Carbohydrate moiety of bromelain (BioDeep_00001036369)
代谢物信息卡片
Carbohydrate moiety of bromelain
化学式: C39H66N2O29 (1026.3751066000002)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)CO)OC4C(C(C(C(O4)COC5C(C(C(C(O5)CO)O)O)O)O)O)OC6C(C(C(CO6)O)O)O)O)NC(=O)C)CO)O)NC(=O)C)O)O)O
InChI: InChI=1S/C39H66N2O29/c1-9-19(48)24(53)29(58)38(62-9)69-32-18(41-11(3)46)34(59)63-15(6-44)31(32)68-35-17(40-10(2)45)23(52)30(14(5-43)65-35)67-39-33(70-37-27(56)20(49)12(47)7-60-37)26(55)22(51)16(66-39)8-61-36-28(57)25(54)21(50)13(4-42)64-36/h9,12-39,42-44,47-59H,4-8H2,1-3H3,(H,40,45)(H,41,46)/t9-,12+,13+,14+,15+,16+,17+,18+,19+,20-,21+,22+,23+,24+,25-,26-,27+,28-,29-,30+,31+,32+,33-,34?,35-,36-,37-,38-,39-/m0/s1
描述信息
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Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
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0 个相关的代谢反应过程信息。
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Po-An Hu, Sz-Han Wang, Chia-Hui Chen, Bei-Chia Guo, Jenq-Wen Huang, Tzong-Shyuan Lee. New Mechanisms of Bromelain in Alleviating Non-Alcoholic Fatty Liver Disease-Induced Deregulation of Blood Coagulation.
Nutrients.
2022 Jun; 14(11):. doi:
10.3390/nu14112329. [PMID: 35684129] - Jordana Grazziela A Coelho Dos Reis, Geovane Marques Ferreira, Alice Aparecida Lourenço, Ágata Lopes Ribeiro, Camila Pacheco da Silveira Martins da Mata, Patrícia de Melo Oliveira, Daisymara Priscila de Almeida Marques, Linziane Lopes Ferreira, Felipe Alves Clarindo, Murillo Ferreira da Silva, Heitor Portella Póvoas Filho, Nilson Roberto Ribeiro Oliveira, Maisah Meyhr D'Carmo Sodré, Sandra Rocha Gadelha, George Rego Albuquerque, Bianca Mendes Maciel, Ana Paula Melo Mariano, Mylene de Melo Silva, Renato Fontana, Lauro Juliano Marin, Renata Santiago Alberto Carlos, Amanda Teixeira Sampaio Lopes, Fabrício Barbosa Ferreira, Uener Ribeiro Dos Santos, Íris Terezinha Santos de Santana, Hllytchaikra Ferraz Fehlberg, Rachel Passos Rezende, João Carlos T Dias, Eduardo Gross, Gisele Assis Castro Goulart, Marie Gabriele Santiago, Ana Paula Motta Lavigne de Lemos, Aline O da Conceição, Carla Cristina Romano, Luciana Debortoli de Carvalho, Olindo Assis Martins Filho, Claudio Almeida Quadros, David L Morris, Sarah J Valle. Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 04; 148(?):112753. doi:
10.1016/j.biopha.2022.112753. [PMID: 35272139] - Megha Sahu, Arun K Sharma, Gunjan Sharma, Ashish Kumar, Mukesh Nandave, Varsha Babu. Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats.
Canadian journal of physiology and pharmacology.
2022 Mar; 100(3):210-219. doi:
10.1139/cjpp-2021-0129. [PMID: 34910610] - Trina Ekawati Tallei, Fatimawali, Ahmad Akroman Adam, Mona M Elseehy, Ahmed M El-Shehawi, Eman A Mahmoud, Adinda Dwi Tania, Nurdjannah Jane Niode, Diah Kusumawaty, Souvia Rahimah, Yunus Effendi, Rinaldi Idroes, Ismail Celik, Md Jamal Hossain, Talha Bin Emran. Fruit Bromelain-Derived Peptide Potentially Restrains the Attachment of SARS-CoV-2 Variants to hACE2: A Pharmacoinformatics Approach.
Molecules (Basel, Switzerland).
2022 Jan; 27(1):. doi:
10.3390/molecules27010260. [PMID: 35011492] - Maede Hasannasab, Jhamak Nourmohammadi, Mohammad Mehdi Dehghan, Azadeh Ghaee. Immobilization of bromelain and ZnO nanoparticles on silk fibroin nanofibers as an antibacterial and anti-inflammatory burn dressing.
International journal of pharmaceutics.
2021 Dec; 610(?):121227. doi:
10.1016/j.ijpharm.2021.121227. [PMID: 34699950] - Pawel Hikisz, Joanna Bernasinska-Slomczewska. Beneficial Properties of Bromelain.
Nutrients.
2021 Nov; 13(12):. doi:
10.3390/nu13124313. [PMID: 34959865] - Nada F Abo El-Magd, Nehal M Ramadan, Salma M Eraky. The ameliorative effect of bromelain on STZ-induced type 1 diabetes in rats through Oxi-LDL/LPA/LPAR1 pathway.
Life sciences.
2021 Nov; 285(?):119982. doi:
10.1016/j.lfs.2021.119982. [PMID: 34592232] - Hadir M Maher, Aliyah Almomen, Nourah Z Alzoman, Shereen M Shehata, Ashwaq A Alanazi. Development and validation of UPLC-MS/MS method for the simultaneous quantification of anaplastic lymphoma kinase inhibitors, alectinib, ceritinib, and crizotinib in Wistar rat plasma with application to bromelain-induced pharmacokinetic interaction.
Journal of pharmaceutical and biomedical analysis.
2021 Sep; 204(?):114276. doi:
10.1016/j.jpba.2021.114276. [PMID: 34325247] - Ahmet Özer Şehirli, Serkan Sayiner, Gökçe Savtekin, Ayliz Velioğlu-Öğünç. Protective effect of bromelain on corrosive burn in rats.
Burns : journal of the International Society for Burn Injuries.
2021 09; 47(6):1352-1358. doi:
10.1016/j.burns.2020.12.006. [PMID: 33934907] - Javed Akhter, Grégory Quéromès, Krishna Pillai, Vahan Kepenekian, Samina Badar, Ahmed H Mekkawy, Emilie Frobert, Sarah J Valle, David L Morris. The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2.
Viruses.
2021 03; 13(3):. doi:
10.3390/v13030425. [PMID: 33800932] - Satish Sagar, Ashok Kumar Rathinavel, William E Lutz, Lucas R Struble, Surender Khurana, Andy T Schnaubelt, Nitish Kumar Mishra, Chittibabu Guda, Nicholas Y Palermo, Mara J Broadhurst, Tobias Hoffmann, Kenneth W Bayles, St Patrick M Reid, Gloria E O Borgstahl, Prakash Radhakrishnan. Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein.
Clinical and translational medicine.
2021 02; 11(2):e281. doi:
10.1002/ctm2.281. [PMID: 33635001] - Ahmed O Bakare, Bamidele V Owoyele. Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in sciatic nerve ligated Wistar rats.
Scientific reports.
2021 01; 11(1):289. doi:
10.1038/s41598-020-79421-9. [PMID: 33432004] - Fatma M El-Demerdash, Hoda H Baghdadi, Nora F Ghanem, Ansam B Al Mhanna. Nephroprotective role of bromelain against oxidative injury induced by aluminium in rats.
Environmental toxicology and pharmacology.
2020 Nov; 80(?):103509. doi:
10.1016/j.etap.2020.103509. [PMID: 33010469] - B V Owoyele, A O Bakare, M O Ologe. Bromelain: A Review on its Potential as a Therapy for the Management of Covid-19.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2020 06; 35(1):10-19. doi:
NULL. [PMID: 33084621] - Po-An Hu, Chia-Hui Chen, Bei-Chia Guo, Yu Ru Kou, Tzong-Shyuan Lee. Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Nutrients.
2020 May; 12(5):. doi:
10.3390/nu12051458. [PMID: 32443556] - Rahul Debnath, Debabrata Majumder, Priyatosh Nath, Durgadas Ghosh, Debasish Maiti. Bromelain plus peroxidase reduces non-Hodgkin lymphoma progression in invivo via up-regulation of antioxidant enzymes and modulating apoptotic protein expression.
Nutrition and cancer.
2020; 72(7):1200-1210. doi:
10.1080/01635581.2019.1670217. [PMID: 31591915] - Mai H Mekkawy, Hanan A Fahmy, Ahmed S Nada, Ola S Ali. Study of the Radiosensitizing and Radioprotective Efficacy of Bromelain (a Pineapple Extract): In Vitro and In Vivo.
Integrative cancer therapies.
2020 Jan; 19(?):1534735420950468. doi:
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Molecular biotechnology.
2019 Oct; 61(10):715-724. doi:
10.1007/s12033-019-00200-7. [PMID: 31350687] - Paulo Eduardo Orlandi-Mattos, Rodrigo Barbosa Aguiar, Itabajara da Silva Vaz, Jane Zveiter Moraes, Elisaldo Luiz de Araujo Carlini, Maria Aparecida Juliano, Luiz Juliano. Enkephalin related peptides are released from jejunum wall by orally ingested bromelain.
Peptides.
2019 05; 115(?):32-42. doi:
10.1016/j.peptides.2019.02.008. [PMID: 30836111] - Yuanzi Wu, Zhen Cai, Shuigen Wu, Wenli Xiong, Shanyun Ma. Protein purification by chemo-selective precipitation using thermoresponsive polymers.
Biopolymers.
2018 Jun; 109(6):e23222. doi:
10.1002/bip.23222. [PMID: 29732533] - D Passali, G C Passali, L M Bellussi, C Sarafoleanu, M Loglisci, C Manea, C Iosif, F M Passali. Bromelain's penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis.
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale.
2018 Jun; 38(3):225-228. doi:
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Analytical and bioanalytical chemistry.
2018 Apr; 410(11):2781-2791. doi:
10.1007/s00216-018-0958-1. [PMID: 29480389] - Sonam Agarwal, Bharti Chaudhary, Renu Bist. Protective propensity of bacoside A and bromelain on renal cholinesterases, γ-Aminobutyric acid and serotonin level of Mus musculus intoxicated with dichlorvos.
Chemico-biological interactions.
2017 Jan; 261(?):139-144. doi:
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International journal of biological macromolecules.
2017 Jan; 94(Pt B):819-826. doi:
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Clinical rheumatology.
2016 Oct; 35(10):2531-40. doi:
10.1007/s10067-016-3363-1. [PMID: 27470088] - Chit Moy Ley, Qing Ni, Xing Liao, Huai-Lin Gao, Nicola Robinson. Bromelain and cardiovascular risk factors in diabetes: An exploratory randomized, placebo controlled, double blind clinical trial.
Chinese journal of integrative medicine.
2016 Oct; 22(10):728-37. doi:
10.1007/s11655-016-2521-2. [PMID: 27412590] - Harmanpreet Kaur, Kathryn Corscadden, Carlene Lott, Hisham S Elbatarny, Maha Othman. Bromelain has paradoxical effects on blood coagulability: a study using thromboelastography.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2016 Oct; 27(7):745-752. doi:
10.1097/mbc.0000000000000244. [PMID: 25517253] - Sonam Agarwal, Bharti Chaudhary, Renu Bist. Bacoside A and bromelain relieve dichlorvos induced changes in oxidative responses in mice serum.
Chemico-biological interactions.
2016 Jul; 254(?):173-8. doi:
10.1016/j.cbi.2016.05.017. [PMID: 27180203] - Rubab Mahmood. Purification of anti-bromelain antibodies by affinity precipitation using pNIPAm-linked bromelain.
Preparative biochemistry & biotechnology.
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Acta biologica Hungarica.
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Alternative therapies in health and medicine.
2012 Sep; 18(5):9-17. doi:
NULL. [PMID: 22894886] - Ewa Gorodkiewicz, Joanna Breczko, Anna Sankiewicz. Surface Plasmon Resonance Imaging biosensor for cystatin determination based on the application of bromelain, ficin and chymopapain.
Folia histochemica et cytobiologica.
2012 Apr; 50(1):130-6. doi:
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Polskie Archiwum Medycyny Wewnetrznej.
2012; 122(10):514-6. doi:
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International archives of allergy and immunology.
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Urology.
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Journal of agricultural and food chemistry.
2009 Sep; 57(18):8612-6. doi:
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British journal of biomedical science.
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Glycobiology.
2007 Feb; 17(2):220-30. doi:
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Transfusion.
2006 Sep; 46(9):1521-5. doi:
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The Journal of surgical research.
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10.1016/j.jss.2005.12.005. [PMID: 16458926] - Rolis Chien-Wei Hou, Yuh-Shuen Chen, Jing-Rong Huang, Kee-Ching G Jeng. Cross-linked bromelain inhibits lipopolysaccharide-induced cytokine production involving cellular signaling suppression in rats.
Journal of agricultural and food chemistry.
2006 Mar; 54(6):2193-8. doi:
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Fish & shellfish immunology.
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Shock (Augusta, Ga.).
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International immunopharmacology.
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Alternative medicine review : a journal of clinical therapeutic.
2003 Feb; 8(1):55-8. doi:
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Clinical immunology (Orlando, Fla.).
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Infection and immunity.
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Cancer chemotherapy and pharmacology.
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Cancer chemotherapy and pharmacology.
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