Glucose monomycolate (BioDeep_00001031303)
代谢物信息卡片
Glucose monomycolate
化学式: C66H126O8 (1046.9452196)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCCCC=CCCCCCCCCC=CCCCCCCCCCCCCCCCCCCCC(C(CCCCCCCC)C(=O)OCC1C(C(C(C(O1)O)O)O)O)O
InChI: InChI=1S/C66H126O8/c1-3-5-7-9-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29-30-31-32-33-34-35-36-37-38-39-40-41-42-43-44-45-46-47-48-49-50-51-53-55-57-60(67)59(56-54-52-10-8-6-4-2)65(71)73-58-61-62(68)63(69)64(70)66(72)74-61/h24-25,34-35,59-64,66-70,72H,3-23,26-33,36-58H2,1-2H3/b25-24-,35-34-/t59-,60-,61+,62-,63+,64-,66-/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kattya Lopez, Sarah K Iwany, Sara Suliman, Josephine F Reijneveld, Tonatiuh A Ocampo, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B Murray, D Branch Moody, Ildiko Van Rhijn. CD1b Tetramers Broadly Detect T Cells That Correlate With Mycobacterial Exposure but Not Tuberculosis Disease State.
Frontiers in immunology.
2020; 11(?):199. doi:
10.3389/fimmu.2020.00199. [PMID: 32117314] - Erik D Layton, Krystle K Q Yu, Malisa T Smith, Thomas J Scriba, Stephen C De Rosa, Chetan Seshadri. Validation of a CD1b tetramer assay for studies of human mycobacterial infection or vaccination.
Journal of immunological methods.
2018 07; 458(?):44-52. doi:
10.1016/j.jim.2018.04.004. [PMID: 29684428] - Stephanie Gras, Ildiko Van Rhijn, Adam Shahine, Tan-Yun Cheng, Mugdha Bhati, Li Lynn Tan, Hanim Halim, Kathryn D Tuttle, Laurent Gapin, Jérôme Le Nours, D Branch Moody, Jamie Rossjohn. T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.
Nature communications.
2016 10; 7(?):13257. doi:
10.1038/ncomms13257. [PMID: 27807341] - Phillip L van der Peet, Masahiro Nagata, Sayali Shah, Jonathan M White, Sho Yamasaki, Spencer J Williams. Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle.
Organic & biomolecular chemistry.
2016 Oct; 14(39):9267-9277. doi:
10.1039/c6ob01781a. [PMID: 27714279] - Chetan Seshadri, Lin Lin, Thomas J Scriba, Glenna Peterson, David Freidrich, Nicole Frahm, Stephen C DeRosa, D Branch Moody, Jacques Prandi, Martine Gilleron, Hassan Mahomed, Wenxin Jiang, Greg Finak, Willem A Hanekom, Raphael Gottardo, M Juliana McElrath, Thomas R Hawn. T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents.
Journal of immunology (Baltimore, Md. : 1950).
2015 Nov; 195(10):4595-603. doi:
10.4049/jimmunol.1501285. [PMID: 26466957] - Norihito Kawasaki, Cory D Rillahan, Tan-Yun Cheng, Ildiko Van Rhijn, Matthew S Macauley, D Branch Moody, James C Paulson. Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.
Journal of immunology (Baltimore, Md. : 1950).
2014 Aug; 193(4):1560-6. doi:
10.4049/jimmunol.1303278. [PMID: 25000981] - Anne G Kasmar, Ildiko van Rhijn, Tan-Yun Cheng, Marie Turner, Chetan Seshadri, Andre Schiefner, Ravi C Kalathur, John W Annand, Annemieke de Jong, John Shires, Luis Leon, Michael Brenner, Ian A Wilson, John D Altman, D Branch Moody. CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans.
The Journal of experimental medicine.
2011 Aug; 208(9):1741-7. doi:
10.1084/jem.20110665. [PMID: 21807869] - Thi Kim Anh Nguyen, Willemien Wieland, Wiebren Santema, Jeroen Hoeboer, Willem van Eden, Victor Rutten, Ad Koets, Ildiko Van Rhijn. Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein.
Veterinary immunology and immunopathology.
2011 Aug; 142(3-4):265-70. doi:
10.1016/j.vetimm.2011.05.016. [PMID: 21640388] - Yutaka Enomoto, Masahiko Sugita, Isamu Matsunaga, Takashi Naka, Akimasa Sato, Tetsuo Kawashima, Kazuo Shimizu, Hidemi Takahashi, Yoshihiko Norose, Ikuya Yano. Temperature-dependent biosynthesis of glucose monomycolate and its recognition by CD1-restricted T cells.
Biochemical and biophysical research communications.
2005 Nov; 337(2):452-6. doi:
10.1016/j.bbrc.2005.09.070. [PMID: 16198315] - Thil Batuwangala, Dawn Shepherd, Stephan D Gadola, Kevin J C Gibson, Nathan R Zaccai, Alan R Fersht, Gurdyal S Besra, Vincenzo Cerundolo, E Yvonne Jones. The crystal structure of human CD1b with a bound bacterial glycolipid.
Journal of immunology (Baltimore, Md. : 1950).
2004 Feb; 172(4):2382-8. doi:
10.4049/jimmunol.172.4.2382. [PMID: 14764708] - Christopher C Dascher, Kenji Hiromatsu, Xiaowei Xiong, Caroline Morehouse, Gerald Watts, Gui Liu, David N McMurray, Kenneth P LeClair, Steven A Porcelli, Michael B Brenner. Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis.
International immunology.
2003 Aug; 15(8):915-25. doi:
10.1093/intimm/dxg091. [PMID: 12882829] - Timo Ulrichs, D Branch Moody, Ethan Grant, Stefan H E Kaufmann, Steven A Porcelli. T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection.
Infection and immunity.
2003 Jun; 71(6):3076-87. doi:
10.1128/iai.71.6.3076-3087.2003. [PMID: 12761085] - Xiaochun Cao, Masahiko Sugita, Nicole Van Der Wel, Jean Lai, Rick A Rogers, Peter J Peters, Michael B Brenner. CD1 molecules efficiently present antigen in immature dendritic cells and traffic independently of MHC class II during dendritic cell maturation.
Journal of immunology (Baltimore, Md. : 1950).
2002 Nov; 169(9):4770-7. doi:
10.4049/jimmunol.169.9.4770. [PMID: 12391186] - D Branch Moody, Volker Briken, Tan-Yun Cheng, Carme Roura-Mir, Mark R Guy, David H Geho, Mark L Tykocinski, Gurdyal S Besra, Steven A Porcelli. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation.
Nature immunology.
2002 May; 3(5):435-42. doi:
10.1038/ni780. [PMID: 11938350] - K Niazi, M Chiu, R Mendoza, M Degano, S Khurana, D Moody, A Melián, I Wilson, M Kronenberg, S Porcelli, R Modlin. The A' and F' pockets of human CD1b are both required for optimal presentation of lipid antigens to T cells.
Journal of immunology (Baltimore, Md. : 1950).
2001 Feb; 166(4):2562-70. doi:
10.4049/jimmunol.166.4.2562. [PMID: 11160317] - A Melián, G F Watts, A Shamshiev, G De Libero, A Clatworthy, M Vincent, M B Brenner, S Behar, K Niazi, R L Modlin, S Almo, D Ostrov, S G Nathenson, S A Porcelli. Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.
Journal of immunology (Baltimore, Md. : 1950).
2000 Oct; 165(8):4494-504. doi:
10.4049/jimmunol.165.8.4494. [PMID: 11035089] - D B Moody, M R Guy, E Grant, T Y Cheng, M B Brenner, G S Besra, S A Porcelli. CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection.
The Journal of experimental medicine.
2000 Oct; 192(7):965-76. doi:
10.1084/jem.192.7.965. [PMID: 11015438] - D H Geho, J D Fayen, R M Jackman, D B Moody, S A Porcelli, M L Tykocinski. Glycosyl-phosphatidylinositol reanchoring unmasks distinct antigen-presenting pathways for CD1b and CD1c.
Journal of immunology (Baltimore, Md. : 1950).
2000 Aug; 165(3):1272-7. doi:
10.4049/jimmunol.165.3.1272. [PMID: 10903726] - P A Sieling, M T Ochoa, D Jullien, D S Leslie, S Sabet, J P Rosat, A E Burdick, T H Rea, M B Brenner, S A Porcelli, R L Modlin. Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions.
Journal of immunology (Baltimore, Md. : 1950).
2000 May; 164(9):4790-6. doi:
10.4049/jimmunol.164.9.4790. [PMID: 10779786] - D B Moody, B B Reinhold, V N Reinhold, G S Besra, S A Porcelli. Uptake and processing of glycosylated mycolates for presentation to CD1b-restricted T cells.
Immunology letters.
1999 Jan; 65(1-2):85-91. doi:
10.1016/s0165-2478(98)00129-1. [PMID: 10065632] - W A Ernst, J Maher, S Cho, K R Niazi, D Chatterjee, D B Moody, G S Besra, Y Watanabe, P E Jensen, S A Porcelli, M Kronenberg, R L Modlin. Molecular interaction of CD1b with lipoglycan antigens.
Immunity.
1998 Mar; 8(3):331-40. doi:
10.1016/s1074-7613(00)80538-5. [PMID: 9529150] - D B Moody, B B Reinhold, M R Guy, E M Beckman, D E Frederique, S T Furlong, S Ye, V N Reinhold, P A Sieling, R L Modlin, G S Besra, S A Porcelli. Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells.
Science (New York, N.Y.).
1997 Oct; 278(5336):283-6. doi:
10.1126/science.278.5336.283. [PMID: 9323206]