(R)-[(2R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(4-quinolinyl)methanol (BioDeep_00001030191)
代谢物信息卡片
(R)-[(2R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(4-quinolinyl)methanol
化学式: C19H22N2O (294.1732042)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=CC1CN2CCC1CC2C(C3=CC=NC4=CC=CC=C34)O
InChI: InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14?,18-,19-/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
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代谢反应
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- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Feng Liang, Ying Lv, Xiao Qiao, Shu Zhang, Shanshan Shen, Changcheng Wang, Guifang Xu, Xiaoping Zou, Lei Wang, Bin Zhang. Cinchonine-induced cell death in pancreatic cancer cells by downregulating RRP15.
Cell biology international.
2023 Jan; ?(?):. doi:
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Journal of Asian natural products research.
2021 Feb; 23(2):163-175. doi:
10.1080/10286020.2020.1729136. [PMID: 32091234] - Nataly Allasi Canales, Tobias Nikolaj Gress Hansen, Claus Cornett, Kim Walker, Felix Driver, Alexandre Antonelli, Carla Maldonado, Mark Nesbitt, Christopher J Barnes, Nina Rønsted. Historical chemical annotations of Cinchona bark collections are comparable to results from current day high-pressure liquid chromatography technologies.
Journal of ethnopharmacology.
2020 Mar; 249(?):112375. doi:
10.1016/j.jep.2019.112375. [PMID: 31698039] - Adele Murauer, Markus Ganzera. Quantitative determination of major alkaloids in Cinchona bark by Supercritical Fluid Chromatography.
Journal of chromatography. A.
2018 Jun; 1554(?):117-122. doi:
10.1016/j.chroma.2018.04.038. [PMID: 29699870] - Anne-Sylvie Fabiano-Tixier, Abdelhakim Elomri, Axelle Blanckaert, Elisabeth Seguin, Emmanuel Petitcolas, Farid Chemat. Rapid and green analytical method for the determination of quinoline alkaloids from Cinchona succirubra based on Microwave-Integrated Extraction and Leaching (MIEL) prior to high performance liquid chromatography.
International journal of molecular sciences.
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10.3390/ijms12117846. [PMID: 22174637] - Chensong Pan, Songyun Xu, Hanfa Zou, Zhong Guo, Yu Zhang, Baochuan Guo. Carbon nanotubes as adsorbent of solid-phase extraction and matrix for laser desorption/ionization mass spectrometry.
Journal of the American Society for Mass Spectrometry.
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10.1016/j.jasms.2004.11.005. [PMID: 15694776] - E Solary, L Mannone, D Moreau, D Caillot, R O Casasnovas, H Guy, M Grandjean, J E Wolf, F André, P Fenaux, P Canal, B Chauffert, A Wotawa, M Bayssas, P Genne. Phase I study of cinchonine, a multidrug resistance reversing agent, combined with the CHVP regimen in relapsed and refractory lymphoproliferative syndromes.
Leukemia.
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10.1038/sj.leu.2401945. [PMID: 11187897] - S Khalil. Atomic emission spectrometric determination of ephedrine, cinchonine, chlorpheniramine, atropine and diphenhydramine based on formation of ion associates with ammonium reineckate.
Journal of pharmaceutical and biomedical analysis.
1999 Dec; 21(4):697-702. doi:
10.1016/s0731-7085(99)00130-2. [PMID: 10701933] - P Genne, O Duchamp, E Solary, J Magnette, J P Belon, B Chauffert. Cinchonine per os: efficient circumvention of P-glycoprotein-mediated multidrug resistance.
Anti-cancer drug design.
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. [PMID: 7710633] - D F Stroncek, G P Herr. The chemical and immunoglobulin structural features necessary for reactions of quinine-dependent antibodies to neutrophils.
Transfusion.
1995 Mar; 35(3):247-53. doi:
10.1046/j.1537-2995.1995.35395184282.x. [PMID: 7878718] - P Genne, O Duchamp, E Solary, D Pinard, J P Belon, M T Dimanche-Boitrel, B Chauffert. Comparative effects of quinine and cinchonine in reversing multidrug resistance on human leukemic cell line K562/ADM.
Leukemia.
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. [PMID: 8289482] - J Karbwang, D Bunnag, T Harinasuta, S Chittamas, J Berth, P Druilhe. Pharmacokinetics of quinine, quinidine and Cinchonine when given as combination.
The Southeast Asian journal of tropical medicine and public health.
1992 Dec; 23(4):773-6. doi:
. [PMID: 1298088] - P Genne, M T Dimanche-Boitrel, R Y Mauvernay, G Gutierrez, O Duchamp, J M Petit, F Martin, B Chauffert. Cinchonine, a potent efflux inhibitor to circumvent anthracycline resistance in vivo.
Cancer research.
1992 May; 52(10):2797-801. doi:
. [PMID: 1581892] - A Sabchareon, T Chongsuphajaisiddhi, P Attanath, V Singhasivanon, M M Acmor-Apolinar, C Pojjaroen-Anant. Red cell and plasma concentrations of combined quinine-quinidine and quinine in falciparum malaria.
Annals of tropical paediatrics.
1991; 11(4):315-24. doi:
10.1080/02724936.1991.11747522. [PMID: 1721787] - J el Benna, M T Labro. Effect of quinine and cinchonine on human neutrophils functions in vitro.
The Journal of antimicrobial chemotherapy.
1990 Jun; 25(6):949-57. doi:
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