1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine(1+) (BioDeep_00001031871)
代谢物信息卡片
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine(1+)
化学式: C29H57NO9P+ (594.3770742)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)CCCC=O
InChI: InChI=1S/C29H56NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(32)36-25-27(39-29(33)21-18-19-23-31)26-38-40(34,35)37-24-22-30(2,3)4/h23,27H,5-22,24-26H2,1-4H3/p+1/t27-/m1/s1
描述信息
A 1,2-diacyl-sn-glycero-3-phosphocholine having palmitoyl and 5-oxovaleryl groups at the 1- and 2-positions respectively.
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代谢反应
0 个相关的代谢反应过程信息。
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- U Stemmer, C Ramprecht, E Zenzmaier, B Stojčić, G Rechberger, M Kollroser, A Hermetter. Uptake and protein targeting of fluorescent oxidized phospholipids in cultured RAW 264.7 macrophages.
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PloS one.
2012; 7(1):e30291. doi:
10.1371/journal.pone.0030291. [PMID: 22272327] - Elena Vladykovskaya, Evgeny Ozhegov, J David Hoetker, Zhengzhi Xie, Yonis Ahmed, Jill Suttles, Sanjay Srivastava, Aruni Bhatnagar, Oleg A Barski. Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids.
Journal of lipid research.
2011 Dec; 52(12):2209-2225. doi:
10.1194/jlr.m013854. [PMID: 21957201] - Zhengzhi Xie, Oleg A Barski, Jian Cai, Aruni Bhatnagar, Srinivas M Tipparaju. Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6).
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2011 May; 191(1-3):255-60. doi:
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2010 May; 26(9):6140-4. doi:
10.1021/la100657a. [PMID: 20387820] - Jennifer M P Woo, Zhuofeng Lin, Mohamad Navab, Casey Van Dyck, Yvette Trejo-Lopez, Krystal M T Woo, Hongyun Li, Lawrence W Castellani, Xuping Wang, Noriko Iikuni, Ornella J Rullo, Hui Wu, Antonio La Cava, Alan M Fogelman, Aldons J Lusis, Betty P Tsao. Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.
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The Journal of biological chemistry.
2008 Sep; 283(36):24748-59. doi:
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Clinical & developmental immunology.
2008; 2008(?):723539. doi:
10.1155/2008/723539. [PMID: 18551190] - Nataliya A Pidkovka, Olga A Cherepanova, Tadashi Yoshida, Matthew R Alexander, Rebecca A Deaton, James A Thomas, Norbert Leitinger, Gary K Owens. Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro.
Circulation research.
2007 Oct; 101(8):792-801. doi:
10.1161/circresaha.107.152736. [PMID: 17704209] - J Qin, R Goswami, R Balabanov, G Dawson. Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain.
Journal of neuroscience research.
2007 Apr; 85(5):977-84. doi:
10.1002/jnr.21206. [PMID: 17304573] - Alexandra Moumtzi, Michael Trenker, Karlheinz Flicker, Elfriede Zenzmaier, Robert Saf, Albin Hermetter. Import and fate of fluorescent analogs of oxidized phospholipids in vascular smooth muscle cells.
Journal of lipid research.
2007 Mar; 48(3):565-82. doi:
10.1194/jlr.m600394-jlr200. [PMID: 17135656] - Ke Wei Gong, Wei Zhao, Ning Li, Berenice Barajas, Michael Kleinman, Constantinos Sioutas, Steve Horvath, Aldons J Lusis, Andre Nel, Jesus A Araujo. Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells.
Genome biology.
2007; 8(7):R149. doi:
10.1186/gb-2007-8-7-r149. [PMID: 17655762] - Gilbert O Fruhwirth, Alexandra Moumtzi, Alexandra Loidl, Elisabeth Ingolic, Albin Hermetter. The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells.
Biochimica et biophysica acta.
2006 Sep; 1761(9):1060-9. doi:
10.1016/j.bbalip.2006.06.001. [PMID: 16904371] - Joakim Huber, Alexander Fürnkranz, Valery N Bochkov, Mary K Patricia, Hans Lee, Catherine C Hedrick, Judith A Berliner, Bernd R Binder, Norbert Leitinger. Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase.
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2006 May; 47(5):1054-62. doi:
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Circulation research.
2006 Mar; 98(5):642-50. doi:
10.1161/01.res.0000207394.39249.fc. [PMID: 16456101] - Diana M Stafforini, James R Sheller, Timothy S Blackwell, Adam Sapirstein, Fiona E Yull, Thomas M McIntyre, Joseph V Bonventre, Stephen M Prescott, L Jackson Roberts. Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases.
The Journal of biological chemistry.
2006 Feb; 281(8):4616-23. doi:
10.1074/jbc.m507340200. [PMID: 16371369] - Agnès Boullier, Peter Friedman, Richard Harkewicz, Karsten Hartvigsen, Simone R Green, Felicidad Almazan, Edward A Dennis, Daniel Steinberg, Joseph L Witztum, Oswald Quehenberger. Phosphocholine as a pattern recognition ligand for CD36.
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2004 Dec; 279(51):53395-406. doi:
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2004 Dec; 200(11):1359-70. doi:
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Free radical biology & medicine.
2004 Apr; 36(8):1025-33. doi:
10.1016/j.freeradbiomed.2004.01.006. [PMID: 15059643] - Subroto Chatterjee, Judith A Berliner, Ganesamoorthy G Subbanagounder, Anil K Bhunia, Steve Koh. Identification of a biologically active component in minimally oxidized low density lipoprotein (MM-LDL) responsible for aortic smooth muscle cell proliferation.
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