Asparaginate (BioDeep_00001029826)
代谢物信息卡片
Asparaginate
化学式: C4H7N2O3- (131.0457)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C(=O)[O-])N)C(=O)N
InChI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/p-1
描述信息
An alpha-amino-acid anion that is the conjugate base of asparagine, arising from deprotonation of the carboxy group.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jasmeet Sidhu, Ashish Narayan Masurekar, Manash Pratim Gogoi, Caroline Fong, Tasos Ioannou, Taha Lodhi, Catriona Parker, Jizhong Liu, Amy A Kirkwood, Anthony V Moorman, Kiranmoy Das, Nicholas J Goulden, Ajay Vora, Vaskar Saha, Shekhar Krishnan. Activity and toxicity of intramuscular 1000 iu/m2 polyethylene glycol-E. coli L-asparaginase in the UKALL 2003 and UKALL 2011 clinical trials.
British journal of haematology.
2022 07; 198(1):142-150. doi:
10.1111/bjh.18158. [PMID: 35348200] - Sara Zarnegar-Lumley, Cosby A Stone, Christine M Smith, Laura L Hall, Kate E Luck, Grace Koo, Jessica H Plager, Elizabeth J Phillips, Debra L Friedman. Oncologist counseling practice and COVID-19 vaccination outcomes for patients with history of PEG-asparaginase hypersensitivity.
Pediatric blood & cancer.
2022 07; 69(7):e29686. doi:
10.1002/pbc.29686. [PMID: 35353440] - Eric Tse, Wei-Li Zhao, Jie Xiong, Yok-Lam Kwong. How we treat NK/T-cell lymphomas.
Journal of hematology & oncology.
2022 06; 15(1):74. doi:
10.1186/s13045-022-01293-5. [PMID: 35659326] - Arthur J L Cooper, Thambi Dorai, John T Pinto, Travis T Denton. The metabolic importance of the overlooked asparaginase II pathway.
Analytical biochemistry.
2022 05; 644(?):114084. doi:
10.1016/j.ab.2020.114084. [PMID: 33347861] - Yan Wu, Shengli Wan, Yun Chen, Jingchuan Fan, Yao Li, Tingting Wang, Ziyi Yuan, Qiang Yang, Hong Qin, Jingxin Xu, Jingqing Zhang. Biomimetic lipidic nanovectors for effective asparaginase supramolecule delivery.
Nanomedicine : nanotechnology, biology, and medicine.
2022 04; 41(?):102518. doi:
10.1016/j.nano.2022.102518. [PMID: 35032628] - Amanda C Santos, Marcelo G P Land, Elisangela C Lima. Ammonia level as a proxy of asparaginase inactivation in children: A strategy for classification of infusion reactions.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2022 Apr; 28(3):551-559. doi:
10.1177/1078155221998738. [PMID: 33645327] - Jing Yang, Xiangyun Guo, Sutang Guo, Hongxia Yan, Limin Chai, Yimeng Guo, Zhenhua Li, Zhiying Hao, Liping Su. Management of adverse effects associated with pegylated Escherichia coli asparaginase on coagulation in the treatment of patients with NK/T-cell lymphoma.
Medicine.
2022 Mar; 101(10):e25578. doi:
10.1097/md.0000000000025578. [PMID: 35451376] - Taisuke Nakagawa, Mari Kojima, Koichi Ohno, James K Chambers, Kazuyuki Uchida, Aki Ohmi, Yuko Goto-Koshino, Hirotaka Tomiyasu, Hajime Tsujimoto. Efficacy and adverse events of continuous l-asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin.
Veterinary and comparative oncology.
2022 Mar; 20(1):102-108. doi:
10.1111/vco.12749. [PMID: 34213084] - Christina Egnell, Mats Heyman, Ólafur Gisli Jónsson, Raheel A Raja, Riitta Niinimäki, Birgitte Klug Albertsen, Kjeld Schmiegelow, Niklas Stabell, Goda Vaitkeviciene, Kristi Lepik, Arja Harila-Saari, Susanna Ranta. Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia.
British journal of haematology.
2022 03; 196(5):1239-1247. doi:
10.1111/bjh.17936. [PMID: 34726257] - Tapasvi Modi, David Gervais. Improved pharmacokinetic and pharmacodynamic profile of a novel PEGylated native Erwinia chrysanthemi L-Asparaginase.
Investigational new drugs.
2022 02; 40(1):21-29. doi:
10.1007/s10637-021-01173-8. [PMID: 34468906] - Cassandra Rush, Kelly E Faulk, Zanette Kanani Bradley, Aubree Turner, Maija Krumins, Matthew Greenhawt. The safety of SARS-CoV-2 vaccines in persons with a known history of pegaspargase allergy: A single institution experience.
The journal of allergy and clinical immunology. In practice.
2022 02; 10(2):630-632. doi:
10.1016/j.jaip.2021.11.025. [PMID: 34883262] - Koshi Akahane, Shunsuke Kimura, Kunio Miyake, Atsushi Watanabe, Keiko Kagami, Kentaro Yoshimura, Tamao Shinohara, Daisuke Harama, Shin Kasai, Kumiko Goi, Tomoko Kawai, Kenichiro Hata, Nobutaka Kiyokawa, Katsuyoshi Koh, Toshihiko Imamura, Keizo Horibe, A Thomas Look, Masayoshi Minegishi, Kanji Sugita, Junko Takita, Takeshi Inukai. Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.
Blood advances.
2022 01; 6(1):212-224. doi:
10.1182/bloodadvances.2021004271. [PMID: 34535013] - Alaeddin Khalil, Gudrun Würthwein, Jana Golitsch, Georg Hempel, Manfred Fobker, Joachim Gerss, Anja Möricke, Martin Zimmermann, Petr Smisek, Massimo Zucchetti, Christa Nath, Andishe Attarbaschi, Arend Von Stackelberg, Nicola Gökbuget, Carmelo Rizzari, Valentino Conter, Martin Schrappe, Joachim Boos, Claudia Lanvers-Kaminsky. Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia.
Haematologica.
2022 01; 107(1):49-57. doi:
10.3324/haematol.2020.258525. [PMID: 33299233] - Grace Koo, Sara Anvari, Debra L Friedman, Sara Zarnegar-Lumley, Vibha Szafron, Basil M Kahwash, K Michelle Onasch, Laura Hall, Elizabeth J Phillips, Cosby A Stone. mRNA COVID-19 vaccine safety in patients with previous immediate hypersensitivity to pegaspargase.
The journal of allergy and clinical immunology. In practice.
2022 01; 10(1):322-325. doi:
10.1016/j.jaip.2021.09.051. [PMID: 34678498] - Montserrat Mesegué, Anna Alonso-Saladrigues, Sara Pérez-Jaume, Ariadna Comes-Escoda, José Luís Dapena, Anna Faura, Nuria Conde, Albert Català, Anna Ruiz-Llobet, Edgar Zapico-Muñiz, Mireia Camós, Susana Rives. Lower incidence of clinical allergy with PEG-asparaginase upfront versus the sequential use of native E. coli asparaginase followed by PEG-ASP in pediatric patients with acute lymphoblastic leukemia.
Hematological oncology.
2021 Dec; 39(5):687-696. doi:
10.1002/hon.2914. [PMID: 34397119] - Tong Lin, Todd Dumas, Josh Kaullen, N Seth Berry, Mi Rim Choi, Katie Zomorodi, Jeffrey A Silverman. Population Pharmacokinetic Model Development and Simulation for Recombinant Erwinia Asparaginase Produced in Pseudomonas fluorescens (JZP-458).
Clinical pharmacology in drug development.
2021 12; 10(12):1503-1513. doi:
10.1002/cpdd.1002. [PMID: 34310867] - Ji Shen, Juan Qiao, Dong-Pyo Kim, Li Qi. Study on controllable enzymolysis by chiral capillary electrophoresis with an ultraviolet-visible responsive polymer membrane based l-asparaginase reactor.
Talanta.
2021 Nov; 234(?):122676. doi:
10.1016/j.talanta.2021.122676. [PMID: 34364476] - Catherine Mark, Sumit Gupta, Angela Punnett, Julia Upton, Julia Orkin, Adelle Atkinson, Lindsay Clarke, Alice Heisey, Christine McGovern, Sarah Alexander. Safety of administration of BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccine in youths and young adults with a history of acute lymphoblastic leukemia and allergy to PEG-asparaginase.
Pediatric blood & cancer.
2021 11; 68(11):e29295. doi:
10.1002/pbc.29295. [PMID: 34398511] - Jie Xiong, Nan Wang, Hui-Juan Zhong, Bo-Wen Cui, Shu Cheng, Rui Sun, Jia-Yi Chen, Peng-Peng Xu, Gang Cai, Li Wang, Xiao-Jian Sun, Jin-Yan Huang, Wei-Li Zhao. SLC1A1 mediated glutamine addiction and contributed to natural killer T-cell lymphoma progression with immunotherapeutic potential.
EBioMedicine.
2021 Oct; 72(?):103614. doi:
10.1016/j.ebiom.2021.103614. [PMID: 34628354] - John C Panetta, Yiwei Liu, Teodoro Bottiglieri, Erland Arning, Cheng Cheng, Seth E Karol, Jun J Yang, Yinmei Zhou, Hiroto Inaba, Ching-Hon Pui, Sima Jeha, Mary V Relling. Pharmacodynamics of cerebrospinal fluid asparagine after asparaginase.
Cancer chemotherapy and pharmacology.
2021 10; 88(4):655-664. doi:
10.1007/s00280-021-04315-0. [PMID: 34170389] - Phumin Chaweephisal, Trai Tharnpanich, Aphinya Suroengrit, Pattramon Aungbamnet, Panya Seksarn, Darintr Sosothikul, Supanun Lauhasurayotin, Kanhatai Chiengthong, Hansamon Poparn, Piti Techavichit. A Pharmacokinetic Study of Native E.coli Asparaginase for Acute Lymphoblastic Leukemia Treated with ThaiPOG Protocol.
Asian Pacific journal of cancer prevention : APJCP.
2021 10; 22(10):3309-3315. doi:
10.31557/apjcp.2021.22.10.3309. [PMID: 34711008] - Søren Thorgaard Bønløkke, Hans Beier Ommen, Anne-Mette Hvas. Altered Fibrinolysis in Hematological Malignances.
Seminars in thrombosis and hemostasis.
2021 Jul; 47(5):569-580. doi:
10.1055/s-0041-1725099. [PMID: 34058766] - Satya Prakash Yadav, Teena Wadhwa, Dhwanee Thakkar, Rohit Kapoor, Neha Rastogi, Smita Sarma. COVID-19 reinfection in two children with cancer.
Pediatric hematology and oncology.
2021 05; 38(4):403-405. doi:
10.1080/08880018.2020.1855276. [PMID: 33625290] - Stephanie Bath De Morais, Tatiana De Arruda Campos Brasil De Souza. Human L‑asparaginase: Acquiring knowledge of its activation (Review).
International journal of oncology.
2021 04; 58(4):. doi:
10.3892/ijo.2021.5191. [PMID: 33649831] - Katherine A Dunn, Jessica Connors, Joseph P Bielawski, Jacob T Nearing, Morgan G I Langille, Johan Van Limbergen, Conrad V Fernandez, Tamara MacDonald, Ketan Kulkarni. Investigating the gut microbial community and genes in children with differing levels of change in serum asparaginase activity during pegaspargase treatment for acute lymphoblastic leukemia.
Leukemia & lymphoma.
2021 04; 62(4):927-936. doi:
10.1080/10428194.2020.1850718. [PMID: 33258724] - João C F Nunes, Raquel O Cristóvão, Mara G Freire, Valéria C Santos-Ebinuma, Joaquim L Faria, Cláudia G Silva, Ana P M Tavares. Recent Strategies and Applications for l-Asparaginase Confinement.
Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
10.3390/molecules25245827. [PMID: 33321857] - Zegeng Chen, Xiaojie Fang, He Huang, Zhao Wang, Huangming Hong, Meiting Chen, Quanguang Ren, Yuyi Yao, Limei Zhang, Ying Tian, Suxia Lin, Tongyu Lin. A proposal for a prognostic index for non-nasal type natural killer/T cell lymphoma after asparaginase-based treatment.
Annals of hematology.
2020 Dec; 99(12):2811-2819. doi:
10.1007/s00277-020-04278-x. [PMID: 32975588] - Jean-Baptiste Bachet, Hélène Blons, Pascal Hammel, Iman El Hariry, Fabienne Portales, Laurent Mineur, Jean-Philippe Metges, Claire Mulot, Camille Bourreau, Jason Cain, Jérôme Cros, Pierre Laurent-Puig. Circulating Tumor DNA is Prognostic and Potentially Predictive of Eryaspase Efficacy in Second-line in Patients with Advanced Pancreatic Adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020 10; 26(19):5208-5216. doi:
10.1158/1078-0432.ccr-20-0950. [PMID: 32605910] - Rohiverth Guarecuco, Robert T Williams, Lou Baudrier, Konnor La, Maria C Passarelli, Naz Ekizoglu, Mert Mestanoglu, Hanan Alwaseem, Bety Rostandy, Justine Fidelin, Javier Garcia-Bermudez, Henrik Molina, Kıvanç Birsoy. Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells.
Science advances.
2020 10; 6(41):. doi:
10.1126/sciadv.abc7120. [PMID: 33036978] - David Sayag, Gabriel Chamel, Christian Bédard, Guy Beauchamp, Solange Couturier, Frédérique Ponce, Benoit Rannou. Proof-of-concept study: Evaluation of plasma and urinary electrolytes as markers of response to L-asparaginase therapy in dogs with high-grade lymphoma.
Veterinary clinical pathology.
2020 Sep; 49(3):476-483. doi:
10.1111/vcp.12893. [PMID: 32955128] - Hande Orhan, Deniz Aktaş Uygun. Immobilization of L-Asparaginase on Magnetic Nanoparticles for Cancer Treatment.
Applied biochemistry and biotechnology.
2020 Aug; 191(4):1432-1443. doi:
10.1007/s12010-020-03276-z. [PMID: 32103470] - Ashish K Sharma, Esha Shukla, Deepak S Janoti, Krishna J Mukherjee, Joseph Shiloach. A novel knock out strategy to enhance recombinant protein expression in Escherichia coli.
Microbial cell factories.
2020 Jul; 19(1):148. doi:
10.1186/s12934-020-01407-z. [PMID: 32703203] - Corentin Orvain, Marie Balsat, Emmanuelle Tavernier, Jean-Pierre Marolleau, Thomas Pabst, Patrice Chevallier, Noémie de Gunzburg, Victoria Cacheux, Françoise Huguet, Sylvain Chantepie, Denis Caillot, Yves Chalandon, Jamilé Frayfer, Caroline Bonmati, Véronique Lheritier, Norbert Ifrah, Hervé Dombret, Nicolas Boissel, Mathilde Hunault-Berger. Thromboembolism prophylaxis in adult patients with acute lymphoblastic leukemia treated in the GRAALL-2005 study.
Blood.
2020 07; 136(3):328-338. doi:
10.1182/blood.2020004919. [PMID: 32321172] - Jing Gu, Yongjia Huang, Zijun Yan, Dan He, Yonghong Zhang, Jingyu Xu, Yao Li, Xuemei Xie, Jiaxi Xie, Da Shi, Ruben Abagyan, Jingqing Zhang, Qunyou Tan. Biomimetic Membrane-Structured Nanovesicles Carrying a Supramolecular Enzyme to Cure Lung Cancer.
ACS applied materials & interfaces.
2020 Jul; 12(28):31112-31123. doi:
10.1021/acsami.0c06207. [PMID: 32544316] - Masuho Saburi, Masao Ogata, Yasuhiro Soga, Kazuhito Itani, Kazuhiro Kohno, Toshiyuki Nakayama. L-asparaginase-induced Parotitis in an Elderly Patient with Acute Lymphoblastic Leukemia.
Internal medicine (Tokyo, Japan).
2020 Jul; 59(14):1745-1748. doi:
10.2169/internalmedicine.4335-19. [PMID: 32296003] - Manjunath Nookala Krishnamurthy, Gaurav Narula, Khushboo Gandhi, Ankita Awase, Ruta Pandit, Sunil Raut, Ritu Singh, Vikram Gota, Shripad Dinanath Banavali. Randomized, Parallel Group, Open-Label Bioequivalence Trial of Intramuscular Pegaspargase in Patients With Relapsed Acute Lymphoblastic Leukemia.
JCO global oncology.
2020 07; 6(?):1009-1016. doi:
10.1200/go.20.00113. [PMID: 32628582] - John C Panetta, Yiwei Liu, Hope D Swanson, Seth E Karol, Ching-Hon Pui, Hiroto Inaba, Sima Jeha, Mary V Relling. Higher plasma asparaginase activity after intramuscular than intravenous Erwinia asparaginase.
Pediatric blood & cancer.
2020 07; 67(7):e28244. doi:
10.1002/pbc.28244. [PMID: 32323890] - Elena V Kudryashova, Marina V Pokrovskaya, Svetlana S Alexandrova, Alexander A Vinogradov, Nikolay N Sokolov. FTIR-based L-asparaginase activity assay enables continuous measurements in optically dense media including blood plasma.
Analytical biochemistry.
2020 06; 598(?):113694. doi:
10.1016/j.ab.2020.113694. [PMID: 32217095] - J Porter Hunt, Kristen M Wilding, R Jordan Barnett, Hannah Robinson, Mehran Soltani, Jae Eun Cho, Bradley C Bundy. Engineering Cell-Free Protein Synthesis for High-Yield Production and Human Serum Activity Assessment of Asparaginase: Toward On-Demand Treatment of Acute Lymphoblastic Leukemia.
Biotechnology journal.
2020 Apr; 15(4):e1900294. doi:
10.1002/biot.201900294. [PMID: 31904183] - Ruo-Jing Li, Runyan Jin, Chao Liu, Xianhua Cao, Michael L Manning, Xu Michael Di, Donna Przepiorka, Frances Namuswe, Albert Deisseroth, Kirsten B Goldberg, Gideon M Blumenthal, Richard Pazdur. FDA Approval Summary: Calaspargase Pegol-mknl For Treatment of Acute Lymphoblastic Leukemia in Children and Young Adults.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020 01; 26(2):328-331. doi:
10.1158/1078-0432.ccr-19-1255. [PMID: 31444252] - Kimberly M Lau, Ila M Saunders, Aaron Goodman. Pegaspargase-induced hypertriglyceridemia in a patient with acute lymphoblastic leukemia.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2020 Jan; 26(1):193-199. doi:
10.1177/1078155219833438. [PMID: 30823860] - Keith J August, Sana Farooki, Joy M Fulbright, Amanda August, Jay M Portnoy, Lauren Pommert, Michael J Burke, Erin M Guest. Desensitization to pegaspargase in children with acute lymphoblastic leukemia and lymphoblastic lymphoma.
Pediatric blood & cancer.
2020 01; 67(1):e28021. doi:
10.1002/pbc.28021. [PMID: 31571395] - Takashi Ishihara, Keiji Nogami, Satoshi Ochi, Toshiaki Ishida, Yoshiyuki Kosaka, Akihisa Sawada, Masami Inoue, Shinya Osone, Toshihiko Imamura, Hajime Hosoi, Midori Shima. Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L-asparaginase induction therapy in pediatric acute lymphoblastic leukemia.
Pediatric blood & cancer.
2020 01; 67(1):e28016. doi:
10.1002/pbc.28016. [PMID: 31556233] - Juan Wu, Changcheng Chen, Shiying Huang, Shuhong Shen, Jing Chen, Shunguo Zhang. Correlation of L-asp Activity, Anti-L-asp Antibody, Asn and Gln With Adverse Events Especially Anaphylaxis Risks in PEG-asp-Contained Regime Treated Pediatric ALL Patients.
Technology in cancer research & treatment.
2020 Jan; 19(?):1533033820980113. doi:
10.1177/1533033820980113. [PMID: 33287663] - Claudia Lanvers-Kaminsky, Andreas Niemann, Maria Eveslage, Joachim Beck, Thomas Köhnke, Sonja Martin, Maike de Wit, Bernd Spriewald, Holger Hauspurg, Dieter Hoelzer, Joachim Boos, Nicola Gökbuget. Asparaginase activities during intensified treatment with pegylated E. coli asparaginase in adults with newly-diagnosed acute lymphoblastic leukemia.
Leukemia & lymphoma.
2020 01; 61(1):138-145. doi:
10.1080/10428194.2019.1658099. [PMID: 31480965] - Shinya Osone, Keitaro Fukushima, Michihiro Yano, Mariko Kakazu, Hirozumi Sano, Yoko Kato, Yuichi Shinkoda, Kunihiro Shinoda, Naoko Mori, Souichi Adachi. Supportive care for hemostatic complications associated with pediatric leukemia: a national survey in Japan.
International journal of hematology.
2019 Dec; 110(6):743-750. doi:
10.1007/s12185-019-02740-9. [PMID: 31559563] - Abdolmajid Ghasemian, Ali-Hussein Al-Marzoqi, Hiba Riyadh Al-Abodi, Yasemin Khudiar Alghanimi, Samah Ahmed Kadhum, Seyyed Khalil Shokouhi Mostafavi, Azam Fattahi. Bacterial l-asparaginases for cancer therapy: Current knowledge and future perspectives.
Journal of cellular physiology.
2019 11; 234(11):19271-19279. doi:
10.1002/jcp.28563. [PMID: 30993718] - Eric Tse, Rex Au-Yeung, Yok-Lam Kwong. Recent advances in the diagnosis and treatment of natural killer/T-cell lymphomas.
Expert review of hematology.
2019 11; 12(11):927-935. doi:
10.1080/17474086.2019.1660640. [PMID: 31487202] - Sanjay Rathod, Manda Ramsey, Danielle DiGiorgio, Roberto Berrios, Fred D Finkelman, Christian A Fernandez. Asparaginase immune complexes induce Fc-γRIII-dependent hypersensitivity in naive mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 10; 33(10):10996-11005. doi:
10.1096/fj.201900857. [PMID: 31284767] - Rosanna K Jackson, Martina Liebich, Philip Berry, Julie Errington, Jizhong Liu, Catriona Parker, John Moppett, Sujith Samarasinghe, Rachael Hough, Clare Rowntree, Nick J Goulden, Ajay Vora, Pamela R Kearns, Vaskar Saha, Georg Hempel, Julie A E Irving, Gareth J Veal. Impact of dose and duration of therapy on dexamethasone pharmacokinetics in childhood acute lymphoblastic leukaemia-a report from the UKALL 2011 trial.
European journal of cancer (Oxford, England : 1990).
2019 10; 120(?):75-85. doi:
10.1016/j.ejca.2019.07.026. [PMID: 31499383] - Joanna Zawitkowska, Monika Lejman, Agnieszka Zaucha-Prażmo, Natasza Sekuła, Teresa Greczkowska-Chmiel, Katarzyna Drabko. Severe drug-induced hypertriglyceridemia treated with plasmapheresis in children with acute lymphoblastic leukemia.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2019 Oct; 58(5):634-637. doi:
10.1016/j.transci.2019.08.025. [PMID: 31515171] - Natasha Kamal, Christopher Koh, Niharika Samala, Robert J Fontana, Andrew Stolz, Francisco Durazo, Paul H Hayashi, Elizabeth Phillips, Tongrong Wang, Jay H Hoofnagle. Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis.
Hepatology international.
2019 Sep; 13(5):641-648. doi:
10.1007/s12072-019-09971-2. [PMID: 31392570] - Harold Tvedten, Inger Lilliehöök, Henrik Rönnberg, Lena Pelander. Massive uric acid crystalluria and cylinduria in a dog after l-asparaginase treatment for lymphoma.
Veterinary clinical pathology.
2019 Sep; 48(3):425-428. doi:
10.1111/vcp.12719. [PMID: 31093999] - Carmelo Rizzari, Claudia Lanvers-Kaminsky, Maria Grazia Valsecchi, Andrea Ballerini, Cristina Matteo, Joachim Gerss, Gudrun Wuerthwein, Daniela Silvestri, Antonella Colombini, Valentino Conter, Andrea Biondi, Martin Schrappe, Anja Moericke, Martin Zimmermann, Arend von Stackelberg, Christin Linderkamp, Michael C Frühwald, Sabine Legien, Andishe Attarbaschi, Bettina Reismüller, David Kasper, Petr Smisek, Jan Stary, Luciana Vinti, Elena Barisone, Rosanna Parasole, Concetta Micalizzi, Massimo Zucchetti, Joachim Boos. Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study.
Haematologica.
2019 09; 104(9):1812-1821. doi:
10.3324/haematol.2018.206433. [PMID: 30705097] - Yiwei Liu, Colton A Smith, John C Panetta, Wenjian Yang, Lauren E Thompson, Jacob P Counts, Alejandro R Molinelli, Deqing Pei, Nancy M Kornegay, Kristine R Crews, Hope Swanson, Cheng Cheng, Seth E Karol, William E Evans, Hiroto Inaba, Ching-Hon Pui, Sima Jeha, Mary V Relling. Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2019 08; 37(23):2051-2061. doi:
10.1200/jco.18.02439. [PMID: 31188727] - Xiao-Xiao Wang, Peng-Fei Li, Bing Bai, Yan Gao, Qi-Xiang Rong, Qing-Qing Cai, Su-Xia Lin, Yu-Jing Zhang, Zhi-Ming Li, Wen-Qi Jiang, Hui-Qiang Huang. Differential clinical significance of pre-, interim-, and post-treatment plasma Epstein-Barr virus DNA load in NK/T-cell lymphoma treated with P-GEMOX protocol.
Leukemia & lymphoma.
2019 08; 60(8):1917-1925. doi:
10.1080/10428194.2018.1563690. [PMID: 30646796] - Clémence Merlen, Arnaud Bonnefoy, Cynthia Afeich, Yves Théorêt, Caroline Laverdière, Jean-Marie Leclerc, Georges-Etienne Rivard. Antithrombin and fibrinogen levels as predictors for plasma L-asparaginase activity in children with acute lymphoblastic leukemia.
Pediatric blood & cancer.
2019 07; 66(7):e27729. doi:
10.1002/pbc.27729. [PMID: 30938058] - Reuven J Schore, Meenakshi Devidas, Archie Bleyer, Gregory H Reaman, Naomi Winick, Mignon L Loh, Elizabeth A Raetz, William L Carroll, Stephen P Hunger, Anne L Angiolillo. Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children's Oncology Group AALL07P4.
Leukemia & lymphoma.
2019 07; 60(7):1740-1748. doi:
10.1080/10428194.2018.1542146. [PMID: 30626253] - Karin Torres-Obreque, Giovanna Pastore Meneguetti, Débora Custódio, Gisele Monteiro, Adalberto Pessoa-Junior, Carlota de Oliveira Rangel-Yagui. Production of a novel N-terminal PEGylated crisantaspase.
Biotechnology and applied biochemistry.
2019 May; 66(3):281-289. doi:
10.1002/bab.1723. [PMID: 30597637] - Benjamin Ole Wolthers, Pernille R Mogensen, Thomas L Frandsen, Jonas Abrahamsson, Mikael Behrendtz, Mats Heyman, Olli Lohi, Ulrika Norén-Nyström, Ellen Ruud, Kjeld Schmiegelow. Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia.
Pediatric blood & cancer.
2019 01; 66(1):e27437. doi:
10.1002/pbc.27437. [PMID: 30216644] - Rajashekar Sindhu, Hanumanthappa Pradeep, Haravey K Manonmani. Polyethylene Glycol Acts as a Mechanistic Stabilizer of L-asparaginase: A Computational Probing.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2019; 15(6):705-714. doi:
10.2174/1573406415666190206232816. [PMID: 30727907] - Dai Chihara, Yasuhiro Oki. NK-Cell Lymphomas.
Cancer treatment and research.
2019 ; 176(?):163-184. doi:
10.1007/978-3-319-99716-2_8. [PMID: 30596218] - Giovanna Pastore Meneguetti, João Henrique Picado Madalena Santos, Karin Mariana Torres Obreque, Christiano Marcello Vaz Barbosa, Gisele Monteiro, Sandra Helena Poliselli Farsky, Adriano Marim de Oliveira, Claudia Blanes Angeli, Giuseppe Palmisano, Sónia Patrícia Marques Ventura, Adalberto Pessoa-Junior, Carlota de Oliveira Rangel-Yagui. Novel site-specific PEGylated L-asparaginase.
PloS one.
2019; 14(2):e0211951. doi:
10.1371/journal.pone.0211951. [PMID: 30753228] - Seth E Karol, Laura J Janke, John C Panetta, Laura B Ramsey, Xiangjun Cai, Monique A Payton, David A Jenkins, William E Evans, Mary V Relling. Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models.
PloS one.
2019; 14(5):e0216328. doi:
10.1371/journal.pone.0216328. [PMID: 31059548] - Mei Zhang, Yong Zhang, Siqi Ren, Zunjian Zhang, Yongren Wang, Rui Song. Optimization of a Precolumn OPA Derivatization HPLC Assay for Monitoring of l-Asparagine Depletion in Serum during l-Asparaginase Therapy.
Journal of chromatographic science.
2018 Oct; 56(9):794-801. doi:
10.1093/chromsci/bmy053. [PMID: 29878070] - Hesham Saeed, Hadeer Soudan, Amany El-Sharkawy, Aida Farag, Amira Embaby, Farid Ataya. Expression and Functional Characterization of Pseudomonas aeruginosa Recombinant L.Asparaginase.
The protein journal.
2018 10; 37(5):461-471. doi:
10.1007/s10930-018-9789-3. [PMID: 30097831] - J Cong, L Yang, J Ye, L Q Wei, X Li, J W Wang. [Management of toxicities associated with pegaspargase in treatment of patients with lymphoid malignancy: experience from 443 cases in a single center].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi.
2018 Aug; 39(8):654-660. doi:
10.3760/cma.j.issn.0253-2727.2018.08.009. [PMID: 30180467] - Inge M van der Sluis, Hester de Groot-Kruseman, Maroeska Te Loo, Wim J E Tissing, Cor van den Bos, Gertjan J L Kaspers, Marc Bierings, Wouter J W Kollen, Thorsten König, Uwe Pichlmeier, Hans-Jürgen Kühnel, Rob Pieters. Efficacy and safety of recombinant E. coli asparaginase in children with previously untreated acute lymphoblastic leukemia: A randomized multicenter study of the Dutch Childhood Oncology Group.
Pediatric blood & cancer.
2018 08; 65(8):e27083. doi:
10.1002/pbc.27083. [PMID: 29727043] - Chintan Vyas, Sandeep Jain, Gauri Kapoor, Anurag Mehta, Parul Takkar Chugh. Experience with generic pegylated L-asparaginase in children with acute lymphoblastic leukemia and monitoring of serum asparaginase activity.
Pediatric hematology and oncology.
2018 Aug; 35(5-6):331-340. doi:
10.1080/08880018.2018.1538277. [PMID: 30488741] - Jaleh Varshosaz, Negin Anvari. Enhanced stability of L-asparaginase by its bioconjugation to poly(styrene-co-maleic acid) and Ecoflex nanoparticles.
IET nanobiotechnology.
2018 Jun; 12(4):466-472. doi:
10.1049/iet-nbt.2017.0156. [PMID: 29768231] - Priscila Pini Zenatti, Natacha Azussa Migita, Nathália Moreno Cury, Rosângela Aparecida Mendes-Silva, Fabio Cesar Gozzo, Pedro Otavio de Campos-Lima, José Andrés Yunes, Silvia Regina Brandalise. Low Bioavailability and High Immunogenicity of a New Brand of E. colil-Asparaginase with Active Host Contaminating Proteins.
EBioMedicine.
2018 Apr; 30(?):158-166. doi:
10.1016/j.ebiom.2018.03.005. [PMID: 29550241] - Shoya Shiromizu, Naoki Kusunose, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo. Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.
Journal of pharmacological sciences.
2018 Apr; 136(4):228-233. doi:
10.1016/j.jphs.2018.01.008. [PMID: 29605274] - Rachel E Rau, ZoAnn Dreyer, Mi Rim Choi, Wei Liang, Roman Skowronski, Krishna P Allamneni, Meenakshi Devidas, Elizabeth A Raetz, Peter C Adamson, Susan M Blaney, Mignon L Loh, Stephen P Hunger. Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group.
Pediatric blood & cancer.
2018 03; 65(3):. doi:
10.1002/pbc.26873. [PMID: 29090524] - Abbie L Speas, Sarah E Lyles, Kimberly A Wirth, Christine E Fahey, Kelvin Kow, Amandine T Lejeune, Rowan J Milner. Plasma ammonia concentration after L-asparaginase therapy in 27 dogs with high-grade lymphoma or leukemia.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2018 Mar; 28(2):130-139. doi:
10.1111/vec.12695. [PMID: 29469204] - Dorsa Golestaneh, Jaleh Varshosaz. Enhancement in Biological Activity of L-Asparginase by its Conjugation on Silica Nanoparticles.
Recent patents on nanotechnology.
2018 Feb; 12(1):70-82. doi:
10.2174/0929867324666170823143634. [PMID: 28831914] - Swantje Völler, Uwe Pichlmeier, Anke Zens, Georg Hempel. Pharmacokinetics of recombinant asparaginase in children with acute lymphoblastic leukemia.
Cancer chemotherapy and pharmacology.
2018 02; 81(2):305-314. doi:
10.1007/s00280-017-3492-5. [PMID: 29204688] - Aaron Shmookler, Stephen Smith. Pegaspargase-induced hypertriglyceridemia.
Journal of clinical apheresis.
2018 Feb; 33(1):97-98. doi:
10.1002/jca.21571. [PMID: 28752901] - Ashkan Emadi, Jennie Y Law, Erin T Strovel, Rena G Lapidus, Linda J B Jeng, Myounghee Lee, Miriam G Blitzer, Brandon A Carter-Cooper, Danielle Sewell, Isabella Van Der Merwe, Sunita Philip, Mohammad Imran, Stephen L Yu, Hongxia Li, Philip C Amrein, Vu H Duong, Edward A Sausville, Maria R Baer, Amir T Fathi, Zeba Singh, Søren M Bentzen. Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia.
Cancer chemotherapy and pharmacology.
2018 01; 81(1):217-222. doi:
10.1007/s00280-017-3459-6. [PMID: 29119293] - Yong Zhang, Yongren Wang, Ru Wang, Yan Shen, Jing Xu, Thomas J Webster, Yongjun Fang. Personalized nanomedicine: a rapid, sensitive, and selective UV-vis spectrophotometry method for the quantification of nanostructured PEG-asparaginase activity in children's plasma.
International journal of nanomedicine.
2018; 13(?):6337-6344. doi:
10.2147/ijn.s167380. [PMID: 30410325] - David M Charbonneau, Julien Breault-Turcot, Daniel Sinnett, Maja Krajinovic, Jean-Marie Leclerc, Jean-François Masson, Joelle N Pelletier. Tracking Silent Hypersensitivity Reactions to Asparaginase during Leukemia Therapy Using Single-Chip Indirect Plasmonic and Fluorescence Immunosensing.
ACS sensors.
2017 12; 2(12):1761-1766. doi:
10.1021/acssensors.7b00584. [PMID: 29168384] - Louise Tram Henriksen, Sofie Gottschalk Højfeldt, Kjeld Schmiegelow, Thomas Leth Frandsen, Peder Skov Wehner, Henrik Schrøder, Birgitte Klug Albertsen. Prolonged first-line PEG-asparaginase treatment in pediatric acute lymphoblastic leukemia in the NOPHO ALL2008 protocol-Pharmacokinetics and antibody formation.
Pediatric blood & cancer.
2017 Dec; 64(12):. doi:
10.1002/pbc.26686. [PMID: 28660740] - Jalaja Vidya, Syed Sajitha, Mrudula Vasudevan Ushasree, Raveendran Sindhu, Parameswaran Binod, Aravind Madhavan, Ashok Pandey. Genetic and metabolic engineering approaches for the production and delivery of L-asparaginases: An overview.
Bioresource technology.
2017 Dec; 245(Pt B):1775-1781. doi:
10.1016/j.biortech.2017.05.057. [PMID: 28596071] - Peng-Peng Xu, Jie Xiong, Shu Cheng, Xia Zhao, Chao-Fu Wang, Gang Cai, Hui-Juan Zhong, Heng-Ye Huang, Jia-Yi Chen, Wei-Li Zhao. A Phase II Study of Methotrexate, Etoposide, Dexamethasone and Pegaspargase Sandwiched with Radiotherapy in the Treatment of Newly Diagnosed, Stage IE to IIE Extranodal Natural-Killer/T-Cell Lymphoma, Nasal-Type.
EBioMedicine.
2017 Nov; 25(?):41-49. doi:
10.1016/j.ebiom.2017.10.011. [PMID: 29056540] - S M Kang, J L Rosales, V Meier-Stephenson, S Kim, K Y Lee, A Narendran. Genome-wide loss-of-function genetic screening identifies opioid receptor μ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia.
Oncogene.
2017 10; 36(42):5910-5913. doi:
10.1038/onc.2017.211. [PMID: 28650467] - A J Innes, B H Mullish, F Fernando, G Adams, J R Marchesi, J F Apperley, E Brannigan, F Davies, J Pavlů. Faecal microbiota transplant: a novel biological approach to extensively drug-resistant organism-related non-relapse mortality.
Bone marrow transplantation.
2017 10; 52(10):1452-1454. doi:
10.1038/bmt.2017.151. [PMID: 28714946] - Ali Ghasemi, Sedigheh Asad, Mahboubeh Kabiri, Bahareh Dabirmanesh. Cloning and characterization of Halomonas elongata L-asparaginase, a promising chemotherapeutic agent.
Applied microbiology and biotechnology.
2017 Oct; 101(19):7227-7238. doi:
10.1007/s00253-017-8456-5. [PMID: 28801829] - Chitose Ogawa, Fumi Taguchi, Hiroaki Goto, Katsuyoshi Koh, Daisuke Tomizawa, Akira Ohara, Atsushi Manabe. Plasma asparaginase activity, asparagine concentration, and toxicity after administration of Erwinia asparaginase in children and young adults with acute lymphoblastic leukemia: Phase I/II clinical trial in Japan.
Pediatric blood & cancer.
2017 Sep; 64(9):. doi:
10.1002/pbc.26475. [PMID: 28244643] - Andrea Ballerini, Federico Moro, Ilaria Fuso Nerini, Claudio Marcello Marzo, Angelo Di Clemente, Mariella Ferrari, Maurizio D'Incalci, Andrea Biondi, Antonella Colombini, Valentino Conter, Luca Porcu, Luigi Cervo, Carmelo Rizzari, Massimo Zucchetti. Pharmacodynamic effects in the cerebrospinal fluid of rats after intravenous administration of different asparaginase formulations.
Cancer chemotherapy and pharmacology.
2017 Jun; 79(6):1267-1271. doi:
10.1007/s00280-017-3307-8. [PMID: 28424964] - Eric Tse, Yok-Lam Kwong. The diagnosis and management of NK/T-cell lymphomas.
Journal of hematology & oncology.
2017 04; 10(1):85. doi:
10.1186/s13045-017-0452-9. [PMID: 28410601] - Sebastiaan D T Sassen, Ron A A Mathôt, Rob Pieters, Robin Q H Kloos, Valérie de Haas, Gertjan J L Kaspers, Cor van den Bos, Wim J E Tissing, Maroeska Te Loo, Marc B Bierings, Wouter J W Kollen, Christian M Zwaan, Inge M van der Sluis. Population pharmacokinetics of intravenous Erwinia asparaginase in pediatric acute lymphoblastic leukemia patients.
Haematologica.
2017 03; 102(3):552-561. doi:
10.3324/haematol.2016.149195. [PMID: 28250007] - Laurens T van der Meer, Samantha Y A Terry, Dorette S van Ingen Schenau, Kiki C Andree, Gerben M Franssen, Debbie M Roeleveld, Josbert M Metselaar, Thomas Reinheckel, Peter M Hoogerbrugge, Otto C Boerman, Frank N van Leeuwen. In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2017 02; 58(2):214-220. doi:
10.2967/jnumed.116.177741. [PMID: 27493268] - Laurence Rozen, Denis Noubouossie, Laurence Dedeken, Sophie Huybrechts, Phu Quoc Lê, Alina Ferster, Anne Demulder. Different profile of thrombin generation in children with acute lymphoblastic leukaemia treated with native or pegylated asparaginase: A cohort study.
Pediatric blood & cancer.
2017 02; 64(2):294-301. doi:
10.1002/pbc.26228. [PMID: 27605400] - Ana Tinoco, Artur Ribeiro, César Oliveira, Pier Parpot, Andreia Gomes, Artur Cavaco-Paulo. Albumin/asparaginase capsules prepared by ultrasound to retain ammonia.
Applied microbiology and biotechnology.
2016 Nov; 100(22):9499-9508. doi:
10.1007/s00253-016-7668-4. [PMID: 27314846] - Nikolaos E Labrou, Magdy Mohamed Muharram. Biochemical characterization and immobilization of Erwinia carotovoral-asparaginase in a microplate for high-throughput biosensing of l-asparagine.
Enzyme and microbial technology.
2016 Oct; 92(?):86-93. doi:
10.1016/j.enzmictec.2016.06.013. [PMID: 27542748] - Jingshi Wang, Yini Wang, Lin Wu, Jia Zhang, Wenyuan Lai, Zhao Wang. PEG-aspargase and DEP regimen combination therapy for refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.
Journal of hematology & oncology.
2016 09; 9(1):84. doi:
10.1186/s13045-016-0317-7. [PMID: 27613189] - Mousumee Panigrahi, Trupti Rekha Swain, Rabindra Kumar Jena, Ashutosh Panigrahi. L-asparaginase-induced abnormality in plasma glucose level in patients of acute lymphoblastic leukemia admitted to a tertiary care hospital of Odisha.
Indian journal of pharmacology.
2016 Sep; 48(5):595-598. doi:
10.4103/0253-7613.190762. [PMID: 27721550] - Sabine M Poppenborg, Julia Wittmann, Wolfgang Walther, Gunda Brandenburg, Ralf Krähmer, Joachim Baumgart, Frank Leenders. Impact of anti-PEG IgM antibodies on the pharmacokinetics of pegylated asparaginase preparations in mice.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Aug; 91(?):122-30. doi:
10.1016/j.ejps.2016.06.007. [PMID: 27292820] - Marina Bolzoni, Martina Chiu, Fabrizio Accardi, Rosanna Vescovini, Irma Airoldi, Paola Storti, Katia Todoerti, Luca Agnelli, Gabriele Missale, Roberta Andreoli, Massimiliano G Bianchi, Manfredi Allegri, Amelia Barilli, Francesco Nicolini, Albertina Cavalli, Federica Costa, Valentina Marchica, Denise Toscani, Cristina Mancini, Eugenia Martella, Valeria Dall'Asta, Gaetano Donofrio, Franco Aversa, Ovidio Bussolati, Nicola Giuliani. Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target.
Blood.
2016 08; 128(5):667-79. doi:
10.1182/blood-2016-01-690743. [PMID: 27268090] - Zhong-Ling Wei, Lai-Quan Huang, Yan Dai, Gui-Ping Su, Yi-Zhi Jiang, Dong-Ping Huang. [Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation for Treating Patient with Primary Cutaneous γΔ T Cell Lymphoma].
Zhongguo shi yan xue ye xue za zhi.
2016 Jun; 24(3):749-54. doi:
10.7534/j.issn.1009-2137.2016.03.021. [PMID: 27342503]
