1,1-Diethyl-2,2-cyanine (BioDeep_00001030294)
代谢物信息卡片
1,1-Diethyl-2,2-cyanine
化学式: C23H23N2+ (327.1861138)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN1C(=CC2=[N+](C3=CC=CC=C3C=C2)CC)C=CC4=CC=CC=C41
InChI: InChI=1S/C23H23N2/c1-3-24-20(15-13-18-9-5-7-11-22(18)24)17-21-16-14-19-10-6-8-12-23(19)25(21)4-2/h5-17H,3-4H2,1-2H3/q+1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- John Sebastiani, M Danielle McDonald. The role of uptake and degradation in the regulation of peripheral serotonin dynamics in Gulf toadfish, Opsanus beta.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2021 08; 258(?):110980. doi:
10.1016/j.cbpa.2021.110980. [PMID: 34023534] - Melodi A Bowman, Nathan C Mitchell, W Anthony Owens, Rebecca E Horton, Wouter Koek, Lynette C Daws. Effect of concurrent organic cation transporter blockade on norepinephrine clearance inhibiting- and antidepressant-like actions of desipramine and venlafaxine.
European journal of pharmacology.
2020 Sep; 883(?):173285. doi:
10.1016/j.ejphar.2020.173285. [PMID: 32697958] - Takashi Sonobe, Tsuyoshi Akiyama, Cheng-Kun Du, James T Pearson. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo.
Physiological reports.
2019 11; 7(22):e14297. doi:
10.14814/phy2.14297. [PMID: 31782271] - Rheaclare Fraser-Spears, Anwen M Krause-Heuer, Mohamed Basiouny, Felix P Mayer, Retrouvailles Manishimwe, Naomi A Wyatt, Jeremy C Dobrowolski, Maxine P Roberts, Ivan Greguric, Naresh Kumar, Wouter Koek, Harald H Sitte, Paul D Callaghan, Benjamin H Fraser, Lynette C Daws. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter.
European journal of pharmacology.
2019 Jan; 842(?):351-364. doi:
10.1016/j.ejphar.2018.10.028. [PMID: 30473490] - J Wang. The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Clinical pharmacology and therapeutics.
2016 Nov; 100(5):489-499. doi:
10.1002/cpt.442. [PMID: 27506881] - Patrick S Hosford, Julian Millar, Andrew G Ramage. Cardiovascular afferents cause the release of 5-HT in the nucleus tractus solitarii; this release is regulated by the low- (PMAT) not the high-affinity transporter (SERT).
The Journal of physiology.
2015 Apr; 593(7):1715-29. doi:
10.1113/jphysiol.2014.285312. [PMID: 25694117] - Patrick S Hosford, Steve W Mifflin, Andrew G Ramage. 5-hydroxytryptamine-mediated neurotransmission modulates spontaneous and vagal-evoked glutamate release in the nucleus of the solitary tract effect of uptake blockade.
The Journal of pharmacology and experimental therapeutics.
2014 May; 349(2):288-96. doi:
10.1124/jpet.113.211334. [PMID: 24618127] - Rebecca E Horton, Deana M Apple, W Anthony Owens, Nicole L Baganz, Sonia Cano, Nathan C Mitchell, Melissa Vitela, Georgianna G Gould, Wouter Koek, Lynette C Daws. Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Jun; 33(25):10534-43. doi:
10.1523/jneurosci.5687-11.2013. [PMID: 23785165] - Catherine E Hagan, James O Schenk, John F Neumaier. The contribution of low-affinity transport mechanisms to serotonin clearance in synaptosomes.
Synapse (New York, N.Y.).
2011 Oct; 65(10):1015-23. doi:
10.1002/syn.20929. [PMID: 21437992] - Jonathan E Hill, Khadijah Makky, Lalita Shrestha, Cecilia J Hillard, Paul J Gasser. Natural and synthetic corticosteroids inhibit uptake 2-mediated transport in CNS neurons.
Physiology & behavior.
2011 Aug; 104(2):306-11. doi:
10.1016/j.physbeh.2010.11.012. [PMID: 21081135] - Gary C H Mo, Christopher M Yip. Supported lipid bilayer templated J-aggregate growth: role of stabilizing cation-pi interactions and headgroup packing.
Langmuir : the ACS journal of surfaces and colloids.
2009 Sep; 25(18):10719-29. doi:
10.1021/la901227h. [PMID: 19645500] - John M Yarbrough, Michael E Himmel, Shi-You Ding. Plant cell wall characterization using scanning probe microscopy techniques.
Biotechnology for biofuels.
2009 Aug; 2(?):17. doi:
10.1186/1754-6834-2-17. [PMID: 19703302] - Li Xia, Mingyan Zhou, Thomas F Kalhorn, Horace T B Ho, Joanne Wang. Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity.
American journal of physiology. Renal physiology.
2009 Jun; 296(6):F1307-13. doi:
10.1152/ajprenal.00046.2009. [PMID: 19357181] - Kazi Mirajul Hoque, Linxi Chen, George P H Leung, Chung-Ming Tse. A purine-selective nucleobase/nucleoside transporter in PK15NTD cells.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Jun; 294(6):R1988-95. doi:
10.1152/ajpregu.00016.2008. [PMID: 18417653] - M Yu Iniouchine, D A Sibarov, A B Volnova, C A Jimenez-Rivera, A D Nozdrachev. Blockers of monoamine transporters influence high dopamine concentration uptake in rat brain slices.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections.
2008 Mar; 419(?):80-2. doi:
10.1134/s0012496608020038. [PMID: 18536267] - Karen Engel, Joanne Wang. Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Molecular pharmacology.
2005 Nov; 68(5):1397-407. doi:
10.1124/mol.105.016832. [PMID: 16099839] - R Monteiro, C Calhau, F Martel, A Faria, N Mateus, I Azevedo. Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells.
Naunyn-Schmiedeberg's archives of pharmacology.
2005 Aug; 372(2):147-52. doi:
10.1007/s00210-005-0012-7. [PMID: 16193318] - A J Dudley, K Bleasby, C D Brown. The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers.
British journal of pharmacology.
2000 Sep; 131(1):71-9. doi:
10.1038/sj.bjp.0703518. [PMID: 10960071] - D Gründemann, S Köster, N Kiefer, T Breidert, M Engelhardt, F Spitzenberger, N Obermüller, E Schömig. Transport of monoamine transmitters by the organic cation transporter type 2, OCT2.
The Journal of biological chemistry.
1998 Nov; 273(47):30915-20. doi:
10.1074/jbc.273.47.30915. [PMID: 9812985] - V Gorboulev, J C Ulzheimer, A Akhoundova, I Ulzheimer-Teuber, U Karbach, S Quester, C Baumann, F Lang, A E Busch, H Koepsell. Cloning and characterization of two human polyspecific organic cation transporters.
DNA and cell biology.
1997 Jul; 16(7):871-81. doi:
10.1089/dna.1997.16.871. [PMID: 9260930] - H Russ, B Friedgen, B Königs, C Schumacher, K H Graefe, E Schömig. Pharmacokinetic and alpha 1-adrenoceptor antagonistic properties of two cyanine-type inhibitors of extraneuronal monoamine transport.
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1993 Dec; 36(26):4208-13. doi:
10.1021/jm00078a010. [PMID: 8277503] - E Schömig, J Babin-Ebell, H Russ. 1,1'-diethyl-2,2'-cyanine (decynium22) potently inhibits the renal transport of organic cations.
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