Leupeptin cation (BioDeep_00001038255)
代谢物信息卡片
Leupeptin cation
化学式: C20H39N6O4+ (427.3032634)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCC[NH+]=C(N)N)C=O)NC(=O)C
InChI: InChI=1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lifeng Fu, Shuai Shao, Yong Feng, Fei Ye, Xue Sun, Qingling Wang, Feng Yu, Qisheng Wang, Baoying Huang, Peihua Niu, Xuebing Li, Catherine C L Wong, Jianxun Qi, Wenjie Tan, George Fu Gao. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs.
mBio.
2021 10; 12(5):e0222021. doi:
10.1128/mbio.02220-21. [PMID: 34579576] - Y R Juste, A M Cuervo. Analysis of Chaperone-Mediated Autophagy.
Methods in molecular biology (Clifton, N.J.).
2019; 1880(?):703-727. doi:
10.1007/978-1-4939-8873-0_47. [PMID: 30610733] - Pi-Jung Hsiao, Hsin-Ying Clair Chiou, He-Jiun Jiang, Mei-Yueh Lee, Tusty-Jiuan Hsieh, Kung-Kai Kuo. Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis.
Scientific reports.
2017 08; 7(1):9030. doi:
10.1038/s41598-017-09702-3. [PMID: 28831172] - Margit A Krenn, Melanie Schürz, Bernhard Teufl, Koji Uchida, Peter M Eckl, Nikolaus Bresgen. Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal "metastability" in primary hepatocytes determining in vitro cell survival.
Free radical biology & medicine.
2015 Mar; 80(?):48-58. doi:
10.1016/j.freeradbiomed.2014.12.007. [PMID: 25532933] - Y Nakatsuka, T Nagasawa, Y Yumoto, F Nakazawa, Y Furuichi. Inhibitory effects of sword bean extract on alveolar bone resorption induced in rats by Porphyromonas gingivalis infection.
Journal of periodontal research.
2014 Dec; 49(6):801-9. doi:
10.1111/jre.12166. [PMID: 24494651] - Tamir Kanias, Jason P Acker. G.B. Quan et al., Inhibition of high glucose-induced erythrocyte phosphatidylserine exposure by leupeptin and disaccharides, Cryobiology 56 (1) (2008) 53-61.
Cryobiology.
2009 Apr; 58(2):240. doi:
10.1016/j.cryobiol.2008.12.010. [PMID: 19168046] - Guo Bo Quan, Ying Han, Chao Yang, Wen Bo Hu, An Liu, Jie Xi Wang, Yan Wang, Min Xia Liu. Inhibition of high glucose-induced erythrocyte phosphatidylserine exposure by leupeptin and disaccharides.
Cryobiology.
2008 Feb; 56(1):53-61. doi:
10.1016/j.cryobiol.2007.11.001. [PMID: 18093577] - Lie-Feng Zhang, Qi Rui, Peng Zhang, Xiao-yuan Wang, Lang-Lai Xu. A novel 51-kDa fragment of the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase formed in the stroma of chloroplasts in dark-induced senescing wheat leaves.
Physiologia plantarum.
2007 Sep; 131(1):64-71. doi:
10.1111/j.1399-3054.2007.00928.x. [PMID: 18251925] - Assaf Vardi, Doron Eisenstadt, Omer Murik, Ilana Berman-Frank, Tamar Zohary, Alex Levine, Aaron Kaplan. Synchronization of cell death in a dinoflagellate population is mediated by an excreted thiol protease.
Environmental microbiology.
2007 Feb; 9(2):360-9. doi:
10.1111/j.1462-2920.2006.01146.x. [PMID: 17222134] - Eva-Maria Krämer-Albers, Katja Gehrig-Burger, Christoph Thiele, Jacqueline Trotter, Klaus-Armin Nave. Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Nov; 26(45):11743-52. doi:
10.1523/jneurosci.3581-06.2006. [PMID: 17093095] - Yuki Ohsaki, Yuko Sugimoto, Michitaka Suzuki, Hiroshi Hosokawa, Tamotsu Yoshimori, Joanna P Davies, Yiannis A Ioannou, Marie T Vanier, Kousaku Ohno, Haruaki Ninomiya. Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4.
Journal of cell science.
2006 Jul; 119(Pt 13):2643-53. doi:
10.1242/jcs.02993. [PMID: 16757520] - André L S Santos, Claudia M d'Avila-Levy, Felipe A Dias, Rachel O Ribeiro, Fernanda M Pereira, Camila G R Elias, Thaïs Souto-Padrón, Angela H C S Lopes, Celuta S Alviano, Marta H Branquinha, Rosangela M A Soares. Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion.
International journal for parasitology.
2006 Jan; 36(1):47-56. doi:
10.1016/j.ijpara.2005.09.004. [PMID: 16310789] - Piyali Guha Thakurta, Sampa Biswas, Chandana Chakrabarti, Monica Sundd, Medicherla V Jagannadham, Jiban K Dattagupta. Structural basis of the unusual stability and substrate specificity of ervatamin C, a plant cysteine protease from Ervatamia coronaria.
Biochemistry.
2004 Feb; 43(6):1532-40. doi:
10.1021/bi0357659. [PMID: 14769029] - S Bhattacharya, S Ghosh, S Chakraborty, A K Bera, B P Mukhopadhayay, I Dey, A Banerjee. Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water.
BMC structural biology.
2001; 1(?):4. doi:
10.1186/1472-6807-1-4. [PMID: 11602025] - A Kamaguch, K Nakayama, T Ohyama, T Watanabe, M Okamoto, H Baba. Coaggregation of Porphyromonas gingivalis and Prevotella intermedia.
Microbiology and immunology.
2001; 45(9):649-56. doi:
10.1111/j.1348-0421.2001.tb01298.x. [PMID: 11694077] - J Pourahmad, S Ross, P J O'Brien. Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).
Free radical biology & medicine.
2001 Jan; 30(1):89-97. doi:
10.1016/s0891-5849(00)00450-0. [PMID: 11134899] - A J Walker, P E Urwin, H J Atkinson, P Brain, D M Glen, P R Shewry. Transgenic Arabidopsis leaf tissue expressing a modified oryzacystatin shows resistance to the field slug Deroceras reticulatum (Müller).
Transgenic research.
1999 Apr; 8(2):95-103. doi:
10.1023/a:1008814317199. [PMID: 10481309] - N L Li, Z X Zheng, B H Shen, G Y Chou. [Modulation of T-cell-mediated immune responses by trichosanthin via antigen processing and presentation].
Shi yan sheng wu xue bao.
1997 Jun; 30(2):165-71. doi:
". [PMID: 11039025] - K F Dobinson, N Lecomte, G Lazarovits. Production of an extracellular trypsin-like protease by the fungal plant pathogen Verticillium dahliae.
Canadian journal of microbiology.
1997 Mar; 43(3):227-33. doi:
10.1139/m97-031. [PMID: 9090111] - M R Groves, M A Taylor, M Scott, N J Cummings, R W Pickersgill, J A Jenkins. The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
Structure (London, England : 1993).
1996 Oct; 4(10):1193-203. doi:
10.1016/s0969-2126(96)00127-x. [PMID: 8939744] - J P Montenez, B K Kishore, P Maldague, P M Tulkens. Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts.
Toxicology letters.
1994 Sep; 73(3):201-8. doi:
10.1016/0378-4274(94)90059-0. [PMID: 8091428] - C H van Aswegen, P J du Toit, D J du Plessis. Modulation of lipoxidase activity by urokinase-type plasminogen activator.
Prostaglandins, leukotrienes, and essential fatty acids.
1994 Sep; 51(3):183-6. doi:
10.1016/0952-3278(94)90132-5. [PMID: 7824532] - S L Pelech, M Samiei, D L Charest, S L Howard, H Salari. Characterization of calcium-independent forms of protein kinase C-beta in phorbol ester-treated rabbit platelets.
The Journal of biological chemistry.
1991 May; 266(14):8696-705. doi:
10.1016/s0021-9258(18)31502-3. [PMID: 2026587] - G O Ivy, S Kanai, M Ohta, Y Sato, K Otsubo, K Kitani. Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats.
Mechanisms of ageing and development.
1991 Mar; 57(3):213-31. doi:
10.1016/0047-6374(91)90048-5. [PMID: 2056777] - N M Hasan, R B Cundall, G E Adams. Effects of hypoxia and reoxygenation on the conversion of xanthine dehydrogenase to oxidase in Chinese hamster V79 cells.
Free radical biology & medicine.
1991; 11(2):179-85. doi:
10.1016/0891-5849(91)90169-4. [PMID: 1937136] - W G Dougherty, T D Parks, S M Cary, J F Bazan, R J Fletterick. Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase.
Virology.
1989 Sep; 172(1):302-10. doi:
10.1016/0042-6822(89)90132-3. [PMID: 2475971] - A V Vasil'ev, Li Kva Ren, A N Orekhov, V V Tertov, K J Kim, V A Tutel'ian. [Lysosomal proteinases of the human aortal intima and atherogenesis].
Voprosy meditsinskoi khimii.
1989 Jul; 35(4):124-7. doi:
NULL. [PMID: 2683376] - A Faragó, J Seprõdi, A Spät. Subcellular distribution of protein kinase C in rat adrenal glomerulosa cells.
Biochemical and biophysical research communications.
1988 Oct; 156(2):628-33. doi:
10.1016/s0006-291x(88)80889-1. [PMID: 3190673] - P F Verhallen, E M Bevers, P Comfurius, R F Zwaal. Fluoride-dependent calcium-induced platelet procoagulant activity shows that calpain is involved in increased phospholipid transbilayer movement.
Biochimica et biophysica acta.
1988 Jul; 942(1):150-8. doi:
10.1016/0005-2736(88)90284-2. [PMID: 2838083] - A Livne, M A Packham, M A Guccione, J F Mustard. Aggregation-related association of lipid with the cytoskeleton of rabbit and human platelets prelabeled with [3H]palmitic acid. Similar effects of adenosine diphosphate- and thrombin-induced aggregation.
The Journal of clinical investigation.
1988 Feb; 81(2):288-99. doi:
10.1172/jci113320. [PMID: 2828426] - H Glaumann, J Ahlberg. Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity--formation of crinosomes.
Experimental and molecular pathology.
1987 Dec; 47(3):346-62. doi:
10.1016/0014-4800(87)90018-9. [PMID: 3678466] - A Yatani, J Codina, Y Imoto, J P Reeves, L Birnbaumer, A M Brown. A G protein directly regulates mammalian cardiac calcium channels.
Science (New York, N.Y.).
1987 Nov; 238(4831):1288-92. doi:
10.1126/science.2446390. [PMID: 2446390] - J D Kramer, B J Bogitsh. Schistosoma japonicum: biochemistry and cytochemistry of dipeptidyl aminopeptidase-II-like activity in adults.
Experimental parasitology.
1985 Oct; 60(2):163-70. doi:
10.1016/0014-4894(85)90019-0. [PMID: 3896835] - L C Morejohn, T E Bureau, D E Fosket. Inhibition of plant cell proteolytic activities that degrade tubulin.
Cell biology international reports.
1985 Sep; 9(9):849-57. doi:
10.1016/0309-1651(85)90104-3. [PMID: 2864138] - K Furuno, K Miyamoto, T Ishikawa, K Kato. Characterization of subfractions of autolysosomes isolated from rat liver after leupeptin treatment.
Journal of biochemistry.
1984 Mar; 95(3):671-8. doi:
10.1093/oxfordjournals.jbchem.a134656. [PMID: 6725229]