8,5-Cyclo-2-deoxyadenosine (BioDeep_00001032276)
代谢物信息卡片
化学式: C10H11N5O3 (249.0862)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C2C(C3=NC4=C(N=CN=C4N3C1O2)N)O)O
InChI: InChI=1S/C10H11N5O3/c11-8-5-9(13-2-12-8)15-4-1-3(16)7(18-4)6(17)10(15)14-5/h2-4,6-7,16-17H,1H2,(H2,11,12,13)/t3-,4+,6-,7-/m0/s1
描述信息
An organic heterotetracyclic compound obtained by intramolecular formation of a C-C bond between positions 8 and 5 of 2-deoxyadenosine.
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Peter J Weng, Yang Gao, Mark T Gregory, Pengcheng Wang, Yinsheng Wang, Wei Yang. Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase η at atomic resolution.
Proceedings of the National Academy of Sciences of the United States of America.
2018 10; 115(42):10660-10665. doi:
10.1073/pnas.1812856115. [PMID: 30275308] - Melis Kant, Merve Akış, Mehmet Çalan, Tuğba Arkan, Fırat Bayraktar, Miral Dizdaroglu, Hüray İşlekel. Elevated urinary levels of 8-oxo-2'-deoxyguanosine, (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines, and 8-iso-prostaglandin F2α as potential biomarkers of oxidative stress in patients with prediabetes.
DNA repair.
2016 12; 48(?):1-7. doi:
10.1016/j.dnarep.2016.09.004. [PMID: 27769710] - Pawel Jaruga, Rafal Rozalski, Arkadiusz Jawien, Arkadiusz Migdalski, Ryszard Olinski, Miral Dizdaroglu. DNA damage products (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines as potential biomarkers in human urine for atherosclerosis.
Biochemistry.
2012 Mar; 51(9):1822-4. doi:
10.1021/bi201912c. [PMID: 22360777] - Pawel Jaruga, Miral Dizdaroglu. Identification and quantification of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines in human urine as putative biomarkers of oxidatively induced damage to DNA.
Biochemical and biophysical research communications.
2010 Jun; 397(1):48-52. doi:
10.1016/j.bbrc.2010.05.050. [PMID: 20471371] - Güldal Kirkali, Nadja C de Souza-Pinto, Pawel Jaruga, Vilhelm A Bohr, Miral Dizdaroglu. Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice.
DNA repair.
2009 Feb; 8(2):274-8. doi:
10.1016/j.dnarep.2008.09.009. [PMID: 18992371]
