vibsanin B (BioDeep_00001029372)
代谢物信息卡片
化学式: C25H36O5 (416.2562606)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCCC1(CC=C(C(=O)C=CC(C(C=C1)OC(=O)C=C(C)C)(C)O)CO)C)C
InChI: InChI=1S/C25H36O5/c1-18(2)8-7-12-24(5)13-9-20(17-26)21(27)10-15-25(6,29)22(11-14-24)30-23(28)16-19(3)4/h8-11,14-16,22,26,29H,7,12-13,17H2,1-6H3/b14-11+,15-10+,20-9-/t22-,24+,25-/m1/s1
描述信息
A vibsane diterpenoid that is (2Z,6E,10E)-cycloundeca-2,6,10-trien-1-one which is substituted at positions 2, 5, 5, 8, 9, and 9 by hydroxymethyl, methyl, 2-methylpent-2-en-5-yl, 3-methylbut-2-enoyloxy, hydroxy, and methyl groups, respectively (the 5S,8R,9R stereoisomer). It has been found to inhibit root growth in rice seedlings (IC50 0.14 mM).
同义名列表
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiao-Bian Xue, Tian-Ming Lv, Jiao-Yang Hou, Dan-Qi Li, Xiao-Xiao Huang, Shao-Jiang Song, Guo-Dong Yao. Vibsane-type diterpenoids from Viburnum odoratissimum inhibit hepatocellular carcinoma cells via the PI3K/AKT pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 108(?):154499. doi:
10.1016/j.phymed.2022.154499. [PMID: 36270223] - Qingxiu He, Han Chu, Yuxuan Wang, Haiqiong Guo, Yuanqiang Wang, Siyi Wang, Zhiwei Feng, Xiang-Qun Xie, Yong Hu, Haibin Liu, Zhihua Lin. In silico design novel vibsanin B derivatives as inhibitor for heat shock protein 90 based on 3D-QSAR, molecular docking and molecular dynamics simulation.
Journal of biomolecular structure & dynamics.
2020 Sep; 38(14):4313-4324. doi:
10.1080/07391102.2019.1671900. [PMID: 31542999] - Li-Dong Shao, Jia Su, Baixin Ye, Jiang-Xin Liu, Zhi-Li Zuo, Yan Li, Yue-Ying Wang, Chengfeng Xia, Qin-Shi Zhao. Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors.
Journal of medicinal chemistry.
2017 11; 60(21):9053-9066. doi:
10.1021/acs.jmedchem.7b01395. [PMID: 29019670] - Bai-Xin Ye, Xu Deng, Li-Dong Shao, Ying Lu, Run Xiao, Yi-Jie Liu, Yi Jin, Yin-Yin Xie, Yan Zhao, Liu-Fei Luo, Shun Ma, Ming Gao, Lian-Ru Zhang, Juan He, Wei-Na Zhang, Yi Chen, Cheng-Feng Xia, Min Deng, Ting-Xi Liu, Qin-Shi Zhao, Sai-Juan Chen, Zhu Chen. Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950).
2015 May; 194(9):4489-97. doi:
10.4049/jimmunol.1402798. [PMID: 25810397] - Yoshiyasu Fukuyama, Hiromi Fujii, Hiroyuki Minami, Hironobu Takahashi, Miwa Kubo. Neovibsanin F and its congeners, rearranged vibsane-type diterpenes from Viburnum suspensum.
Journal of natural products.
2006 Jul; 69(7):1098-100. doi:
10.1021/np068005i. [PMID: 16872155]