CID 9890474 (BioDeep_00001037191)
代谢物信息卡片
CID 9890474
化学式: C30H52O3 (460.3916242)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)O)C)C)O)C)O)C
InChI: InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30?/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yang Ruan, Guoqing Ren, Mingchun Wang, Weichao Lv, Kuniyoshi Shimizu, Chaofeng Zhang. The dual role of 20(S)-protopanaxadiol in alleviating pulmonary fibrosis through the gut-lung axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155699. doi:
10.1016/j.phymed.2024.155699. [PMID: 38733907] - Zhu Zhu, Yao Cheng, Xu Han, Tiantian Wang, Hantao Zhang, Qi Yao, Feiyan Chen, Ling Gu, Dongqing Yang, Lin Chen, Yunan Zhao. 20(S)-Protopanaxadiol Exerts Antidepressive Effects in Chronic Corticosterone-Induced Rodent Animal Models as an Activator of Brain-Type Creatine Kinase.
Journal of agricultural and food chemistry.
2024 May; 72(18):10376-10390. doi:
10.1021/acs.jafc.4c00415. [PMID: 38661058] - Kang-Xi Zhang, Yue Zhu, Shu-Xia Song, Qing-Yun Bu, Xiao-Yan You, Hong Zou, Guo-Ping Zhao. Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism.
Molecules (Basel, Switzerland).
2024 Mar; 29(5):. doi:
10.3390/molecules29051108. [PMID: 38474620] - Yanyan Li, Ke Yang, Linxian Zhao, Chunyi Xu, Weiling Zhou, Zhanguo Wang, Huiling Hu, Yu You. Effects of schisandra lignans on the absorption of protopanaxadiol-type ginsenosides mediated by P-glycoprotein and protopanaxatriol-type ginsenosides mediated by CYP3A4.
Journal of ethnopharmacology.
2023 Aug; 318(Pt B):117057. doi:
10.1016/j.jep.2023.117057. [PMID: 37597677] - Likang Lu, Hui Ao, Jingxin Fu, Manzhen Li, Yaoyao Guo, Yifei Guo, Meihua Han, Rongxing Shi, Xiangtao Wang. Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jul; 163(?):114870. doi:
10.1016/j.biopha.2023.114870. [PMID: 37187019] - Shangkun Qiu, Lars M Blank. Recent Advances in Yeast Recombinant Biosynthesis of the Triterpenoid Protopanaxadiol and Glycosylated Derivatives Thereof.
Journal of agricultural and food chemistry.
2023 Feb; 71(5):2197-2210. doi:
10.1021/acs.jafc.2c06888. [PMID: 36696911] - Yiping Li, Yang Liu, Zhiwei Chen, Kaiyue Tang, Lili Yang, Yuwei Jiang, Jue Wang, Ping Huang, Jianyi Wang, Peiyong Zheng, Haiyan Song. Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jan; 160(?):114319. doi:
10.1016/j.biopha.2023.114319. [PMID: 36724639] - Hong-Ping Wang, Zi-Jian Wang, Jing Du, Zhao-Zhou Lin, Chen Zhao, Run Zhang, Qiong Yin, Chun-Lan Fan, Ping Peng, Zhi-Bin Wang. Comprehensive Identification of Ginsenosides in the Roots and Rhizomes of Panax ginseng Based on Their Molecular Features-Oriented Precursor Ions Selection and Targeted MS/MS Analysis.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28030941. [PMID: 36770610] - Yuan Zhu, Jianxiu Li, Longyun Peng, Lijun Meng, Mengxue Diao, Shuiyuan Jiang, Jianbin Li, Nengzhong Xie. High-yield production of protopanaxadiol from sugarcane molasses by metabolically engineered Saccharomyces cerevisiae.
Microbial cell factories.
2022 Nov; 21(1):230. doi:
10.1186/s12934-022-01949-4. [PMID: 36335407] - Chaiwat Monmai, Jin-Suk Kim, So-Hyeon Baek. Transgenic Rice Seed Extracts Exert Immunomodulatory Effects by Modulating Immune-Related Biomarkers in RAW264.7 Macrophage Cells.
Nutrients.
2022 Oct; 14(19):. doi:
10.3390/nu14194143. [PMID: 36235795] - Ye-Wei Huang, Meng Zhang, Li-Tian Wang, Yan Nie, Jin-Bo Yang, Wen-Luer Meng, Xuan-Jun Wang, Jun Sheng. 20(S)-Protopanaxadiol decreases atherosclerosis in ApoE KO mice by increasing the levels of LDLR and inhibiting its binding with PCSK9.
Food & function.
2022 Jul; 13(13):7020-7028. doi:
10.1039/d2fo00392a. [PMID: 35723202] - He Zhang, Yuyao Zhang, Xiaolei Tang, Wenjie Su, Chunhui Yang, Daian Pan, Daqing Zhao, Bin Qi, Xiangyan Li. Hemostatic Effect of 20(S)-Panaxadiol by Induced Platelet Aggregation Depending on Calcium Signaling Pathway.
BioMed research international.
2022; 2022(?):8265898. doi:
10.1155/2022/8265898. [PMID: 36177062] - Su-Nyeong Jang, So-Young Park, Hyunyoung Lee, Hyojin Jeong, Ji-Hyeon Jeon, Im-Sook Song, Mi Jeong Kwon, Kwang-Hyeon Liu. In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5'-diphospho-glucuronosyltransferase activity and expression.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Oct; 51(10):1087-1094. doi:
10.1080/00498254.2021.1963503. [PMID: 34338601] - Se-A Kim, Eun-Bi Jeong, Deok-Kun Oh. Complete Bioconversion of Protopanaxadiol-Type Ginsenosides to Compound K by Extracellular Enzymes from the Isolated Strain Aspergillus tubingensis.
Journal of agricultural and food chemistry.
2021 Jan; 69(1):315-324. doi:
10.1021/acs.jafc.0c07424. [PMID: 33372793] - Zhen-Zhen Lai, Hui-Li Yang, Jia-Wei Shi, Hui-Hui Shen, Yan Wang, Kai-Kai Chang, Tao Zhang, Jiang-Feng Ye, Jian-Song Sun, Xue-Min Qiu, Ming-Qing Li. Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners.
International journal of biological sciences.
2021; 17(8):1878-1894. doi:
10.7150/ijbs.58657. [PMID: 34131393] - Eun-Bi Jeong, Se-A Kim, Kyung-Chul Shin, Deok-Kun Oh. Biotransformation of Protopanaxadiol-Type Ginsenosides in Korean Ginseng Extract into Food-Available Compound K by an Extracellular Enzyme from Aspergillus niger.
Journal of microbiology and biotechnology.
2020 Oct; 30(10):1560-1567. doi:
10.4014/jmb.2007.07003. [PMID: 32807754] - Jingya Ruan, Fan Sun, Ying Zhang, Dandan Zheng, Guilin Xiang, Wei Zhao, Yi Zhang, Tao Wang. New 20(S)-protopanaxadiol type saponins from the leaves of Panax notoginseng and their potential anti-inflammatory activities.
Steroids.
2020 10; 162(?):108696. doi:
10.1016/j.steroids.2020.108696. [PMID: 32649999] - Dan Zhang, Wei Li, Zhong-Jian Chen, Fu-Gang Wei, Yun-Long Liu, Li-Zhi Gao. SMRT- and Illumina-based RNA-seq analyses unveil the ginsinoside biosynthesis and transcriptomic complexity in Panax notoginseng.
Scientific reports.
2020 09; 10(1):15310. doi:
10.1038/s41598-020-72291-1. [PMID: 32943706] - Di Sun, Shi-Yan Guo, Li Yang, Ya-Ru Wang, Xiao-Hui Wei, Sha Song, Yi-Wei Yang, Yong Gan, Zheng-Tao Wang. Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery.
Acta pharmacologica Sinica.
2020 Jan; 41(1):119-128. doi:
10.1038/s41401-019-0288-7. [PMID: 31534201] - Ning Jiang, Jing-Wei Lv, Hai-Xia Wang, Qiong Wang, Cong Lu, Yu-Jie Yang, Hong Huang, Tian-Ji Xia, Guang-Hua Lv, Xin-Min Liu. Antidepressant-like effects of 20(S)-protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms.
Phytotherapy research : PTR.
2019 Oct; 33(10):2726-2736. doi:
10.1002/ptr.6446. [PMID: 31353678] - Jung Yeon Han, So-Hyeon Baek, Hye Jeong Jo, Do Won Yun, Yong Eui Choi. Genetically modified rice produces ginsenoside aglycone (protopanaxadiol).
Planta.
2019 Oct; 250(4):1103-1110. doi:
10.1007/s00425-019-03204-4. [PMID: 31168665] - Hui Zhang, Hongbing Liu, Pan Qi, Silin Wang, Haibin Hu, Jingxin Gou, Yu Zhang, Haibing He, Xing Tang, Tian Yin, Yue Yuan. Enhanced the Bioavailability of Sterile 20(S)-Protopanaxadiol Nanocrystalline Suspension Coated by Bovine Serum Albumin for Intramuscular Injection: In Vitro and In Vivo Evaluation.
AAPS PharmSciTech.
2019 Sep; 20(7):305. doi:
10.1208/s12249-019-1498-5. [PMID: 31506831] - Tiehua Zhang, Yuan Liang, Peng Zuo, Mi Yan, Siyuan Jing, Tiezhu Li, Yongjun Wang, Jie Zhang, Zhengyi Wei. Identification of 20(R, S)-protopanaxadiol and 20(R, S)-protopanaxatriol for potential selective modulation of glucocorticoid receptor.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Sep; 131(?):110642. doi:
10.1016/j.fct.2019.110642. [PMID: 31247261] - Chang-Hao Cui, Byeong-Min Jeon, Yaoyao Fu, Wan-Taek Im, Sun-Chang Kim. High-density immobilization of a ginsenoside-transforming β-glucosidase for enhanced food-grade production of minor ginsenosides.
Applied microbiology and biotechnology.
2019 Sep; 103(17):7003-7015. doi:
10.1007/s00253-019-09951-4. [PMID: 31289903] - Liying Zhang, Congcong Xu, Jingjing Mao, Weiwei Wang, Han Han, Yiqiong Pu, Tong Zhang. Formulation and Characterization of Novel Dry Suspension and Dry Emulsion of 20(S)-Protopanaxadiol.
AAPS PharmSciTech.
2019 Aug; 20(7):275. doi:
10.1208/s12249-019-1487-8. [PMID: 31388863] - Chuhe Liu, Hongli Li, Zhenyu Zhou, Junxiao Li, Hui Chen, Yalei Liu, Cheng Huang, Shengjie Fan. Protopanaxadiol alleviates obesity in high-fat diet-fed mice via activation of energy-sensing neuron in the paraventricular nucleus of hypothalamus.
Biochemical and biophysical research communications.
2019 06; 513(4):1092-1099. doi:
10.1016/j.bbrc.2019.04.031. [PMID: 31010683] - Zhihua Wang, Unchol Kim, Yanting Jiao, Chaowen Li, Yingying Guo, Xiaoyao Ma, Min Jiang, Zhihong Jiang, Yuanyuan Hou, Gang Bai. Quantitative Proteomics Combined with Affinity MS Revealed the Molecular Mechanism of Ginsenoside Antitumor Effects.
Journal of proteome research.
2019 05; 18(5):2100-2108. doi:
10.1021/acs.jproteome.8b00972. [PMID: 30860844] - Jian Li, Lan Ma, Shuting Zhang, Cailian Zuo, Na Song, Shusheng Zhu, Jinsong Wu. Transcriptome analysis of 1- and 3-year-old Panax notoginseng roots and functional characterization of saponin biosynthetic genes DS and CYP716A47-like.
Planta.
2019 Apr; 249(4):1229-1237. doi:
10.1007/s00425-018-03083-1. [PMID: 30607503] - Xue Wang, Hua-Ying Xia, Hong-You Qin, Xiang-Ping Kang, Hai-Yan Hu, Jing Zheng, Jia-Ye Jiang, Ling-Ai Yao, Yan-Wu Xu, Tong Zhang, Xue-Li Zhang. 20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway.
Journal of cellular biochemistry.
2019 04; 120(4):5085-5096. doi:
10.1002/jcb.27785. [PMID: 30259568] - Mohamed Ben-Eltriki, Mohamed Hassona, Gray Meckling, Hans Adomat, Subrata Deb, Emma S Tomlinson Guns. Pharmacokinetic interaction of calcitriol with 20(S)-protopanaxadiol in mice: Determined by LC/MS analysis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Mar; 130(?):173-180. doi:
10.1016/j.ejps.2019.01.016. [PMID: 30654110] - Li Yang, Chun-Yang Wang, Xiao-Nv Xie, Yi-Cheng Wang, Jing-Bo Peng, Wei-Hua Huang, Yao Chen, Dong-Sheng Ouyang, Zhi-Rong Tan. LC-MS/MS determination of ginsenoside compound K and its metabolite 20 (S)-protopanaxadiol in human plasma and urine: applications in a clinical study.
Bioanalysis.
2019 Mar; 11(5):365-380. doi:
10.4155/bio-2018-0185. [PMID: 30873858] - Hong Ri Jin, Charles H Du, Chong-Zhi Wang, Chun-Su Yuan, Wei Du. Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death.
Phytotherapy research : PTR.
2019 Mar; 33(3):610-617. doi:
10.1002/ptr.6249. [PMID: 30537241] - Jianqiang Zhang, Qian Zhang, Yangrong Xu, Huixiang Li, Fenglan Zhao, Chaoming Wang, Zhi Liu, Pan Liu, Yanan Liu, Qingguo Meng, Feng Zhao. Synthesis and In Vitro Anti-inflammatory Activity of C20 Epimeric Ocotillol-Type Triterpenes and Protopanaxadiol.
Planta medica.
2019 Mar; 85(4):292-301. doi:
10.1055/a-0770-0994. [PMID: 30380571] - Min-Hwan Kim, Ki-Taek Kim, Seo-Yeon Sohn, Jae-Young Lee, Chang Hyung Lee, Hee Yang, Bo Kyung Lee, Ki Won Lee, Dae-Duk Kim. Formulation And Evaluation Of Nanostructured Lipid Carriers (NLCs) Of 20(S)-Protopanaxadiol (PPD) By Box-Behnken Design.
International journal of nanomedicine.
2019; 14(?):8509-8520. doi:
10.2147/ijn.s215835. [PMID: 31749618] - Kyo Bin Kang, Murukarthick Jayakodi, Yun Sun Lee, Van Binh Nguyen, Hyun-Seung Park, Hyun Jo Koo, Ik Young Choi, Dae Hyun Kim, You Jin Chung, Byeol Ryu, Dong Young Lee, Sang Hyun Sung, Tae-Jin Yang. Identification of candidate UDP-glycosyltransferases involved in protopanaxadiol-type ginsenoside biosynthesis in Panax ginseng.
Scientific reports.
2018 08; 8(1):11744. doi:
10.1038/s41598-018-30262-7. [PMID: 30082711] - Jin-Qi Li, Jia-Feng Wang, Jie Li, Shu-Han Zhang, Dan He, Rong-Sheng Tong, Shu-Ya She. Simultaneous determination of 20(S)-protopanaxadiol and its three metabolites in rat plasma by LC-MS/MS: application to their pharmacokinetic studies.
Biomedical chromatography : BMC.
2018 Aug; 32(8):e4252. doi:
10.1002/bmc.4252. [PMID: 29607527] - Guangfei Wei, Fugang Wei, Can Yuan, Zhongjian Chen, Yong Wang, Jiang Xu, Yongqing Zhang, Linlin Dong, Shilin Chen. Integrated Chemical and Transcriptomic Analysis Reveals the Distribution of Protopanaxadiol- and Protopanaxatriol-Type Saponins in Panax notoginseng.
Molecules (Basel, Switzerland).
2018 Jul; 23(7):. doi:
10.3390/molecules23071773. [PMID: 30029488] - Kyung-Chul Shin, Tae-Hun Kim, Ji-Hyeon Choi, Deok-Kun Oh. Complete Biotransformation of Protopanaxadiol-Type Ginsenosides to 20- O-β-Glucopyranosyl-20( S)-protopanaxadiol Using a Novel and Thermostable β-Glucosidase.
Journal of agricultural and food chemistry.
2018 Mar; 66(11):2822-2829. doi:
10.1021/acs.jafc.7b06108. [PMID: 29468877] - Cong Lu, Jingwei Lv, Liming Dong, Ning Jiang, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu. The protective effect of 20(S)-protopanaxadiol (PPD) against chronic sleep deprivation (CSD)-induced memory impairments in mice.
Brain research bulletin.
2018 03; 137(?):249-256. doi:
10.1016/j.brainresbull.2017.12.012. [PMID: 29287793] - Lin Dai, Weiyan Zhu, Chuanling Si, Jiandu Lei. 'Nano-Ginseng' for Enhanced Cytotoxicity AGAINST Cancer Cells.
International journal of molecular sciences.
2018 Feb; 19(2):. doi:
10.3390/ijms19020627. [PMID: 29473838] - Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu. 20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice.
Chemico-biological interactions.
2018 Jan; 279(?):64-72. doi:
10.1016/j.cbi.2017.11.008. [PMID: 29133030] - Er-Yun Zhang, Bo Gao, Hai-Lian Shi, Ling-Fang Huang, Li Yang, Xiao-Jun Wu, Zheng-Tao Wang. 20(S)-Protopanaxadiol enhances angiogenesis via HIF-1α-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice.
Experimental & molecular medicine.
2017 10; 49(10):e387. doi:
10.1038/emm.2017.151. [PMID: 29075038] - Jin Ling, Yingjia Yu, Jianan Feng, Changjiang Xu, Jiebing Jiang, Liping Wang, Jiakun Long, Yan Li, Gengli Duan. Restricted access magnetic core-mesoporous shell microspheres with C8-modified interior pore walls for the identification of 20(S)-protopanaxadiol metabolites in rat plasma using UPLC-Q-TOF-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jun; 1054(?):73-79. doi:
10.1016/j.jchromb.2017.04.004. [PMID: 28432922] - Mohamed El-Agamy Farh, Yeon-Ju Kim, Priyanka Singh, Deok-Chun Yang. Cross Interaction Between Ilyonectria mors-panacis Isolates Infecting Korean Ginseng and Ginseng Saponins in Correlation with Their Pathogenicity.
Phytopathology.
2017 05; 107(5):561-569. doi:
10.1094/phyto-05-16-0210-r. [PMID: 27918242] - Qi-Le Zhou, Di-Na Zhu, Yan-Fang Yang, Wei Xu, Xiu-Wei Yang. Simultaneous quantification of twenty-one ginsenosides and their three aglycones in rat plasma by a developed UFLC-MS/MS assay: Application to a pharmacokinetic study of red ginseng.
Journal of pharmaceutical and biomedical analysis.
2017 Apr; 137(?):1-12. doi:
10.1016/j.jpba.2017.01.009. [PMID: 28086165] - Gyo In, Hyun Kyu Seo, Hee-Won Park, Kyoung Hwa Jang. A Metabolomic Approach for the Discrimination of Red Ginseng Root Parts and Targeted Validation.
Molecules (Basel, Switzerland).
2017 Mar; 22(3):. doi:
10.3390/molecules22030471. [PMID: 28294969] - Feifei Yang, Jing Zhou, Chunyu Liu, Xiao Hu, Ruile Pan, Qi Chang, Xinmin Liu, Yonghong Liao. Cytochromes P450 Inhibitory Excipient-Based Self-Microemulsions for the Improved Bioavailability of Protopanaxatriol and Protopanaxadiol: Preparation and Evaluation.
Planta medica.
2017 Mar; 83(5):453-460. doi:
10.1055/s-0042-106726. [PMID: 27220080] - Qi Zhang, Yiqiong Pu, Bing Wang, Yuqin Wang, Tina Tingxia Dong, Tao Guo, Tong Zhang, Zhenzhen Cai. Characterization, Molecular Docking, and In Vitro Dissolution Studies of Solid Dispersions of 20(S)-Protopanaxadiol.
Molecules (Basel, Switzerland).
2017 Feb; 22(2):. doi:
10.3390/molecules22020274. [PMID: 28208662] - Jian Yu, Li-Qiang Gu, Yan-Fei Xin, Yun-Sheng Bai, Sheng Zhang, Hai-Yan Gao, Pan-Sheng Xu, Zhu-Feng Ma, Zhen-Qiang You, Zhi Wang, Yao-Xian Xuan. Potential accumulation of protopanaxadiol-type ginsenosides in six-months toxicokinetic study of SHENMAI injection in dogs.
Regulatory toxicology and pharmacology : RTP.
2017 Feb; 83(?):5-12. doi:
10.1016/j.yrtph.2016.11.012. [PMID: 27840091] - Yiqiong Pu, Xitong Zhang, Qi Zhang, Bing Wang, Yuxi Chen, Chuanqi Zang, Yuqin Wang, Tina Ting-Xia Dong, Tong Zhang. 20(S)-Protopanaxadiol Phospholipid Complex: Process Optimization, Characterization, In Vitro Dissolution and Molecular Docking Studies.
Molecules (Basel, Switzerland).
2016 Oct; 21(10):. doi:
10.3390/molecules21101396. [PMID: 27775578] - Yi Cao, Chao-Qun Wang, Feng Xu, Xiu-Hong Jia, Guang-Xue Liu, Sheng-Chao Yang, Guang-Qiang Long, Zhong-Jian Chen, Fu-Zhou Wei, Shao-Zhou Yang, Kozo Fukuda, Xuan Wang, Shao-Qing Cai. [A semimicroquality evaluation method on Panax notoginseng and its application in analysis of continuous cropping obstacles research samples].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Oct; 41(20):3773-3781. doi:
10.4268/cjcmm20162012. [PMID: 28929655] - Jin Ling, Yingjia Yu, Jiajun Zhu, Yan Li, Li Ling, Liping Wang, Changjiang Xu, Gengli Duan. A highly sensitive HPLC-MS/MS method for quantification of 20(S)-protopanaxadiol in human plasma and its application in phase IIa clinical trial of a novel antidepressant agent.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Sep; 1031(?):214-220. doi:
10.1016/j.jchromb.2016.07.044. [PMID: 27507666] - Kentaro Igami, Yosuke Shimojo, Hisatomi Ito, Toshitsugu Miyazaki, Fusako Nakano, Yoshiki Kashiwada. Fermented Ginseng Contains an Agonist of Peroxisome Proliferator Activated Receptors α and γ.
Journal of medicinal food.
2016 Sep; 19(9):817-22. doi:
10.1089/jmf.2016.3673. [PMID: 27627700] - Meihua Han, Liqiang Ma, Xin Yu, Zhitao Li, Yifei Guo, Xiangtao Wang. A nanoparticulate drug-delivery system for 20(S)-protopanaxadiol: formulation, characterization, increased oral bioavailability and anti-tumor efficacy.
Drug delivery.
2016 Sep; 23(7):2410-2418. doi:
10.3109/10717544.2014.997843. [PMID: 25564965] - Fanglong Zhao, Peng Bai, Ting Liu, Dashuai Li, Xiangmei Zhang, Wenyu Lu, Yingjin Yuan. Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae.
Biotechnology and bioengineering.
2016 08; 113(8):1787-95. doi:
10.1002/bit.25934. [PMID: 26757342] - Ming Peng, Xiaonan Li, Tong Zhang, Yue Ding, Yaxiong Yi, Jian Le, Yongjian Yang, Xijing Chen. Stereoselective pharmacokinetic and metabolism studies of 20(S)- and 20(R)-ginsenoside Rg₃ epimers in rat plasma by liquid chromatography-electrospray ionization mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2016 Mar; 121(?):215-224. doi:
10.1016/j.jpba.2016.01.020. [PMID: 26826673] - Xian-En Zhao, Tao Lv, Shuyun Zhu, Fei Qu, Guang Chen, Yongrui He, Na Wei, Guoliang Li, Lian Xia, Zhiwei Sun, Shijuan Zhang, Jinmao You, Shu Liu, Zhiqiang Liu, Jing Sun, Shuying Liu. Dual ultrasonic-assisted dispersive liquid-liquid microextraction coupled with microwave-assisted derivatization for simultaneous determination of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol by ultra high performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2016 Mar; 1437(?):49-57. doi:
10.1016/j.chroma.2016.02.017. [PMID: 26877173] - Gang Chen, Junhua Liu, Wantao Chen, Qin Xu, Meng Xiao, Lihong Hu, Li Mao, Xu Wang. A 20(S)-protopanoxadiol derivative overcomes multi-drug resistance by antagonizing ATP-binding cassette subfamily B member 1 transporter function.
Oncotarget.
2016 Feb; 7(8):9388-403. doi:
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International journal of pharmaceutics.
2016 Jan; 497(1-2):239-47. doi:
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Pharmacology, biochemistry, and behavior.
2016 Jan; 140(?):17-26. doi:
10.1016/j.pbb.2015.10.018. [PMID: 26528894] - Chong-Zhi Wang, Samantha Anderson, Chun-Su Yuan. Phytochemistry and Anticancer Potential of Notoginseng.
The American journal of Chinese medicine.
2016; 44(1):23-34. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Nov; 1005(?):9-16. doi:
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Plant cell reports.
2015 Sep; 34(9):1551-60. doi:
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Fitoterapia.
2015 Jun; 103(?):97-105. doi:
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Journal of bioscience and bioengineering.
2015 May; 119(5):497-504. doi:
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Chirality.
2015 Feb; 27(2):170-6. doi:
10.1002/chir.22407. [PMID: 25422175] - Bing Wang, Yiqiong Pu, Benliang Xu, Jiansheng Tao, Yuqin Wang, Tong Zhang, Peiying Wu. Self-microemulsifying Drug Delivery System Improved Oral Bioavailability of 20(S)-Protopanaxadiol: From Preparation to Evaluation.
Chemical & pharmaceutical bulletin.
2015; 63(9):688-93. doi:
10.1248/cpb.c15-00247. [PMID: 26084568] - Thi Hong Van Le, Gwang Jin Lee, Huynh Kim Long Vu, Sung Won Kwon, Ngoc Khoi Nguyen, Jeong Hill Park, Minh Duc Nguyen. Ginseng Saponins in Different Parts of Panax vietnamensis.
Chemical & pharmaceutical bulletin.
2015; 63(11):950-4. doi:
10.1248/cpb.c15-00369. [PMID: 26521860] - Suk-Chae Jung, Woohyun Kim, Sung Chul Park, Jinkil Jeong, Myung Keun Park, Soohwan Lim, Yeon Lee, Wan-Taek Im, Jun Hyoung Lee, Giltsu Choi, Sun Chang Kim. Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd.
Plant & cell physiology.
2014 Dec; 55(12):2177-88. doi:
10.1093/pcp/pcu147. [PMID: 25320211] - Ying-Chun Zhang, Geng Li, Chao Jiang, Bin Yang, Hong-Jun Yang, Hai-Yu Xu, Lu-Qi Huang. Tissue-specific distribution of ginsenosides in different aged ginseng and antioxidant activity of ginseng leaf.
Molecules (Basel, Switzerland).
2014 Oct; 19(11):17381-99. doi:
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Functional & integrative genomics.
2014 Sep; 14(3):545-57. doi:
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Functional & integrative genomics.
2014 Sep; 14(3):559-70. doi:
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European journal of medicinal chemistry.
2014 May; 79(?):340-9. doi:
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The Journal of steroid biochemistry and molecular biology.
2014 May; 141(?):94-103. doi:
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Nutrition reviews.
2014 May; 72(5):319-33. doi:
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Rapid communications in mass spectrometry : RCM.
2014 Mar; 28(6):595-604. doi:
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Scientific reports.
2014 Jan; 4(?):3698. doi:
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Applied microbiology and biotechnology.
2013 Sep; 97(18):8031-9. doi:
10.1007/s00253-013-4982-y. [PMID: 23812276] - Cai Xiaojun, Xu Yuping, Pan Yu, Ren Yiping, Xiang Zheng. An UFLC-MS/MS method for quantification of panaxadiol in rat plasma and its application to a pharmacokinetic study.
Planta medica.
2013 Sep; 79(14):1324-8. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Aug; 933(?):59-66. doi:
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Journal of biotechnology.
2013 Aug; 167(1):33-40. doi:
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BMC complementary and alternative medicine.
2013 Jul; 13(?):194. doi:
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Bioorganic & medicinal chemistry.
2013 Jul; 21(14):4279-87. doi:
10.1016/j.bmc.2013.04.067. [PMID: 23683834] - Jian-Li Gao, Gui-Yuan Lv, Bai-Cheng He, Bing-Qiang Zhang, Hongyu Zhang, Ning Wang, Chong-Zhi Wang, Wei Du, Chun-Su Yuan, Tong-Chuan He. Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways.
Oncology reports.
2013 Jul; 30(1):292-8. doi:
10.3892/or.2013.2438. [PMID: 23633038] - Hai-yan Song, Li Zhang, Jie-lu Pan, Li-li Yang, Guang Ji. Bioactivity of five components of Chinese herbal formula Jiangzhi granules against hepatocellular steatosis.
Journal of integrative medicine.
2013 Jul; 11(4):262-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2013 Jul; 41(7):1457-69. doi:
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Fitoterapia.
2013 Apr; 86(?):48-53. doi:
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Die Pharmazie.
2013 Apr; 68(4):287-92. doi:
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Journal of mass spectrometry : JMS.
2013 Mar; 48(3):399-405. doi:
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BMC complementary and alternative medicine.
2013 Jan; 13(?):2. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Jan; 38(2):263-8. doi:
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Journal of Asian natural products research.
2013; 15(10):1139-43. doi:
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Plant & cell physiology.
2012 Sep; 53(9):1535-45. doi:
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Phytochemistry.
2012 Jun; 78(?):65-71. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Mar; 887-888(?):19-24. doi:
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Applied and environmental microbiology.
2012 Jan; 78(1):242-9. doi:
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Molecules (Basel, Switzerland).
2011 Dec; 16(12):10619-30. doi:
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Molecules (Basel, Switzerland).
2011 Dec; 16(12):10093-103. doi:
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Chemistry & biodiversity.
2011 Oct; 8(10):1853-63. doi:
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