 71(9):893-902. doi:
10.5603/kp.2013.0055. [PMID: 24065375] - Andrew P DeFilippis, Oluwasegun S Oloyede, Efstathia Andrikopoulou, Amy K Saenger, Joel M Palachuvattil, Yetunde A Fasoro, Eliseo Guallar, Roger S Blumenthal, Thomas S Kickler, Allan S Jaffe, Gary Gerstenblith, Steven P Schulman, Jeffrey J Rade. Thromboxane A(2) generation, in the absence of platelet COX-1 activity, in patients with and without atherothrombotic myocardial infarction.
Circulation journal : official journal of the Japanese Circulation Society.
2013; 77(11):2786-92. doi:
10.1253/circj.cj-12-1421. [PMID: 23985963] - M T Olson, T S Kickler, J A Lawson, R C McLean, J Jani, G A FitzGerald, J J Rade. Effect of assay specificity on the association of urine 11-dehydro thromboxane B2 determination with cardiovascular risk.
Journal of thrombosis and haemostasis : JTH.
2012 Dec; 10(12):2462-9. doi:
10.1111/jth.12026. [PMID: 23072449] - Alfredo Dragani, Angela Falco, Francesca Santilli, Stefania Basili, Giancarlo Rolandi, Loredana Cerasa, Stefano Lattanzio, Giovanni Ciabattoni, Carlo Patrono, Giovanni Davì. Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism.
Thrombosis and haemostasis.
2012 Sep; 108(3):533-42. doi:
10.1160/th11-12-0899. [PMID: 22782530] - Natale Vazzana, Maria Teresa Guagnano, Chiara Cuccurullo, Elisabetta Ferrante, Stefano Lattanzio, Rossella Liani, Mario Romano, Giovanni Davì. Endogenous secretory RAGE in obese women: association with platelet activation and oxidative stress.
The Journal of clinical endocrinology and metabolism.
2012 Sep; 97(9):E1726-30. doi:
10.1210/jc.2012-1473. [PMID: 22761461] - Marcia Dewi Hartanto, Zita Arieselia, Rianto Setiabudy, Arini Setiawati, Ali Baziad. Urinary 11-dehydro-thromboxane B₂ and 2,3-dinor-6-keto-prostaglandin-F₁α in healthy post-menopausal and pre-menopausal women receiving aspirin 100 mg.
Journal of thrombosis and thrombolysis.
2012 Jul; 34(1):79-84. doi:
10.1007/s11239-012-0689-7. [PMID: 22311294] - Matteo Cesari, Stephen B Kritchevsky, Barbara Nicklas, Alka M Kanaya, Paola Patrignani, Stefania Tacconelli, Gregory J Tranah, Gianni Tognoni, Tamara B Harris, Raffaele Antonelli Incalzi, Anne B Newman, Marco Pahor. Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2012 Jun; 67(6):671-6. doi:
10.1093/gerona/glr246. [PMID: 22389462] - B A Lemkes, L Bähler, P W Kamphuisen, A K Stroobants, E J Van Den Dool, J B Hoekstra, R Nieuwland, V E Gerdes, F Holleman. The influence of aspirin dose and glycemic control on platelet inhibition in patients with type 2 diabetes mellitus.
Journal of thrombosis and haemostasis : JTH.
2012 Apr; 10(4):639-46. doi:
10.1111/j.1538-7836.2012.04632.x. [PMID: 22252020] - C Li, J Hirsh, C Xie, M A Johnston, J W Eikelboom. Reversal of the anti-platelet effects of aspirin and clopidogrel.
Journal of thrombosis and haemostasis : JTH.
2012 Apr; 10(4):521-8. doi:
10.1111/j.1538-7836.2012.04641.x. [PMID: 22268852] - Kathleen B Mullins, John M Thomason, Kari V Lunsford, Lesya M Pinchuk, Vernon C Langston, Robert W Wills, Ronald M McLaughlin, Andrew J Mackin. Effects of carprofen, meloxicam and deracoxib on platelet function in dogs.
Veterinary anaesthesia and analgesia.
2012 Mar; 39(2):206-17. doi:
10.1111/j.1467-2995.2011.00684.x. [PMID: 22248445] - Lenka Sadilkova, Zoltan Paluch, Jirina Mottlova, Frantisek Bednar, Stefan Alusik. The purification step is not crucial in EIA measurements of thromboxane B2 and 11-dehydrothromboxane B2 in human plasma.
Clinical laboratory.
2012; 58(1-2):177-83. doi:
. [PMID: 22372363] - Zanxin Wang, Fei Gao, Jianlong Men, Jing Ren, Paul Modi, Minxin Wei. Aspirin resistance in off-pump coronary artery bypass grafting.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
2012 Jan; 41(1):108-12. doi:
10.1016/j.ejcts.2011.04.021. [PMID: 21636287] - Jean A Hall, Jeffrey A Brockman, Dennis E Jewell. Dietary fish oil alters the lysophospholipid metabolomic profile and decreases urinary 11-dehydro thromboxane B₂ concentration in healthy Beagles.
Veterinary immunology and immunopathology.
2011 Dec; 144(3-4):355-65. doi:
10.1016/j.vetimm.2011.08.007. [PMID: 21925741] - Matteo Nicola Dario Di Minno, Salvatore Pezzullo, Vittorio Palmieri, Antonio Coppola, Armando D'Angelo, Francesca Sampietro, Viviana Cavalca, Elena Tremoli, Giovanni Di Minno. Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis.
Thrombosis research.
2011 Oct; 128(4):e43-8. doi:
10.1016/j.thromres.2011.05.017. [PMID: 21669453] - Galia Spectre, Lisa Arnetz, Claes-Göran Östenson, Kerstin Brismar, Nailin Li, Paul Hjemdahl. Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications.
Thrombosis and haemostasis.
2011 Sep; 106(3):491-9. doi:
10.1160/th11-04-0216. [PMID: 21800009] - J Thomason, K Lunsford, K Mullins, J Stokes, L Pinchuk, R Wills, R McLaughlin, C Langston, S Pruett, A Mackin. Platelet cyclooxygenase expression in normal dogs.
Journal of veterinary internal medicine.
2011 Sep; 25(5):1106-12. doi:
10.1111/j.1939-1676.2011.00781.x. [PMID: 21985141] - Crystal M Hoh, Stephanie A Smith, Maureen A McMichael, Julie K Byron. Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs.
American journal of veterinary research.
2011 Aug; 72(8):1038-45. doi:
10.2460/ajvr.72.8.1038. [PMID: 21801060] - Caoimhe M Lynch, Ruth O'Kelly, Bernard Stuart, Achim Treumann, Ronan Conroy, Carmen L Regan. The role of thromboxane A(2) in the pathogenesis of intrauterine growth restriction associated with maternal smoking in pregnancy.
Prostaglandins & other lipid mediators.
2011 Aug; 95(1-4):63-7. doi:
10.1016/j.prostaglandins.2011.06.007. [PMID: 21723954] - Saeed H M Halawani, David J P Williams, Abiodun Adefurin, John Webster, Michael Greaves, Isobel Ford. Aspirin failure in patients presenting with acute cerebrovascular ischaemia.
Thrombosis and haemostasis.
2011 Aug; 106(2):240-7. doi:
10.1160/th11-01-0045. [PMID: 21544317] - Lillian Harboe Gonçalves, Luci Maria Sant'ana Dusse, Ana Paula Fernandes, Karina Braga Gomes, Mirelle Oliveira Sóter, Michelle Teodoro Alves, Kathryna Fontana Rodrigues, Fernanda Rocha Freitas, Flavia Komatsuzaki, Marinez Oliveira Sousa, Adriana Aparecida Bosco, Gérson Antônio Pianett, Maria das Graças Carvalho. Urinary 11-dehydro thromboxane B₂ levels in type 2 diabetic patients before and during aspirin intake.
Clinica chimica acta; international journal of clinical chemistry.
2011 Jul; 412(15-16):1366-70. doi:
10.1016/j.cca.2011.04.006. [PMID: 21510926] - Tahar Chakroun, Faouzi Addad, Saloua Yacoub, Fatma Abderrezak, Gregoris T Gerotziafas, Sadia Abdelkafi, Mohssen Hassine, Habib Gamra, Mohamed Hatmi, Ismail Elalamy. The cyclooxygenase-1 C50T polymorphism is not associated with aspirin responsiveness status in stable coronary artery disease in Tunisian patients.
Genetic testing and molecular biomarkers.
2011 Jul; 15(7-8):513-6. doi:
10.1089/gtmb.2010.0225. [PMID: 21434767] - Fei Gao, Zan-Xin Wang, Jian-Long Men, Jing Ren, Min-Xin Wei. Effect of polymorphism and type II diabetes on aspirin resistance in patients with unstable coronary artery disease.
Chinese medical journal.
2011 Jun; 124(11):1731-4. doi:
. [PMID: 21740787] - Simona Simeoni, Roberto Biselli, Raffaele D'Amelio, Bianca Rocca, Stefano Lattanzio, Luciana Mucci, Giovanni Davì, Francesca Romana Patacchioli. Stress-induced salivary cortisol secretion during hypobaric hypoxia challenge and in vivo urinary thromboxane production in healthy male subjects.
Stress (Amsterdam, Netherlands).
2011 May; 14(3):282-9. doi:
10.3109/10253890.2010.545458. [PMID: 21434833] - Lianhua Shen, Yukana Matsunami, Nanhu Quan, Kazuko Kobayashi, Eiji Matsuura, Keiji Oguma. In vivo oxidation, platelet activation and simultaneous occurrence of natural immunity in atherosclerosis-prone mice.
The Israel Medical Association journal : IMAJ.
2011 May; 13(5):278-83. doi:
. [PMID: 21845968] - Kimberly Frost-Pineda, Qiwei Liang, Jianmin Liu, Lonnie Rimmer, Yan Jin, Shixia Feng, Sunil Kapur, Paul Mendes, Hans Roethig, Mohamadi Sarkar. Biomarkers of potential harm among adult smokers and nonsmokers in the total exposure study.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.
2011 Mar; 13(3):182-93. doi:
10.1093/ntr/ntq235. [PMID: 21330277] - Gianfranco Lessiani, Natale Vazzana, Chiara Cuccurullo, Dario Di Michele, Giuseppe Laurora, Giuseppe Sgrò, Paolo Di Ruscio, Emilio Simeone, Pierangelo Di Iorio, Stefano Lattanzio, Rossella Liani, Elisabetta Ferrante, Giovanni Davì. Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of iloprost.
Thrombosis and haemostasis.
2011 Feb; 105(2):321-8. doi:
10.1160/th10-07-0499. [PMID: 21103664] - Anna Wójtowicz, Anetta Undas, Hubert Huras, Jacek Musiał, Krzysztof Rytlewski, Alfred Reroń, Maciej Wilczak, Robert Jach. Aspirin resistance may be associated with adverse pregnancy outcomes.
Neuro endocrinology letters.
2011; 32(3):334-9. doi:
. [PMID: 21670728]