LacdiNAc (BioDeep_00001036012)
代谢物信息卡片
LacdiNAc
化学式: C16H28N2O11 (424.16930179999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1C(C(C(OC1O)CO)OC2C(C(C(C(O2)CO)O)O)NC(=O)C)O
InChI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11+,12-,13-,14-,15?,16+/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Takahiro Inoue, Tomonori Kaneko, Shinichi Muramatsu, Hiroko Kimura, Takayuki Yoshino, Takayuki Goto, Atsuro Sawada, Shusuke Akamatsu, Takashi Kobayashi, Toshinari Yamasaki, Takatoshi Kaya, Osamu Ogawa. LacdiNAc-Glycosylated Prostate-specific Antigen Density is a Potential Biomarker of Prostate Cancer.
Clinical genitourinary cancer.
2020 02; 18(1):e28-e36. doi:
10.1016/j.clgc.2019.10.011. [PMID: 31711843] - Jerica Sabotič, Janko Kos. CNL-Clitocybe nebularis Lectin-The Fungal GalNAcβ1-4GlcNAc-Binding Lectin.
Molecules (Basel, Switzerland).
2019 Nov; 24(23):. doi:
10.3390/molecules24234204. [PMID: 31756927] - Tohru Yoneyama, Yuki Tobisawa, Tomonori Kaneko, Takatoshi Kaya, Shingo Hatakeyama, Kazuyuki Mori, Mihoko Sutoh Yoneyama, Teppei Okubo, Koji Mitsuzuka, Wilhelmina Duivenvoorden, Jehonathan H Pinthus, Yasuhiro Hashimoto, Akihiro Ito, Takuya Koie, Yoshihiko Suda, Robert A Gardiner, Chikara Ohyama. Clinical significance of the LacdiNAc-glycosylated prostate-specific antigen assay for prostate cancer detection.
Cancer science.
2019 Aug; 110(8):2573-2589. doi:
10.1111/cas.14082. [PMID: 31145522] - Ladislav Bumba, Dominic Laaf, Vojtěch Spiwok, Lothar Elling, Vladimír Křen, Pavla Bojarová. Poly-N-Acetyllactosamine Neo-Glycoproteins as Nanomolar Ligands of Human Galectin-3: Binding Kinetics and Modeling.
International journal of molecular sciences.
2018 Jan; 19(2):. doi:
10.3390/ijms19020372. [PMID: 29373511] - Omid Haji-Ghassemi, Michel Gilbert, Jenifer Spence, Melissa J Schur, Matthew J Parker, Meredith L Jenkins, John E Burke, Henk van Faassen, N Martin Young, Stephen V Evans. Molecular Basis for Recognition of the Cancer Glycobiomarker, LacdiNAc (GalNAc[β1→4]GlcNAc), by Wisteria floribunda Agglutinin.
The Journal of biological chemistry.
2016 Nov; 291(46):24085-24095. doi:
10.1074/jbc.m116.750463. [PMID: 27601469] - Daisuke Sugahara, Azusa Tomioka, Takashi Sato, Hisashi Narimatsu, Hiroyuki Kaji. Large-scale identification of secretome glycoproteins recognized by Wisteria floribunda agglutinin: A glycoproteomic approach to biomarker discovery.
Proteomics.
2015 Sep; 15(17):2921-33. doi:
10.1002/pmic.201400443. [PMID: 25921242] - Sophia Böcker, Dominic Laaf, Lothar Elling. Galectin Binding to Neo-Glycoproteins: LacDiNAc Conjugated BSA as Ligand for Human Galectin-3.
Biomolecules.
2015 Jul; 5(3):1671-96. doi:
10.3390/biom5031671. [PMID: 26213980] - Takatoshi Kaya, Tomonori Kaneko, Shun Kojima, Yukito Nakamura, Youichi Ide, Kenji Ishida, Yoshihiko Suda, Katsuko Yamashita. High-sensitivity immunoassay with surface plasmon field-enhanced fluorescence spectroscopy using a plastic sensor chip: application to quantitative analysis of total prostate-specific antigen and GalNAcβ1-4GlcNAc-linked prostate-specific antigen for prostate cancer diagnosis.
Analytical chemistry.
2015 Feb; 87(3):1797-803. doi:
10.1021/ac503735e. [PMID: 25546230] - Franz-Georg Hanisch, Hubert Ragge, Thomas Kalinski, Frank Meyer, Hubert Kalbacher, Werner Hoffmann. Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide.
Glycobiology.
2013 Jan; 23(1):2-11. doi:
10.1093/glycob/cws131. [PMID: 22997242] - Sandra Frank, Irma van Die, Rudolf Geyer. Structural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae.
Glycobiology.
2012 May; 22(5):676-95. doi:
10.1093/glycob/cws004. [PMID: 22241826] - Norihiko Sasaki, Masahito Shinomi, Kazumi Hirano, Kumiko Ui-Tei, Shoko Nishihara. LacdiNAc (GalNAcβ1-4GlcNAc) contributes to self-renewal of mouse embryonic stem cells by regulating leukemia inhibitory factor/STAT3 signaling.
Stem cells (Dayton, Ohio).
2011 Apr; 29(4):641-50. doi:
10.1002/stem.615. [PMID: 21305673] - Arjen R de Boer, Cornelis H Hokke, André M Deelder, M Wuhrer. Serum antibody screening by surface plasmon resonance using a natural glycan microarray.
Glycoconjugate journal.
2008 Jan; 25(1):75-84. doi:
10.1007/s10719-007-9100-x. [PMID: 18193481] - Takashi Ohkura, Akira Seko, Sayuri Hara-Kuge, Katsuko Yamashita. Occurrence of secretory glycoprotein-specific GalNAc beta 1-->4GlcNAc sequence in N-glycans in MDCK cells.
Journal of biochemistry.
2002 Dec; 132(6):891-901. doi:
10.1093/oxfordjournals.jbchem.a003302. [PMID: 12473191] - A van Remoortere, G J van Dam, C H Hokke, D H van den Eijnden, I van Die, A M Deelder. Profiles of immunoglobulin M (IgM) and IgG antibodies against defined carbohydrate epitopes in sera of Schistosoma-infected individuals determined by surface plasmon resonance.
Infection and immunity.
2001 Apr; 69(4):2396-401. doi:
10.1128/iai.69.4.2396-2401.2001. [PMID: 11254599] - A van Remoortere, C H Hokke, G J van Dam, I van Die, A M Deelder, D H van den Eijnden. Various stages of schistosoma express Lewis(x), LacdiNAc, GalNAcbeta1-4 (Fucalpha1-3)GlcNAc and GalNAcbeta1-4(Fucalpha1-2Fucalpha1-3)GlcNAc carbohydrate epitopes: detection with monoclonal antibodies that are characterized by enzymatically synthesized neoglycoproteins.
Glycobiology.
2000 Jun; 10(6):601-9. doi:
10.1093/glycob/10.6.601. [PMID: 10814702] - K Y Do, S I Do, R D Cummings. Differential expression of LacdiNAc sequences (GalNAc beta 1-4GlcNAc-R) in glycoproteins synthesized by Chinese hamster ovary and human 293 cells.
Glycobiology.
1997 Mar; 7(2):183-94. doi:
10.1093/glycob/7.2.183. [PMID: 9134425]