1-(2-Hydroxyethyl)pyrrolidinium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate (BioDeep_00001031875)
代谢物信息卡片
化学式: C20H24Cl2N2O3 (410.1163894)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC[NH+](C1)CCO.C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl
InChI: 8H,1-6H2
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Christopher A Jones, Fred K Hoehler, Valeria Frangione, Gilbert Ledesma, Paul P Wisman, Clarence Jones. Safety and Efficacy of the FLECTOR (Diclofenac Epolamine) Topical System in Children with Minor Soft Tissue Injuries: A Phase IV Non-randomized Clinical Trial.
Clinical drug investigation.
2022 Jan; 42(1):43-51. doi:
10.1007/s40261-021-01101-x. [PMID: 34826122] - Angela Burian, Valeria Frangione, Stefano Rovati, Giuseppe Mautone, Chiara Leuratti, Angelo Vaccani, Richard Crevenna, Mohammad Keilani, Bernhard Burian, Martin Brunner, Markus Zeitlinger. An exploratory microdialysis study investigating the effect of repeated application of a diclofenac epolamine medicated plaster on prostaglandin concentrations in skeletal muscle after standardized physical exercise.
British journal of clinical pharmacology.
2013 Dec; 76(6):880-7. doi:
10.1111/bcp.12125. [PMID: 23551197] - C A Paterson, D Jacobs, S Rasmussen, S P Youngberg, N McGuinness. Randomized, open-label, 5-way crossover study to evaluate the pharmacokinetic/pharmacodynamic interaction between furosemide and the non-steroidal anti-inflammatory drugs diclofenac and ibuprofen in healthy volunteers.
International journal of clinical pharmacology and therapeutics.
2011 Aug; 49(8):477-90. doi:
10.5414/cp201492. [PMID: 21781648] - Birte Petersen, Stefano Rovati. Diclofenac epolamine (Flector) patch: evidence for topical activity.
Clinical drug investigation.
2009; 29(1):1-9. doi:
10.2165/0044011-200929010-00001. [PMID: 19067470] - K D Rainsford, W F Kean, G E Ehrlich. Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine.
Current medical research and opinion.
2008 Oct; 24(10):2967-92. doi:
10.1185/03007990802381364. [PMID: 18814824] - Marie Solignac. [Assessment of a topical NSAIDs in the treatment of pain and inflammation. The example of Flector Plaster, a local bioadhesive plaster containing diclofenac epolamine].
Presse medicale (Paris, France : 1983).
2004 Aug; 33(14 Pt 2):3S10-3. doi:
NULL. [PMID: 15509042] - A Conte, G Ronca, M Petrini, G Mautone. Effect of lecithin on epicutaneous absorption of diclofenac epolamine.
Drugs under experimental and clinical research.
2002; 28(6):249-55. doi:
NULL. [PMID: 12776579] - A Fioravanti, M R Cicero, F Nerucci, R Manopulo, R Marcolongo. Double-blind controlled clinical study of the efficacy and tolerability of diclofenac-N-(2-hydroxyethyl)-pyrrolidine lecithin gel compared with diclofenac-N-(2-hydroxyethyl)-pyrrolidine gel in patients with peri and extraarticular inflammatory diseases.
Drugs under experimental and clinical research.
1999; 25(5):235-40. doi:
". [PMID: 10568212] - D N Stocker, A D Christ, R Speich. [Ulcer + ulcer].
Therapeutische Umschau. Revue therapeutique.
1998 Sep; 55(9):565-7. doi:
NULL. [PMID: 9789473] - G Gallacchi, R Marcolongo. Pharmacokinetics of diclofenac hydroxyethylpyrrolidine (DHEP) plasters in patients with monolateral knee joint effusion.
Drugs under experimental and clinical research.
1993; 19(3):95-7. doi:
NULL. [PMID: 8112204] - A Assandri, S Canali, C Giachetti. Local tolerability and pharmacokinetic profile of a new transdermal delivery system, diclofenac hydroxyethylpyrrolidine plaster.
Drugs under experimental and clinical research.
1993; 19(3):89-95. doi:
NULL. [PMID: 8112203] - A Fini, G Fazio, I Orienti, V Zecchi, I Rapaport. Chemical properties-dissolution relationship. IV. Behaviour in solution of the diclofenac/N-(2-hydroxyethyl) pyrrolidine salt (DHEP).
Pharmaceutica acta Helvetiae.
1991; 66(7):201-3. doi:
NULL. [PMID: 1763094] - C A Maggi, P Lualdi, G Mautone. Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man.
European journal of clinical pharmacology.
1990; 38(2):207-8. doi:
10.1007/bf00265987. [PMID: 2338120]