alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1/24:0) (BioDeep_00001030545)

   


代谢物信息卡片


alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1/24:0)

化学式: C60H113NO18 (1135.7957238)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)O)O)O)O)O)O)C(C=CCCCCCCCCCCCCC)O
InChI: InChI=1S/C60H113NO18/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-48(66)61-43(44(65)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2)42-74-58-54(72)51(69)56(46(40-63)76-58)79-60-55(73)52(70)57(47(41-64)77-60)78-59-53(71)50(68)49(67)45(39-62)75-59/h35,37,43-47,49-60,62-65,67-73H,3-34,36,38-42H2,1-2H3,(H,61,66)/b37-35+/t43-,44+,45+,46+,47+,49-,50-,51+,52+,53+,54+,55+,56+,57-,58+,59+,60-/m0/s1

描述信息

A glycotriaosylceramide having alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycotriaosyl component attached to the Cer(d18:1/24:0).

同义名列表

1 个代谢物同义名

alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1/24:0)



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Pankaj Sharma, Xiaolong Zhang, Kevin Ly, Yuxiang Zhang, Yu Hu, Adam Yongxin Ye, Jianqiao Hu, Ji Hyung Kim, Mumeng Lou, Chong Wang, Quinton Celuzza, Yuji Kondo, Keiko Furukawa, David R Bundle, Koichi Furukawa, Frederick W Alt, Florian Winau. The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity. Science (New York, N.Y.). 2024 Feb; 383(6684):eadg0564. doi: 10.1126/science.adg0564. [PMID: 38359115]
  • Allan Wee Ren Ng, Kumaran Narayanan. An antibody binding-based fluorescent assay for the rapid quantification of globotriaosylceramide levels in human Fabry cells. Analytical biochemistry. 2021 09; 628(?):114287. doi: 10.1016/j.ab.2021.114287. [PMID: 34119486]
  • Johanna Detzner, Anna-Lena Klein, Gottfried Pohlentz, Elisabeth Krojnewski, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing. Primary Human Renal Proximal Tubular Epithelial Cells (pHRPTEpiCs): Shiga Toxin (Stx) Glycosphingolipid Receptors, Stx Susceptibility, and Interaction with Membrane Microdomains. Toxins. 2021 07; 13(8):. doi: 10.3390/toxins13080529. [PMID: 34437399]
  • Kirsten Sandvig, Simona Kavaliauskiene, Tore Skotland. The Protein Toxins Ricin and Shiga Toxin as Tools to Explore Cellular Mechanisms of Internalization and Intracellular Transport. Toxins. 2021 05; 13(6):. doi: 10.3390/toxins13060377. [PMID: 34070659]
  • Mouhannad Malek, Anna M Wawrzyniak, Peter Koch, Christian Lüchtenborg, Manuel Hessenberger, Timo Sachsenheimer, Wonyul Jang, Britta Brügger, Volker Haucke. Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites. Nature communications. 2021 05; 12(1):2673. doi: 10.1038/s41467-021-22882-x. [PMID: 33976123]
  • Annette Brandel, Sahaja Aigal, Simon Lagies, Manuel Schlimpert, Ana Valeria Meléndez, Maokai Xu, Anika Lehmann, Daniel Hummel, Daniel Fisch, Josef Madl, Thorsten Eierhoff, Bernd Kammerer, Winfried Römer. The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa. Cellular and molecular life sciences : CMLS. 2021 Apr; 78(7):3637-3656. doi: 10.1007/s00018-021-03766-1. [PMID: 33555391]
  • Junya Sugimoto, Hiroshi Satoyoshi, Kazue Takahata, Shizuko Muraoka. Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75NTR but not mature NGF-TrkA. European journal of pharmacology. 2021 Mar; 895(?):173882. doi: 10.1016/j.ejphar.2021.173882. [PMID: 33482180]
  • Thomas Schubert, Taras Sych, Josef Madl, Maokai Xu, Ramin Omidvar, Lukas J Patalag, Annika Ries, Katharina Kettelhoit, Annette Brandel, Yves Mely, Claudia Steinem, Daniel B Werz, Roland Thuenauer, Winfried Römer. Differential recognition of lipid domains by two Gb3-binding lectins. Scientific reports. 2020 06; 10(1):9752. doi: 10.1038/s41598-020-66522-8. [PMID: 32546842]
  • Satoshi Ishii, Atsumi Taguchi, Nozomu Okino, Makoto Ito, Hiroki Maruyama. Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease. The Journal of biological chemistry. 2020 04; 295(17):5577-5587. doi: 10.1074/jbc.ra120.012665. [PMID: 32179651]
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  • Xing-Li Meng, Taniqua S Day, Nathan McNeill, Paula Ashcraft, Thomas Frischmuth, Seng H Cheng, Zhi-Ping Liu, Jin-Song Shen, Raphael Schiffmann. Molecular basis for globotriaosylceramide regulation and enzyme uptake in immortalized aortic endothelial cells from Fabry mice. Journal of inherited metabolic disease. 2016 05; 39(3):447-455. doi: 10.1007/s10545-016-9920-6. [PMID: 26960552]
  • Catia S Pereira, Clara Sa-Miranda, Gennaro De Libero, Lucia Mori, Maria Fatima Macedo. Globotriaosylceramide inhibits iNKT-cell activation in a CD1d-dependent manner. European journal of immunology. 2016 Jan; 46(1):147-53. doi: 10.1002/eji.201545725. [PMID: 26426881]
  • Daniel Steil, Catherine-Louise Schepers, Gottfried Pohlentz, Nadine Legros, Jana Runde, Hans-Ulrich Humpf, Helge Karch, Johannes Müthing. Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment. Journal of lipid research. 2015 Dec; 56(12):2322-36. doi: 10.1194/jlr.m063040. [PMID: 26464281]
  • Frederic Eghiaian. Lipid Chirality Revisited: A Change in Lipid Configuration Transforms Membrane-Bound Protein Domains. Biophysical journal. 2015 Jun; 108(12):2757-8. doi: 10.1016/j.bpj.2015.05.018. [PMID: 26083912]
  • Ole M Schütte, Lukas J Patalag, Lucas M C Weber, Annika Ries, Winfried Römer, Daniel B Werz, Claudia Steinem. 2-Hydroxy Fatty Acid Enantiomers of Gb3 Impact Shiga Toxin Binding and Membrane Organization. Biophysical journal. 2015 Jun; 108(12):2775-8. doi: 10.1016/j.bpj.2015.05.009. [PMID: 26083916]
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  • Weria Pezeshkian, Vitaly V Chaban, Ludger Johannes, Julian Shillcock, John H Ipsen, Himanshu Khandelia. The effects of globotriaosylceramide tail saturation level on bilayer phases. Soft matter. 2015 Feb; 11(7):1352-61. doi: 10.1039/c4sm02456g. [PMID: 25575293]
  • Vita Solovyeva, Ludger Johannes, Adam Cohen Simonsen. Shiga toxin induces membrane reorganization and formation of long range lipid order. Soft matter. 2015 Jan; 11(1):186-92. doi: 10.1039/c4sm01673d. [PMID: 25376469]
  • Jonas Bergan, Tore Skotland, Anne Berit Dyve Lingelem, Roger Simm, Bjørn Spilsberg, Toril Lindbäck, Tuulia Sylvänne, Helena Simolin, Kim Ekroos, Kirsten Sandvig. The ether lipid precursor hexadecylglycerol protects against Shiga toxins. Cellular and molecular life sciences : CMLS. 2014 Nov; 71(21):4285-300. doi: 10.1007/s00018-014-1624-1. [PMID: 24740796]
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  • Raphael Schiffmann, Sabrina Forni, Caren Swift, Nastry Brignol, Xiaoyang Wu, David J Lockhart, Derek Blankenship, Xuan Wang, Paul A Grayburn, Matthew R G Taylor, Brian D Lowes, Maria Fuller, Elfrida R Benjamin, Lawrence Sweetman. Risk of death in heart disease is associated with elevated urinary globotriaosylceramide. Journal of the American Heart Association. 2014 Feb; 3(1):e000394. doi: 10.1161/jaha.113.000394. [PMID: 24496231]
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