4-(3-{2-[(ethoxycarbonyl)amino]-10H-phenothiazin-10-yl}-3-oxopropyl)morpholin-4-ium chloride (BioDeep_00001033623)
代谢物信息卡片
4-(3-{2-[(ethoxycarbonyl)amino]-10H-phenothiazin-10-yl}-3-oxopropyl)morpholin-4-ium chloride
化学式: C22H26ClN3O4S (463.1332466000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CC[NH+]4CCOCC4.[Cl-]
InChI: 1H
描述信息
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Hiroki Konishi, Kunihiko Morita, Tokuzo Minouchi, Akira Yamaji. Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A.
Pharmacology.
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Xenobiotica; the fate of foreign compounds in biological systems.
1999 Sep; 29(9):945-55. doi:
10.1080/004982599238182. [PMID: 10548454] - L E Richards, H J Pieniaszek, S Shatzmiller, G O Page, K F Blom, J M Read, A F Davidson, P N Confalone. Human moricizine metabolism. I. Isolation and identification of metabolites in human urine.
Xenobiotica; the fate of foreign compounds in biological systems.
1997 Feb; 27(2):217-29. doi:
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1996 Dec; 36(12):1161-8. doi:
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1995 Oct; 35(10):1016-9. doi:
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Methods and findings in experimental and clinical pharmacology.
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1994 Jul; 34(7):725-33. doi:
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1994 Apr; 15(3):243-52. doi:
10.1002/bdd.2510150306. [PMID: 7880984] - M A Vos, T Fazekas, A P Gorgels, J D Leunissen, H J Wellens. Action of MgSO4 differs from moricizine and verapamil on ouabain-induced ventricular tachycardia in normomagnesemic conscious dogs.
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1994 Feb; 23(2):252-8. doi:
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1993 Jun; 15(3):199-203. doi:
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1992 Jun; 32(6):558-63. doi:
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Kardiologiia.
1992 Jun; 32(6):66-8. doi:
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Journal of clinical pharmacology.
1992 May; 32(5):412-4. doi:
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Pharmacological research.
1992 Apr; 25(3):217-25. doi:
10.1016/s1043-6618(05)80070-2. [PMID: 1518765] - H J Pieniaszek, D C Rakestraw, W L Schary, R L Williams. Influence of food on the oral absorption and bioavailability of moricizine.
Journal of clinical pharmacology.
1991 Sep; 31(9):792-5. doi:
10.1002/j.1552-4604.1991.tb01912.x. [PMID: 1804860] - M E Wechsler, J S Steinberg, E G Giardina. Time course of moricizine's effect on signal-averaged and 12 lead electrocardiograms: insights into mechanism of action.
Journal of the American College of Cardiology.
1991 Jun; 17(7):1626-33. doi:
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Journal of clinical pharmacology.
1991 Mar; 31(3):229-32. doi:
10.1002/j.1552-4604.1991.tb04966.x. [PMID: 2019664] - H J Mann. Moricizine: a new class I antiarrhythmic.
Clinical pharmacy.
1990 Nov; 9(11):842-52. doi:
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DICP : the annals of pharmacotherapy.
1990 Jul; 24(7-8):745-53. doi:
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The American journal of cardiology.
1990 Feb; 65(8):21D-25D; discussion 68D. doi:
10.1016/0002-9149(90)91413-z. [PMID: 2407090] - A P Kurapov, O V Nekrasova, E T Gneushev, A P Ryzhenkova, V G Kukes. [Ethmozine pharmacokinetics in liver insufficiency].
Sovetskaia meditsina.
1990; ?(5):34-6. doi:
NULL. [PMID: 2202059] - J M Yang, K Chan, W T Chiang. Distribution of moricizine in human blood: binding to plasma proteins and erythrocytes.
Therapeutic drug monitoring.
1990 Jan; 12(1):59-64. doi:
10.1097/00007691-199001000-00011. [PMID: 1689514] - H L Kennedy, M K Sprague, S M Homan, S M Seiler, R D Wiens, D L Janosik, R M Redd, T A Buckingham. Natural history of potentially lethal ventricular arrhythmias in patients treated with long-term antiarrhythmic drug therapy.
The American journal of cardiology.
1989 Dec; 64(19):1289-97. doi:
10.1016/0002-9149(89)90570-5. [PMID: 2686388] - K Chan, J M Yang, M K Wai, W D Jiang. Disposition of ethmozine in cerebrospinal fluid and plasma of rabbits.
European journal of drug metabolism and pharmacokinetics.
1989 Oct; 14(4):279-82. doi:
10.1007/bf03190111. [PMID: 2699288] - H J Pieniaszek, H S Shen, D M Garner, G O Page, L M Shalaby, R K Isensee, C C Whitney. Determination of unlabeled and 13C6-labeled moricizine in human plasma using thermospray liquid chromatography-mass spectrometry.
Journal of chromatography.
1989 Aug; 493(1):79-92. doi:
10.1016/s0378-4347(00)82711-5. [PMID: 2674179] - J M Yang, K Chan, W D Jiang. Improved column liquid chromatographic method for the determination of moricizine in plasma or serum.
Journal of chromatography.
1989 May; 490(2):458-63. doi:
10.1016/s0378-4347(00)82806-6. [PMID: 2670987] - I N Merkulova, V K Piotrovskiĭ, V I Metelitsa, I N Romina, M L Blank. [Effectiveness of intravenous infusion of ethmozin in patients with chronic ventricular arrhythmias].
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR.
1989; 12(1):25-31. doi:
NULL. [PMID: 2472818] - D R Vincent, P J Gillies, K P Lee, C K Wood, L E Arthaud. Alterations in lipid metabolism and cellular morphology in the liver of female rats treated with ethmozine.
Toxicology and applied pharmacology.
1988 Sep; 95(3):456-63. doi:
10.1016/0041-008x(88)90363-8. [PMID: 3055426] - R L Woosley, J Morganroth, R N Fogoros, F G McMahon, J O Humphries, D T Mason, R L Williams. Pharmacokinetics of moricizine HCl.
The American journal of cardiology.
1987 Oct; 60(11):35F-39F. doi:
10.1016/0002-9149(87)90718-1. [PMID: 3310583] - H L Kennedy, A J Wood, R T MacFarland. Drug interactions with Ethmozine (moricizine HCl).
The American journal of cardiology.
1987 Oct; 60(11):79F-82F. doi:
10.1016/0002-9149(87)90726-0. [PMID: 3310590] - D M Salerno, P J Sharkey, G A Granrud, R W Asinger, M Hodges. Efficacy, safety, hemodynamic effects, and pharmacokinetics of high-dose moricizine during short- and long-term therapy.
Clinical pharmacology and therapeutics.
1987 Aug; 42(2):201-9. doi:
10.1038/clpt.1987.133. [PMID: 3301153] - E M Antman, M Arnold, P L Friedman, H White, M Bosak, T W Smith. Drug interactions with cardiac glycosides: evaluation of a possible digoxin-ethmozine pharmacokinetic interaction.
Journal of cardiovascular pharmacology.
1987 May; 9(5):622-7. doi:
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European journal of clinical pharmacology.
1987; 32(6):607-10. doi:
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1986 Nov; 112(5):932-9. doi:
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1986 Apr; 111(4):667-72. doi:
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Kardiologiia.
1986 Apr; 26(4):45-8. doi:
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American heart journal.
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Farmakologiia i toksikologiia.
1985 Nov; 48(6):62-7. doi:
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1985 Jun; 37(6):665-8. doi:
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Kardiologiia.
1985 Apr; 25(4):32-5. doi:
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1985 Mar; 25(2):138-43. doi:
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Kardiologiia.
1985 Mar; 25(3):43-50. doi:
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Giornale italiano di cardiologia.
1984 Oct; 14(10):788-97. doi:
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Biulleten' eksperimental'noi biologii i meditsiny.
1984 Jul; 98(7):51-3. doi:
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1984 Feb; 69(2):288-97. doi:
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1984 Jan; 97(1):63-5. doi:
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Kardiologiia.
1983 Nov; 23(11):51-5. doi:
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Kardiologiia.
1982 May; 22(5):75-80. doi:
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