1-(3-(9H-Carbazol-9-yl)propyl)-4-(2-methoxyphenyl)piperidin-4-ol (BioDeep_00001029732)
代谢物信息卡片
化学式: C27H30N2O2 (414.230716)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=CC=C1C2(CCN(CC2)CCCN3C4=CC=CC=C4C5=CC=CC=C53)O
InChI: InChI=1S/C27H30N2O2/c1-31-26-14-7-4-11-23(26)27(30)15-19-28(20-16-27)17-8-18-29-24-12-5-2-9-21(24)22-10-3-6-13-25(22)29/h2-7,9-14,30H,8,15-20H2,1H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhenze Liu, Qing Li, Ruling Shen, Lei Ci, Zhipeng Wan, Jiahao Shi, Qin Huang, Xu Yang, Mengjie Zhang, Hua Yang, Ruilin Sun, Zhugang Wang, Fang Huang, Tianfei Lu, Jian Fei. Betaine/GABA transporter-1 (BGT-1) deficiency in mouse prevents acute liver failure in vivo and hepatocytes apoptosis in vitro.
Biochimica et biophysica acta. Molecular basis of disease.
2020 03; 1866(3):165634. doi:
10.1016/j.bbadis.2019.165634. [PMID: 31830527] - Lars Jørgensen, Anas Al-Khawaja, Stefanie Kickinger, Stine B Vogensen, Jonas Skovgaard-Petersen, Emil Rosenthal, Nrupa Borkar, Rebekka Löffler, Karsten K Madsen, Hans Bräuner-Osborne, Arne Schousboe, Gerhard F Ecker, Petrine Wellendorph, Rasmus P Clausen. Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1).
Journal of medicinal chemistry.
2017 11; 60(21):8834-8846. doi:
10.1021/acs.jmedchem.7b00924. [PMID: 28991462] - Stine B Vogensen, Lars Jørgensen, Karsten K Madsen, Andreas Jurik, Nrupa Borkar, Emiliano Rosatelli, Birgitte Nielsen, Gerhard F Ecker, Arne Schousboe, Rasmus P Clausen. Structure activity relationship of selective GABA uptake inhibitors.
Bioorganic & medicinal chemistry.
2015 May; 23(10):2480-8. doi:
10.1016/j.bmc.2015.03.060. [PMID: 25882526] - Ayako Jinzenji, Chiharu Sogawa, Takuya Miyawaki, Xue-Fang Wen, Dan Yi, Kazumi Ohyama, Shigeo Kitayama, Norio Sogawa, Katsuya Morita. Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor.
Journal of pharmacological sciences.
2014; 125(2):217-26. doi:
10.1254/jphs.13146fp. [PMID: 24881960] - Kazuaki Nakada, Mamie Yoshikawa, Soichiro Ide, Akihiro Suemasa, Shuhei Kawamura, Takaaki Kobayashi, Eiji Masuda, Yoshihiko Ito, Wataru Hayakawa, Takahiro Katayama, Shizuo Yamada, Mitsuhiro Arisawa, Masabumi Minami, Satoshi Shuto. Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports.
Bioorganic & medicinal chemistry.
2013 Sep; 21(17):4938-50. doi:
10.1016/j.bmc.2013.06.063. [PMID: 23886812] - Eva S Schaffert, Georg Höfner, Klaus T Wanner. Aminomethyltetrazoles as potential inhibitors of the γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.
Bioorganic & medicinal chemistry.
2011 Nov; 19(21):6492-504. doi:
10.1016/j.bmc.2011.08.039. [PMID: 21940173] - N O Dalby, C Thomsen, A Fink-Jensen, J Lundbeck, B Søkilde, C M Man, P O Sørensen, B Meldrum. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1.
Epilepsy research.
1997 Jul; 28(1):51-61. doi:
10.1016/s0920-1211(97)00033-8. [PMID: 9255599] - C Thomsen, P O Sørensen, J Egebjerg. 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.
British journal of pharmacology.
1997 Mar; 120(6):983-5. doi:
10.1038/sj.bjp.0700957. [PMID: 9134205]