Mersacidin (BioDeep_00001036392)
代谢物信息卡片
化学式: C80H120N20O21S4 (1824.7819350000002)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C1C(=O)NC=CSC(C2C(=O)NC(=C)C(=O)NC(C(=O)NC(CSC(C(C(=O)NC(C(=O)N2)CC(C)C)NC(=O)C3CSC(C(C(=O)NC(C(=O)N4CCCC4C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(C(=O)N3)C(C)C)CC(C)C)NC(=O)C(CC5=CC=CC=C5)NC(=O)C6C(SCC(C(=O)N6)N)C)C)C)C(=O)N1)CCC(=O)O)C
InChI: InChI=1S/C80H120N20O21S4/c1-14-40(8)61-74(115)82-24-26-122-42(10)62-76(117)87-41(9)66(107)88-48(22-23-59(105)106)68(109)92-52(71(112)95-61)35-124-44(12)64(78(119)89-49(27-37(2)3)69(110)97-62)99-72(113)53-36-125-45(13)65(98-70(111)50(29-46-19-16-15-17-20-46)90-77(118)63-43(11)123-34-47(81)67(108)96-63)79(120)91-51(28-38(4)5)80(121)100-25-18-21-54(100)73(114)86-32-57(103)84-30-55(101)83-31-56(102)85-33-58(104)94-60(39(6)7)75(116)93-53/h15-17,19-20,24,26,37-40,42-45,47-54,60-65H,9,14,18,21-23,25,27-36,81H2,1-8,10-13H3,(H,82,115)(H,83,101)(H,84,103)(H,85,102)(H,86,114)(H,87,117)(H,88,107)(H,89,119)(H,90,118)(H,91,120)(H,92,109)(H,93,116)(H,94,104)(H,95,112)(H,96,108)(H,97,110)(H,98,111)(H,99,113)(H,105,106)/b26-24+/t40-,42+,43+,44+,45+,47+,48+,49+,50+,51+,52+,53+,54+,60+,61+,62?,63-,64-,65-/m1/s1
描述信息
A type-B lantibiotic containing 3-methyllanthionine and S-(2-aminovinyl)-3-methylcysteine residues and four intra-chain thioether bridges. It is obtained from Bacillus sp. HIL Y-85,54728 and is active in vivo against methicillin-resistant Staphylococcus aureus (MRSA).
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D001430 - Bacteriocins
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pengfei He, Kun Hao, Jochen Blom, Christian Rückert, Joachim Vater, Zichao Mao, Yixin Wu, Mingsheng Hou, Pengbo He, Yueqiu He, Rainer Borriss. Genome sequence of the plant growth promoting strain Bacillus amyloliquefaciens subsp. plantarum B9601-Y2 and expression of mersacidin and other secondary metabolites.
Journal of biotechnology.
2012 Dec; 164(2):281-91. doi:
10.1016/j.jbiotec.2012.12.014. [PMID: 23357245] - Michaela Wenzel, Bastian Kohl, Daniela Münch, Nadja Raatschen, H Bauke Albada, Leendert Hamoen, Nils Metzler-Nolte, Hans-Georg Sahl, Julia E Bandow. Proteomic response of Bacillus subtilis to lantibiotics reflects differences in interaction with the cytoplasmic membrane.
Antimicrobial agents and chemotherapy.
2012 Nov; 56(11):5749-57. doi:
10.1128/aac.01380-12. [PMID: 22926563] - Kun Hao, Pengfei He, Jochen Blom, Christian Rueckert, Zichao Mao, Yixin Wu, Yueqiu He, Rainer Borriss. The genome of plant growth-promoting Bacillus amyloliquefaciens subsp. plantarum strain YAU B9601-Y2 contains a gene cluster for mersacidin synthesis.
Journal of bacteriology.
2012 Jun; 194(12):3264-5. doi:
10.1128/jb.00545-12. [PMID: 22628498] - Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher. Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.
Antimicrobial agents and chemotherapy.
2011 Feb; 55(2):515-25. doi:
10.1128/aac.00352-10. [PMID: 21078927] - T Böttiger, T Schneider, B Martínez, H-G Sahl, I Wiedemann. Influence of Ca(2+) ions on the activity of lantibiotics containing a mersacidin-like lipid II binding motif.
Applied and environmental microbiology.
2009 Jul; 75(13):4427-34. doi:
10.1128/aem.00262-09. [PMID: 19429551] - Peter Sass, Andrea Jansen, Christiane Szekat, Vera Sass, Hans-Georg Sahl, Gabriele Bierbaum. The lantibiotic mersacidin is a strong inducer of the cell wall stress response of Staphylococcus aureus.
BMC microbiology.
2008 Oct; 8(?):186. doi:
10.1186/1471-2180-8-186. [PMID: 18947397] - Eefjan Breukink, Ben de Kruijff. Lipid II as a target for antibiotics.
Nature reviews. Drug discovery.
2006 Apr; 5(4):321-32. doi:
10.1038/nrd2004. [PMID: 16531990] - Imke Wiedemann, Tim Böttiger, Raquel Regina Bonelli, Tanja Schneider, Hans-Georg Sahl, Beatriz Martínez. Lipid II-based antimicrobial activity of the lantibiotic plantaricin C.
Applied and environmental microbiology.
2006 Apr; 72(4):2809-14. doi:
10.1128/aem.72.4.2809-2814.2006. [PMID: 16597986] - Christiane Szekat, Ralph W Jack, Dirk Skutlarek, Harald Färber, Gabriele Bierbaum. Construction of an expression system for site-directed mutagenesis of the lantibiotic mersacidin.
Applied and environmental microbiology.
2003 Jul; 69(7):3777-83. doi:
10.1128/aem.69.7.3777-3783.2003. [PMID: 12839744] - Shang-Te D Hsu, Eefjan Breukink, Gabriele Bierbaum, Hans-Georg Sahl, Ben de Kruijff, Rob Kaptein, Nico A J van Nuland, Alexandre M J J Bonvin. NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity.
The Journal of biological chemistry.
2003 Apr; 278(15):13110-7. doi:
10.1074/jbc.m211144200. [PMID: 12562773] - Yann Héchard, Hans Georg Sahl. Mode of action of modified and unmodified bacteriocins from Gram-positive bacteria.
Biochimie.
2002 May; 84(5-6):545-57. doi:
10.1016/s0300-9084(02)01417-7. [PMID: 12423799] - Florian Majer, Dietmar G Schmid, Karsten Altena, Gabriele Bierbaum, Thomas Kupke. The flavoprotein MrsD catalyzes the oxidative decarboxylation reaction involved in formation of the peptidoglycan biosynthesis inhibitor mersacidin.
Journal of bacteriology.
2002 Mar; 184(5):1234-43. doi:
10.1128/jb.184.5.1234-1243.2002. [PMID: 11844751] - André Guder, Tim Schmitter, Imke Wiedemann, Hans-Georg Sahl, Gabriele Bierbaum. Role of the single regulator MrsR1 and the two-component system MrsR2/K2 in the regulation of mersacidin production and immunity.
Applied and environmental microbiology.
2002 Jan; 68(1):106-13. doi:
10.1128/aem.68.1.106-113.2002. [PMID: 11772616] - H Brötz, M Josten, I Wiedemann, U Schneider, F Götz, G Bierbaum, H G Sahl. Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics.
Molecular microbiology.
1998 Oct; 30(2):317-27. doi:
10.1046/j.1365-2958.1998.01065.x. [PMID: 9791177] - H Brötz, G Bierbaum, K Leopold, P E Reynolds, H G Sahl. The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II.
Antimicrobial agents and chemotherapy.
1998 Jan; 42(1):154-60. doi:
10.1128/aac.42.1.154. [PMID: 9449277] - H Brötz, G Bierbaum, P E Reynolds, H G Sahl. The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation.
European journal of biochemistry.
1997 May; 246(1):193-9. doi:
10.1111/j.1432-1033.1997.t01-1-00193.x. [PMID: 9210483]