(8S,9S,10R,13S,14S,17S)-17-((R)-2-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (BioDeep_00001039945)
代谢物信息卡片
(8S,9S,10R,13S,14S,17S)-17-((R)-2-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
化学式: C27H46O2 (402.34976159999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)(C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)O
InChI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20?,21-,22-,23-,24-,25-,26-,27+/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xu Xiao, Youngjae Kim, Beatriz Romartinez-Alonso, Kristupas Sirvydis, Daniel S Ory, John W R Schwabe, Michael E Jung, Peter Tontonoz. Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.
Proceedings of the National Academy of Sciences of the United States of America.
2021 01; 118(2):. doi:
10.1073/pnas.2024149118. [PMID: 33376205] - Javier-Germán Rodríguez-Carpena, David Morcuende, María Jesus Petrón, Mario Estévez. Inhibition of cholesterol oxidation products (COPs) formation in emulsified porcine patties by phenolic-rich avocado (Persea americana Mill.) extracts.
Journal of agricultural and food chemistry.
2012 Mar; 60(9):2224-30. doi:
10.1021/jf2040753. [PMID: 22292505] - Hui Xia, Colvin M Redman. Oxysterols suppress constitutive fibrinogen expression.
Thrombosis and haemostasis.
2003 Jul; 90(1):43-51. doi:
10.1055/s-0037-1613597. [PMID: 12876624] - B A Laffitte, J J Repa, S B Joseph, D C Wilpitz, H R Kast, D J Mangelsdorf, P Tontonoz. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Proceedings of the National Academy of Sciences of the United States of America.
2001 Jan; 98(2):507-12. doi:
10.1073/pnas.98.2.507. [PMID: 11149950] - L Matthys, R Castello, A Zilz, E P Widmaier. Differential sensitivity to ACTH, but not stress, in two sources of outbred Sprague-Dawley rats.
Neuroendocrinology.
1998 Jun; 67(6):403-11. doi:
10.1159/000054339. [PMID: 9662720] - J H Nielsen, C E Olsen, C Duedahl, L H Skibsted. Isolation and quantification of cholesterol oxides in dairy products by selected ion monitoring mass spectrometry.
The Journal of dairy research.
1995 Feb; 62(1):101-13. doi:
10.1017/s0022029900033719. [PMID: 7738238] - K Z Liu, T E Cuddy, G N Pierce. Oxidative status of lipoproteins in coronary disease patients.
American heart journal.
1992 Feb; 123(2):285-90. doi:
10.1016/0002-8703(92)90636-a. [PMID: 1736561] - J W Laskey, P V Phelps. Effect of cadmium and other metal cations on in vitro Leydig cell testosterone production.
Toxicology and applied pharmacology.
1991 Apr; 108(2):296-306. doi:
10.1016/0041-008x(91)90119-y. [PMID: 1850171] - B C McNamara, C R Jefcoate. Heterogeneous pools of cholesterol side-chain cleavage activity in adrenal mitochondria from ACTH-treated rats: differential responses to different reducing precursors.
Molecular and cellular endocrinology.
1990 Oct; 73(2-3):123-34. doi:
10.1016/0303-7207(90)90125-r. [PMID: 2176627] - H Guo, J H Calkins, M M Sigel, T Lin. Interleukin-2 is a potent inhibitor of Leydig cell steroidogenesis.
Endocrinology.
1990 Sep; 127(3):1234-9. doi:
10.1210/endo-127-3-1234. [PMID: 2167211] - C Seillan. Oxysterol mediated changes in fatty acid distribution and lipid synthesis in cultured bovine aortic smooth muscle cells.
Lipids.
1990 Mar; 25(3):172-6. doi:
10.1007/bf02544334. [PMID: 2110280] - M W Rooney, S Yachnin, O Kucuk, L J Lis, J W Kauffman. Oxygenated cholesterols synergistically immobilize acyl chains and enhance protein helical structure in human erythrocyte membranes.
Biochimica et biophysica acta.
1985 Oct; 820(1):33-9. doi:
10.1016/0005-2736(85)90212-3. [PMID: 4052416] - P B Hoyer, G D Niswender. The regulation of steroidogenesis is different in the two types of ovine luteal cells.
Canadian journal of physiology and pharmacology.
1985 Mar; 63(3):240-8. doi:
10.1139/y85-045. [PMID: 2985223] - M A Hattori, D R Aquilano, M L Dufau. An early steroidogenic defect in hormone-induced Leydig cell desensitization.
Journal of steroid biochemistry.
1984 Sep; 21(3):265-77. doi:
10.1016/0022-4731(84)90279-6. [PMID: 6548538] - J Klimek, A P Schaap, T Kimura. The relationship between NADPH-dependent lipid peroxidation and degradation of cytochrome P-450 in adrenal cortex mitochondria.
Biochemical and biophysical research communications.
1983 Jan; 110(2):559-66. doi:
10.1016/0006-291x(83)91186-5. [PMID: 6838538] - J L Duncan, L Buckingham. Resistance to streptolysin O in mammalian cells treated with oxygenated derivatives of cholesterol. Cholesterol content of resistant cells and recovery of streptolysin O sensitivity.
Biochimica et biophysica acta.
1980 Dec; 603(2):278-87. doi:
10.1016/0005-2736(80)90374-0. [PMID: 7459354] - K SHIMIZU, S SHIMAO, M TANAKA. CONVERSION IN VITRO OF 20-ALPHA-HYDROXYCHOLESTEROL TO 17-ALPHA, 20-ALPHA-DIHYDROXYCHOLESTEROL BY HUMAN FETAL ADRENALS.
Steroids.
1965; 75(?):SUPPL 1:85-93. doi:
". [PMID: 14283223] - K SHIMIZU, R I DORFMAN, M GUT. Isocaproic acid, a metabolite of 20 alpha-hydroxycholesterol.
The Journal of biological chemistry.
1960 Jun; 235(?):PC25. doi:
10.1016/s0021-9258(19)76898-7. [PMID: 14446007]