2H-3,9a-Methano-1-benzoxepin, octahydro-2,2,5a,9-tetramethyl- (BioDeep_00001031028)
代谢物信息卡片
2H-3,9a-Methano-1-benzoxepin, octahydro-2,2,5a,9-tetramethyl-
化学式: C15H26O (222.1984)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCCC2(C13CC(CC2)C(O3)(C)C)C
InChI: InChI=1S/C15H26O/c1-11-6-5-8-14(4)9-7-12-10-15(11,14)16-13(12,2)3/h11-12H,5-10H2,1-4H3/t11-,12-,14+,15+/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Guangchao Cao, Ruonan Ning, Jie Zhao, Jiaying Yao, Linyue Chang, Hongyan Mu, Rujun Zhang, Zhenhua Chen, Fengbei Gong, Shijun He, Min Jiang, Weimin Zhao. Dihydro-β-agarofuran-type sesquiterpenoids from the seeds of Tripterygium wilfordii (Thunder God Vine) and evaluation of their anti-osteoclastogenesis and immunosuppressive activities.
Bioorganic chemistry.
2023 12; 141(?):106886. doi:
10.1016/j.bioorg.2023.106886. [PMID: 37778191] - Kai-Long Ji, Yao-Yue Fan, Qi Gong, Qun-Fang Liu, Ming-Jun Cui, Kai-Cong Fu, Hai-Yan Zhang, Jian-Min Yue. Densely Functionalized Macrocyclic Sesquiterpene Pyridine Alkaloids from Maytenus austroyunnanensis.
Journal of natural products.
2023 10; 86(10):2315-2325. doi:
10.1021/acs.jnatprod.3c00504. [PMID: 37728995] - Jun Gu Kim, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang. Bioactive molecular network-guided discovery of dihydro-β-agarofurans from the fruits of Celastrus orbiculatus.
Phytochemistry.
2022 Nov; 203(?):113349. doi:
10.1016/j.phytochem.2022.113349. [PMID: 35973614] - Ismail O Ishola, Taiwo G Olubodun-Obadun, Charles O Ochieng, Mary C Nwajuwe, Reign-El U Mukoro, Olufunmilayo O Adeyemi. Monoaminergic system involvement in the antidepressant-like and anxiolytic-like properties of novel β-dihydroagarofuran sesquiterpene alkaloid and triterpenes isolated from Gymnosporia heterophylla aerial parts in mice.
Neurochemistry international.
2022 09; 158(?):105379. doi:
10.1016/j.neuint.2022.105379. [PMID: 35724873] - Ya-Lin Hu, Tian-Qi Xu, Wen-Jing Yin, Huai-Yu Cheng, Xia Zhang, Ying Liu, Yu-Bo Zhang, Guang-Xiong Zhou. Diverse dihydroagarofuran sesquiterpene derivatives from the stem and branch of Tripterygium wilfordii.
Fitoterapia.
2022 Jul; 160(?):105205. doi:
10.1016/j.fitote.2022.105205. [PMID: 35537617] - Ruo-Nan Ning, Jia-Qi Xu, Yi-Xin Xu. [Chemistry research on natural product derivatives of dihydro-β-agarofuran sesquiterpenoids].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Dec; 45(23):5712-5721. doi:
10.19540/j.cnki.cjcmm.20200924.202. [PMID: 33496111] - Peng Zhao, Bin Lin, Zi-Lin Hou, Le Zhou, Qing-Jun He, Guo-Dong Yao, Xiao-Xiao Huang, Shao-Jiang Song. Dihydro-β-agarofuran sesquiterpenoid derivatives with neuroprotective activity from the leaves of Tripterygium wilfordii.
Fitoterapia.
2020 Apr; 142(?):104501. doi:
10.1016/j.fitote.2020.104501. [PMID: 32058050] - Iván González-Chavarría, Felix Duprat, Francisco J Roa, Nery Jara, Jorge R Toledo, Felipe Miranda, José Becerra, Alejandro Inostroza, Alexandra Kelling, Uwe Schilde, Matthias Heydenreich, Cristian Paz. Maytenus disticha Extract and an Isolated β-Dihydroagarofuran Induce Mitochondrial Depolarization and Apoptosis in Human Cancer Cells by Increasing Mitochondrial Reactive Oxygen Species.
Biomolecules.
2020 02; 10(3):. doi:
10.3390/biom10030377. [PMID: 32121436] - Qing-Jun He, Le Zhou, Li-Wei Lu, Feng Zhao, Xiao-Xiao Huang, Bin Lin, Shao-Jiang Song. Dihydro-β-agarofuran sesquiterpenoid derivatives with anti-inflammatory activity from the leaves of Tripterygium wilfordii.
Bioorganic chemistry.
2019 11; 92(?):103288. doi:
10.1016/j.bioorg.2019.103288. [PMID: 31561104] - Le Zhou, Qing-Jun He, Li-Wei Lu, Feng Zhao, Yan Zhang, Xiao-Xiao Huang, Bin Lin, Shao-Jiang Song. Tripterfordins A-O, Dihydro-β-agarofuran Sesquiterpenoids from the Leaves of Tripterygium wilfordii.
Journal of natural products.
2019 10; 82(10):2696-2706. doi:
10.1021/acs.jnatprod.9b00089. [PMID: 31556299] - Fang-You Chen, Yong-Ming Luo, Chuang-Jun Li, Jie Ma, Ji-Wu Huang, Chuan Li, Dong-Ming Zhang. Dihydroagarofuran sesquiterpenoids esterified with organic acids from the leaves of Tripterygium wilfordii.
Fitoterapia.
2019 Sep; 137(?):104185. doi:
10.1016/j.fitote.2019.104185. [PMID: 31150768] - Mario Wibowo, Paul I Forster, Gordon P Guymer, Andreas Hofmann, Rohan A Davis. Using UHPLC-MS Profiling for the Discovery of New Dihydro-β-Agarofurans from Australian Celastraceae Plant Extracts.
Molecules (Basel, Switzerland).
2019 Feb; 24(5):. doi:
10.3390/molecules24050859. [PMID: 30823439] - Tao Yang, Siyi Wang, Hui Zheng, Li Wang, Dan Liu, Xuanqin Chen, Rongtao Li. Understanding dihydro-β-agarofuran sesquiterpenes from Tripterygium hypoglaucum as the modulators of multi-drug resistance in HepG2/Adr cells.
Biochemical and biophysical research communications.
2019 01; 508(3):742-748. doi:
10.1016/j.bbrc.2018.11.188. [PMID: 30528235] - Duplex Wetadieu Kamtcha, Mathieu Tene, Kibrom Gebreheiwot Bedane, Lena Knauer, Lukas Brieger, Carsten Strohmann, Pierre Tane, Souvik Kusari, Michael Spiteller. Cardenolides and dihydro-β-agarofuran sesquiterpenes from the seeds of Salacia staudtiana.
Fitoterapia.
2018 Nov; 131(?):174-181. doi:
10.1016/j.fitote.2018.10.025. [PMID: 30352292] - Mario Wibowo, Qian Wang, Jeff Holst, Jonathan M White, Andreas Hofmann, Rohan A Davis. Dihydro-β-agarofurans from the roots of the Australian endemic rainforest tree Maytenus bilocularis act as leucine transport inhibitors.
Phytochemistry.
2018 Apr; 148(?):71-77. doi:
10.1016/j.phytochem.2018.01.009. [PMID: 29421513] - Fang-You Chen, Chuang-Jun Li, Jie Ma, Jian Zhou, Li Li, Zhao Zhang, Nai-Hong Chen, Dong-Ming Zhang. Neuroprotective Dihydroagarofuran Sesquiterpene Derivatives from the Leaves of Tripterygium wilfordii.
Journal of natural products.
2018 02; 81(2):270-278. doi:
10.1021/acs.jnatprod.7b00615. [PMID: 29355322] - Mario Wibowo, Qian Wang, Jeff Holst, Jonathan M White, Andreas Hofmann, Rohan A Davis. Celastrofurans A-G: Dihydro-β-agarofurans from the Australian Rainforest Vine Celastrus subspicata and Their Inhibitory Effect on Leucine Transport in Prostate Cancer Cells.
Journal of natural products.
2017 06; 80(6):1918-1925. doi:
10.1021/acs.jnatprod.7b00220. [PMID: 28548851] - Jingjing Zhou, Na Han, Guanghui Lv, Lina Jia, Zhihui Liu, Jun Yin. Two New β-Dihydroagarofuran Sesquiterpenes from Celastrus orbiculatus Thunb and Their Anti-Proliferative Activity.
Molecules (Basel, Switzerland).
2017 Jun; 22(6):. doi:
10.3390/molecules22060948. [PMID: 28598409] - Charles O Ochieng, Sylvia A Opiyo, Edward W Mureka, Ismail O Ishola. Cyclooxygenase inhibitory compounds from Gymnosporia heterophylla aerial parts.
Fitoterapia.
2017 Jun; 119(?):168-174. doi:
10.1016/j.fitote.2017.04.015. [PMID: 28476411] - Dongsheng Fan, Guo-Yuan Zhu, Ming Chen, Li-Min Xie, Zhi-Hong Jiang, Liang Xu, Li-Ping Bai. Dihydro-β-agarofuran sesquiterpene polyesters isolated from the stems of Tripterygium regelii.
Fitoterapia.
2016 Jul; 112(?):1-8. doi:
10.1016/j.fitote.2016.04.016. [PMID: 27113553] - Mario Wibowo, Claire Levrier, Martin C Sadowski, Colleen C Nelson, Qian Wang, Jeff Holst, Peter C Healy, Andreas Hofmann, Rohan A Davis. Bioactive Dihydro-β-agarofuran Sesquiterpenoids from the Australian Rainforest Plant Maytenus bilocularis.
Journal of natural products.
2016 05; 79(5):1445-53. doi:
10.1021/acs.jnatprod.6b00190. [PMID: 27120798] - Lina Lu, Zhijun Qi, Qiuli Li, Wenjun Wu. Validation of the Target Protein of Insecticidal Dihydroagarofuran Sesquiterpene Polyesters.
Toxins.
2016 Mar; 8(3):. doi:
10.3390/toxins8030079. [PMID: 26999207] - Oliver Callies, María P Sánchez-Cañete, Francisco Gamarro, Ignacio A Jiménez, Santiago Castanys, Isabel L Bazzocchi. Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-β-agarofuran Sesquiterpenes from Celastrus vulcanicola.
Journal of natural products.
2015 Apr; 78(4):736-45. doi:
10.1021/np500903a. [PMID: 25695368] - Zhao-Feng Gao, Bo-Hang Zhou, Jie-Yu Zhao, Fang-Jun Cao, Le Zhou, Hui-Ling Geng. Further Study on Chemical Constituents of Parnassia wightiana Wall: Four New Dihydro-β-agarofuran Sesquiterpene Polyesters.
International journal of molecular sciences.
2015 Apr; 16(5):9119-33. doi:
10.3390/ijms16059119. [PMID: 25915027] - Claire Levrier, Martin C Sadowski, Colleen C Nelson, Peter C Healy, Rohan A Davis. Denhaminols A-H, dihydro-β-agarofurans from the endemic Australian rainforest plant Denhamia celastroides.
Journal of natural products.
2015 Jan; 78(1):111-9. doi:
10.1021/np500740f. [PMID: 25579619] - Hai-Long Jiang, Wei Ha, Yan-Ping Shi. New eudesmane-type sesquiterpenoids from the root bark of Pseudolarix kaempferi.
Journal of Asian natural products research.
2015; 17(12):1180-7. doi:
10.1080/10286020.2015.1117455. [PMID: 26666458] - Dong-Mei Wang, Cheng-Chen Zhang, Qiang Zhang, Nusrat Shafiq, Gennaro Pescitelli, Deng-Wu Li, Jin-Ming Gao. Wightianines A-E, dihydro-β-agarofuran sesquiterpenes from Parnassia wightiana, and their antifungal and insecticidal activities.
Journal of agricultural and food chemistry.
2014 Jul; 62(28):6669-76. doi:
10.1021/jf501767s. [PMID: 24945753] - Chao Lv, Zuo-Lue Zheng, Fang Miao, Hui-Ling Geng, Le Zhou, La-Ping Liu. New dihydro-β-agarofuran sesquiterpenes from Parnassia wightiana wall: isolation, identification and cytotoxicity against cancer cells.
International journal of molecular sciences.
2014 Jun; 15(6):11111-25. doi:
10.3390/ijms150611111. [PMID: 24955789] - Zhen-Zhen Liu, Rong-Hua Zhao, Yue-Tao Liu, Hong-Wu Zhang, Gang Ding, Zhuo Ma, Zhong-Mei Zou. A new dihydroagarofuranoid sesquiterpene from the roots of Tripterygium hypoglaucum.
Journal of Asian natural products research.
2014; 16(3):327-31. doi:
10.1080/10286020.2013.873410. [PMID: 24456254] - Jing-Ru Weng, Ming-Hong Yen, Wei-Yu Lin. Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells.
Phytochemistry.
2013 Oct; 94(?):211-9. doi:
10.1016/j.phytochem.2013.05.022. [PMID: 23810286] - Manuela E García, Rubén D Motrich, Beatriz L Caputto, Marianela Sánchez, Jorge A Palermo, Ana Estévez-Braun, Angel G Ravelo, Viviana E Nicotra. Agarofuran sesquiterpenes from Schaefferia argentinensis.
Phytochemistry.
2013 Oct; 94(?):260-7. doi:
10.1016/j.phytochem.2013.06.003. [PMID: 23827326] - Jiang-Jiang Tang, Fei-Yu Zhang, Dong-Mei Wang, Jun-Mian Tian, Shuai Dong, Jin-Ming Gao. Semisynthesis and antifeedant activity of new derivatives of a dihydro-β-agarofuran from Parnassia wightiana.
International journal of molecular sciences.
2013 Sep; 14(10):19484-93. doi:
10.3390/ijms141019484. [PMID: 24077121] - Chao Wang, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Xiao-Guang Chen, Qi Hou, Dong-Ming Zhang. Anti-inflammatory sesquiterpene derivatives from the leaves of Tripterygium wilfordii.
Journal of natural products.
2013 Jan; 76(1):85-90. doi:
10.1021/np300759u. [PMID: 23268606] - Yinggang Luo, Min Zhou, Qi Ye, Qiang Pu, Guolin Zhang. Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii.
Journal of natural products.
2012 Jan; 75(1):98-102. doi:
10.1021/np200493t. [PMID: 22148431] - Shaopeng Wei, Jinming Gao, Wenjun Wu, Zhiqin Ji, Jiwen Zhang. Simultaneous identification of multiple celangulins from the root bark of Celastrus angulatus using high-performance liquid chromatography-diode array detector-electrospray ionisation-tandem mass spectrometry.
Phytochemical analysis : PCA.
2012 Jan; 23(1):23-33. doi:
10.1002/pca.1321. [PMID: 21520311] - Fátima Gutiérrez-Nicolás, Juan C Oberti, Luis Ariza-Espinar, Angel G Ravelo, Ana Estévez-Braun. Dihydro-β-agarofuran sesquiterpenoids from Plenckia integerrima.
Planta medica.
2011 Oct; 77(15):1718-24. doi:
10.1055/s-0030-1271088. [PMID: 21567358] - Tsung-Hsien Chou, Ih-Sheng Chen, Ping-Jyun Sung, Chien-Fang Peng, Po-Chuen Shieh, Jih-Jung Chen. A new dihydroagarofuranoid sesquiterpene from Microtropis fokienensis with antituberculosis activity.
Chemistry & biodiversity.
2007 Jul; 4(7):1594-600. doi:
10.1002/cbdv.200790139. [PMID: 17638341] - Jean-François Cavalli, Félix Tomi, Antoine-François Bernardini, Joseph Casanova. Dihydroagarofurans: the fourth isomer isolated from Cedrelopsis grevei bark oil.
Magnetic resonance in chemistry : MRC.
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