Ferriheme hydroxide (BioDeep_00001029428)
代谢物信息卡片
Ferriheme hydroxide
化学式: C34H34FeN4O5 (634.1878464)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C(=C3CCC(=O)O)C)CCC(=O)O.O.[Fe+2]
InChI: +2
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jian Wang, Diheng Gu, Ke Jin, Hualong Shen, Yaohua Qian. Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage.
Neuroreport.
2024 Jun; 35(9):590-600. doi:
10.1097/wnr.0000000000002035. [PMID: 38652514] - Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa. Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation.
Journal of pharmacological sciences.
2024 Jun; 155(2):44-51. doi:
10.1016/j.jphs.2024.04.001. [PMID: 38677785] - Bicheng Li, Minqiao Lu, Hui Wang, Siqi Sheng, Shuyuan Guo, Jia Li, Ye Tian. Macrophage Ferroptosis Promotes MMP2/9 Overexpression Induced by Hemin in Hemorrhagic Plaque.
Thrombosis and haemostasis.
2024 Jun; 124(6):568-580. doi:
10.1055/a-2173-3602. [PMID: 37696298] - Sheng-Yun Wu, Ke-Ru Cheng, Yan-Yun Zhou, Yin-Fang Wang. [Microtubule-associated tumor suppressor 1 inhibits hemin-induced apoptosis of vascular endothelial cells via hemeoxygenase 1].
Sheng li xue bao : [Acta physiologica Sinica].
2024 Apr; 76(2):215-223. doi:
". [PMID: 38658371] - Rajendra P Giri, Subhadip Chowdhury, Mrinmay K Mukhopadhyay, Abhijit Chakrabarti, Milan K Sanyal. Ganglioside GM1 Drives Hemin and Protoporphyrin Adsorption in Phospholipid Membranes: A Structural Study.
The journal of physical chemistry. B.
2024 Mar; 128(11):2745-2754. doi:
10.1021/acs.jpcb.3c08239. [PMID: 38447189] - Li Lin, Xiao-Na Li, Zhen-Yan Xie, Yong-Zhen Hu, Qing-Shan Long, Yi-Qi Wen, Xiao-Bing Wei, Li-Yang Zhang, Xue-Song Li. Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage.
Journal of molecular neuroscience : MN.
2024 Feb; 74(1):24. doi:
10.1007/s12031-023-02187-y. [PMID: 38386166] - Jiayi Jiang, Bin Wang, Linghuan Luo, Na Ying, Gaofan Shi, Mengmeng Zhang, Haoyuan Su, Dongdong Zeng. A two-step electrochemical biosensor based on Tetrazyme for the detection of fibrin.
Biotechnology and applied biochemistry.
2024 Feb; 71(1):193-201. doi:
10.1002/bab.2531. [PMID: 37904286] - Xiao-Yu Zhu, Tian-Yu Wang, Hao-Ran Jia, Shun-Yu Wu, Cheng-Zhe Gao, Yan-Hong Li, Xinping Zhang, Bai-Hui Shan, Fu-Gen Wu. A ferroptosis-reinforced nanocatalyst enhances chemodynamic therapy through dual H2O2 production and oxidative stress amplification.
Journal of controlled release : official journal of the Controlled Release Society.
2024 Jan; ?(?):. doi:
10.1016/j.jconrel.2024.01.049. [PMID: 38278369] - Fengyan Meng, Naijie Feng, Dianfeng Zheng, Meiling Liu, Hang Zhou, Rongjun Zhang, XiXin Huang, Anqi Huang. Exogenous Hemin enhances the antioxidant defense system of rice by regulating the AsA-GSH cycle under NaCl stress.
PeerJ.
2024; 12(?):e17219. doi:
10.7717/peerj.17219. [PMID: 38650645] - Ya-Di Yang, Naihao Lu, Rong Tian. The interaction of perfluorooctane sulfonate with hemoproteins and its relevance to molecular toxicology.
International journal of biological macromolecules.
2024 Jan; 254(Pt 3):128069. doi:
10.1016/j.ijbiomac.2023.128069. [PMID: 37967600] - Juxing Qi, Chengjie Meng, Jianbing Mo, Taotao Shou, Liang Ding, Tongle Zhi. CircAFF2 Promotes Neuronal Cell Injury in Intracerebral Hemorrhage by Regulating the miR-488/CLSTN3 Axis.
Neuroscience.
2023 Dec; 535(?):75-87. doi:
10.1016/j.neuroscience.2023.10.014. [PMID: 37884088] - Qiang Wang, Dong-Kun Zheng, Shu-Ping Jiang, Jing Li, Zhen Xie, Lu-Hua He, Lin Liu, Yang Liu. Lycopodium Alkaloids from Phlegmariurus carinatus with Cytotoxic and Neuroprotective Effects.
Chemistry & biodiversity.
2023 Nov; ?(?):e202301449. doi:
10.1002/cbdv.202301449. [PMID: 37966166] - Hui-Min Zhao, Dian-Feng Zheng, Nai-Jie Feng, Guang-Sheng Zhou, Aaqil Khan, Xu-Tong Lu, Peng Deng, Hang Zhou, You-Wei Du. Regulatory effects of Hemin on prevention and rescue of salt stress in rapeseed (Brassica napus L.) seedlings.
BMC plant biology.
2023 Nov; 23(1):558. doi:
10.1186/s12870-023-04595-z. [PMID: 37957575] - Qianwen Guo, Ziyue Yin, Junfei Cheng, Xiaojing Zhang, Rong Wang, Wenbin Li. Protective effect of heme chloride on hypoxia-induced tissue injury in mice.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2023 Oct; 48(10):1437-1444. doi:
10.11817/j.issn.1672-7347.2023.230204. [PMID: 38432874] - Yunxiang Yan, Yong Liu, Juanjuan Li, Ye Li, Haoheng Wu, Hong Li, Xiang Ma, Yanqiong Tang, Yuan Tong, Kexian Yi, Quanfeng Liang, Zhu Liu. A Molecular Switch-Integrated Nanoplatform Enables Photo-Unlocked Antibacterial Drug Delivery for Synergistic Abscess Therapy.
Advanced healthcare materials.
2023 10; 12(27):e2301157. doi:
10.1002/adhm.202301157. [PMID: 37392145] - Jiaming Zhang, Yangyang Jia, Wenjin Wu, Yingying Zhang, Ping Chen, Xiaofang Li, Xuetuan Wei, Chunmei Li, Kaikai Li. Influence of hemin on structure and emulsifying properties of soybean protein isolate.
Food chemistry.
2023 Sep; 421(?):136183. doi:
10.1016/j.foodchem.2023.136183. [PMID: 37116442] - Hong Liu, Xuliang Yang, Bo Huang, Hongxiang Liu. A universal approach for synthesis of copper nanoclusters templated by G-rich oligonucleotide sequences and their applications in sensing.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2023 Sep; 297(?):122740. doi:
10.1016/j.saa.2023.122740. [PMID: 37080047] - Yan Zhang, Yang Liu, V Wee Yong, Mengzhou Xue. Omarigliptin inhibits brain cell ferroptosis after intracerebral hemorrhage.
Scientific reports.
2023 09; 13(1):14339. doi:
10.1038/s41598-023-41635-y. [PMID: 37658227] - Yongdong Dai, Xiang Lin, Na Liu, Libing Shi, Feng Zhuo, Qianmeng Huang, Weijia Gu, Fanxuan Zhao, Yi Zhang, Yinli Zhang, Yinbin Pan, Songying Zhang. Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis-associated infertility patients.
The Journal of pathology.
2023 07; 260(3):248-260. doi:
10.1002/path.6079. [PMID: 36992523] - G P Coló, K Schweitzer, G M Oresti, E G Alonso, L Fernández Chávez, M Mascaró, G Giorgi, A C Curino, M M Facchinetti. Proteomic analysis of the effect of hemin in breast cancer.
Scientific reports.
2023 06; 13(1):10091. doi:
10.1038/s41598-023-35125-4. [PMID: 37344532] - Lili Huang, Tongtong Nie, Lixian Jiang, Ying Chen, Yixuan Zhou, Xiaojun Cai, Yuanyi Zheng, Longchen Wang, Jianrong Wu, Tao Ying. Acidity-Biodegradable Iridium-Coordinated Nanosheets for Amplified Ferroptotic Cell Death Through Multiple Regulatory Pathways.
Advanced healthcare materials.
2023 04; 12(10):e2202562. doi:
10.1002/adhm.202202562. [PMID: 36610060] - Yang Yu, Xinghui Li, Xiuquan Wu, Xinglong Li, Jialiang Wei, Xianjin Chen, Zhouyuan Sun, Qinghua Zhang. Sodium hydrosulfide inhibits hemin-induced ferroptosis and lipid peroxidation in BV2 cells via the CBS/H2S system.
Cellular signalling.
2023 Apr; 104(?):110594. doi:
10.1016/j.cellsig.2023.110594. [PMID: 36646297] - L Zhu, S Sun, W Wu, Y Zhang, C Lin, L Ji. Xanthotoxol alleviates secondary brain injury after intracerebral hemorrhage by inhibiting microglia-mediated neuroinflammation and oxidative stress.
Neuro-Chirurgie.
2023 Mar; 69(3):101426. doi:
10.1016/j.neuchi.2023.101426. [PMID: 36921390] - Sherif Elsabbagh, Marius Landau, Harald Gross, Anita Schultz, Joachim E Schultz. Heme b inhibits class III adenylyl cyclases.
Cellular signalling.
2023 Mar; 103(?):110568. doi:
10.1016/j.cellsig.2022.110568. [PMID: 36565898] - Yanhong Su, Zhao Zhang, Leo Tsz On Lee, Ling Peng, Ligong Lu, Xu He, Xuanjun Zhang. Amphiphilic Dendrimer Doping Enhanced pH-Sensitivity of Liposomal Vesicle for Effective Co-delivery toward Synergistic Ferroptosis-Apoptosis Therapy of Hepatocellular Carcinoma.
Advanced healthcare materials.
2023 01; 12(6):e2202663. doi:
10.1002/adhm.202202663. [PMID: 36653312] - Fahong Yun, Dengjing Huang, Meiling Zhang, Chunlei Wang, Yuzheng Deng, Rong Gao, Xuemei Hou, Zesheng Liu, Weibiao Liao. Comprehensive transcriptome analysis unravels the crucial genes during adventitious root development induced by carbon monoxide in Cucumis sativus L.
Molecular biology reports.
2022 Dec; 49(12):11327-11340. doi:
10.1007/s11033-022-07797-0. [PMID: 35906509] - Nahla E El-Ashmawy, Ghada M Al-Ashmawy, Amr A Farag, Amera O Ibrahim. Hemin versus erythropoietin: Possible role in Nrf2/HO-1 signaling pathway in rats with nephrotoxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Dec; 156(?):113971. doi:
10.1016/j.biopha.2022.113971. [PMID: 36411647] - Rong Tian, Lan Zhou, Naihao Lu. Binding of Quercetin to Hemoglobin Reduced Hemin Release and Lipid Oxidation.
Journal of agricultural and food chemistry.
2022 Oct; 70(40):12925-12934. doi:
10.1021/acs.jafc.2c04129. [PMID: 36169386] - Pakawit Lerksaipheng, Kittiphong Paiboonsukwong, Pimtip Sanvarinda, Rataya Leuchapudiporn, Ken-Ichi Yamada, Noppawan Phumala Morales. Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113624. doi:
10.1016/j.biopha.2022.113624. [PMID: 36057220] - Zhigang Ke, Yiwen Bai, Hao Zhu, Xingwei Xiang, Shulai Liu, Xuxia Zhou, Yuting Ding. Characteristics of myoglobin degradation by cold plasma and its pro-oxidative activity on lipid in washed fish muscle.
Food chemistry.
2022 Sep; 389(?):132972. doi:
10.1016/j.foodchem.2022.132972. [PMID: 35500412] - K Zarean Mousaabadi, Ali A Ensafi, Behzad Rezaei. Simultaneous determination of some opioid drugs using Cu-hemin MOF@MWCNTs as an electrochemical sensor.
Chemosphere.
2022 Sep; 303(Pt 3):135149. doi:
10.1016/j.chemosphere.2022.135149. [PMID: 35660395] - Shenwu Zhang, Xinxin Sun, Ziyue Wang, Jin Sun, Zhonggui He, Bingjun Sun, Cong Luo. Molecularly Self-Engineered Nanoamplifier for Boosting Photodynamic Therapy via Cascade Oxygen Elevation and Lipid ROS Accumulation.
ACS applied materials & interfaces.
2022 Aug; 14(34):38497-38505. doi:
10.1021/acsami.2c09209. [PMID: 35977115] - Semhar Ghirmai, Haizhou Wu, Michael Axelsson, Takashi Matsuhira, Hiromi Sakai, Ingrid Undeland. Exploring how plasma- and muscle-related parameters affect trout hemolysis as a route to prevent hemoglobin-mediated lipid oxidation of fish muscle.
Scientific reports.
2022 08; 12(1):13446. doi:
10.1038/s41598-022-16363-4. [PMID: 35927386] - Zhao Gao, Ziyue Zhang, Daqian Gu, Yunqian Li, Kun Zhang, Xiaoli Dong, Lingli Liu, Jiye Zhang, Jimin Chen, Duozhi Wu, Min Zeng. Hemin mitigates contrast-induced nephropathy by inhibiting ferroptosis via HO-1/Nrf2/GPX4 pathway.
Clinical and experimental pharmacology & physiology.
2022 Aug; 49(8):858-870. doi:
10.1111/1440-1681.13673. [PMID: 35598290] - Naidu Babu Ommi, Maaged Abdullah, Lalitha Guruprasad, Phanithi Prakash Babu. Docosahexaenoic acid is potent against the growth of mature stages of Plasmodium falciparum; inhibition of hematin polymerization a possible target.
Parasitology international.
2022 Aug; 89(?):102581. doi:
10.1016/j.parint.2022.102581. [PMID: 35395394] - Ana Díaz-Fernández, Elena E Ferapontova. Covalent Hemin/G4 complex-linked sandwich bioassay on magnetic beads for femtomolar HER-2/neu detection in human serum via direct electrocatalytic reduction of oxygen.
Analytica chimica acta.
2022 Aug; 1219(?):340049. doi:
10.1016/j.aca.2022.340049. [PMID: 35715131] - Amir M Alsharabasy, Sharon Glynn, Pau Farràs, Abhay Pandit. Protein nitration induced by Hemin/NO: A complementary mechanism through the catalytic functions of hemin and NO-scavenging.
Nitric oxide : biology and chemistry.
2022 07; 124(?):49-67. doi:
10.1016/j.niox.2022.04.005. [PMID: 35513288] - Xuanxiang Mao, Fangni He, Dehui Qiu, Shijiong Wei, Rengan Luo, Yun Chen, Xiaobo Zhang, Jianping Lei, David Monchaud, Jean-Louis Mergny, Huangxian Ju, Jun Zhou. Efficient Biocatalytic System for Biosensing by Combining Metal-Organic Framework (MOF)-Based Nanozymes and G-Quadruplex (G4)-DNAzymes.
Analytical chemistry.
2022 05; 94(20):7295-7302. doi:
10.1021/acs.analchem.2c00600. [PMID: 35549161] - Lan Yang, Xingyan Ye, Xiating Li, Zhihong Huang, Fengping Chen, Weijuan Yang, Zongwen Wang. Colorimetric aptasensor for sensitive detection of quinclorac based on exonuclease III-assisted cyclic release of phosphorodiamidate morpholino oligomer mimic enzyme strategy.
Analytica chimica acta.
2022 May; 1207(?):339815. doi:
10.1016/j.aca.2022.339815. [PMID: 35491044] - Fatma F Ali, Sahar A Mokhemer, Doaa M Elroby Ali. Administration of hemin ameliorates ovarian ischemia reperfusion injury via modulation of heme oxygenase-1 and p-JNK/p-NF-κBp65/iNOS signaling pathway.
Life sciences.
2022 May; 296(?):120431. doi:
10.1016/j.lfs.2022.120431. [PMID: 35218766] - Nana Su, Ze Liu, Lu Wang, Yuanyuan Liu, Mengyang Niu, Xin Chen, Jin Cui. Improving the anthocyanin accumulation of hypocotyls in radish sprouts by hemin-induced NO.
BMC plant biology.
2022 Apr; 22(1):224. doi:
10.1186/s12870-022-03605-w. [PMID: 35490232] - Shion Imoto, Tohru Sawamura, Yukiko Shibuya, Mari Kono, Ayako Ohbuchi, Takashi Suzuki, Yuji Mizokoshi, Katsuyasu Saigo. Labile iron, ROS, and cell death are prominently induced by haemin, but not by non-transferrin-bound iron.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2022 Apr; 61(2):103319. doi:
10.1016/j.transci.2021.103319. [PMID: 34801431] - Guilherme C Lechuga, Paloma Napoleão-Pêgo, Carlos M Morel, David W Provance, Salvatore G De-Simone. New Insights into Hemopexin-Binding to Hemin and Hemoglobin.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073789. [PMID: 35409149] - Nuanfei Zhu, Chengbin Liu, Rui Liu, Xiangheng Niu, Dinghui Xiong, Kun Wang, Daqiang Yin, Zhen Zhang. Biomimic Nanozymes with Tunable Peroxidase-like Activity Based on the Confinement Effect of Metal-Organic Frameworks (MOFs) for Biosensing.
Analytical chemistry.
2022 03; 94(11):4821-4830. doi:
10.1021/acs.analchem.2c00058. [PMID: 35262349] - Xueqing Lei, Zhiwei Qin, Bo Ye, Yao Wu, Ling Liu. Effect of pH on lipid oxidation mediated by hemoglobin in washed chicken muscle.
Food chemistry.
2022 Mar; 372(?):131253. doi:
10.1016/j.foodchem.2021.131253. [PMID: 34818728] - Vasiliki-Dimitra C Tsolaki, Sofia K Georgiou-Siafis, Athina I Tsamadou, Stefanos A Tsiftsoglou, Martina Samiotaki, George Panayotou, Asterios S Tsiftsoglou. Hemin accumulation and identification of a heme-binding protein clan in K562 cells by proteomic and computational analysis.
Journal of cellular physiology.
2022 02; 237(2):1315-1340. doi:
10.1002/jcp.30595. [PMID: 34617268] - Laura E Diepeveen, Gaby Stegemann, Erwin T Wiegerinck, Rian Roelofs, Myrthe Naber, Olivier Lóreal, Bart Smeets, Frank Thévenod, Dorine W Swinkels, Rachel P L van Swelm. Investigating the Molecular Mechanisms of Renal Hepcidin Induction and Protection upon Hemoglobin-Induced Acute Kidney Injury.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031352. [PMID: 35163276] - Wen Yang, Zixiang Huang, Zhifei Xu, Xin Ma, Shan Huang, Jingying Li, Juan Li, Huanghao Yang. Selective and Nongenetic Peroxidase Tag of Membrane Protein: a Nucleic Acid Tool for Proximity Labeling.
Analytical chemistry.
2022 01; 94(2):1101-1107. doi:
10.1021/acs.analchem.1c04148. [PMID: 34968407] - Waleed Abdelbagi Almahi, K N Yu, Fathelrahman Mohammed, Peizhong Kong, Wei Han. Hemin enhances radiosensitivity of lung cancer cells through ferroptosis.
Experimental cell research.
2022 01; 410(1):112946. doi:
10.1016/j.yexcr.2021.112946. [PMID: 34826424] - Hui Yang, Li Zhang, Jie Chen, Xiaoqian Zhang, Zhongfu Zhao, Longfeng Zhao. Heme Oxygenase-1 Inhibits the Proliferation of Hepatic Stellate Cells by Activating PPARγ and Suppressing NF-κB.
Computational and mathematical methods in medicine.
2022; 2022(?):8920861. doi:
10.1155/2022/8920861. [PMID: 35047060] - Xu Zhao, Dongge Qiao, Dongsheng Guan, Kun Wang, Yinglin Cui. Chrysophanol Ameliorates Hemin-Induced Oxidative Stress and Endoplasmic Reticulum Stress by Regulating MicroRNA-320-5p/Wnt3a Pathway in HT22 Cells.
Oxidative medicine and cellular longevity.
2022; 2022(?):9399658. doi:
10.1155/2022/9399658. [PMID: 35936221] - Yue Tang, Xiaohuan Huang, Xueli Wang, Chunxiao Wang, Han Tao, Yuangen Wu. G-quadruplex DNAzyme as peroxidase mimetic in a colorimetric biosensor for ultrasensitive and selective detection of trace tetracyclines in foods.
Food chemistry.
2022 Jan; 366(?):130560. doi:
10.1016/j.foodchem.2021.130560. [PMID: 34284183] - Wenqin Chen, Zhiyang Li, Wenqian Cheng, Tao Wu, Jia Li, Xinyu Li, Lin Liu, Huijie Bai, Shijia Ding, Xinmin Li, Xiaolin Yu. Surface plasmon resonance biosensor for exosome detection based on reformative tyramine signal amplification activated by molecular aptamer beacon.
Journal of nanobiotechnology.
2021 Dec; 19(1):450. doi:
10.1186/s12951-021-01210-x. [PMID: 34952586] - Jiarong Zhang, Qilan Xu, Wei Pei, Ling Cai, Xinyu Yu, Huijun Jiang, Jin Chen. Self-assembled recombinant camel serum albumin nanoparticles-encapsulated hemin with peroxidase-like activity for colorimetric detection of hydrogen peroxide and glucose.
International journal of biological macromolecules.
2021 Dec; 193(Pt B):2103-2112. doi:
10.1016/j.ijbiomac.2021.11.042. [PMID: 34793815] - Dong-Hwi Kim, Hee-Seop Ahn, Hyeon-Jeong Go, Da-Yoon Kim, Jae-Hyeong Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Sang-Do Ha, Changsun Choi, In-Soo Choi. Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction.
Scientific reports.
2021 11; 11(1):21462. doi:
10.1038/s41598-021-01054-3. [PMID: 34728736] - Huifeng Zheng, Xiaoting Liang, Qian Han, Zhuang Shao, Yuxiao Zhang, Linli Shi, Yimei Hong, Weifeng Li, Cong Mai, Qingwen Mo, Qingling Fu, Xiaoxue Ma, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang. Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence.
Journal of nanobiotechnology.
2021 Oct; 19(1):332. doi:
10.1186/s12951-021-01077-y. [PMID: 34674708] - Qing Wang, Naijie Wei, Jingru Guo, Kai Feng, Yin Kwan Wong, Jingwei Zhang, Jigang Wang, Xiaolian Sun. Hemin-lipid assembly as an artemisinin oral delivery system for enhanced cancer chemotherapy and immunotherapy.
Nanoscale.
2021 Aug; 13(31):13231-13240. doi:
10.1039/d1nr01302e. [PMID: 34477731] - Guilherme C Lechuga, Franklin Souza-Silva, Carolina Q Sacramento, Monique R O Trugilho, Richard H Valente, Paloma Napoleão-Pêgo, Suelen S G Dias, Natalia Fintelman-Rodrigues, Jairo R Temerozo, Nicolas Carels, Carlos R Alves, Mirian C S Pereira, David W Provance, Thiago M L Souza, Salvatore G De-Simone. SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22169035. [PMID: 34445741] - Yufen Lai, Mengyan Li, Xiaofei Liao, Li Zou. Smartphone-Assisted Colorimetric Detection of Glutathione and Glutathione Reductase Activity in Human Serum and Mouse Liver Using Hemin/G-Quadruplex DNAzyme.
Molecules (Basel, Switzerland).
2021 Aug; 26(16):. doi:
10.3390/molecules26165016. [PMID: 34443603] - Kamila Malecka, Elena E Ferapontova. Femtomolar Detection of Thrombin in Serum and Cerebrospinal Fluid via Direct Electrocatalysis of Oxygen Reduction by the Covalent G4-Hemin-Aptamer Complex.
ACS applied materials & interfaces.
2021 Aug; 13(32):37979-37988. doi:
10.1021/acsami.1c03784. [PMID: 33878266] - Tianrun Zheng, Junyi Zhan, Ming Yang, Maojia Wang, Wenjun Sun, Zhi Shan, Hui Chen. Hemin-induced increase in saponin content contributes to the alleviation of osmotic and cold stress damage to Conyza blinii in a heme oxygenase 1-dependent manner.
Journal of Zhejiang University. Science. B.
2021 Aug; 22(8):682-694. doi:
10.1631/jzus.b2000697. [PMID: 34414702] - Satsuki Obara, Keita Nakane, Chizu Fujimura, Shusuke Tomoshige, Minoru Ishikawa, Shinichi Sato. Functionalization of Human Serum Albumin by Tyrosine Click.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168676. [PMID: 34445381] - Abdulla A-B Badawy. Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.
Bioscience reports.
2021 07; 41(7):. doi:
10.1042/bsr20210935. [PMID: 34251022] - Rui Zhang, Jie Wu, Hang Ao, Jinling Fu, Bin Qiao, Qiang Wu, Huangxian Ju. A Rolling Circle-Amplified G-Quadruplex/Hemin DNAzyme for Chemiluminescence Immunoassay of the SARS-CoV-2 Protein.
Analytical chemistry.
2021 07; 93(28):9933-9938. doi:
10.1021/acs.analchem.1c02229. [PMID: 34227801] - Zhijuan Yang, Yujie Zhu, Ziliang Dong, Wei Li, Nailin Yang, Xianwen Wang, Liangzhu Feng, Zhuang Liu. Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses.
Nature communications.
2021 07; 12(1):4299. doi:
10.1038/s41467-021-24604-9. [PMID: 34262038] - Hao Wu, Jun Wu, Hongyong Wang, Yaling Liu, Guoqing Han, Pei Zou. Sensitive and label-free chemiluminescence detection of malathion using exonuclease-assisted dual signal amplification and G-quadruplex/hemin DNAzyme.
Journal of hazardous materials.
2021 06; 411(?):124784. doi:
10.1016/j.jhazmat.2020.124784. [PMID: 33450635] - Yumeng Yang, Shaowei Liu, Xiaofeng Cui, Li Yang, Jianli Zhang, Xiaoxia Mao, Yingchun Gao. Sensitive detection of miRNA based on enzyme-propelled multiple photoinduced electron transfer strategy.
Mikrochimica acta.
2021 06; 188(6):219. doi:
10.1007/s00604-021-04874-2. [PMID: 34075480] - Sheila Maestro, Karol M Córdoba, Cristina Olague, Josepmaria Argemi, Matías A Ávila, Gloria González-Aseguinolaza, Cristian Smerdou, Antonio Fontanellas. Heme oxygenase-1 inducer hemin does not inhibit SARS-CoV-2 virus infection.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111384. doi:
10.1016/j.biopha.2021.111384. [PMID: 33761605] - Nantawat Tatiyaborworntham, Jie Yin, Mark P Richards. Factors influencing the antioxidant effect of phospholipase A2 against lipid oxidation promoted by trout hemoglobin and hemin in washed muscle.
Food chemistry.
2021 May; 343(?):128428. doi:
10.1016/j.foodchem.2020.128428. [PMID: 33131955] - Yahiya Y Syed. Givosiran: A Review in Acute Hepatic Porphyria.
Drugs.
2021 May; 81(7):841-848. doi:
10.1007/s40265-021-01511-3. [PMID: 33871817] - Guiyin Li, Huafu Feng, Xiaohang Shi, Min Chen, Jintao Liang, Zhide Zhou. Highly sensitive electrochemical aptasensor for Glypican-3 based on reduced graphene oxide-hemin nanocomposites modified on screen-printed electrode surface.
Bioelectrochemistry (Amsterdam, Netherlands).
2021 Apr; 138(?):107696. doi:
10.1016/j.bioelechem.2020.107696. [PMID: 33254049] - Vincent Normant, Ariane Brault, Mariano Avino, Thierry Mourer, Tobias Vahsen, Jude Beaudoin, Simon Labbé. Hemeprotein Tpx1 interacts with cell-surface heme transporter Str3 in Schizosaccharomyces pombe.
Molecular microbiology.
2021 04; 115(4):699-722. doi:
10.1111/mmi.14638. [PMID: 33140466] - Shemsu Ligani Fereja, Zhongying Fang, Ping Li, Jinhan Guo, Tadesse Haile Fereja, Wei Chen. 'Turn-off' sensing probe based on fluorescent gold nanoclusters for the sensitive detection of hemin.
Analytical and bioanalytical chemistry.
2021 Mar; 413(6):1639-1649. doi:
10.1007/s00216-020-03126-1. [PMID: 33483839] - Charles M Bridges, Daniel J Gage. Development and application of aerobic, chemically defined media for Dysgonomonas.
Anaerobe.
2021 Feb; 67(?):102302. doi:
10.1016/j.anaerobe.2020.102302. [PMID: 33271360] - Maxime Rossi, Michael Piagnerelli, Alain Van Meerhaeghe, Karim Zouaoui Boudjeltia. Heme oxygenase-1 (HO-1) cytoprotective pathway: A potential treatment strategy against coronavirus disease 2019 (COVID-19)-induced cytokine storm syndrome.
Medical hypotheses.
2020 Nov; 144(?):110242. doi:
10.1016/j.mehy.2020.110242. [PMID: 33254548] - Hongxia Li, Dongyao Wang, Huiwen Wu, Hui Shen, Diya Lv, Yinyin Zhang, Hongtao Lu, Jianxin Yang, Yuxiao Tang, Min Li. SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes.
Metabolism: clinical and experimental.
2020 09; 110(?):154306. doi:
10.1016/j.metabol.2020.154306. [PMID: 32621820] - Vandana Thakur, Sumit Jamwal, Mandeep Kumar, Vikrant Rahi, Puneet Kumar. Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.
Neurotoxicity research.
2020 Aug; 38(2):359-369. doi:
10.1007/s12640-020-00231-y. [PMID: 32506340] - Ion Romulus Scorei, Andrei Biţă, George Dan Mogoşanu. Letter to the Editor: Boron enhances the antiviral activity of the curcumin against SARS-CoV-2.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.
2020 Jul; 61(3):967-970. doi:
10.47162/rjme.61.3.39. [PMID: 33817742] - Kai Wang, Yuting Liang, Yu Su, Liping Wang. DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway.
The Biochemical journal.
2020 06; 477(12):2363-2381. doi:
10.1042/bcj20200402. [PMID: 32510127] - Hongli Shi, Jianyuan Dai, Fang Wang, Yushun Xia, Dan Xiao, Cuisong Zhou. Rapid and colorimetric detection of nucleic acids based on entropy-driven circuit and DNAzyme-mediated autocatalytic reactions.
Analytical methods : advancing methods and applications.
2020 06; 12(21):2779-2784. doi:
10.1039/d0ay00341g. [PMID: 32930309] - Xinyu Yu, Zhihui Xu, Xi Wang, Qilan Xu, Jin Chen. Bactrian camel serum albumins-based nanocomposite as versatile biocargo for drug delivery, biocatalysis and detection of hydrogen peroxide.
Materials science & engineering. C, Materials for biological applications.
2020 Apr; 109(?):110627. doi:
10.1016/j.msec.2020.110627. [PMID: 32229010] - José Bustos, Ledmar Vargas, Ricardo Quintero. Acute intermittent porphyria: A case report.
Biomedica : revista del Instituto Nacional de Salud.
2020 03; 40(1):14-19. doi:
10.7705/biomedica.4767. [PMID: 32220159] - Syeda Anum Fatima, Humaira Jurair, Qalab Abbas, Arshalooz Jamila Rehman. Paediatric porphyria and human hemin: a treatment challenge in a lower middle income country.
BMJ case reports.
2020 Jan; 13(1):. doi:
10.1136/bcr-2019-232236. [PMID: 31919062] - Rui Deng, Yaming Liu, Haiwei He, Hao Zhang, Chenling Zhao, Zhen Cui, Yimei Hong, Xin Li, Fang Lin, Dongsheng Yuan, Xiaoting Liang, Yuelin Zhang. Haemin pre-treatment augments the cardiac protection of mesenchymal stem cells by inhibiting mitochondrial fission and improving survival.
Journal of cellular and molecular medicine.
2020 01; 24(1):431-440. doi:
10.1111/jcmm.14747. [PMID: 31660694] - Hea-Jong Chung, Hyeon-Jin Kim, Seong-Tshool Hong. Tumor-specific delivery of a paclitaxel-loading HSA-haemin nanoparticle for cancer treatment.
Nanomedicine : nanotechnology, biology, and medicine.
2020 01; 23(?):102089. doi:
10.1016/j.nano.2019.102089. [PMID: 31487550] - Shinichi Sato, Hiroyuki Nakamura. Labeling of Peroxide-Induced Oxidative Stress Hotspots by Hemin-Catalyzed Tyrosine Click.
Chemical & pharmaceutical bulletin.
2020; 68(9):885-890. doi:
10.1248/cpb.c20-00434. [PMID: 32879229] - Zhen Zhen, Jin-Wen Liu, Qian Wen, Zhan Wu, Jian-Hui Jiang. Homogeneous label-free protein binding assay using small-molecule-labeled DNA nanomachine with DNAzyme-Based chemiluminescence detection.
Talanta.
2020 Jan; 206(?):120175. doi:
10.1016/j.talanta.2019.120175. [PMID: 31514861] - Haohan Chen, Xiaofan Sun, Rongfeng Cai, Yaping Tian, Nandi Zhou. Switchable DNA tweezer and G-quadruplex nanostructures for ultrasensitive voltammetric determination of the K-ras gene fragment.
Mikrochimica acta.
2019 11; 186(12):843. doi:
10.1007/s00604-019-3993-5. [PMID: 31768709] - Ling Lan, Rui-Li Wang, Li Liu, Liang Cheng. A label-free colorimetric detection of microRNA via G-quadruplex-based signal quenching strategy.
Analytica chimica acta.
2019 Nov; 1079(?):207-211. doi:
10.1016/j.aca.2019.06.063. [PMID: 31387713] - Karl E Anderson. Acute hepatic porphyrias: Current diagnosis & management.
Molecular genetics and metabolism.
2019 11; 128(3):219-227. doi:
10.1016/j.ymgme.2019.07.002. [PMID: 31311713] - Kyungeun Kim, Prestan Park, Ji Hoon Lee. Cost-effective monitoring of microRNA-205 applied as a biomarker using G-quadruplex DNAzyme and 1,1'-oxalyldiimidazole chemiluminescence.
Journal of pharmaceutical and biomedical analysis.
2019 Oct; 175(?):112780. doi:
10.1016/j.jpba.2019.112780. [PMID: 31351249] - Yaocai Wang, Luzhu Yang, Yanjun Wang, Wei Liu, Baoxin Li, Yan Jin. Target-controlled in situ formation of G-quadruplex DNAzyme for a sensitive visual assay of telomerase activity.
The Analyst.
2019 Oct; 144(20):5959-5964. doi:
10.1039/c9an01271k. [PMID: 31441909] - Nelci A de Moura, Brunno F R Caetano, Lucas T Bidinotto, Maria A M Rodrigues, Luis F Barbisan. Dietary hemin promotes colonic preneoplastic lesions and DNA damage but not tumor development in a medium-term model of colon carcinogenesis in rats.
Mutation research. Genetic toxicology and environmental mutagenesis.
2019 Oct; 846(?):403076. doi:
10.1016/j.mrgentox.2019.07.006. [PMID: 31585636] - Noppawan Phumala Morales, Pacharaporn Chunephisal, Jindaporn Janprasit, Yuma Ishida, Rataya Luechapudiporn, Ken-Ichi Yamada. Kinetics and localisation of haemin-induced lipoprotein oxidation.
Free radical research.
2019 Oct; 53(9-10):968-978. doi:
10.1080/10715762.2019.1660323. [PMID: 31452415] - Ricard Bou, Mar Llauger, Rachel Joosse, José Antonio García-Regueiro. Effect of high hydrostatic pressure on the oxidation of washed muscle with added chicken hemoglobin.
Food chemistry.
2019 Sep; 292(?):227-236. doi:
10.1016/j.foodchem.2019.04.067. [PMID: 31054669] - Xiaoyue Zhang, You Yu, Jinglin Shen, Wei Qi, Hua Wang. Fabrication of polyethyleneimine-functionalized reduced graphene oxide-hemin-bovine serum albumin (PEI-rGO-hemin-BSA) nanocomposites as peroxidase mimetics for the detection of multiple metabolites.
Analytica chimica acta.
2019 Sep; 1070(?):80-87. doi:
10.1016/j.aca.2019.04.028. [PMID: 31103170] - Urszula Śliwińska-Hill, Katarzyna Wiglusz. Multispectroscopic studies of the interaction of folic acid with glycated human serum albumin.
Journal of biomolecular structure & dynamics.
2019 09; 37(14):3731-3739. doi:
10.1080/07391102.2018.1526713. [PMID: 30238853] - Somanathapura K NaveenKumar, Mahadevappa Hemshekhar, Kempaiah Kemparaju, Kesturu S Girish. Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin.
Biochimica et biophysica acta. Molecular basis of disease.
2019 09; 1865(9):2303-2316. doi:
10.1016/j.bbadis.2019.05.009. [PMID: 31102787] - Zhengbo Zhu, Yifan Huang, Xue Wu, Zili Liu, Jianwen Zou, Yahua Chen, Nana Su, Jin Cui. Increased antioxidative capacity and decreased cadmium uptake contribute to hemin-induced alleviation of cadmium toxicity in Chinese cabbage seedlings.
Ecotoxicology and environmental safety.
2019 Aug; 177(?):47-57. doi:
10.1016/j.ecoenv.2019.03.113. [PMID: 30959312]