(2-Methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1-biphenyl]-4-yl)(1-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4-piperidin]-5(2H)-yl)methanone (BioDeep_00001029222)
代谢物信息卡片
化学式: C32H32N4O3 (520.2474282)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6
InChI: InChI=1S/C32H32N4O3/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32/h4-9,16-18H,10-15,19H2,1-3H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Walid Tajeddinn, Torbjörn Persson, Javier Calvo-Garrido, Mohammed Seed Ahmed, Silvia Maioli, Swetha Vijayaraghavan, Mehmet Selim Kazokoglu, Cristina Parrado-Fernández, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarsland. Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2016 05; 53(1):349-61. doi:
10.3233/jad-160046. [PMID: 27163814] - Chelsi D Cassilly, Marcus M Maddox, Philip T Cherian, John J Bowling, Mark T Hamann, Richard E Lee, Todd B Reynolds. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
PloS one.
2016; 11(5):e0154932. doi:
10.1371/journal.pone.0154932. [PMID: 27183222] - Frank Scott Hall, Ichiro Sora, René Hen, George R Uhl. Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout.
PloS one.
2014; 9(12):e115009. doi:
10.1371/journal.pone.0115009. [PMID: 25514162] - Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaier. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes.
Synapse (New York, N.Y.).
2012 Dec; 66(12):1024-34. doi:
10.1002/syn.21608. [PMID: 22961814] - E Muñoz-Islas, S Gupta, L R Jiménez-Mena, J Lozano-Cuenca, A Sánchez-López, D Centurión, S Mehrotra, A MaassenVanDenBrink, C M Villalón. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.
British journal of pharmacology.
2006 Sep; 149(1):82-91. doi:
10.1038/sj.bjp.0706839. [PMID: 16880765] - Minke E Jongsma, Fokko J Bosker, Thomas I F H Cremers, Ben H C Westerink, Johan A den Boer. The effect of chronic selective serotonin reuptake inhibitor treatment on serotonin 1B receptor sensitivity and HPA axis activity.
Progress in neuro-psychopharmacology & biological psychiatry.
2005 Jun; 29(5):738-44. doi:
10.1016/j.pnpbp.2005.04.026. [PMID: 15961207] - Ian A Pullar, John R Boot, Richard J Broadmore, Tina A Eyre, Jane Cooper, Graham J Sanger, Susan Wedley, Stephen N Mitchell. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig.
European journal of pharmacology.
2004 Jun; 493(1-3):85-93. doi:
10.1016/j.ejphar.2004.04.029. [PMID: 15189767]