(S)-donepezil (BioDeep_00001030948)

   


代谢物信息卡片


(S)-donepezil

化学式: C24H29NO3 (379.2147)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
InChI: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3/t20-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

(S)-donepezil



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Irving H Gomolin, Candace Smith, Thomas M Jeitner. Donepezil dosing strategies: pharmacokinetic considerations. Journal of the American Medical Directors Association. 2011 Oct; 12(8):606-608. doi: 10.1016/j.jamda.2011.02.004. [PMID: 21943887]
  • Xin Qiu, Guo-hua Chen, Tao Wang. [Effects of huanglian jiedu decoction on free radicals metabolism and pathomorphism of the hippocampus in App/PS1 double transgenic mice]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2011 Oct; 31(10):1379-82. doi: ". [PMID: 22097209]
  • Jintanaporn Wattanathorn, Jinatta Jittiwat, Terdthai Tongun, Supaporn Muchimapura, Kornkanok Ingkaninan. Zingiber officinale Mitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic Rat. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):429505. doi: 10.1155/2011/429505. [PMID: 21197427]
  • Ji Hoon Oh, Bong Jae Choi, Mun Seog Chang, Seong Kyu Park. Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression. Neuroscience letters. 2009 Sep; 461(1):41-4. doi: 10.1016/j.neulet.2009.05.045. [PMID: 19463889]
  • Xian-Wen Peng, Ke-Li Dong. [Clinical observation on acupuncture combined with Yizhi Jiannao granules for treatment of Alzheimer's disease]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2009 Apr; 29(4):269-71. doi: ". [PMID: 19565731]
  • Yuan-Zheng Sun, Peng-Yu Zhu, Miao Zhang, Yan Zhang. [Clinical observation on Yuanluo Tongjing needling method for treatment of mild cognitive impairment]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2007 Nov; 27(11):810-2. doi: ". [PMID: 18085142]
  • Zhi-Hua Yu, Dong-Jian Wang, Shui-Miao Lin. [Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA, Bcl-2 mRNA level in brain of rat with Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 May; 32(9):839-42. doi: ". [PMID: 17639989]
  • Mario Thevis, Frauke Wilkens, Hans Geyer, Wilhelm Schänzer. Determination of therapeutics with growth-hormone secretagogue activity in human urine for doping control purposes. Rapid communications in mass spectrometry : RCM. 2006; 20(22):3393-402. doi: 10.1002/rcm.2758. [PMID: 17051614]
  • Da-yong Cai, Jin-xing Chen, Wei Zhang, Xue Wang, Li-ping Sun, Jia-jun Zhang, Qi-fu Huang. [Protective effect of Danzhi-xiaoyao San on rat brain energy or material metabolism (correction of matebolism) dealt with D-galactose]. Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering. 2005 Feb; 18(1):32-6. doi: ". [PMID: 15852547]
  • Chris Meier, Christian Ducho, Ulf Görbig, Robert Esnouf, Jan Balzarini. Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship. Journal of medicinal chemistry. 2004 May; 47(11):2839-52. doi: 10.1021/jm031032a. [PMID: 15139762]
  • S Nishiyama, H Tsukada, K Sato, T Kakiuchi, H Ohba, N Harada, K Takahashi. Evaluation of PET ligands (+)N-[(11)C]ethyl-3-piperidyl benzilate and (+)N-[(11)C]propyl-3-piperidyl benzilate for muscarinic cholinergic receptors: a PET study with microdialysis in comparison with (+)N-[(11)C]methyl-3-piperidyl benzilate in the conscious monkey brain. Synapse (New York, N.Y.). 2001 Jun; 40(3):159-69. doi: 10.1002/syn.1038. [PMID: 11304753]
  • R Luboshitzky, Z Shen-Orr, O Tzischichinsky, M Maldonado, P Herer, P Lavie. Actigraphic sleep-wake patterns and urinary 6-sulfatoxymelatonin excretion in patients with Alzheimer's disease. Chronobiology international. 2001 May; 18(3):513-24. doi: 10.1081/cbi-100103973. [PMID: 11475420]