(R)-alpha-Methylhistamine (BioDeep_00001029249)
代谢物信息卡片
(R)-alpha-Methylhistamine
化学式: C6H11N3 (125.0952926)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CN=CN1)N
InChI: InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Walid Beghdadi, Adeline Porcherie, Bradley S Schneider, Séverine Morisset, David Dubayle, Roger Peronet, Michel Dy, Jacques Louis, Jean-Michel Arrang, Salaheddine Mécheri. Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria.
PloS one.
2009 Jun; 4(6):e6004. doi:
10.1371/journal.pone.0006004. [PMID: 19547708] - Hayato Kurata, Toshihide Fujii, Hidenobu Tsutsui, Tomoaki Katayama, Mamoru Ohkita, Masanori Takaoka, Nobuo Tsuruoka, Yoshinobu Kiso, Yukihiro Ohno, Yoshihide Fujisawa, Takatoshi Shokoji, Akira Nishiyama, Youichi Abe, Yasuo Matsumura. Renoprotective effects of l-carnosine on ischemia/reperfusion-induced renal injury in rats.
The Journal of pharmacology and experimental therapeutics.
2006 Nov; 319(2):640-7. doi:
10.1124/jpet.106.110122. [PMID: 16916994] - Raquel Poveda, Víctor Fernández-Dueñas, Alejandro Fernández, Sílvia Sánchez, Margarita M Puig, Eulàlia Planas. Synergistic interaction between fentanyl and the histamine H3 receptor agonist R-(alpha)-methylhistamine, on the inhibition of nociception and plasma extravasation in mice.
European journal of pharmacology.
2006 Jul; 541(1-2):53-6. doi:
10.1016/j.ejphar.2006.05.008. [PMID: 16762339] - K Malmlöf, F Zaragoza, V Golozoubova, H H F Refsgaard, T Cremers, K Raun, B S Wulff, P B Johansen, B Westerink, K Rimvall. Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight.
International journal of obesity (2005).
2005 Dec; 29(12):1402-12. doi:
10.1038/sj.ijo.0803036. [PMID: 16151415] - Kathleen M Krueger, David G Witte, Lynne Ireland-Denny, Thomas R Miller, John L Baranowski, Steve Buckner, Ivan Milicic, Timothy A Esbenshade, Arthur A Hancock. G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations.
The Journal of pharmacology and experimental therapeutics.
2005 Jul; 314(1):271-81. doi:
10.1124/jpet.104.078865. [PMID: 15821027] - V O Chaĭka, L I Havrysh, T D Khil'ko, L I Ostapchenko. [Participation of cyclic nucleotides and phospholipidis in signal transduction of histamin receptor H3 of the gastric mucosa parietal cells in rats with experimental ulcer].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2005 Mar; 77(2):118-22. doi:
NULL. [PMID: 16335243] - Violina Lozeva, Juhani Tarhanen, Martti Attila, Pekka T Männistö, Leena Tuomisto. Brain histamine and histamine H3 receptors following repeated L-histidine administration in rats.
Life sciences.
2003 Aug; 73(12):1491-503. doi:
10.1016/s0024-3205(03)00478-8. [PMID: 12865089] - Robbie L McLeod, Charlie A Rizzo, Robert E West, Robert Aslanian, Kevin McCormick, Matthew Bryant, Yunsheng Hsieh, Walter Korfmacher, Garfield G Mingo, LoriAnn Varty, Shirley M Williams, Neng-Yang Shih, Robert W Egan, John A Hey. Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687).
The Journal of pharmacology and experimental therapeutics.
2003 Jun; 305(3):1037-44. doi:
10.1124/jpet.103.049254. [PMID: 12649305] - Jingcai Chen, Changlu Liu, Timothy W Lovenberg. Molecular and pharmacological characterization of the mouse histamine H3 receptor.
European journal of pharmacology.
2003 Apr; 467(1-3):57-65. doi:
10.1016/s0014-2999(03)01635-2. [PMID: 12706455] - Mark O'Reilly, Robbin Alpert, Stephen Jenkinson, Ronald P Gladue, Shane Foo, Steven Trim, Beate Peter, Mike Trevethick, Mark Fidock. Identification of a histamine H4 receptor on human eosinophils--role in eosinophil chemotaxis.
Journal of receptor and signal transduction research.
2002 Feb; 22(1-4):431-48. doi:
10.1081/rrs-120014612. [PMID: 12503632] - T Yamasaki, I Tamai, Y Matsumura. Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs.
American journal of physiology. Regulatory, integrative and comparative physiology.
2001 May; 280(5):R1450-6. doi:
10.1152/ajpregu.2001.280.5.r1450. [PMID: 11294767] - Y Zhu, D Michalovich, H Wu, K B Tan, G M Dytko, I J Mannan, R Boyce, J Alston, L A Tierney, X Li, N C Herrity, L Vawter, H M Sarau, R S Ames, C M Davenport, J P Hieble, S Wilson, D J Bergsma, L R Fitzgerald. Cloning, expression, and pharmacological characterization of a novel human histamine receptor.
Molecular pharmacology.
2001 Mar; 59(3):434-41. doi:
10.1124/mol.59.3.434. [PMID: 11179436] - H Stark, M Krause, A Rouleau, M Garbarg, J C Schwartz, W Schunack. Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-alpha-methylhistamine.
Bioorganic & medicinal chemistry.
2001 Jan; 9(1):191-8. doi:
10.1016/s0968-0896(00)00237-6. [PMID: 11197341]