Morpholine (4-methoxyphenyl)(morpholino)phosphinodithioate (BioDeep_00001029291)
代谢物信息卡片
Morpholine (4-methoxyphenyl)(morpholino)phosphinodithioate
化学式: C15H25N2O3PS2 (376.104415)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=C(C=C1)P(=S)(N2CCOCC2)S.C1COCCN1
InChI: 5H,1-4H2
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
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COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Giovanna Casili, Elisa Randi, Theodora Panagaki, Karim Zuhra, Maria Petrosino, Csaba Szabo. Inhibition of the 3-mercaptopyruvate sulfurtransferase-hydrogen sulfide system promotes cellular lipid accumulation.
GeroScience.
2022 Aug; 44(4):2271-2289. doi:
10.1007/s11357-022-00600-9. [PMID: 35680713] - Jianhua Li, Mengyu Li, Ling Li, Jiamin Ma, Chengye Yao, Shanglong Yao. Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury.
Molecular immunology.
2022 01; 141(?):318-327. doi:
10.1016/j.molimm.2021.12.003. [PMID: 34952420] - Wenxi Xu, Kenji Watanabe, Yoichi Mizukami, Yoshinari Yamamoto, Takuya Suzuki. Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrest.
Archives of biochemistry and biophysics.
2021 11; 712(?):109044. doi:
10.1016/j.abb.2021.109044. [PMID: 34597656] - Subir Kumar Juin, Sathnur Pushpakumar, Utpal Sen. GYY4137 Regulates Extracellular Matrix Turnover in the Diabetic Kidney by Modulating Retinoid X Receptor Signaling.
Biomolecules.
2021 10; 11(10):. doi:
10.3390/biom11101477. [PMID: 34680110] - Bedoor Qabazard, Mariam Yousif, Alyaa Mousa, Oludotun Adebayo Phillips. GYY4137 attenuates functional impairment of corpus cavernosum and reduces fibrosis in rats with STZ-induced diabetes by inhibiting the TGF-β1/Smad/CTGF pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jun; 138(?):111486. doi:
10.1016/j.biopha.2021.111486. [PMID: 34311523] - Feng Liao, Zongdong Zhu, Chengwei Xiao, Jiabin Yuan, Bin Geng, Jiang Hu. Hydrogen sulfide inhibits calcium and phosphorus loss after fracture by negatively regulating glucocorticoid/glucocorticoid receptor α.
Life sciences.
2021 Jun; 274(?):119363. doi:
10.1016/j.lfs.2021.119363. [PMID: 33737083] - Mo-Li Zhu, Fan-Rong Zhao, Tian-Tian Zhu, Qian-Qian Wang, Ze-Qing Wu, Ping Song, Jian Xu, Guang-Rui Wan, Ya-Ling Yin, Peng Li. The antihypertension effect of hydrogen sulfide (H2S) is induced by activating VEGFR2 signaling pathway.
Life sciences.
2021 Feb; 267(?):118831. doi:
10.1016/j.lfs.2020.118831. [PMID: 33253721] - Shuang Zhao, Tianyu Song, Yue Gu, Yihua Zhang, Siyi Cao, Qing Miao, Xiyue Zhang, Hongshan Chen, Yuanqing Gao, Lei Zhang, Yi Han, Hong Wang, Jun Pu, Liping Xie, Yong Ji. Hydrogen Sulfide Alleviates Liver Injury Through the S-Sulfhydrated-Kelch-Like ECH-Associated Protein 1/Nuclear Erythroid 2-Related Factor 2/Low-Density Lipoprotein Receptor-Related Protein 1 Pathway.
Hepatology (Baltimore, Md.).
2021 01; 73(1):282-302. doi:
10.1002/hep.31247. [PMID: 32219872] - Hongmei Zhao, Yun Qiu, Yichen Wu, Hong Sun, Sumin Gao. Protective Effects of GYY4137 on Renal Ischaemia/Reperfusion Injury through Nrf2-Mediated Antioxidant Defence.
Kidney & blood pressure research.
2021; 46(3):257-265. doi:
10.1159/000509933. [PMID: 33910212] - Yaofu Zheng, Ping Lv, Jun Huang, Junsong Ke, Jumei Yan. GYY4137 exhibits anti-atherosclerosis effect in apolipoprotein E (-/-) mice via PI3K/Akt and TLR4 signalling.
Clinical and experimental pharmacology & physiology.
2020 07; 47(7):1231-1239. doi:
10.1111/1440-1681.13298. [PMID: 32144792] - Leigh J Ellmers, Evelyn M Templeton, Anna P Pilbrow, Chris Frampton, Isao Ishii, Philip K Moore, Madhav Bhatia, A Mark Richards, Vicky A Cameron. Hydrogen Sulfide Treatment Improves Post-Infarct Remodeling and Long-Term Cardiac Function in CSE Knockout and Wild-Type Mice.
International journal of molecular sciences.
2020 Jun; 21(12):. doi:
10.3390/ijms21124284. [PMID: 32560137] - Maria Romerowicz-Misielak, Katarzyna Kozioł, Sławomir Nowak, Anna Lewińska, Marek Koziorowski. Altered dynamics in the circadian oscillation of clock genes in serum-shocked NIH-3T3 cells by the treatment of GYY4137 or AOAA.
Archives of biochemistry and biophysics.
2020 02; 680(?):108237. doi:
10.1016/j.abb.2019.108237. [PMID: 31881188] - Gabriela Palma Zochio, Jose Sergio Possomato-Vieira, Jessica Sabbatine Chimini, Maria Luiza Santos da Silva, Carlos Alan Dias-Junior. Effects of fast versus slow-releasing hydrogen sulfide donors in hypertension in pregnancy and fetoplacental growth restriction.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 12; 392(12):1561-1568. doi:
10.1007/s00210-019-01697-0. [PMID: 31363805] - Jun Ma, Changgui Shi, Zhongyang Liu, Bin Han, Lei Guo, Lei Zhu, Tianwen Ye. Hydrogen sulfide is a novel regulator implicated in glucocorticoids-inhibited bone formation.
Aging.
2019 09; 11(18):7537-7552. doi:
10.18632/aging.102269. [PMID: 31525733] - Suravi Majumder, Lu Ren, Sathnur Pushpakumar, Utpal Sen. Hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through Akt/FOXO1 signalling cascade.
Cellular signalling.
2019 09; 61(?):66-77. doi:
10.1016/j.cellsig.2019.05.003. [PMID: 31085234] - Laura Grasa, Leticia Abecia, Ainize Peña-Cearra, Sofia Robles, Elena Layunta, Eva Latorre, José Emilio Mesonero, Raquel Forcén. TLR2 and TLR4 interact with sulfide system in the modulation of mouse colonic motility.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2019 09; 31(9):e13648. doi:
10.1111/nmo.13648. [PMID: 31119834] - Meng-Wan Zhang, Guang Yang, Yu-Fu Zhou, Christopher Qian, Ming-Dao Mu, Ya Ke, Zhong-Ming Qian. Regulating ferroportin-1 and transferrin receptor-1 expression: A novel function of hydrogen sulfide.
Journal of cellular physiology.
2019 04; 234(4):3158-3169. doi:
10.1002/jcp.27431. [PMID: 30370692] - Xu Cao, Wencan Zhang, Philip K Moore, Jinsong Bian. Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity.
International journal of molecular sciences.
2019 Jan; 20(2):. doi:
10.3390/ijms20020313. [PMID: 30646560] - Gregory J Weber, Jaleyea Foster, Sathnur B Pushpakumar, Utpal Sen. Altered microRNA regulation of short chain fatty acid receptors in the hypertensive kidney is normalized with hydrogen sulfide supplementation.
Pharmacological research.
2018 08; 134(?):157-165. doi:
10.1016/j.phrs.2018.06.012. [PMID: 29909116] - Shouzhe Lin, Dameng Lian, Weihua Liu, Aaron Haig, Ian Lobb, Ahmed Hijazi, Hassan Razvi, Jeremy Burton, Matthew Whiteman, Alp Sener. Daily therapy with a slow-releasing H2S donor GYY4137 enables early functional recovery and ameliorates renal injury associated with urinary obstruction.
Nitric oxide : biology and chemistry.
2018 06; 76(?):16-28. doi:
10.1016/j.niox.2018.03.002. [PMID: 29522906] - Shouzhe Lin, Smriti Juriasingani, Alp Sener. Is hydrogen sulfide a potential novel therapy to prevent renal damage during ureteral obstruction?.
Nitric oxide : biology and chemistry.
2018 02; 73(?):15-21. doi:
10.1016/j.niox.2017.12.004. [PMID: 29269061] - Meng Lu, Xian Jiang, Liquan Tong, Feng Zhang, Lin Ma, Xuesong Dong, Xueying Sun. MicroRNA-21-Regulated Activation of the Akt Pathway Participates in the Protective Effects of H2S against Liver Ischemia-Reperfusion Injury.
Biological & pharmaceutical bulletin.
2018 Feb; 41(2):229-238. doi:
10.1248/bpb.b17-00769. [PMID: 29187695] - László Potor, Péter Nagy, Gábor Méhes, Zoltán Hendrik, Viktória Jeney, Dávid Pethő, Anita Vasas, Zoltán Pálinkás, Enikő Balogh, Ágnes Gyetvai, Matthew Whiteman, Roberta Torregrossa, Mark E Wood, Sándor Olvasztó, Péter Nagy, György Balla, József Balla. Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion.
Oxidative medicine and cellular longevity.
2018; 2018(?):3812568. doi:
10.1155/2018/3812568. [PMID: 29560080] - Zhong-Shi Xu, Feng Dai, Ji Chen, Meng Lv, Ji-Wu Cheng, Xiao-Ming Zhang, Bo-Wen Lin. Experimental research into the potential therapeutic effect of GYY4137 on Ovariectomy-induced osteoporosis.
Cellular & molecular biology letters.
2018; 23(?):47. doi:
10.1186/s11658-018-0114-0. [PMID: 30305826] - Justin M Carter, Eric M Brown, James P Grace, Aliasger K Salem, Erin E Irish, Ned B Bowden. Improved growth of pea, lettuce, and radish plants using the slow release of hydrogen sulfide from GYY-4137.
PloS one.
2018; 13(12):e0208732. doi:
10.1371/journal.pone.0208732. [PMID: 30557337] - Jennifer Pichette, Nancy Fynn-Sackey, Jeffrey Gagnon. Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice.
Endocrinology.
2017 10; 158(10):3416-3425. doi:
10.1210/en.2017-00391. [PMID: 28977605] - A M Sashi Papu John, Sourav Kundu, Sathnur Pushpakumar, Maura Fordham, Gregory Weber, Manas Mukhopadhyay, Utpal Sen. GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney.
Scientific reports.
2017 09; 7(1):10924. doi:
10.1038/s41598-017-11256-3. [PMID: 28883608] - Benedikt L Nußbaum, Josef Vogt, Ulrich Wachter, Oscar McCook, Martin Wepler, José Matallo, Enrico Calzia, Michael Gröger, Michael Georgieff, Mark E Wood, Matthew Whiteman, Peter Radermacher, Sebastian Hafner. Metabolic, Cardiac, and Renal Effects of the Slow Hydrogen Sulfide-Releasing Molecule GYY4137 During Resuscitated Septic Shock in Swine with Pre-Existing Coronary Artery Disease.
Shock (Augusta, Ga.).
2017 08; 48(2):175-184. doi:
10.1097/shk.0000000000000834. [PMID: 28107215] - Gregory J Weber, Sathnur B Pushpakumar, Utpal Sen. Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism.
American journal of physiology. Heart and circulatory physiology.
2017 May; 312(5):H874-H885. doi:
10.1152/ajpheart.00637.2016. [PMID: 28213404] - Yan-Feng Liang, Dong-Dong Zhang, Xiao-Jing Yu, Hong-Li Gao, Kai-Li Liu, Jie Qi, Hong-Bao Li, Qiu-Yue Yi, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Yu-Ming Kang. Hydrogen sulfide in paraventricular nucleus attenuates blood pressure by regulating oxidative stress and inflammatory cytokines in high salt-induced hypertension.
Toxicology letters.
2017 Mar; 270(?):62-71. doi:
10.1016/j.toxlet.2017.02.004. [PMID: 28185984] - Bo Tang, Lan Ma, Xiaoyi Yao, Gang Tan, Peng Han, Tianchi Yu, Bing Liu, Xueying Sun. Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.
Journal of vascular surgery.
2017 02; 65(2):501-508.e1. doi:
10.1016/j.jvs.2015.10.010. [PMID: 26781077] - Fan Yang, Linxue Zhang, Zhaopeng Gao, Xiaojiao Sun, Miao Yu, Shiyun Dong, Jichao Wu, Yajun Zhao, Changqing Xu, Weihua Zhang, Fanghao Lu. Exogenous H2S Protects Against Diabetic Cardiomyopathy by Activating Autophagy via the AMPK/mTOR Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 43(3):1168-1187. doi:
10.1159/000481758. [PMID: 28977784] - Adrian Drapala, Dominik Koszelewski, Lenka Tomasova, Ryszard Ostaszewski, Marian Grman, Karol Ondrias, Marcin Ufnal. Parenteral Na2S, a fast-releasing H2S donor, but not GYY4137, a slow-releasing H2S donor, lowers blood pressure in rats.
Acta biochimica Polonica.
2017; 64(3):561-566. doi:
10.18388/abp.2017_1569. [PMID: 28753683] - L Rodrigues, E Ekundi-Valentim, J Florenzano, A R A Cerqueira, A G Soares, T P Schmidt, K T Santos, S A Teixeira, M T C P Ribela, S F Rodrigues, M H de Carvalho, G De Nucci, M Wood, M Whiteman, M N Muscará, S K P Costa. Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice.
Pharmacological research.
2017 01; 115(?):255-266. doi:
10.1016/j.phrs.2016.11.006. [PMID: 27840098] - Shouzhe Lin, Fazil Visram, Weihua Liu, Aaron Haig, Jifu Jiang, Amy Mok, Dameng Lian, Mark E Wood, Robert Torregrossa, Matthew Whiteman, Ian Lobb, Alp Sener. GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy.
The Journal of urology.
2016 12; 196(6):1778-1787. doi:
10.1016/j.juro.2016.05.029. [PMID: 27177428] - Shanwen Chen, Dingfang Bu, Yuanyuan Ma, Jing Zhu, Lie Sun, Shuai Zuo, Ju Ma, Tengyu Li, Zeyang Chen, Youwen Zheng, Xin Wang, Yisheng Pan, Pengyuan Wang, Yucun Liu. GYY4137 ameliorates intestinal barrier injury in a mouse model of endotoxemia.
Biochemical pharmacology.
2016 Oct; 118(?):59-67. doi:
10.1016/j.bcp.2016.08.016. [PMID: 27553476] - Mi Liu, Zhanjun Jia, Ying Sun, Aihua Zhang, Tianxin Yang. A H 2 S Donor GYY4137 Exacerbates Cisplatin-Induced Nephrotoxicity in Mice.
Mediators of inflammation.
2016; 2016(?):8145785. doi:
10.1155/2016/8145785. [PMID: 27340345] - Kenji Honda, Naotake Yamada, Riichiro Yoshida, Hideshi Ihara, Tomohiro Sawa, Takaaki Akaike, Sumio Iwai. 8-Mercapto-Cyclic GMP Mediates Hydrogen Sulfide-Induced Stomatal Closure in Arabidopsis.
Plant & cell physiology.
2015 Aug; 56(8):1481-9. doi:
10.1093/pcp/pcv069. [PMID: 25975264] - Jiao-Jiao Li, Qian Li, Hua-Ping Du, Ya-Li Wang, Shou-Jiang You, Fen Wang, Xing-Shun Xu, Jian Cheng, Yong-Jun Cao, Chun-Feng Liu, Li-Fang Hu. Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter.
International journal of molecular sciences.
2015 Jun; 16(6):12560-77. doi:
10.3390/ijms160612560. [PMID: 26047341] - Chin-Yi Tsai, Meng Teng Peh, Wei Feng, Brian William Dymock, Philip Keith Moore. Hydrogen sulfide promotes adipogenesis in 3T3L1 cells.
PloS one.
2015; 10(3):e0119511. doi:
10.1371/journal.pone.0119511. [PMID: 25822632] - Suowen Xu, Zhiping Liu, Peiqing Liu. Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis.
International journal of cardiology.
2014 Mar; 172(2):313-7. doi:
10.1016/j.ijcard.2014.01.068. [PMID: 24491853] - Eberhard Grambow, Fabian Mueller-Graf, Evgenya Delyagina, Marcus Frank, Angela Kuhla, Brigitte Vollmar. Effect of the hydrogen sulfide donor GYY4137 on platelet activation and microvascular thrombus formation in mice.
Platelets.
2014; 25(3):166-74. doi:
10.3109/09537104.2013.786823. [PMID: 23586391] - Romy Greiner, Zoltán Pálinkás, Katrin Bäsell, Dörte Becher, Haike Antelmann, Péter Nagy, Tobias P Dick. Polysulfides link H2S to protein thiol oxidation.
Antioxidants & redox signaling.
2013 Nov; 19(15):1749-65. doi:
10.1089/ars.2012.5041. [PMID: 23646934] - Zhen Liu, Yi Han, Ling Li, Hui Lu, Guoliang Meng, Xiaozhen Li, Mohammed Shirhan, Meng Teng Peh, Liping Xie, Suming Zhou, Xiaowei Wang, Qi Chen, Weilu Dai, Choon-Hong Tan, Shiyang Pan, Philip K Moore, Yong Ji. The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-/-) mice.
British journal of pharmacology.
2013 Aug; 169(8):1795-809. doi:
10.1111/bph.12246. [PMID: 23713790] - Zhong-Guang Li, Shi-Zhong Yang, Wei-Biao Long, Guo-Xian Yang, Zhen-Zhen Shen. Hydrogen sulphide may be a novel downstream signal molecule in nitric oxide-induced heat tolerance of maize (Zea mays L.) seedlings.
Plant, cell & environment.
2013 Aug; 36(8):1564-72. doi:
10.1111/pce.12092. [PMID: 23489239] - Keqing Wang, Shakil Ahmad, Meng Cai, Jillian Rennie, Takeshi Fujisawa, Fatima Crispi, James Baily, Mark R Miller, Melissa Cudmore, Patrick W F Hadoke, Rui Wang, Eduard Gratacós, Irina A Buhimschi, Catalin S Buhimschi, Asif Ahmed. Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia.
Circulation.
2013 Jun; 127(25):2514-22. doi:
10.1161/circulationaha.113.001631. [PMID: 23704251] - Brian DellaValle, Trine Staalsoe, Jørgen Anders Lindholm Kurtzhals, Casper Hempel. Investigation of hydrogen sulfide gas as a treatment against P. falciparum, murine cerebral malaria, and the importance of thiolation state in the development of cerebral malaria.
PloS one.
2013; 8(3):e59271. doi:
10.1371/journal.pone.0059271. [PMID: 23555646] - Miroslav Lisjak, Tihana Teklić, Ian D Wilson, Mark Wood, Matt Whiteman, John T Hancock. Hydrogen sulfide effects on stomatal apertures.
Plant signaling & behavior.
2011 Oct; 6(10):1444-6. doi:
10.4161/psb.6.10.17104. [PMID: 21904118] - M Lisjak, N Srivastava, T Teklic, L Civale, K Lewandowski, I Wilson, M E Wood, M Whiteman, J T Hancock. A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation.
Plant physiology and biochemistry : PPB.
2010 Dec; 48(12):931-5. doi:
10.1016/j.plaphy.2010.09.016. [PMID: 20970349] - Fang Yu, Jing Zhao, Chao-shu Tang, Bin Geng. [Effect of synthesized GYY4137, a slowly releasing hydrogen sulfide donor, on cell viability and distribution of hydrogen sulfide in mice].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2010 Oct; 42(5):493-7. doi:
NULL. [PMID: 20957002] - Ling Li, Manuel Salto-Tellez, Choon-Hong Tan, Matthew Whiteman, Philip K Moore. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.
Free radical biology & medicine.
2009 Jul; 47(1):103-13. doi:
10.1016/j.freeradbiomed.2009.04.014. [PMID: 19375498] - Ling Li, Matthew Whiteman, Yan Yi Guan, Kay Li Neo, Yvonne Cheng, Shiau Wei Lee, Yujun Zhao, Rajamanian Baskar, Choon-Hong Tan, Philip K Moore. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.
Circulation.
2008 May; 117(18):2351-60. doi:
10.1161/circulationaha.107.753467. [PMID: 18443240]