S-hexanoyl-4-phosphopantetheine (BioDeep_00001030070)

   


代谢物信息卡片


S-hexanoyl-4-phosphopantetheine

化学式: C17H33N2O8PS (456.16951480000006)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)O)O
InChI: InChI=1S/C17H33N2O8PS/c1-4-5-6-7-14(21)29-11-10-18-13(20)8-9-19-16(23)15(22)17(2,3)12-27-28(24,25)26/h15,22H,4-12H2,1-3H3,(H,18,20)(H,19,23)(H2,24,25,26)/t15-/m0/s1

描述信息

An S-acyl-4-phosphopantetheine obtained by formal condensation of the thiol group of D-pantetheine 4-phosphate with the carboxy group of hexanoic acid.

同义名列表

1 个代谢物同义名

S-hexanoyl-4-phosphopantetheine



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Bingru Nan, Xia Sun, Shijing Yang, Qingyu Huang, Heqing Shen. Integrative proteomics and metabolomics analysis of non-observable acute effect level PM2.5 induced accumulative effects in AC16 cells. Journal of applied toxicology : JAT. 2023 Nov; 43(11):1613-1629. doi: 10.1002/jat.4500. [PMID: 37278136]
  • Huan Xu, Qing Wen, Xiuduan Xu, Zhihui Liu, Shasha Liu, Hongli Wang, Chongchong Zhang, Delian Wan, Kun Liu, Lina Du, Chao Yuan, Lun Song. Induction of heme oxygenase-1 antagonizes PM2.5-induced pulmonary VEGFA expression through regulating HIF-1α. Journal of biochemical and molecular toxicology. 2023 Aug; ?(?):e23494. doi: 10.1002/jbt.23494. [PMID: 37563788]
  • Can Can Guo, Zhao Meng Xu, Yi Lyu, Xiao Hui Li, Zhao Fei Li, Hui He, Feng Jie Tian, Jin Ping Zheng. PM2.5 induces autophagy-dependent ferroptosis by endoplasmic reticulum stress in SH-SY5Y cells. Journal of applied toxicology : JAT. 2023 07; 43(7):1013-1025. doi: 10.1002/jat.4439. [PMID: 36700298]
  • Demei Huang, Zherui Shen, Sijing Zhao, Caixia Pei, Nan Jia, Yilan Wang, Yongcan Wu, Xiaomin Wang, Shihua Shi, Yacong He, Zhenxing Wang, Fei Wang. Sipeimine attenuates PM2.5-induced lung toxicity via suppression of NLRP3 inflammasome-mediated pyroptosis through activation of the PI3K/AKT pathway. Chemico-biological interactions. 2023 May; 376(?):110448. doi: 10.1016/j.cbi.2023.110448. [PMID: 36898572]
  • Zimple Kurlawala, Parul Singh, Bradford G Hill, Petra Haberzettl. Fine Particulate Matter (PM2.5)-Induced Pulmonary Oxidative Stress Contributes to Changes in the Plasma Lipidome and Liver Transcriptome in Mice. Toxicological sciences : an official journal of the Society of Toxicology. 2023 Mar; ?(?):. doi: 10.1093/toxsci/kfad020. [PMID: 36857595]
  • Tianyang Zhao, Xu Li, Honghao Qian, Xiaohan Miao, Ying Zhu, Jia Wang, Ju Hui, Liting Zhou, Lin Ye. PM2.5 induces the abnormal lipid metabolism and leads to atherosclerosis via Notch signaling pathway in rats. Toxicology. 2023 Feb; 485(?):153415. doi: 10.1016/j.tox.2022.153415. [PMID: 36603807]
  • Yingying Chen, Yueyue Xi, Milu Li, Yaling Wu, Wei Yan, Jun Dai, Mingfu Wu, Wenjun Ding, Jinjin Zhang, Fang Zhang, Su Zhou, Shixuan Wang. Maternal exposure to PM2.5 decreases ovarian reserve in neonatal offspring mice through activating PI3K/AKT/FoxO3a pathway and ROS-dependent NF-κB pathway. Toxicology. 2022 11; 481(?):153352. doi: 10.1016/j.tox.2022.153352. [PMID: 36243239]
  • Yomade Ayodeji Jimoh, Akeem Olalekan Lawal, Ige Joseph Kade, Damilola Moses Olatunde, Oluwafunso Oluwayomi. Diphenyl diselenide modulates antioxidant status, inflammatory and redox-sensitive genes in diesel exhaust particle-induced neurotoxicity. Chemico-biological interactions. 2022 Nov; 367(?):110196. doi: 10.1016/j.cbi.2022.110196. [PMID: 36174737]
  • Chien-Hung Lin, Christopher J B Nicol, Chuan Wan, Shiang-Jiuun Chen, Rong-Nan Huang, Ming-Chang Chiang. Exposure to PM2.5 induces neurotoxicity, mitochondrial dysfunction, oxidative stress and inflammation in human SH-SY5Y neuronal cells. Neurotoxicology. 2022 01; 88(?):25-35. doi: 10.1016/j.neuro.2021.10.009. [PMID: 34718062]
  • Qiang Wan, Tao Ding, Yulin Xu, Cuicui Zheng, Mengting Tu, Tong Zhao. Urban fine particulate air pollution exposure promotes atherosclerosis in apolipoprotein E-deficient mice by activating perivascular adipose tissue inflammation via the Wnt5a/Ror2 signaling pathway. Ecotoxicology and environmental safety. 2021 Dec; 227(?):112912. doi: 10.1016/j.ecoenv.2021.112912. [PMID: 34673409]
  • Jonathan C Behlen, Carmen H Lau, Yixin Li, Prit Dhagat, Jone A Stanley, Aline Rodrigues Hoffman, Michael C Golding, Renyi Zhang, Natalie M Johnson. Gestational Exposure to Ultrafine Particles Reveals Sex- and Dose-Specific Changes in Offspring Birth Outcomes, Placental Morphology, and Gene Networks. Toxicological sciences : an official journal of the Society of Toxicology. 2021 11; 184(2):204-213. doi: 10.1093/toxsci/kfab118. [PMID: 34609516]
  • Shuiqing Qu, Kai Li, Ting Yang, Yuanmin Yang, Zhongyuzn Zheng, Hui Liu, Xi Wang, Yu Zhang, Shuoqiu Deng, Xiaoxin Zhu, Lina Chen, Yujie Li. Shenlian extract protects against ultrafine particulate matter-aggravated myocardial ischemic injury by inhibiting inflammation response via the activation of NLRP3 inflammasomes. Environmental toxicology. 2021 Jul; 36(7):1349-1361. doi: 10.1002/tox.23131. [PMID: 33729688]
  • Jiayu Liu, Jiaxin Zhou, Jiazhen Zhou, Mengcheng Li, Enzhao Chen, Guanqing Jiang, Yuyang Chen, Jianjun Wu, Qiaoyuan Yang. Fine particulate matter exposure induces DNA damage by downregulating Rad51 expression in human bronchial epithelial Beas-2B cells in vitro. Toxicology. 2020 11; 444(?):152581. doi: 10.1016/j.tox.2020.152581. [PMID: 32911023]
  • Maoyong Fan, Yi Wang. The impact of PM2.5 on mortality in older adults: evidence from retirement of coal-fired power plants in the United States. Environmental health : a global access science source. 2020 03; 19(1):28. doi: 10.1186/s12940-020-00573-2. [PMID: 32126999]
  • Qiang Wan, Zhongyong Liu, Ming Yang, Jianguang Wu. Acceleratory effects of ambient fine particulate matter on the development and progression of atherosclerosis in apolipoprotein E knockout mice by down-regulating CD4+CD25+Foxp3+ regulatory T cells. Toxicology letters. 2019 Nov; 316(?):27-34. doi: 10.1016/j.toxlet.2019.09.005. [PMID: 31513887]
  • Simona Leogrande, Ester Rita Alessandrini, Massimo Stafoggia, Angela Morabito, Alessandra Nocioni, Carla Ancona, Lucia Bisceglia, Francesca Mataloni, Roberto Giua, Antonia Mincuzzi, Sante Minerba, Stefano Spagnolo, Tiziano Pastore, Annalisa Tanzarella, Giorgio Assennato, Francesco Forastiere. Industrial air pollution and mortality in the Taranto area, Southern Italy: A difference-in-differences approach. Environment international. 2019 11; 132(?):105030. doi: 10.1016/j.envint.2019.105030. [PMID: 31398654]
  • Rui Shi, Wei-Wei Su, Zhi-Ting Zhu, Min-Yi Guan, Ke-Ling Cheng, Wei-Yang Fan, Gu-Yi Wei, Pei-Bo Li, Zhong-Yi Yang, Hong-Liang Yao. Regulation effects of naringin on diesel particulate matter-induced abnormal airway surface liquid secretion. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Oct; 63(?):153004. doi: 10.1016/j.phymed.2019.153004. [PMID: 31301536]
  • Fen Yin, Rajat Gupta, Laurent Vergnes, Will S Driscoll, Jerry Ricks, Gajalakshmi Ramanathan, James A Stewart, Diana M Shih, Kym F Faull, Simon W Beaven, Aldons J Lusis, Karen Reue, Michael E Rosenfeld, Jesús A Araujo. Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis. Arteriosclerosis, thrombosis, and vascular biology. 2019 09; 39(9):1776-1786. doi: 10.1161/atvbaha.119.312736. [PMID: 31340670]
  • Dong Chang Lee, Hyunsu Choi, Jeong-Min Oh, Do Hee Lee, Sung Won Kim, Soo Whan Kim, Byung Guk Kim, Jin Hee Cho, Joohyung Lee. Protective effects of α-lipoic acid on cultured human nasal fibroblasts exposed to urban particulate matter. International forum of allergy & rhinology. 2019 06; 9(6):638-647. doi: 10.1002/alr.22296. [PMID: 30758914]
  • Huichu Li, Renjie Chen, Jing Cai, Xiao Cui, Nan Huang, Haidong Kan. Short-term exposure to fine particulate air pollution and genome-wide DNA methylation: A randomized, double-blind, crossover trial. Environment international. 2018 11; 120(?):130-136. doi: 10.1016/j.envint.2018.07.041. [PMID: 30081103]
  • Chiara Milani, Paola Antonia Corsetto, Francesca Farina, Laura Botto, Elena Lonati, Luca Massimino, Angela Maria Rizzo, Alessandra Bulbarelli, Paola Palestini. Early evidence of stress in immortalized neurons exposed to diesel particles: the role of lipid reshaping behind oxidative stress and inflammation. Toxicology. 2018 11; 409(?):63-72. doi: 10.1016/j.tox.2018.07.017. [PMID: 30055298]
  • Qing Sun, Guoqing Zhang, Rucheng Chen, Ran Li, Huanhuan Wang, Apei Jiang, Zhenwei Li, Liya Kong, Laura K Fonken, Sanjay Rajagopalan, Qinghua Sun, Cuiqing Liu. Central IKK2 Inhibition Ameliorates Air Pollution-Mediated Hepatic Glucose and Lipid Metabolism Dysfunction in Mice With Type II Diabetes. Toxicological sciences : an official journal of the Society of Toxicology. 2018 07; 164(1):240-249. doi: 10.1093/toxsci/kfy079. [PMID: 29635361]
  • Xihao Du, Shuo Jiang, Xuejiao Zeng, Jia Zhang, Kun Pan, Ji Zhou, Yuquan Xie, Haidong Kan, Weimin Song, Qinghua Sun, Jinzhuo Zhao. Air pollution is associated with the development of atherosclerosis via the cooperation of CD36 and NLRP3 inflammasome in ApoE-/- mice. Toxicology letters. 2018 Jun; 290(?):123-132. doi: 10.1016/j.toxlet.2018.03.022. [PMID: 29571893]
  • Arianna Romani, Carlo Cervellati, Ximena M Muresan, Giuseppe Belmonte, Alessandra Pecorelli, Franco Cervellati, Mascia Benedusi, Pablo Evelson, G Valacchi. Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure. Mechanisms of ageing and development. 2018 06; 172(?):86-95. doi: 10.1016/j.mad.2017.11.007. [PMID: 29103985]
  • Michal Pardo, Fanfan Xu, Xinghua Qiu, Tong Zhu, Yinon Rudich. Seasonal variations in fine particle composition from Beijing prompt oxidative stress response in mouse lung and liver. The Science of the total environment. 2018 Jun; 626(?):147-155. doi: 10.1016/j.scitotenv.2018.01.017. [PMID: 29335169]
  • Chen-Wei Liu, Tzu-Lin Lee, Yu-Chen Chen, Chan-Jung Liang, Shu-Huei Wang, June-Horng Lue, Jaw-Shiun Tsai, Shih-Wei Lee, Shun-Hua Chen, Yi-Fan Yang, Tzu-Yi Chuang, Yuh-Lien Chen. PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway. Particle and fibre toxicology. 2018 01; 15(1):4. doi: 10.1186/s12989-018-0240-x. [PMID: 29329563]
  • Longfei Guan, Xiaokun Geng, Jiamei Shen, James Yip, Fengwu Li, Huishan Du, Zhili Ji, Yuchuan Ding. PM2.5 inhalation induces intracranial atherosclerosis which may be ameliorated by omega 3 fatty acids. Oncotarget. 2018 Jan; 9(3):3765-3778. doi: 10.18632/oncotarget.23347. [PMID: 29423081]
  • Yining Qiu, Ze Zheng, Hyunbae Kim, Zhao Yang, Gary Zhang, Xiangyang Shi, Fei Sun, Changya Peng, Yuchuan Ding, Aixia Wang, Lung-Chi Chen, Sanjay Rajagopalan, Qinghua Sun, Kezhong Zhang. Inhalation Exposure to PM2.5 Counteracts Hepatic Steatosis in Mice Fed High-fat Diet by Stimulating Hepatic Autophagy. Scientific reports. 2017 11; 7(1):16286. doi: 10.1038/s41598-017-16490-3. [PMID: 29176715]
  • Ziying Hu, Minjie Chen, Huifen Zhou, Anui Tharakan, Xiaoke Wang, Lianglin Qiu, Shuai Liang, Xiaobo Qin, Yuhao Zhang, Wanjun Wang, Yanyi Xu, Zhekang Ying. Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5. Toxicology. 2017 09; 390(?):100-108. doi: 10.1016/j.tox.2017.09.009. [PMID: 28917655]
  • Kyung-Won Lee, Mi-Hyun Nam, Hee-Ra Lee, Chung-Oui Hong, Kwang-Won Lee. Protective effects of chebulic acid on alveolar epithelial damage induced by urban particulate matter. BMC complementary and alternative medicine. 2017 Jul; 17(1):373. doi: 10.1186/s12906-017-1870-5. [PMID: 28724416]
  • Toby B Cole, Jacki Coburn, Khoi Dao, Pam Roqué, Yu-Chi Chang, Vrinda Kalia, Tomas R Guilarte, Jennifer Dziedzic, Lucio G Costa. Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology. 2016 Dec; 374(?):1-9. doi: 10.1016/j.tox.2016.11.010. [PMID: 27865893]
  • Yuki Ito, Yukie Yanagiba, Doni Hikmat Ramdhan, Yumi Hayashi, Yufei Li, Akira K Suzuki, Michihiro Kamijima, Tamie Nakajima. Nanoparticle-rich diesel exhaust-induced liver damage via inhibited transactivation of peroxisome proliferator-activated receptor alpha. Environmental toxicology. 2016 Dec; 31(12):1985-1995. doi: 10.1002/tox.22199. [PMID: 26419227]
  • Sofia Pavanello, Matteo Bonzini, Laura Angelici, Valeria Motta, Laura Pergoli, Mirjam Hoxha, Laura Cantone, Angela Cecilia Pesatori, Pietro Apostoli, Armando Tripodi, Andrea Baccarelli, Valentina Bollati. Extracellular vesicle-driven information mediates the long-term effects of particulate matter exposure on coagulation and inflammation pathways. Toxicology letters. 2016 Sep; 259(?):143-150. doi: 10.1016/j.toxlet.2016.08.002. [PMID: 27506416]
  • Michal Pardo, Ziv Porat, Assaf Rudich, James J Schauer, Yinon Rudich. Repeated exposures to roadside particulate matter extracts suppresses pulmonary defense mechanisms, resulting in lipid and protein oxidative damage. Environmental pollution (Barking, Essex : 1987). 2016 Mar; 210(?):227-37. doi: 10.1016/j.envpol.2015.12.009. [PMID: 26735168]
  • Biao Yang, Dongmei Chen, Hui Zhao, Chunling Xiao. The effects for PM2.5 exposure on non-small-cell lung cancer induced motility and proliferation. SpringerPlus. 2016; 5(1):2059. doi: 10.1186/s40064-016-3734-8. [PMID: 27995036]
  • Ruijin Li, Xiaojing Kou, Hong Geng, Jingfang Xie, Zhenhua Yang, Yuexia Zhang, Zongwei Cai, Chuan Dong. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Chemical research in toxicology. 2015 Mar; 28(3):408-18. doi: 10.1021/tx5003723. [PMID: 25560372]
  • Valentina Bollati, Laura Angelici, Giovanna Rizzo, Laura Pergoli, Federica Rota, Mirjam Hoxha, Francesco Nordio, Matteo Bonzini, Letizia Tarantini, Laura Cantone, Angela C Pesatori, Pietro Apostoli, Andrea A Baccarelli, Pier Alberto Bertazzi. Microvesicle-associated microRNA expression is altered upon particulate matter exposure in healthy workers and in A549 cells. Journal of applied toxicology : JAT. 2015 Jan; 35(1):59-67. doi: 10.1002/jat.2987. [PMID: 24515752]
  • Chaoyun Wang, Chunhua Wang, Chunlei Ma, Qingxian Huang, Hongliu Sun, Xiaomin Zhang, Xianyong Bai. Hydroxysafflor yellow A of Carthamus tinctorius attenuates lung injury of aged rats exposed to gasoline engine exhaust by down-regulating platelet activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Feb; 21(3):199-206. doi: 10.1016/j.phymed.2013.09.018. [PMID: 24192212]
  • Cuiqing Liu, Xiaohua Xu, Yuntao Bai, Tse-Yao Wang, Xiaoquan Rao, Aixia Wang, Lixian Sun, Zhekang Ying, Liubov Gushchina, Andrei Maiseyeu, Masako Morishita, Qinghua Sun, Jack R Harkema, Sanjay Rajagopalan. Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice. Environmental health perspectives. 2014 Jan; 122(1):17-26. doi: 10.1289/ehp.1306841. [PMID: 24149114]
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