(6R,7R)-3-(Acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (BioDeep_00001034514)
代谢物信息卡片
(6R,7R)-3-(Acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
化学式: C16H16N5O7S2- (454.0491126)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)[O-]
InChI: InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/p-1/b20-9-/t10-,14-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DD - Third-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Stan J F Hartman, Parth J Upadhyay, Ron A A Mathôt, Michiel van der Flier, Michiel F Schreuder, Roger J Brüggemann, Catherijne A Knibbe, Saskia N de Wildt. Population pharmacokinetics of intravenous cefotaxime indicates that higher doses are required for critically ill children.
The Journal of antimicrobial chemotherapy.
2022 05; 77(6):1725-1732. doi:
10.1093/jac/dkac095. [PMID: 35383374] - Katarzyna Pauter, Małgorzata Szultka-Młyńska, Michał Szumski, Anna Król-Górniak, Paweł Pomastowski, Bogusław Buszewski. CE-DAD-MS/MS in the simultaneous determination and identification of selected antibiotic drugs and their metabolites in human urine samples.
Electrophoresis.
2022 May; 43(9-10):978-989. doi:
10.1002/elps.202100190. [PMID: 34624141] - Luke T Richardson, Elizabeth K Neumann, Richard M Caprioli, Jeffrey M Spraggins, Touradj Solouki. Referenced Kendrick Mass Defect Annotation and Class-Based Filtering of Imaging MS Lipidomics Experiments.
Analytical chemistry.
2022 04; 94(14):5504-5513. doi:
10.1021/acs.analchem.1c03715. [PMID: 35344335] - Charlotta Edlund, Anders Ternhag, Gunilla Skoog Ståhlgren, Petra Edquist, Åse Östholm Balkhed, Simon Athlin, Emeli Månsson, Maria Tempé, Jakob Bergström, Christian G Giske, Håkan Hanberger. The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden.
The Lancet. Infectious diseases.
2022 03; 22(3):390-400. doi:
10.1016/s1473-3099(21)00407-2. [PMID: 34756180] - Yarmarly C Guerra Valero, Tavey Dorofaeff, Jason A Roberts, Jeffrey Lipman, Mark G Coulthard, Louise Sparkes, Steven C Wallis, Suzanne L Parker. Development and validation of a UHPLC-MS/MS method to measure cefotaxime and metabolite desacetylcefotaxime in blood plasma: a pilot study suitable for capillary microsampling in critically ill children.
Analytical and bioanalytical chemistry.
2021 Jul; 413(17):4483-4491. doi:
10.1007/s00216-021-03411-7. [PMID: 34041575] - Kazuhiro Horiba, Michio Suzuki, Nobuyuki Tetsuka, Yoshihiko Kawano, Makoto Yamaguchi, Toshihiko Okumura, Takako Suzuki, Yuka Torii, Jun-Ichi Kawada, Makoto Morita, Shinya Hara, Tomoo Ogi, Yoshinori Ito. Pediatric sepsis cases diagnosed with group B streptococcal meningitis using next-generation sequencing: a report of two cases.
BMC infectious diseases.
2021 Jun; 21(1):531. doi:
10.1186/s12879-021-06231-3. [PMID: 34090359] - Filippo Migliorini, Nicola Maffulli, Filippo Spiezia, Giuseppe Maria Peretti, Markus Tingart, Riccardo Giorgino. Potential of biomarkers during pharmacological therapy setting for postmenopausal osteoporosis: a systematic review.
Journal of orthopaedic surgery and research.
2021 May; 16(1):351. doi:
10.1186/s13018-021-02497-0. [PMID: 34059108] - Benoît Pilmis, Olivier Jiang, Assaf Mizrahi, Jean-Claude Nguyen Van, Julie Lourtet-Hascoët, Olivier Voisin, Erwan Le Lorc'h, Sidonie Hubert, Elodie Ménage, Philippe Azria, Marie-Françoise Borie, Annabelle Mahé, Jean-Jacques Mourad, Eloïse Trabattoni, Olivier Ganansia, Jean-Ralph Zahar, Alban Le Monnier. No significant difference between ceftriaxone and cefotaxime in the emergence of antibiotic resistance in the gut microbiota of hospitalized patients: A pilot study.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Mar; 104(?):617-623. doi:
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International journal of antimicrobial agents.
2021 Mar; 57(3):106298. doi:
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Poultry science.
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BMC infectious diseases.
2021 Jan; 21(1):16. doi:
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Frontiers in immunology.
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International heart journal.
2020 Nov; 61(6):1307-1310. doi:
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Microbial drug resistance (Larchmont, N.Y.).
2020 Nov; 26(11):1421-1428. doi:
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PLoS neglected tropical diseases.
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Scientific reports.
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Emerging infectious diseases.
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Cellular and molecular biology (Noisy-le-Grand, France).
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The Journal of antimicrobial chemotherapy.
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Diagnosis (Berlin, Germany).
2020 01; 7(1):69-73. doi:
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The Journal of antimicrobial chemotherapy.
2020 01; 75(1):65-71. doi:
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Infection and immunity.
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Anaesthesia, critical care & pain medicine.
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Journal of pharmaceutical and biomedical analysis.
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Microbial drug resistance (Larchmont, N.Y.).
2019 Sep; 25(7):1041-1049. doi:
10.1089/mdr.2019.0016. [PMID: 30994417] - Stan J F Hartman, Navin P Boeddha, Ebru Ekinci, Birgit C P Koch, Rogier Donders, Jan A Hazelzet, Gertjan J Driessen, Saskia N de Wildt. Target attainment of cefotaxime in critically ill children with meningococcal septic shock as a model for cefotaxime dosing in severe pediatric sepsis.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2019 Jul; 38(7):1255-1260. doi:
10.1007/s10096-019-03535-w. [PMID: 30968258] - Charles Burdet, Nathalie Grall, Morgane Linard, Antoine Bridier-Nahmias, Michèle Benhayoun, Khadija Bourabha, Mélanie Magnan, Olivier Clermont, Camille d'Humières, Olivier Tenaillon, Erick Denamur, Laurent Massias, Sarah Tubiana, Loubna Alavoine, Antoine Andremont, France Mentré, Xavier Duval. Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens.
Antimicrobial agents and chemotherapy.
2019 06; 63(6):. doi:
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BMC infectious diseases.
2019 May; 19(1):386. doi:
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Veterinary microbiology.
2019 May; 232(?):58-64. doi:
10.1016/j.vetmic.2019.04.005. [PMID: 31030845] - Ivan Manga, Henrik Hasman, Jana Smidkova, Matej Medvecky, Monika Dolejska, Alois Cizek. Fecal Carriage and Whole-Genome Sequencing-Assisted Characterization of CMY-2 Beta-Lactamase-Producing Escherichia coli in Calves at Czech Dairy Cow Farm.
Foodborne pathogens and disease.
2019 01; 16(1):42-53. doi:
10.1089/fpd.2018.2531. [PMID: 30673354] - Dejenie Shiferaw Teklu, Abebe Aseffa Negeri, Melese Hailu Legese, Tesfaye Legesse Bedada, Hiwot Ketema Woldemariam, Kassu Desta Tullu. Extended-spectrum beta-lactamase production and multi-drug resistance among Enterobacteriaceae isolated in Addis Ababa, Ethiopia.
Antimicrobial resistance and infection control.
2019; 8(?):39. doi:
10.1186/s13756-019-0488-4. [PMID: 30815254] - W Biasino, L De Zutter, J Woollard, W Mattheus, S Bertrand, M Uyttendaele, I Van Damme. Reduced contamination of pig carcasses using an alternative pluck set removal procedure during slaughter.
Meat science.
2018 Nov; 145(?):23-30. doi:
10.1016/j.meatsci.2018.05.019. [PMID: 29859421] - Agathe Béranger, Mehdi Oualha, Saïk Urien, Mathieu Genuini, Sylvain Renolleau, Radia Aboura, Déborah Hirt, Claire Heilbronner, Julie Toubiana, Jean-Marc Tréluyer, Sihem Benaboud. Population Pharmacokinetic Model to Optimize Cefotaxime Dosing Regimen in Critically Ill Children.
Clinical pharmacokinetics.
2018 07; 57(7):867-875. doi:
10.1007/s40262-017-0602-9. [PMID: 28980166] - Manal Mohamed Elhassan Taha, Hisham Elraih Homeida, Omer Mohammed Elhassan Dafalla, Siddig Ibrahim Abdelwahab. Multidrug resistance, prevalence and phylogenetic analysis of genes encoding class II and III integrons in clinically isolated Escherichia coli.
Cellular and molecular biology (Noisy-le-Grand, France).
2018 Apr; 64(5):122-126. doi:
10.14715/cmb/2018.64.5.21. [PMID: 29729705] - Abdul A S Katakweba, Amandus P Muhairwa, Athumani M Lupindu, Peter Damborg, Jesper T Rosenkrantz, Uswege M Minga, Madundo M A Mtambo, John E Olsen. First Report on a Randomized Investigation of Antimicrobial Resistance in Fecal Indicator Bacteria from Livestock, Poultry, and Humans in Tanzania.
Microbial drug resistance (Larchmont, N.Y.).
2018 Apr; 24(3):260-268. doi:
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Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
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Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2018 Mar; 37(3):485-493. doi:
10.1007/s10096-018-3194-x. [PMID: 29380225] - Tatsuya Nakayama, Ryuji Kawahara, Yuko Kumeda, Yoshimasa Yamamoto. Extended-spectrum β-lactamase-producing Escherichia coli contributes to the survival of cefotaxime-susceptible E. coli under high concentrations of cefotaxime by acquisition of increased AmpC expression.
FEMS microbiology letters.
2018 03; 365(5):. doi:
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The Pediatric infectious disease journal.
2018 02; 37(2):e43-e45. doi:
10.1097/inf.0000000000001734. [PMID: 28787387] - P R Niumsup, U Tansawai, A Na-Udom, D Jantapalaboon, K Assawatheptawee, A Kiddee, T Romgaew, S Lamlertthon, T R Walsh. Prevalence and risk factors for intestinal carriage of CTX-M-type ESBLs in Enterobacteriaceae from a Thai community.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2018 Jan; 37(1):69-75. doi:
10.1007/s10096-017-3102-9. [PMID: 28918585] - Holden Hutchinson, Sarah Finney, Lohendy Muñoz-Vargas, Sydnee Feicht, Margaret Masterson, Gregory Habing. Prevalence and Transmission of Antimicrobial Resistance in a Vertically Integrated Veal Calf Production System.
Foodborne pathogens and disease.
2017 12; 14(12):711-718. doi:
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Transfusion.
2017 11; 57(11):2571-2577. doi:
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Microbial drug resistance (Larchmont, N.Y.).
2017 Sep; 23(6):695-702. doi:
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Microbial pathogenesis.
2017 Aug; 109(?):45-48. doi:
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European journal of drug metabolism and pharmacokinetics.
2017 Aug; 42(4):635-645. doi:
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Mikrobiyoloji bulteni.
2017 Jul; 51(3):195-208. doi:
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Journal of global antimicrobial resistance.
2017 06; 9(?):130-134. doi:
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Human pathology.
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Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology.
2017 Jun; 18(2):104-107. doi:
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Infectious diseases (London, England).
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The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi.
2017 Feb; 69(2):129-134. doi:
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Journal of medical microbiology.
2017 Feb; 66(2):169-174. doi:
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Journal of water and health.
2017 ; 15(5):813-822. doi:
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PloS one.
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Scientific reports.
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Preventive veterinary medicine.
2016 Nov; 134(?):122-127. doi:
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Revista Argentina de microbiologia.
2016 Oct; 48(4):320-324. doi:
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Antimicrobial agents and chemotherapy.
2016 08; 60(8):4734-42. doi:
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Antimicrobial agents and chemotherapy.
2016 06; 60(6):3587-90. doi:
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Antimicrobial agents and chemotherapy.
2016 06; 60(6):3365-71. doi:
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Journal of labelled compounds & radiopharmaceuticals.
2016 Mar; 59(3):109-16. doi:
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European journal of gastroenterology & hepatology.
2016 Mar; 28(3):e10-8. doi:
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Veterinary microbiology.
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Letters in applied microbiology.
2015 Nov; 61(5):429-36. doi:
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Antimicrobial agents and chemotherapy.
2015 Sep; 59(9):5847-50. doi:
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Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2015 Apr; 31(4):528-31. doi:
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Journal of pharmaceutical and biomedical analysis.
2015 Mar; 107(?):325-32. doi:
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Clinical pediatrics.
2015 Mar; 54(3):296-8. doi:
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Clinical chemistry.
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PloS one.
2015; 10(1):e0113033. doi:
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Journal of enzyme inhibition and medicinal chemistry.
2015; 30(4):622-8. doi:
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Journal of Korean medical science.
2015 Jan; 30(1):110-4. doi:
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Journal of neonatal-perinatal medicine.
2015; 8(4):349-57. doi:
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BMC infectious diseases.
2014 Sep; 14(?):486. doi:
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Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.
2014 Jul; 88(4):430-7. doi:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2014 Jun; 23(?):8-13. doi:
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APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
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Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
2014 Apr; 21(4):399-401. doi:
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Antimicrobial agents and chemotherapy.
2013 Dec; 57(12):6351-3. doi:
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Antimicrobial agents and chemotherapy.
2013 Nov; 57(11):5423-5. doi:
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International journal of antimicrobial agents.
2013 Oct; 42(4):371-2. doi:
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European journal of pediatrics.
2013 Sep; 172(9):1243-8. doi:
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Journal of pharmaceutical sciences.
2013 Sep; 102(9):3451-7. doi:
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Journal of medical microbiology.
2013 Sep; 62(Pt 9):1326-1331. doi:
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Antimicrobial agents and chemotherapy.
2013 Jun; 57(6):2738-42. doi:
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Annals of laboratory medicine.
2013 Mar; 33(2):141-4. doi:
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World journal of gastroenterology.
2013 Feb; 19(8):1271-7. doi:
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Applied and environmental microbiology.
2013 Feb; 79(3):794-8. doi:
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Journal of veterinary pharmacology and therapeutics.
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Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
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Letters in applied microbiology.
2012 Dec; 55(6):407-13. doi:
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Pediatric emergency care.
2012 Dec; 28(12):1374-6. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 Aug; 46(5):435-45. doi:
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The Journal of antimicrobial chemotherapy.
2012 Jul; 67(7):1769-74. doi:
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