(4S,4aS,5aR,12aS)-9-[[2-(tert-butylamino)-1-oxoethyl]amino]-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide (BioDeep_00001035459)
代谢物信息卡片
(4S,4aS,5aR,12aS)-9-[[2-(tert-butylamino)-1-oxoethyl]amino]-4,7-bis(dimethylamino)-10,12a-dihydroxy-1,3,11,12-tetraoxo-4,4a,5,5a,6,11a-hexahydrotetracene-2-carboxamide
化学式: C29H39N5O8 (585.2798494)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)NCC(=O)NC1=CC(=C2CC3CC4C(C(=O)C(C(=O)C4(C(=O)C3C(=O)C2=C1O)O)C(=O)N)N(C)C)N(C)C
InChI: InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,18,20-21,31,36,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,18?,20?,21-,29-/m0/s1
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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2009 Sep; 17 Suppl 4(?):37-57. doi:
NULL. [PMID: 20428019] - J M Hansen, H Fjeldsøe-Nielsen, S Sulim, M Kemp, J J Christensen. Actinomyces species: A danish survey on human infections and microbiological characteristics.
The open microbiology journal.
2009 Jul; 3(?):113-20. doi:
10.2174/1874285800903010113. [PMID: 19657460] - T Mazzei, A Novelli. Pharmacological rationale for antibiotic treatment of intra-abdominal infections.
Journal of chemotherapy (Florence, Italy).
2009 Jul; 21 Suppl 1(?):19-29. doi:
10.1179/joc.2009.21.supplement-1.19. [PMID: 19622447] - A Japoni, S Farshad, M Ziyaeyan, S Ziaian. Detection of Van-positive and negative vancomycin resistant entrococci and their antibacterial susceptibility patterns to the newly introduced antibiotics.
Pakistan journal of biological sciences : PJBS.
2009 Jun; 12(11):844-51. doi:
10.3923/pjbs.2009.844.851. [PMID: 19803118] - Marcella McGuinn, Ronald C Hershow, William M Janda. Escherichia coli and Klebsiella pneumoniae carbapenemase in long-term care facility, Illinois, USA.
Emerging infectious diseases.
2009 Jun; 15(6):988-9. doi:
10.3201/eid1506.081735. [PMID: 19523317] - Pornpan Koomanachai, Aryun Kim, David P Nicolau. Pharmacodynamic evaluation of tigecycline against Acinetobacter baumannii in a murine pneumonia model.
The Journal of antimicrobial chemotherapy.
2009 May; 63(5):982-7. doi:
10.1093/jac/dkp056. [PMID: 19279050] - Nuggehally R Srinivas. Tigecycline and cyclosporine interaction-an interesting case of biliary-excreted drug enhancing the oral bioavailability of cyclosporine.
European journal of clinical pharmacology.
2009 May; 65(5):543-4. doi:
10.1007/s00228-009-0631-x. [PMID: 19224202] - Dylan R Pillai, Roberto Melano, Prasad Rawte, Stephen Lo, Nathalie Tijet, Milan Fuksa, Nancy Roda, David J Farrell, Sigmund Krajden. Klebsiella pneumoniae Carbapenemase, Canada.
Emerging infectious diseases.
2009 May; 15(5):827-9. doi:
10.3201/eid1505.081536. [PMID: 19402984] - Vladimíra Vojtová, Karel Urbánek. [Pharmacokinetics of tetracyclines and glycylcyclines].
Klinicka mikrobiologie a infekcni lekarstvi.
2009 Feb; 15(1):17-21. doi:
NULL. [PMID: 19399726] - April Barbour, Stephan Schmidt, Benjamin Ma, Lars Schiefelbein, Kenneth H Rand, Olaf Burkhardt, Hartmut Derendorf. Clinical pharmacokinetics and pharmacodynamics of tigecycline.
Clinical pharmacokinetics.
2009; 48(9):575-84. doi:
10.2165/11317100-000000000-00000. [PMID: 19725592] - Anita N Stumpf, Christian Schmidt, Wolfgang Hiddemann, Armin Gerbitz. High serum concentrations of cyclosporin related to administration of tigecycline.
European journal of clinical pharmacology.
2009 Jan; 65(1):101-3. doi:
10.1007/s00228-008-0557-8. [PMID: 18795273] - Matthew E Falagas, Drosos E Karageorgopoulos, George Dimopoulos. Clinical significance of the pharmacokinetic and pharmacodynamic characteristics of tigecycline.
Current drug metabolism.
2009 Jan; 10(1):13-21. doi:
10.2174/138920009787048356. [PMID: 19149509] - Vincenzo Savini, Chiara Catavitello, Franca Pompetti, Marzia Talia, Lara Costanzi, Andrea Balbinot, Fabio Febbo, Silvia Di Zacomo, Francesca Esattore, Domenico D'Antonio. Isolation of uncommon respiratory and enteric Acinetobacter baumannii from hematologic patients and emergence of tigecycline-resistance.
The Journal of infection.
2008 Dec; 57(6):497-500. doi:
10.1016/j.jinf.2008.10.004. [PMID: 19027170] - F Timurkaynak, H Arslan, O Kurt Azap, S Serin Senger, O Başaran, S Ozbalikci Karaman, M Haberal. In vitro activity of tigecycline against resistant micro-organisms isolated from burn patients.
Burns : journal of the International Society for Burn Injuries.
2008 Nov; 34(7):1033-6. doi:
10.1016/j.burns.2008.03.005. [PMID: 18539397] - Derrick E Fouts, Heather L Tyler, Robert T DeBoy, Sean Daugherty, Qinghu Ren, Jonathan H Badger, Anthony S Durkin, Heather Huot, Susmita Shrivastava, Sagar Kothari, Robert J Dodson, Yasmin Mohamoud, Hoda Khouri, Luiz F W Roesch, Karen A Krogfelt, Carsten Struve, Eric W Triplett, Barbara A Methé. Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice.
PLoS genetics.
2008 Jul; 4(7):e1000141. doi:
10.1371/journal.pgen.1000141. [PMID: 18654632] - James J Zimmerman, Donald G Raible, Dawn M Harper, Kyle Matschke, John L Speth. Evaluation of a potential tigecycline-warfarin drug interaction.
Pharmacotherapy.
2008 Jul; 28(7):895-905. doi:
10.1592/phco.28.7.895. [PMID: 18576904] - George Samonis, Elpis Mantadakis, Emmanouel Barbounakis, Diamantis Kofteridis, George Papadakis, Loukia Sifaki, Sofia Maraki. Effects of tigecycline and daptomycin on murine gut colonization by Candida albicans.
Mycoses.
2008 Jul; 51(4):324-7. doi:
10.1111/j.1439-0507.2008.01500.x. [PMID: 18855845] - Lisa C Crossman, Virginia C Gould, J Maxwell Dow, Georgios S Vernikos, Aki Okazaki, Mohammed Sebaihia, David Saunders, Claire Arrowsmith, Tim Carver, Nicholas Peters, Ellen Adlem, Arnaud Kerhornou, Angela Lord, Lee Murphy, Katharine Seeger, Robert Squares, Simon Rutter, Michael A Quail, Mari-Adele Rajandream, David Harris, Carol Churcher, Stephen D Bentley, Julian Parkhill, Nicholas R Thomson, Matthew B Avison. The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants.
Genome biology.
2008 Apr; 9(4):R74. doi:
10.1186/gb-2008-9-4-r74. [PMID: 18419807] - Burke A Cunha. Vancomycin revisited: a reappraisal of clinical use.
Critical care clinics.
2008 Apr; 24(2):393-420, x. doi:
10.1016/j.ccc.2007.12.012. [PMID: 18361953] - Teresita Mazzei, Andrea Novelli. [Pharmacological rationale for choice of antibiotics for intraabdominal infections].
Le infezioni in medicina.
2008 Feb; 16 Suppl 1(?):31-45. doi:
NULL. [PMID: 18382149] - Q Chen, E C Tung, S L Ciccotto, J R Strauss, R Ortiga, K A Ramsay, W Tang. Effect of the anticoagulant ethylenediamine tetra-acetic acid (EDTA) on the estimation of pharmacokinetic parameters: A case study with tigecycline and ciprofloxacin.
Xenobiotica; the fate of foreign compounds in biological systems.
2008 Jan; 38(1):76-86. doi:
10.1080/00498250701678955. [PMID: 17963190] - Ralf Rene Reinert, Donald E Low, Flávia Rossi, Xiaojiang Zhang, Chand Wattal, Michael J Dowzicky. Antimicrobial susceptibility among organisms from the Asia/Pacific Rim, Europe and Latin and North America collected as part of TEST and the in vitro activity of tigecycline.
The Journal of antimicrobial chemotherapy.
2007 Nov; 60(5):1018-29. doi:
10.1093/jac/dkm310. [PMID: 17855724] - A Deplano, O Denis, C Nonhoff, F Rost, B Byl, F Jacobs, V Vankerckhoven, H Goossens, M J Struelens. Outbreak of hospital-adapted clonal complex-17 vancomycin-resistant Enterococcus faecium strain in a haematology unit: role of rapid typing for early control.
The Journal of antimicrobial chemotherapy.
2007 Oct; 60(4):849-54. doi:
10.1093/jac/dkm270. [PMID: 17650516] - Matthew Hoffmann, William DeMaio, Ronald A Jordan, Rasmy Talaat, Dawn Harper, John Speth, JoAnn Scatina. Metabolism, excretion, and pharmacokinetics of [14C]tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Sep; 35(9):1543-53. doi:
10.1124/dmd.107.015735. [PMID: 17537869] - Allena J Ji, James P Saunders, Nandan D Wadgaonkar, Peter J Petersen, Kenneth O'Leary, Williams E McWilliams, Peter Amorusi, Mauricio Leal, Eric N Fluhler. A novel antibiotic bone assay by liquid chromatography/tandem mass spectrometry for quantitation of tigecycline in rat bone.
Journal of pharmaceutical and biomedical analysis.
2007 Aug; 44(4):970-9. doi:
10.1016/j.jpba.2007.04.017. [PMID: 17537611] - Gail E Reid, Shellee A Grim, Christine A Aldeza, William M Janda, Nina M Clark. Rapid development of Acinetobacter baumannii resistance to tigecycline.
Pharmacotherapy.
2007 Aug; 27(8):1198-201. doi:
10.1592/phco.27.8.1198. [PMID: 17655518] - Fernanda S Almeida, Viviane Nakano, Mario J Avila-Campos. Occurrence of enterotoxigenic and nonenterotoxigenic Bacteroides fragilis in calves and evaluation of their antimicrobial susceptibility.
FEMS microbiology letters.
2007 Jul; 272(1):15-21. doi:
10.1111/j.1574-6968.2007.00732.x. [PMID: 17488333] - James J Zimmerman, Dawn M Harper, Kyle Matschke, John L Speth, Donald G Raible, Richard J Fruncillo. Absence of an interaction between tigecycline and digoxin in healthy men.
Pharmacotherapy.
2007 Jun; 27(6):835-44. doi:
10.1592/phco.27.6.835. [PMID: 17542766] - Rajiv Mallick, Steven Sun, Scott R Schell. Predictors of efficacy and health resource utilization in treatment of complicated intra-abdominal infections: evidence for pooled clinical studies comparing tigecycline with imipenem-cilastatin.
Surgical infections.
2007 Apr; 8(2):159-72. doi:
10.1089/sur.2005.058. [PMID: 17437361] - Keith A Rodvold, Mark H Gotfried, Michael Cwik, Joan M Korth-Bradley, Gary Dukart, Evelyn J Ellis-Grosse. Serum, tissue and body fluid concentrations of tigecycline after a single 100 mg dose.
The Journal of antimicrobial chemotherapy.
2006 Dec; 58(6):1221-9. doi:
10.1093/jac/dkl403. [PMID: 17012300] - Marc H Scheetz, Pavani Reddy, David P Nicolau, Gary A Noskin, Michael J Postelnick, Valentina Stosor, Teresa R Zembower. Peritoneal fluid penetration of tigecycline.
The Annals of pharmacotherapy.
2006 Nov; 40(11):2064-7. doi:
10.1345/aph.1h229. [PMID: 17047138] - Thien-Ly Doan, Horatio B Fung, Dhara Mehta, Paul F Riska. Tigecycline: a glycylcycline antimicrobial agent.
Clinical therapeutics.
2006 Aug; 28(8):1079-1106. doi:
10.1016/j.clinthera.2006.08.011. [PMID: 16982286] - Nishaminy Kasbekar. Tigecycline: a new glycylcycline antimicrobial agent.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2006 Jul; 63(13):1235-43. doi:
10.2146/ajhp050487. [PMID: 16790575] - Iciar Rodríguez-Avial, Carmen Rodríguez-Avial, Olga López, Esther Culebras, Juan J Picazo. In vitro activity of tigecycline (GAR-936) and other antimicrobials against tetracycline- and ciprofloxacin-resistant Campylobacter clinical isolates.
International journal of antimicrobial agents.
2006 Apr; 27(4):303-6. doi:
10.1016/j.ijantimicag.2005.11.016. [PMID: 16540293] - Alison K Meagher, Paul G Ambrose, Thaddeus H Grasela, Evelyn J Ellis-Grosse. The pharmacokinetic and pharmacodynamic profile of tigecycline.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2005 Sep; 41 Suppl 5(?):S333-40. doi:
10.1086/431674. [PMID: 16080071] - Alison K Meagher, Paul G Ambrose, Thaddeus H Grasela, Evelyn J Ellis-Grosse. Pharmacokinetic/pharmacodynamic profile for tigecycline-a new glycylcycline antimicrobial agent.
Diagnostic microbiology and infectious disease.
2005 Jul; 52(3):165-71. doi:
10.1016/j.diagmicrobio.2005.05.006. [PMID: 16105560]