Protoporphyrinate (BioDeep_00001029363)
代谢物信息卡片
Protoporphyrinate
化学式: C34H32N4O4-2 (560.2423431999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O
InChI: InChI=1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42)/p-2
描述信息
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
COVID info from COVID-19 Disease Map
D003879 - Dermatologic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Peiyu Xu, Jing Liu, Ying Yi, Zhi Cai, Yihua Yin, Weiquan Cai, Jingli Zhang, Zhixia Gong, Yaqi Xiao. A dew-responsive pectin-based herbicide for enhanced photodynamic inactivation.
Carbohydrate polymers.
2024 Jul; 336(?):122114. doi:
10.1016/j.carbpol.2024.122114. [PMID: 38670775] - Rajendra P Giri, Subhadip Chowdhury, Mrinmay K Mukhopadhyay, Abhijit Chakrabarti, Milan K Sanyal. Ganglioside GM1 Drives Hemin and Protoporphyrin Adsorption in Phospholipid Membranes: A Structural Study.
The journal of physical chemistry. B.
2024 Mar; 128(11):2745-2754. doi:
10.1021/acs.jpcb.3c08239. [PMID: 38447189] - Giovanni Genovese, Carlo Alberto Maronese, Chiara Moltrasio, Roberta Piccinno, Dario Antonio Marletta, Giacomo De Luca, Giovanna Graziadei, Francesca Granata, Elena Di Pierro, Maria Domenica Cappellini, Angelo Valerio Marzano. Ultraviolet A phototest positivity is associated with higher free erythrocyte protoporphyrin IX concentration and lower transferrin saturation values in erythropoietic protoporphyria.
Photodermatology, photoimmunology & photomedicine.
2022 Mar; 38(2):141-149. doi:
10.1111/phpp.12727. [PMID: 34420239] - Liyun Zeng, Qiongyan Zou, Peng Huang, Li Xiong, Yan Cheng, Qitong Chen, Yitong Li, Hongye He, Wenjun Yi, Wu Wei. Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Oct; 142(?):111994. doi:
10.1016/j.biopha.2021.111994. [PMID: 34411921] - Natalia Sh Lebedeva, Yury A Gubarev, Galina M Mamardashvili, Svetlana V Zaitceva, Sergey A Zdanovich, Alena S Malyasova, Julia V Romanenko, Mikhail O Koifman, Oskar I Koifman. Theoretical and experimental study of interaction of macroheterocyclic compounds with ORF3a of SARS-CoV-2.
Scientific reports.
2021 09; 11(1):19481. doi:
10.1038/s41598-021-99072-8. [PMID: 34593970] - Anna Walke, Simone König. Protoporphyrin IX purification from blood and serum for mass analysis - Considerations with respect to neurosurgery.
Rapid communications in mass spectrometry : RCM.
2021 09; 35(17):e9138. doi:
10.1002/rcm.9138. [PMID: 34089543] - Guilherme C Lechuga, Franklin Souza-Silva, Carolina Q Sacramento, Monique R O Trugilho, Richard H Valente, Paloma Napoleão-Pêgo, Suelen S G Dias, Natalia Fintelman-Rodrigues, Jairo R Temerozo, Nicolas Carels, Carlos R Alves, Mirian C S Pereira, David W Provance, Thiago M L Souza, Salvatore G De-Simone. SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22169035. [PMID: 34445741] - François Halloy, Pavithra S Iyer, Alice Ghidini, Veronika Lysenko, Jasmin Barman-Aksözen, Chia-Pei Grubenmann, Jessica Jucker, Nicole Wildner-Verhey van Wijk, Marc-David Ruepp, Elisabeth I Minder, Anna-Elisabeth Minder, Xiaoye Schneider-Yin, Alexandre P A Theocharides, Daniel Schümperli, Jonathan Hall. Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria.
Cell chemical biology.
2021 08; 28(8):1221-1234.e6. doi:
10.1016/j.chembiol.2021.02.021. [PMID: 33756123] - Xuerong Dong, Xiang Zhang, Manyuan Wang, Liwei Gu, Jing Li, Muxin Gong. Heparin-decorated nanostructured lipid carriers of artemether-protoporphyrin IX-transferrin combination for therapy of malaria.
International journal of pharmaceutics.
2021 Aug; 605(?):120813. doi:
10.1016/j.ijpharm.2021.120813. [PMID: 34144137] - Taiga Yamada, Teruyuki Komatsu. Methemoglobin-Albumin Cluster Incorporating Protoporphyrin IX: Dual Functional Protein Drug for Photodynamic Therapy.
Chembiochem : a European journal of chemical biology.
2021 08; 22(15):2526-2529. doi:
10.1002/cbic.202100213. [PMID: 34156148] - Thibaud Lefebvre, Muriel Coupaye, Marina Esposito-Farèse, Nathalie Gault, Neila Talbi, Caroline Quintin, Caroline Schmitt, Soumeya Bekri, André Bado, Hervé Puy, Simon Msika, Carole Brasse-Lagnel, Zoubida Karim. Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study.
Nutrients.
2021 Jul; 13(8):. doi:
10.3390/nu13082516. [PMID: 34444676] - Dhiman Maitra, Benjamin M Pinsky, Amenah Soherawardy, Haiyan Zheng, Ruma Banerjee, M Bishr Omary. Protein-aggregating ability of different protoporphyrin-IX nanostructures is dependent on their oxidation and protein-binding capacity.
The Journal of biological chemistry.
2021 07; 297(1):100778. doi:
10.1016/j.jbc.2021.100778. [PMID: 34023387] - Lilia Coronato Courrol, Flávia Rodrigues de Oliveira Silva, Valdivel Masilamani. SARS-CoV-2, hemoglobin and protoporphyrin IX: Interactions and perspectives.
Photodiagnosis and photodynamic therapy.
2021 Jun; 34(?):102324. doi:
10.1016/j.pdpdt.2021.102324. [PMID: 33965601] - Kit Man Chan, Jonathan Gleadle, Jordan Li, Thomas Danny Michl, Krasimir Vasilev, Melanie MacGregor. Improving hexaminolevulinate enabled cancer cell detection in liquid biopsy immunosensors.
Scientific reports.
2021 03; 11(1):7283. doi:
10.1038/s41598-021-86649-6. [PMID: 33790357] - Shengsheng Lu, Xiaoyan Pan, Daiwei Chen, Xi Xie, Yan Wu, Weijuan Shang, Xiaming Jiang, Yuan Sun, Sheng Fan, Jian He. Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses.
Bioorganic chemistry.
2021 02; 107(?):104619. doi:
10.1016/j.bioorg.2020.104619. [PMID: 33450541] - Kulwinder Sagoo, Nathan Cumberbatch, Adam Holland, Graham Hungerford. Rapid (FLASH-FLIM) imaging of protoporphyrin IX in a lipid mixture using a CMOS based widefield fluorescence lifetime imaging camera in real time for margin demarcation applications.
Methods and applications in fluorescence.
2021 Jan; 9(1):. doi:
10.1088/2050-6120/abbcc6. [PMID: 32992309] - Yuan-Yuan Li, Min Han, Rui-Hua Wang, Ming-Gang Gao. Comparative transcriptome analysis identifies genes associated with chlorophyll levels and reveals photosynthesis in green flesh of radish taproot.
PloS one.
2021; 16(5):e0252031. doi:
10.1371/journal.pone.0252031. [PMID: 34043661] - Richard Howley, Matthew Mansi, Janhavi Shinde, Juliana Restrepo, Bin Chen. Evaluation of aminolevulinic acid-mediated protoporphyrin IX fluorescence and enhancement by ABCG2 inhibitors in renal cell carcinoma cells.
Journal of photochemistry and photobiology. B, Biology.
2020 Oct; 211(?):112017. doi:
10.1016/j.jphotobiol.2020.112017. [PMID: 32919173] - Atefeh Vejdani Noghreiyan, Armin Imanparast, Elham Shayesteh Ara, Samaneh Soudmand, Vajiheh Vejdani Noghreiyan, Ameneh Sazgarnia. In-vitro investigation of cold atmospheric plasma induced photodynamic effect by Indocyanine green and Protoporphyrin IX.
Photodiagnosis and photodynamic therapy.
2020 Sep; 31(?):101822. doi:
10.1016/j.pdpdt.2020.101822. [PMID: 32428573] - R D R Tiveron, D A Costa, M D I Leite, C B S Vaz, M Sousa, S M C F Carlos, C J F Oliveira, R R Machado, T P Paulino. Evaluation of cell damage and modulation of cytokines TNF-α, IL-6 and IL-10 in macrophages exposed to PpIX-mediated photodynamic therapy.
Brazilian journal of biology = Revista brasleira de biologia.
2020 Sep; 80(3):497-505. doi:
10.1590/1519-6984.193748. [PMID: 31576928] - Ya-Xuan Zhu, Hao-Ran Jia, Qiu-Yi Duan, Xiaoyang Liu, Jing Yang, Yi Liu, Fu-Gen Wu. Photosensitizer-Doped and Plasma Membrane-Responsive Liposomes for Nuclear Drug Delivery and Multidrug Resistance Reversal.
ACS applied materials & interfaces.
2020 Aug; 12(33):36882-36894. doi:
10.1021/acsami.0c09110. [PMID: 32666795] - Takahiro Nishimura, Keisuke Hara, Norihiro Honda, Shigetoshi Okazaki, Hisanao Hazama, Kunio Awazu. Determination and analysis of singlet oxygen quantum yields of talaporfin sodium, protoporphyrin IX, and lipidated protoporphyrin IX using near-infrared luminescence spectroscopy.
Lasers in medical science.
2020 Aug; 35(6):1289-1297. doi:
10.1007/s10103-019-02907-0. [PMID: 31853809] - Hana Manceau, Sophie D Lefevre, Arienne Mirmiran, Claude Hattab, Hugo R Sugier, Caroline Schmitt, Katell Peoc'h, Hervé Puy, Mariano A Ostuni, Laurent Gouya, Jean-Jacques Lacapere. TSPO2 translocates 5-aminolevulinic acid into human erythroleukemia cells.
Biology of the cell.
2020 Apr; 112(4):113-126. doi:
10.1111/boc.201900098. [PMID: 31989647] - Irena Maliszewska, Dominika Wawrzyńczyk, Ewelina Wanarska. The effect of glucose and human serum on 5-aminolevulinic acid mediated photodynamic inactivation of Candida albicans.
Photodiagnosis and photodynamic therapy.
2020 Mar; 29(?):101623. doi:
10.1016/j.pdpdt.2019.101623. [PMID: 31904553] - Tiago N Figueira, Marco M Domingues, Françoise Illien, Iris Cadima-Couto, Toni Todorovski, David Andreu, Sandrine Sagan, Miguel A R B Castanho, Astrid Walrant, Ana Salomé Veiga. Enfuvirtide-Protoporphyrin IX Dual-Loaded Liposomes: In Vitro Evidence of Synergy against HIV-1 Entry into Cells.
ACS infectious diseases.
2020 02; 6(2):224-236. doi:
10.1021/acsinfecdis.9b00285. [PMID: 31855415] - Deborah Piffaretti, Floriana Burgio, Marcus Thelen, Alain Kaelin-Lang, Paolo Paganetti, Michael Reinert, Maria Luisa D'Angelo. Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization.
Journal of photochemistry and photobiology. B, Biology.
2019 Dec; 201(?):111640. doi:
10.1016/j.jphotobiol.2019.111640. [PMID: 31734545] - Kit Man Chan, Krasimir Vasilev, Hanieh Safizadeh Shirazi, Kym McNicholas, Jordan Li, Jonathan Gleadle, Melanie MacGregor. Biosensor device for the photo-specific detection of immuno-captured bladder cancer cells using hexaminolevulinate: An ex-vivo study.
Photodiagnosis and photodynamic therapy.
2019 Dec; 28(?):238-247. doi:
10.1016/j.pdpdt.2019.08.001. [PMID: 31394301] - Hong Cheng, Gui-Ling Fan, Jing-Hao Fan, Ping Yuan, Fu-An Deng, Xiao-Zhong Qiu, Xi-Yong Yu, Shi-Ying Li. Epigenetics-inspired photosensitizer modification for plasma membrane-targeted photodynamic tumor therapy.
Biomaterials.
2019 12; 224(?):119497. doi:
10.1016/j.biomaterials.2019.119497. [PMID: 31541935] - Tao-Cheng Wu, Jia-Shiong Chen, Chao-Hung Wang, Po-Hsun Huang, Feng-Yen Lin, Liang-Yu Lin, Shing-Jong Lin, Jaw-Wen Chen. Activation of heme oxygenase-1 by Ginkgo biloba extract differentially modulates endothelial and smooth muscle-like progenitor cells for vascular repair.
Scientific reports.
2019 11; 9(1):17316. doi:
10.1038/s41598-019-53818-7. [PMID: 31754254] - John Phillips, Collin Farrell, Yongming Wang, Ashwani K Singal, Karl Anderson, Manisha Balwani, Montgomery Bissell, Herbert Bonkovsky, Toni Seay, Barry Paw, Robert Desnick, Joseph Bloomer. Strong correlation of ferrochelatase enzymatic activity with Mitoferrin-1 mRNA in lymphoblasts of patients with protoporphyria.
Molecular genetics and metabolism.
2019 11; 128(3):391-395. doi:
10.1016/j.ymgme.2018.10.005. [PMID: 30391163] - Jasmin Barman-Aksözen, Francois Halloy, Pavithra S Iyer, Daniel Schümperli, Anna Elisabeth Minder, Jonathan Hall, Elisabeth I Minder, Xiaoye Schneider-Yin. Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria.
Molecular genetics and metabolism.
2019 11; 128(3):304-308. doi:
10.1016/j.ymgme.2019.04.013. [PMID: 31076252] - Lizette Mares, Felipe Vilchis, Bertha Chávez, Luis Ramos. Expression and regulation of ABCG2/BCRP1 by sex steroids in the Harderian gland of the Syrian hamster (Mesocricetus auratus).
Comptes rendus biologies.
2019 Nov; 342(9-10):279-289. doi:
10.1016/j.crvi.2019.11.003. [PMID: 31780416] - Charles J Parker, Robert J Desnick, Montgomery D Bissel, Joseph R Bloomer, Ashwani Singal, Laurent Gouya, Herve Puy, Karl E Anderson, Manisha Balwani, John D Phillips. Results of a pilot study of isoniazid in patients with erythropoietic protoporphyria.
Molecular genetics and metabolism.
2019 11; 128(3):309-313. doi:
10.1016/j.ymgme.2019.07.017. [PMID: 31395332] - Pamela S Jones, Anudeep Yekula, Elizabeth Lansbury, Julia L Small, Caroline Ayinon, Scott Mordecai, Fred H Hochberg, John Tigges, Bethany Delcuze, Alain Charest, Ionita Ghiran, Leonora Balaj, Bob S Carter. Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma.
EBioMedicine.
2019 Oct; 48(?):23-35. doi:
10.1016/j.ebiom.2019.09.025. [PMID: 31628025] - Keita Iwaki, Tohru Fujiwara, Takako Ito, Chie Suzuki, Katsuyuki Sasaki, Koya Ono, Kei Saito, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Shinichi Fujimaki, Tohru Tanaka, Hideto Tamura, Minami Fujiwara, Hideo Harigae. Flow Cytometry-Based Photodynamic Diagnosis with 5-Aminolevulinic Acid for the Detection of Minimal Residual Disease in Multiple Myeloma.
The Tohoku journal of experimental medicine.
2019 09; 249(1):19-28. doi:
10.1620/tjem.249.19. [PMID: 31511451] - Jingcheng Dai, Yaqi Liu, Shuangyuan Liu, Shuyang Li, Na Gao, Jing Wang, Jizhong Zhou, Dongru Qiu. Differential gene content and gene expression for bacterial evolution and speciation of Shewanella in terms of biosynthesis of heme and heme-requiring proteins.
BMC microbiology.
2019 07; 19(1):173. doi:
10.1186/s12866-019-1549-9. [PMID: 31362704] - Pei Liu, Jinghua Ren, Yuxuan Xiong, Zhe Yang, Wei Zhu, Qianyuan He, Zushun Xu, Wenshan He, Jing Wang. Enhancing magnetic resonance/photoluminescence imaging-guided photodynamic therapy by multiple pathways.
Biomaterials.
2019 04; 199(?):52-62. doi:
10.1016/j.biomaterials.2019.01.044. [PMID: 30738335] - Marta Mascaraque, Pablo Delgado-Wicke, Alejandra Damian, Silvia Rocío Lucena, Elisa Carrasco, Ángeles Juarranz. Mitotic Catastrophe Induced in HeLa Tumor Cells by Photodynamic Therapy with Methyl-aminolevulinate.
International journal of molecular sciences.
2019 Mar; 20(5):. doi:
10.3390/ijms20051229. [PMID: 30862116] - Christopher Trent Brewer, Lei Yang, Anne Edwards, Yan Lu, Jonathan Low, Jing Wu, Richard E Lee, Taosheng Chen. The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 03; 168(1):209-224. doi:
10.1093/toxsci/kfy294. [PMID: 30517741] - Ai-Nv Zhang, Wei Wu, Chi Zhang, Qiu-Yang Wang, Ze-Nan Zhuang, Han Cheng, Xian-Zheng Zhang. A versatile bacterial membrane-binding chimeric peptide with enhanced photodynamic antimicrobial activity.
Journal of materials chemistry. B.
2019 02; 7(7):1087-1095. doi:
10.1039/c8tb03094d. [PMID: 32254776] - Pawel Brzezowski, Brigitte Ksas, Michel Havaux, Bernhard Grimm, Marie Chazaux, Gilles Peltier, Xenie Johnson, Jean Alric. The function of PROTOPORPHYRINOGEN IX OXIDASE in chlorophyll biosynthesis requires oxidised plastoquinone in Chlamydomonas reinhardtii.
Communications biology.
2019; 2(?):159. doi:
10.1038/s42003-019-0395-5. [PMID: 31069268] - Zhengyu Cao, Tianyi Zhang, Xin Sun, Mingyu Liu, Zhaoqian Shen, Bicheng Li, Xuezhu Zhao, Hong Jin, Zhiguo Zhang, Ye Tian. Membrane-permeabilized sonodynamic therapy enhances drug delivery into macrophages.
PloS one.
2019; 14(6):e0217511. doi:
10.1371/journal.pone.0217511. [PMID: 31181129] - Hong Cheng, Rong-Rong Zheng, Gui-Ling Fan, Jing-Hao Fan, Lin-Ping Zhao, Xue-Yan Jiang, Bin Yang, Xi-Yong Yu, Shi-Ying Li, Xian-Zheng Zhang. Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy.
Biomaterials.
2019 01; 188(?):1-11. doi:
10.1016/j.biomaterials.2018.10.005. [PMID: 30312907] - Alejandro M Armas, Manuel Balparda, Agustina Terenzi, Maria V Busi, Maria A Pagani, Diego F Gomez-Casati. Ferrochelatase activity of plant frataxin.
Biochimie.
2019 Jan; 156(?):118-122. doi:
10.1016/j.biochi.2018.10.009. [PMID: 30342111] - Gihan Mahmoud, Jarmila Jedelská, Samia Mohamed Omar, Boris Strehlow, Marc Schneider, Udo Bakowsky. Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy.
Drug delivery.
2018 Nov; 25(1):1526-1536. doi:
10.1080/10717544.2018.1482970. [PMID: 29996694] - Sabrina Kröger, Ann-Christin Niehoff, Astrid Jeibmann, Michael Sperling, Werner Paulus, Walter Stummer, Uwe Karst. Complementary Molecular and Elemental Mass-Spectrometric Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery.
Analytical chemistry.
2018 10; 90(20):12253-12260. doi:
10.1021/acs.analchem.8b03516. [PMID: 30215510] - Irene Marginedas-Freixa, Cora L Alvarez, Martina Moras, Claude Hattab, Guillaume Bouyer, Arnaud Chene, Sophie D Lefevre, Caroline Le Van Kim, Frederic Bihel, Pablo J Schwarzbaum, Mariano A Ostuni. Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands.
International journal of molecular sciences.
2018 Oct; 19(10):. doi:
10.3390/ijms19103098. [PMID: 30308949] - Tzan-Chain Lee, Tin-Han Shih, Meng-Yuan Huang, Kuan-Hung Lin, Wen-Dar Huang, Chi-Ming Yang. Eliminating interference by anthocyanins when determining the porphyrin ratio of red plant leaves.
Journal of photochemistry and photobiology. B, Biology.
2018 Oct; 187(?):106-112. doi:
10.1016/j.jphotobiol.2018.08.007. [PMID: 30121420] - Hao-Ran Jia, Ya-Xuan Zhu, Ke-Fei Xu, Xiaoyang Liu, Fu-Gen Wu. Plasma membrane-anchorable photosensitizing nanomicelles for lipid raft-responsive and light-controllable intracellular drug delivery.
Journal of controlled release : official journal of the Controlled Release Society.
2018 09; 286(?):103-113. doi:
10.1016/j.jconrel.2018.07.027. [PMID: 30026079] - Yasushi Nakai, Makito Miyake, Satoshi Anai, Shunta Hori, Yoshihiro Tatsumi, Yosuke Morizawa, Sayuri Onisi, Nobumichi Tanaka, Kiyohide Fujimoto. Spectrophotometric photodynamic diagnosis of prostate cancer cells excreted in voided urine using 5-aminolevulinic acid.
Lasers in medical science.
2018 Sep; 33(7):1557-1563. doi:
10.1007/s10103-018-2519-4. [PMID: 29725946] - Manuela Lualdi, Adalberto Cavalleri, Luigi Battaglia, Ambrogio Colombo, Giulia Garrone, Daniele Morelli, Emanuele Pignoli, Elisa Sottotetti, Ermanno Leo. Early detection of colorectal adenocarcinoma: a clinical decision support tool based on plasma porphyrin accumulation and risk factors.
BMC cancer.
2018 Aug; 18(1):841. doi:
10.1186/s12885-018-4754-2. [PMID: 30134852] - Debashree Das, Pradip K Tarafdar, Abhijit Chakrabarti. Structure-activity relationship of heme and its analogues in membrane damage and inhibition of fusion.
FEBS letters.
2018 07; 592(14):2458-2465. doi:
10.1002/1873-3468.13165. [PMID: 29923605] - Beibei Dong, Zhishen Zhang, Keliang Xie, Yongyan Yang, Yuan Shi, Chenxu Wang, Yonghao Yu. Hemopexin promotes angiogenesis via up-regulating HO-1 in rats after cerebral ischemia-reperfusion injury.
BMC anesthesiology.
2018 01; 18(1):2. doi:
10.1186/s12871-017-0466-4. [PMID: 29298658] - Shuwei Ning, Qiaozhen Kang, Dandan Fan, Jingjing Liu, Chaoyue Xue, Xiaolin Zhang, Cong Ding, Jianying Zhang, Qian Peng, Zhenyu Ji. Protein 4.1R is Involved in the Transport of 5-Aminolevulinic Acid by Interaction with GATs in MEF Cells.
Photochemistry and photobiology.
2018 01; 94(1):173-178. doi:
10.1111/php.12842. [PMID: 28881432] - Mizuho Inai, Norihiro Honda, Hisanao Hazama, Sharmin Akter, Shinichiro Fuse, Hiroyuki Nakamura, Tomoyuki Nishikawa, Yasufumi Kaneda, Kunio Awazu. Photodynamic therapy using a cytotoxic photosensitizer porphyrus envelope that targets the cell membrane.
Photodiagnosis and photodynamic therapy.
2017 Dec; 20(?):238-245. doi:
10.1016/j.pdpdt.2017.10.017. [PMID: 29079353] - M Biewenga, R H S Matawlie, E C H Friesema, H Koole-Lesuis, M Langeveld, J H P Wilson, J G Langendonk. Osteoporosis in patients with erythropoietic protoporphyria.
The British journal of dermatology.
2017 12; 177(6):1693-1698. doi:
10.1111/bjd.15893. [PMID: 28815553] - Rita Hargitai, Nóra Boross, Susanne Hámori, Eszter Neuberger, Zoltán Nyiri. Eggshell Biliverdin and Protoporphyrin Pigments in a Songbird: Are They Derived from Erythrocytes, Blood Plasma, or the Shell Gland?.
Physiological and biochemical zoology : PBZ.
2017 Nov; 90(6):613-626. doi:
10.1086/694297. [PMID: 28937855] - Naoyuki Fujimori, Michiharu Komatsu, Naoki Tanaka, Mai Iwaya, Hajime Nakano, Ayumi Sugiura, Tomoo Yamazaki, Soichiro Shibata, Yugo Iwaya, Takashi Muraki, Yuki Ichikawa, Takefumi Kimura, Satoru Joshita, Takeji Umemura, Akihiro Matsumoto, Eiji Tanaka. Cimetidine/lactulose therapy ameliorates erythropoietic protoporphyria-related liver injury.
Clinical journal of gastroenterology.
2017 Oct; 10(5):452-458. doi:
10.1007/s12328-017-0760-1. [PMID: 28676994] - Hao-Ran Jia, Yao-Wen Jiang, Ya-Xuan Zhu, Yan-Hong Li, Hong-Yin Wang, Xiaofeng Han, Zhi-Wu Yu, Ning Gu, Peidang Liu, Zhan Chen, Fu-Gen Wu. Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cellular influx for photodynamic cancer therapy.
Journal of controlled release : official journal of the Controlled Release Society.
2017 06; 255(?):231-241. doi:
10.1016/j.jconrel.2017.04.030. [PMID: 28442408] - Christine Cruz-Oliveira, Andreza F Almeida, João M Freire, Marjolly B Caruso, Maria A Morando, Vivian N S Ferreira, Iranaia Assunção-Miranda, Andre M O Gomes, Miguel A R B Castanho, Andrea T Da Poian. Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX.
Antimicrobial agents and chemotherapy.
2017 06; 61(6):. doi:
10.1128/aac.00053-17. [PMID: 28348154] - Liya Jiao, Hezhou Ding, Lihong Wang, Qing Zhou, Xiaohua Huang. Bisphenol A effects on the chlorophyll contents in soybean at different growth stages.
Environmental pollution (Barking, Essex : 1987).
2017 Apr; 223(?):426-434. doi:
10.1016/j.envpol.2017.01.042. [PMID: 28139326] - Mian Wang, Benjamin M Geilich, Michael Keidar, Thomas J Webster. Killing malignant melanoma cells with protoporphyrin IX-loaded polymersome-mediated photodynamic therapy and cold atmospheric plasma.
International journal of nanomedicine.
2017; 12(?):4117-4127. doi:
10.2147/ijn.s129266. [PMID: 28615940] - Shunsuke Nakae, Kazuhiro Murayama, Hikaru Sasaki, Masanobu Kumon, Yuya Nishiyama, Shigeo Ohba, Kazuhide Adachi, Shinya Nagahisa, Takuro Hayashi, Joji Inamasu, Masato Abe, Mitsuhiro Hasegawa, Yuichi Hirose. Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters.
Journal of neuro-oncology.
2017 01; 131(2):403-412. doi:
10.1007/s11060-016-2313-8. [PMID: 27837434] - Daniel Hey, Patricia Ortega-Rodes, Tingting Fan, Florian Schnurrer, Lea Brings, Boris Hedtke, Bernhard Grimm. Transgenic Tobacco Lines Expressing Sense or Antisense FERROCHELATASE 1 RNA Show Modified Ferrochelatase Activity in Roots and Provide Experimental Evidence for Dual Localization of Ferrochelatase 1.
Plant & cell physiology.
2016 Dec; 57(12):2576-2585. doi:
10.1093/pcp/pcw171. [PMID: 27818378] - Leszek Sułkowski, Bartosz Pawełczak, Mariola Chudzik, Małgorzata Maciążek-Jurczyk. Characteristics of the Protoporphyrin IX Binding Sites on Human Serum Albumin Using Molecular Docking.
Molecules (Basel, Switzerland).
2016 Nov; 21(11):. doi:
10.3390/molecules21111519. [PMID: 27869697] - Le Zhang, Qing Cheng, Longjie Zhang, Yijun Wang, Gary F Merrill, Tal Ilani, Deborah Fass, Elias S J Arnér, Jinsong Zhang. Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
Free radical biology & medicine.
2016 10; 99(?):426-435. doi:
10.1016/j.freeradbiomed.2016.08.028. [PMID: 27581528] - Michael Winter, Jürgen Funk, Annette Körner, Daniela Alberati, Francois Christen, Georg Schmitt, Bernd Altmann, Andreas Pospischil, Thomas Singer. Effects of GlyT1 inhibition on erythropoiesis and iron homeostasis in rats.
Experimental hematology.
2016 10; 44(10):964-974.e4. doi:
10.1016/j.exphem.2016.07.003. [PMID: 27403535] - Dongru Qiu, Ming Xie, Jingcheng Dai, Weixing An, Hehong Wei, Chunyuan Tian, Megan L Kempher, Aifen Zhou, Zhili He, Baohua Gu, Jizhong Zhou. Differential Regulation of the Two Ferrochelatase Paralogues in Shewanella loihica PV-4 in Response to Environmental Stresses.
Applied and environmental microbiology.
2016 09; 82(17):5077-88. doi:
10.1128/aem.00203-16. [PMID: 27287322] - Leo Veenman, Alex Vainshtein, Nasra Yasin, Maya Azrad, Moshe Gavish. Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands.
International journal of molecular sciences.
2016 Jun; 17(6):. doi:
10.3390/ijms17060880. [PMID: 27271616] - Louise Norén, Peter Kindgren, Paulina Stachula, Mark Rühl, Maria E Eriksson, Vaughan Hurry, Åsa Strand. Circadian and Plastid Signaling Pathways Are Integrated to Ensure Correct Expression of the CBF and COR Genes during Photoperiodic Growth.
Plant physiology.
2016 06; 171(2):1392-406. doi:
10.1104/pp.16.00374. [PMID: 27208227] - Alexandru Babes, Susanne K Sauer, Lavanya Moparthi, Tatjana I Kichko, Cristian Neacsu, Barbara Namer, Milos Filipovic, Peter M Zygmunt, Peter W Reeh, Michael J M Fischer. Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2016 05; 36(19):5264-78. doi:
10.1523/jneurosci.4268-15.2016. [PMID: 27170124] - Shabnam Tarahi Tabrizi, Artur Sawicki, Shuaixiang Zhou, Meizhong Luo, Robert D Willows. GUN4-Protoporphyrin IX Is a Singlet Oxygen Generator with Consequences for Plastid Retrograde Signaling.
The Journal of biological chemistry.
2016 Apr; 291(17):8978-84. doi:
10.1074/jbc.c116.719989. [PMID: 26969164] - Marinka van der Hoeven, Mieke Faber, Jennifer Osei, Annamarie Kruger, Cornelius M Smuts. Effect of African leafy vegetables on the micronutrient status of mildly deficient farm-school children in South Africa: a randomized controlled study.
Public health nutrition.
2016 Apr; 19(5):935-45. doi:
10.1017/s1368980015002037. [PMID: 26146039] - Yukiko Ninomiya, Yasuhito Kokunai, Hideaki Tanizaki, Eijiro Akasaka, Hajime Nakano, Shinichi Moriwaki. X-linked dominant protoporphyria: The first reported Japanese case.
The Journal of dermatology.
2016 Apr; 43(4):414-8. doi:
10.1111/1346-8138.13101. [PMID: 26387792] - Magdalena Przybylo, Daria Glogocka, Jerzy W Dobrucki, Kaja Fraczkowska, Halina Podbielska, Marta Kopaczynska, Tomasz Borowik, Marek Langner. The cellular internalization of liposome encapsulated protoporphyrin IX by HeLa cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Mar; 85(?):39-46. doi:
10.1016/j.ejps.2016.01.028. [PMID: 26827924] - U Urbanski, J Frank, N J Neumann. [Erythropoietic protoporphyria : Clinical manifestations, diagnosis and new therapeutic possibilities].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.
2016 Mar; 67(3):211-5. doi:
10.1007/s00105-015-3733-7. [PMID: 26669872] - Yasushi Nakai, Yoshihiro Tatsumi, Makito Miyake, Satoshi Anai, Masaomi Kuwada, Sayuri Onishi, Yoshitomo Chihara, Nobumichi Tanaka, Yoshihiko Hirao, Kiyohide Fujimoto. Expression of ferrochelatase has a strong correlation in protoporphyrin IX accumulation with photodynamic detection of bladder cancer.
Photodiagnosis and photodynamic therapy.
2016 Mar; 13(?):225-232. doi:
10.1016/j.pdpdt.2015.07.174. [PMID: 26226642] - V Brancaleoni, M Balwani, F Granata, G Graziadei, P Missineo, V Fiorentino, S Fustinoni, M D Cappellini, H Naik, R J Desnick, E Di Pierro. X-chromosomal inactivation directly influences the phenotypic manifestation of X-linked protoporphyria.
Clinical genetics.
2016 Jan; 89(1):20-6. doi:
10.1111/cge.12562. [PMID: 25615817] - Shoji Tachikawa, Shinichi Sato, Hisanao Hazama, Yasufumi Kaneda, Kunio Awazu, Hiroyuki Nakamura. Localization-dependent cell-killing effects of protoporphyrin (PPIX)-lipid micelles and liposomes in photodynamic therapy.
Bioorganic & medicinal chemistry.
2015 Dec; 23(24):7578-84. doi:
10.1016/j.bmc.2015.11.001. [PMID: 26602828] - Ghaseb Naser Makhadmeh, Azlan Abdul Aziz, Khairunisak Abdul Razak, Osama Abu Noqta. Encapsulation efficacy of natural and synthetic photosensitizers by silica nanoparticles for photodynamic applications.
IET nanobiotechnology.
2015 Dec; 9(6):381-5. doi:
10.1049/iet-nbt.2015.0003. [PMID: 26647815] - Eric W Gou, Manisha Balwani, D Montgomery Bissell, Joseph R Bloomer, Herbert L Bonkovsky, Robert J Desnick, Hetanshi Naik, John D Phillips, Ashwani K Singal, Bruce Wang, Sioban Keel, Karl E Anderson. Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias.
Clinical chemistry.
2015 Dec; 61(12):1453-6. doi:
10.1373/clinchem.2015.245456. [PMID: 26482161] - Johandie Gildenhuys, Chandre J Sammy, Ronel Müller, Victor A Streltsov, Tanya le Roex, David Kuter, Katherine A de Villiers. Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution.
Dalton transactions (Cambridge, England : 2003).
2015 Oct; 44(38):16767-77. doi:
10.1039/c5dt02671g. [PMID: 26335948] - Xiaobing Wang, Yali Jia, Xiaomin Su, Pan Wang, Kun Zhang, Xiaolan Feng, Quanhong Liu. Combination of Protoporphyrin IX-mediated Sonodynamic Treatment with Doxorubicin Synergistically Induced Apoptotic Cell Death of a Multidrug-Resistant Leukemia K562/DOX Cell Line.
Ultrasound in medicine & biology.
2015 Oct; 41(10):2731-9. doi:
10.1016/j.ultrasmedbio.2015.06.001. [PMID: 26166458] - Marie Morfouace, Satish Cheepala, Sadhana Jackson, Yu Fukuda, Yogesh T Patel, Soghra Fatima, Daisuke Kawauchi, Anang A Shelat, Clinton F Stewart, Brian P Sorrentino, John D Schuetz, Martine F Roussel. ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.
Cancer research.
2015 Sep; 75(18):3879-89. doi:
10.1158/0008-5472.can-15-0030. [PMID: 26199091] - Hugo Nóbrega da Rocha Filho, Evelin Caroline da Silva, Flávia R O Silva, Lilia Coronato Courrol, Carlos Henrique de Mesquita, Maria Helena Bellini. Expression of Genes Involved in Porphyrin Biosynthesis Pathway in the Human Renal Cell Carcinoma.
Journal of fluorescence.
2015 Sep; 25(5):1363-9. doi:
10.1007/s10895-015-1626-x. [PMID: 26245452] - Haseena Banu Hedayathullah Khan, S Vani, Shanthi Palanivelu, Sachdanandam Panchanadham. Erythrocyte Protoporphyrin Fluorescence as a Biomarker to Monitor the Anticancer Effect of Semecarpus Anacardium in DMBA Induced Mammary Carcinoma Rat Model.
Journal of fluorescence.
2015 Jul; 25(4):907-15. doi:
10.1007/s10895-015-1571-8. [PMID: 25943985] - Yasushi Nakai, Satoshi Anai, Sayuri Onishi, Kuwada Masaomi, Yoshihiro Tatsumi, Makito Miyake, Yoshitomo Chihara, Nobumichi Tanaka, Yoshihiko Hirao, Kiyohide Fujimoto. Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer.
Photodiagnosis and photodynamic therapy.
2015 Jun; 12(2):282-8. doi:
10.1016/j.pdpdt.2014.12.010. [PMID: 25595357] - Kyoung-Jin Jang, Hiroto Mano, Koji Aoki, Tatsunari Hayashi, Akihiko Muto, Yukiko Nambu, Katsu Takahashi, Katsuhiko Itoh, Shigeru Taketani, Stephen L Nutt, Kazuhiko Igarashi, Akira Shimizu, Manabu Sugai. Mitochondrial function provides instructive signals for activation-induced B-cell fates.
Nature communications.
2015 Apr; 6(?):6750. doi:
10.1038/ncomms7750. [PMID: 25857523] - Liya Jiao, Lihong Wang, Zhiyong Qiu, Qingqing Wang, Qing Zhou, Xiaohua Huang. Effects of bisphenol A on chlorophyll synthesis in soybean seedlings.
Environmental science and pollution research international.
2015 Apr; 22(8):5877-86. doi:
10.1007/s11356-014-3764-0. [PMID: 25352395] - Karina de Oliveira Gonçalves, Monica Nascimento da Silva, Letícia Bonfante Sicchieri, Flávia Rodrigues de Oliveira Silva, Ricardo Almeida de Matos, Lilia Coronato Courrol. Aminolevulinic acid with gold nanoparticles: a novel theranostic agent for atherosclerosis.
The Analyst.
2015 Mar; 140(6):1974-80. doi:
10.1039/c4an02166e. [PMID: 25671550] - Michael Scharfenberg, Lukas Mittermayr, Edda VON Roepenack-Lahaye, Hagen Schlicke, Bernhard Grimm, Dario Leister, Tatjana Kleine. Functional characterization of the two ferrochelatases in Arabidopsis thaliana.
Plant, cell & environment.
2015 Feb; 38(2):280-98. doi:
10.1111/pce.12248. [PMID: 24329537] - Andrea W U Busch, Beronda L Montgomery. Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response.
Redox biology.
2015; 4(?):260-71. doi:
10.1016/j.redox.2015.01.010. [PMID: 25618582] - Y Daijima, T Komatsu. Haemoglobin wrapped covalently by human serum albumin mutants containing Mn(III) protoporphyrin IX: an O2 complex stable in H2O2 solution.
Chemical communications (Cambridge, England).
2014 Dec; 50(94):14716-9. doi:
10.1039/c4cc06076h. [PMID: 25234722] - Richard B Banati, Ryan J Middleton, Ronald Chan, Claire R Hatty, Winnie Wai-Ying Kam, Candice Quin, Manuel B Graeber, Arvind Parmar, David Zahra, Paul Callaghan, Sandra Fok, Nicholas R Howell, Marie Gregoire, Alexander Szabo, Tien Pham, Emma Davis, Guo-Jun Liu. Positron emission tomography and functional characterization of a complete PBR/TSPO knockout.
Nature communications.
2014 Nov; 5(?):5452. doi:
10.1038/ncomms6452. [PMID: 25406832] - Jihane Laafi, Chadi Homedan, Caroline Jacques, Naig Gueguen, Caroline Schmitt, Hervé Puy, Pascal Reynier, Maria Carmen Martinez, Yves Malthièry. Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells.
Biochimie.
2014 Nov; 106(?):157-66. doi:
10.1016/j.biochi.2014.08.014. [PMID: 25220386] - Tai Tien Tran, Anfeng Mu, Yuka Adachi, Yasushi Adachi, Shigeru Taketani. Neurotransmitter transporter family including SLC6A6 and SLC6A13 contributes to the 5-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin IX and photodamage, through uptake of ALA by cancerous cells.
Photochemistry and photobiology.
2014 Sep; 90(5):1136-43. doi:
10.1111/php.12290. [PMID: 24842606] - Shoji Tachikawa, Mohamed E El-Zaria, Ryu Inomata, Shinichi Sato, Hiroyuki Nakamura. Synthesis of protoporphyrin-lipids and biological evaluation of micelles and liposomes.
Bioorganic & medicinal chemistry.
2014 Sep; 22(17):4745-51. doi:
10.1016/j.bmc.2014.07.003. [PMID: 25066052] - Yasushi Nakai, Satoshi Anai, Masaomi Kuwada, Makito Miyake, Yoshitomo Chihara, Nobumichi Tanaka, Akihide Hirayama, Katsunori Yoshida, Yoshihiko Hirao, Kiyohide Fujimoto. Photodynamic diagnosis of shed prostate cancer cells in voided urine treated with 5-aminolevulinic acid.
BMC urology.
2014 Aug; 14(?):59. doi:
10.1186/1471-2490-14-59. [PMID: 25086448] - Yoshihiro Uto, Dai Tamatani, Yusuke Mizuki, Yoshio Endo, Ikuo Nakanishi, Kei Ohkubo, Shunichi Fukuzumi, Masahiro Ishizuka, Tohru Tanaka, Daisuke Kuchiike, Kentaro Kubo, Toshio Inui, Hitoshi Hori. Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos.
Anticancer research.
2014 Aug; 34(8):4583-7. doi:
NULL. [PMID: 25075103]