(17R)-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one (BioDeep_00001038992)
代谢物信息卡片
化学式: C21H30O6 (378.204228)
中文名称: 6β-羟基可的松
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(=O)C=C1C(CC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O)O
InChI: InChI=1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12-,13-,15?,16-,18+,19-,20-,21-/m0/s1
描述信息
同义名列表
2 个代谢物同义名
(8S,9S,10R,11S,13S,14S,17R)-6,11,17-Trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one; (17R)-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- B I Kantemirova, A Kh Chernysheva, A K Starodubtsev, D A Sychev. [Study on phenotypical activity of isoenzyme CYP3A4 in children].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].
2012; 57(1-2):23-5. doi:
NULL
. [PMID: 22741198] - Rong Liu, Faju Chen, Kun Zou, Tangbin Yang. One-step monoclonal antibody based enzyme-linked immunosorbent assay for direct determination of cortisol in serum.
Hybridoma (2005).
2011 Jun; 30(3):279-86. doi:
10.1089/hyb.2010.0115
. [PMID: 21707363] - P A Baranov, S A Appolonova, G M Rodchenkov, A K Sariev, V P Zherdev. [Effect of mexidol on 6beta/free hydroxycortisol ratio. Possibility of CYP3A4 activation].
Eksperimental'naia i klinicheskaia farmakologiia.
2010 Nov; 73(11):39-40. doi:
NULL
. [PMID: 21254598] - Ursula Lutz, Nataly Bittner, Mike Ufer, Werner K Lutz. Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Jan; 878(1):97-101. doi:
10.1016/j.jchromb.2009.11.023
. [PMID: 19959402] - Deepen Patel, Paul Ratner, Diane Clements, Wei Wu, Melissa Faris, Edward Philpot. Lack of effect on adult and adolescent hypothalamic-pituitary-adrenal axis function with use of fluticasone furoate nasal spray.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2008 May; 100(5):490-6. doi:
10.1016/s1081-1206(10)60476-0
. [PMID: 18517083] - Karin Dilger, Richard Fux, Daniel Röck, Klaus Mörike, Christoph H Gleiter. Effect of high-dose metronidazole on pharmacokinetics of oral budesonide and vice versa: a double drug interaction study.
Journal of clinical pharmacology.
2007 Dec; 47(12):1532-9. doi:
10.1177/0091270007308617
. [PMID: 18048573] - Tewari Tushar, Thomas Vinod, Sundaram Rajan, Chanolean Shashindran, Chandrasekaran Adithan. Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers.
Basic & clinical pharmacology & toxicology.
2007 Apr; 100(4):269-72. doi:
10.1111/j.1742-7843.2006.00039.x
. [PMID: 17371531] - F Capolongo, M Tapparo, R Merlanti, L Ravarotto, E Tealdo, G Gallina, C Montesissa, M Dacasto. Illicit treatments in cattle and urinary 6beta-hydroxycortisol/cortisol ratio.
Analytica chimica acta.
2007 Mar; 586(1-2):228-32. doi:
10.1016/j.aca.2006.09.033
. [PMID: 17386716] - Ehab S Eldesoky, Sherif I Kamel, Ahlam M Farghaly, Madiha Y Bakheet, Mohsen A Hedaya, Jean-Pascal Siest. Study of the Urinary Ratio of 6 beta-Hydroxycortisol/Cortisol as a Biomarker of CYP3A4 Activity in Egyptian Patients with Chronic Liver Diseases.
Biomarker insights.
2007 Feb; 1(?):157-64. doi:
10.1177/117727190600100003
. [PMID: 19690646] - S Micuda, L Sispera, M Hodac, P Parízek, L Fuksa, E Brcáková, J Cerman, J Cermanová, J Martínková. Diurnal variation of 6beta-hydroxycortisol in cardiac patients.
Physiological research.
2007; 56(3):307-313. doi:
10.33549/physiolres.931029
. [PMID: 16792464] - Nuntiya Somparn, Upa Kukongviriyapan, Wichittra Tassaneeyakul, Arunee Jetsrisuparb, Veerapol Kukongviriyapan. Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients.
European journal of clinical pharmacology.
2007 Jan; 63(1):43-50. doi:
10.1007/s00228-006-0224-x
. [PMID: 17119944] - David E Martin, Robert Blum, Judy Doto, Hal Galbraith, Charles Ballow. Multiple-dose pharmacokinetics and safety of bevirimat, a novel inhibitor of HIV maturation, in healthy volunteers.
Clinical pharmacokinetics.
2007; 46(7):589-98. doi:
10.2165/00003088-200746070-00004
. [PMID: 17596104] - N Mochizuki, K Matsumoto, K Ohno, T Shimamura, H Furukawa, S Todo, S Kishino. Effects of hepatic CYP3A4 activity on disposition of micafungin in liver transplant recipients with markedly small-for-size grafts.
Transplantation proceedings.
2006 Dec; 38(10):3649-50. doi:
10.1016/j.transproceed.2006.10.146
. [PMID: 17175357] - Thomas Remer, Christiane Maser-Gluth, Kai R Boye, Michaela F Hartmann, Eberhard Heinze, Stefan A Wudy. Exaggerated adrenarche and altered cortisol metabolism in Type 1 diabetic children.
Steroids.
2006 Jul; 71(7):591-8. doi:
10.1016/j.steroids.2006.02.005
. [PMID: 16616286] - Toshiyuki Shimizu, Kei Akimoto, Takuya Yoshimura, Takuro Niwa, Kaoru Kobayashi, Michio Tsunoo, Kan Chiba. Autoinduction of MKC-963 [(R)-1-(1-cyclohexylethylamino)-4-phenylphthalazine] metabolism in healthy volunteers and its retrospective evaluation using primary human hepatocytes and cDNA-expressed enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Jun; 34(6):950-4. doi:
10.1124/dmd.105.007997
. [PMID: 16531475] - Jonathan G Scammell, Jenne M Westberry, Patti W Sadosky, Tina R Hubler, Lawrence E Williams, Susan V Gibson, Ravinder J Singh, Robert L Taylor, Cedric H L Shackleton. Cortisol metabolism in the Bolivian squirrel monkey (Saimiri boliviensis boliviensis).
Comparative medicine.
2006 Apr; 56(2):128-35. doi:
NULL
. [PMID: 16639980] - Kwee Poo Yeo, Stephen L Lowe, Ming Tung Lim, James R Voelker, Jennifer L Burkey, Stephen D Wise. Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin-mediated CYP3A4 induction.
British journal of clinical pharmacology.
2006 Feb; 61(2):200-10. doi:
10.1111/j.1365-2125.2005.02540.x
. [PMID: 16433874] - M Hoshiro, Y Ohno, H Masaki, H Iwase, N Aoki. Comprehensive study of urinary cortisol metabolites in hyperthyroid and hypothyroid patients.
Clinical endocrinology.
2006 Jan; 64(1):37-45. doi:
10.1111/j.1365-2265.2005.02412.x
. [PMID: 16402926] - Zheyi Hu, Qian Gong, Xiaolei Hu, Liqing Wang, Yajie Cao, Wei Cao, Qi Yu, Zeneng Cheng. Simultaneous determination of 6beta-hydroxycortisol and cortisol in human urine and plasma by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Nov; 826(1-2):238-43. doi:
10.1016/j.jchromb.2005.09.007
. [PMID: 16183337] - Akihiro Ohnishi, Shigeto Murakami, Setsuko Akizuki, Junko Mochizuki, Hirotoshi Echizen, Ichiro Takagi. In vivo metabolic activity of CYP2C19 and CYP3A in relation to CYP2C19 genetic polymorphism in chronic liver disease.
Journal of clinical pharmacology.
2005 Nov; 45(11):1221-9. doi:
10.1177/0091270005280787
. [PMID: 16239354] - Yu Chen Barrett, Billy Akinsanya, Shu-Ying Chang, Ole Vesterqvist. Automated on-line SPE LC-MS/MS method to quantitate 6beta-hydroxycortisol and cortisol in human urine: use of the 6beta-hydroxycortisol to cortisol ratio as an indicator of CYP3A4 activity.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Jul; 821(2):159-65. doi:
10.1016/j.jchromb.2005.04.030
. [PMID: 15941677] - S van Marle, A van Vliet, F Sollie, Y Kambayashi, T Yamada-Sawada. Safety, tolerability and pharmacokinetics of oral S-3304, a novel matrix metalloproteinase inhibitor, in single and multiple dose escalation studies in healthy volunteers.
International journal of clinical pharmacology and therapeutics.
2005 Jun; 43(6):282-93. doi:
10.5414/cpp43282
. [PMID: 15968885] - Karin Dilger, Annette Denk, Malte H J Heeg, Ulrich Beuers. No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis.
Hepatology (Baltimore, Md.).
2005 Mar; 41(3):595-602. doi:
10.1002/hep.20568
. [PMID: 15726657] - An Wang, Bang-Ning Yu, Chen-Hui Luo, Zhi-Rong Tan, Gan Zhou, Lian-Sheng Wang, Wei Zhang, Zhi Li, Jie Liu, Hong-Hao Zhou. Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients.
European journal of clinical pharmacology.
2005 Feb; 60(12):843-8. doi:
10.1007/s00228-004-0848-7
. [PMID: 15650881] - Christian Puozzo, Simone Lens, Christian Reh, Karl Michaelis, Dominique Rosillon, Xavier Deroubaix, Dominique Deprez. Lack of interaction of milnacipran with the cytochrome p450 isoenzymes frequently involved in the metabolism of antidepressants.
Clinical pharmacokinetics.
2005; 44(9):977-88. doi:
10.2165/00003088-200544090-00007
. [PMID: 16122284] - Ophelia Q P Yin, Xiaojin Shi, Brian Tomlinson, Moses S S Chow. Interindividual and intraindividual variability of the urinary 6beta-Hydroxycortisol/Cortisol ratio in Chinese subjects: implications of its use for evaluating CYP3A activity.
Journal of clinical pharmacology.
2004 Dec; 44(12):1412-7. doi:
10.1177/0091270004269760
. [PMID: 15545313] - Atsuhiro Kawaguchi, Masami Ohmori, Shu-Ichi Tsuruoka, Kenta Nishiki, Kenichi Harada, Isamu Miyamori, Ryo-Ichi Yano, Toshiaki Nakamura, Mikio Masada, Akio Fujimura. Drug interaction between St John's Wort and quazepam.
British journal of clinical pharmacology.
2004 Oct; 58(4):403-10. doi:
10.1111/j.1365-2125.2004.02171.x
. [PMID: 15373933] - Satoshi Kishino, Maki Ogawa, Yoh Takekuma, Mitsuru Sugawara, Tsuyoshi Shimamura, Hiroyuki Furukawa, Satoru Todo, Katsumi Miyazaki. The variability of liver graft function and urinary 6beta-hydroxycortisol to cortisol ratio during liver regeneration in liver transplant recipients.
Clinical transplantation.
2004 Apr; 18(2):124-9. doi:
10.1046/j.1399-0012.2003.00133.x
. [PMID: 15016124] - Takashi Furuta, Chieko Mori, Atsushi Suzuki, Hiromi Shibasaki, Akitomo Yokokawa, Yasuji Kasuya. Simultaneous determination of 6beta-hydroxycortisol and cortisol in human urine by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity determined by the cortisol 6beta-hydroxylation clearance.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Mar; 801(2):165-71. doi:
10.1016/j.jchromb.2003.11.001
. [PMID: 14751784] - Steven G Simonson, Paul D Martin, Mike J Warwick, Patrick D Mitchell, Dennis W Schneck. The effect of rosuvastatin on oestrogen & progestin pharmacokinetics in healthy women taking an oral contraceptive.
British journal of clinical pharmacology.
2004 Mar; 57(3):279-86. doi:
10.1046/j.1365-2125.2003.02015.x
. [PMID: 14998424] - Norbert H Brockmeyer, T Gambichler, A Bader, A Kreuter, M Kurowski, P Sander, P Altmeyer. Impact of amphotericin B on the cytochrome P450 system in HIV-infected patients.
European journal of medical research.
2004 Feb; 9(2):51-4. doi:
. [PMID: 15090289]
- Ann E Bolton, Bin Peng, Martine Hubert, Axel Krebs-Brown, Renaud Capdeville, Urs Keller, Michael Seiberling. Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects.
Cancer chemotherapy and pharmacology.
2004 Feb; 53(2):102-6. doi:
10.1007/s00280-003-0722-9
. [PMID: 14605865] - Kathie M Dalessandri, Gary L Firestone, Mark D Fitch, H Leon Bradlow, Leonard F Bjeldanes. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer.
Nutrition and cancer.
2004; 50(2):161-7. doi:
10.1207/s15327914nc5002_5
. [PMID: 15623462] - Zhi Chen, Lisa A Dunning, Kristin E Anderson, Jordan L Holtzman, Wei Zheng. Within-person variability of urinary 6beta-hydroxycortisol to urinaryl ratios in Caucasian women.
Steroids.
2004 Jan; 69(1):67-70. doi:
10.1016/j.steroids.2003.10.004
. [PMID: 14715379] - M M Galteau, F Shamsa. Urinary 6beta-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals.
European journal of clinical pharmacology.
2003 Dec; 59(10):713-33. doi:
10.1007/s00228-003-0690-3
. [PMID: 14605790] - Takashi Furuta, Atsushi Suzuki, Chieko Mori, Hiromi Shibasaki, Akitomo Yokokawa, Yasuji Kasuya. Evidence for the validity of cortisol 6 beta-hydroxylation clearance as a new index for in vivo cytochrome P450 3A phenotyping in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2003 Nov; 31(11):1283-7. doi:
10.1124/dmd.31.11.1283
. [PMID: 14570755] - Junji Saruwatari, Kazuko Nakagawa, Junichi Shindo, Shinobu Nachi, Hirotoshi Echizen, Takashi Ishizaki. The in-vivo effects of sho-saiko-to, a traditional Chinese herbal medicine, on two cytochrome P450 enzymes (1A2 and 3A) and xanthine oxidase in man.
The Journal of pharmacy and pharmacology.
2003 Nov; 55(11):1553-9. doi:
10.1211/0022357022061
. [PMID: 14713367] - Atsushi Suzuki, Hiromi Shibasaki, Yasuji Kasuya, Takashi Furuta. Simultaneous determination of endogenous and stable isotope-labelled 6beta-hydroxycortisols in human urine by stable isotope dilution mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Sep; 794(2):373-80. doi:
10.1016/s1570-0232(03)00519-1
. [PMID: 12954389] - E Rouits, M Boisdron-Celle, A Morel, E Gamelin. Simple and sensitive high-performance liquid chromatography method for simultaneous determination of urinary free cortisol and 6beta-hydroxycortisol in routine practice. For CYP 3A4 activity evaluation in basal conditions and after grapefruit juice intake.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Aug; 793(2):357-66. doi:
10.1016/s1570-0232(03)00353-2
. [PMID: 12906911] - I Varga, C Jakab, N Szücs, A Patócs, M Tóth, R Kiss, E Gláz, K Rácz. Plasma and salivary 6beta-hydroxycortisol measurements for assessing adrenocortical activity in patients with adrenocortical adenomas.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2003 Jul; 35(7):421-6. doi:
10.1055/s-2003-41623
. [PMID: 12931273] - Nikolette Szucs, Ibolya Varga, Attila Patócs, Miklós Tóth, Edit Gláz, Károly Rácz. Secretion of 6beta-hydroxycortisol by normal human adrenals and adrenocortical adenomas.
Steroids.
2003 May; 68(5):477-82. doi:
10.1016/s0039-128x(03)00050-3
. [PMID: 12798499] - Nikolette Szücs, Ibolya Varga, A Patócs, M Tóth, Csilla Jakab, Edit Gláz, K Rácz. Plasma 6beta-hydroxycortisol measurements for assessing altered hepatic drug metabolizing enzyme activity.
Acta physiologica Hungarica.
2003; 90(3):217-23. doi:
10.1556/aphysiol.90.2003.3.4
. [PMID: 14594192] - Norihiro Kobayashi, Pi Sun, Yayoi Fujimaki, Toshifumi Niwa, Tadashi Nishio, Junichi Goto, Hiroshi Hosoda. Generation of a novel monoclonal antibody against cortisol-[C-4]-bovine serum albumin conjugate: application to enzyme-linked immunosorbent assay for urinary and serum cortisol.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2002 Dec; 18(12):1309-14. doi:
10.2116/analsci.18.1309
. [PMID: 12502080] - Steffen Bauer, Elke Störmer, Reinhold Kerb, Andreas Johne, Jürgen Brockmöller, Ivar Roots. Differential effects of Saint John's Wort (hypericum perforatum) on the urinary excretion of D-glucaric acid and 6beta-hydroxycortisol in healthy volunteers.
European journal of clinical pharmacology.
2002 Dec; 58(9):581-5. doi:
10.1007/s00228-002-0527-5
. [PMID: 12483450] - Kazuhiro Inagaki, Masami Inagaki, Tomomi Kataoka, Izumi Sekido, Mark A Gill, Mikio Nishida. A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition.
Therapeutic drug monitoring.
2002 Dec; 24(6):722-7. doi:
10.1097/00007691-200212000-00007
. [PMID: 12451288] - Sandra N Nowak, David J Edwards, Anthony Clarke, Gail D Anderson, Linda A Jaber. Pioglitazone: effect on CYP3A4 activity.
Journal of clinical pharmacology.
2002 Dec; 42(12):1299-302. doi:
10.1177/0091270002042012009
. [PMID: 12463723] - Hideki Ushiama, Hirotoshi Echizen, Shinobu Nachi, Akihiro Ohnishi. Dose-dependent inhibition of CYP3A activity by clarithromycin during Helicobacter pylori eradication therapy assessed by changes in plasma lansoprazole levels and partial cortisol clearance to 6beta-hydroxycortisol.
Clinical pharmacology and therapeutics.
2002 Jul; 72(1):33-43. doi:
10.1067/mcp.2002.125559
. [PMID: 12152002] - John M Kovarik, Stefan Hartmann, Joaquim Figueiredo, Marisel Rouilly, Andreas Port, Christiane Rordorf. Effect of rifampin on apparent clearance of everolimus.
The Annals of pharmacotherapy.
2002 Jun; 36(6):981-5. doi:
10.1345/aph.1a384
. [PMID: 12022896] - Uwe Fuhr, Herbert Müller-Peltzer, Rainer Kern, Pablo Lopez-Rojas, Manfred Jünemann, Sebastian Harder, A Horst Staib. Effects of grapefruit juice and smoking on verapamil concentrations in steady state.
European journal of clinical pharmacology.
2002 Apr; 58(1):45-53. doi:
10.1007/s00228-002-0436-7
. [PMID: 11956673] - S Saima, K Furuie, H Yoshimoto, J Fukuda, T Hayashi, H Echizen. The effects of rifampicin on the pharmacokinetics and pharmacodynamics of orally administered nilvadipine to healthy subjects.
British journal of clinical pharmacology.
2002 Feb; 53(2):203-6. doi:
10.1046/j.0306-5251.2001.01545.x
. [PMID: 11851646] - A W Abu-Qare, M B Abou-Donia. DEET (N,N-diethyl-m-toluamide) alone and in combination with permethrin increased urinary excretion of 6beta-hydroxycortisol in rats, a marker of hepatic CYP3A induction.
Journal of toxicology and environmental health. Part A.
2001 Nov; 64(5):373-84. doi:
10.1080/152873901753170722
. [PMID: 11700004] - N Yasui-Furukori, T Kondo, T Kubota, H Otake, T Ohkubo, T Nagasaki, K Sugawara, K Chiba, K Otani, S Kaneko. No correlations between the urinary ratio of 6beta-hydroxycortisol to free cortisol and pharmacokinetics of alprazolam.
European journal of clinical pharmacology.
2001 Jul; 57(4):285-8. doi:
10.1007/s002280100313
. [PMID: 11549205] - D W Boulton, P Arnaud, C L DeVane. A single dose of methadone inhibits cytochrome P-4503A activity in healthy volunteers as assessed by the urinary cortisol ratio.
British journal of clinical pharmacology.
2001 Apr; 51(4):350-4. doi:
10.1046/j.1365-2125.2001.01360.x
. [PMID: 11318772] - K P Hsieh, Y Y Lin, C L Cheng, M L Lai, M S Lin, J P Siest, J D Huang. Novel mutations of CYP3A4 in Chinese.
Drug metabolism and disposition: the biological fate of chemicals.
2001 Mar; 29(3):268-73. doi:
NULL
. [PMID: 11181494] - W Zheng, F Jin, L A Dunning, X O Shu, Q Dai, W Q Wen, Y T Gao, J L Holtzman. Epidemiological study of urinary 6beta-hydroxycortisol to cortisol ratios and breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2001 Mar; 10(3):237-42. doi:
NULL
. [PMID: 11303593] - S Micuda, M Hodac, L Sispera, P Parízek, M Pleskot, G Zimova, J Cerman, J Martínková, V Pidrman. Influence of amiodarone on urinary excretion of 6beta-hydroxycortisol in humans.
Physiological research.
2001; 50(2):191-6. doi:
NULL
. [PMID: 11522047] - . .
.
. doi:
. [PMID: 18797458]