5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide (BioDeep_00001029203)
代谢物信息卡片
化学式: C23H24FN5O2 (421.19139359999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F
InChI: InChI=1S/C23H24FN5O2/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31)
描述信息
FIPI (5-Fluoro-2-indolyl des-chlorohalopemide), a derivative of Halopemide (HY-119093), is a phospholipase D (PLD) inhibitor with IC50s of approximately 25 nM and 20 nM for PLD1 and PLD2, respectively. FIPI inhibits PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. FIPI has the potential for autoimmunity and cancer metastasis research[1][2][3].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:190022
- PubChem: 16739265
- ChEMBL: CHEMBL398567
- CAS: 939055-18-2
- medchemexpress: HY-12807
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Veronika Jablonická, Jörg Ziegler, Zuzana Vatehová, Desana Lišková, Ingo Heilmann, Marek Obložinský, Mareike Heilmann. Inhibition of phospholipases influences the metabolism of wound-induced benzylisoquinoline alkaloids in Papaver somniferum L.
Journal of plant physiology.
2018 Apr; 223(?):1-8. doi:
10.1016/j.jplph.2018.01.007. [PMID: 29433083] - Amanda R Noble, Norman J Maitland, Daniel M Berney, Martin G Rumsby. Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation.
British journal of cancer.
2018 01; 118(2):189-199. doi:
10.1038/bjc.2017.391. [PMID: 29136407] - Yannick Comoglio, Joshua Levitz, Michael A Kienzler, Florian Lesage, Ehud Y Isacoff, Guillaume Sandoz. Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
Proceedings of the National Academy of Sciences of the United States of America.
2014 Sep; 111(37):13547-52. doi:
10.1073/pnas.1407160111. [PMID: 25197053] - Aditya Kulkarni, Phong Quang, Victoriana Curry, Renee Keyes, Weihong Zhou, Hyejin Cho, Jonathan Baffoe, Béla Török, Kimberly Stieglitz. 1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D.
Chemical biology & drug design.
2014 Sep; 84(3):270-81. doi:
10.1111/cbdd.12319. [PMID: 24641677] - David Stegner, Ina Thielmann, Peter Kraft, Michael A Frohman, Guido Stoll, Bernhard Nieswandt. Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report.
Arteriosclerosis, thrombosis, and vascular biology.
2013 Sep; 33(9):2212-7. doi:
10.1161/atvbaha.113.302030. [PMID: 23868933] - Qing Ye, Samuel Kantonen, Julian Gomez-Cambronero. Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion.
Journal of molecular biology.
2013 Feb; 425(4):755-66. doi:
10.1016/j.jmb.2012.11.035. [PMID: 23238254] - Jordan D Secor, Sainath R Kotha, Travis O Gurney, Rishi B Patel, Nicholas R Kefauver, Niladri Gupta, Andrew J Morris, Boyd E Haley, Narasimham L Parinandi. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells.
International journal of toxicology.
2011 Dec; 30(6):619-38. doi:
10.1177/1091581811422413. [PMID: 21994240] - Rishi B Patel, Sainath R Kotha, Shariq I Sherwani, Sean M Sliman, Travis O Gurney, Brooke Loar, Susan O'Connor Butler, Andrew J Morris, Clay B Marsh, Narasimham L Parinandi. Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells.
International journal of toxicology.
2011 Feb; 30(1):69-90. doi:
10.1177/1091581810388850. [PMID: 21131602] - Yuhki Yanase, Nicolas Carvou, Michael A Frohman, Shamshad Cockcroft. Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6.
The Biochemical journal.
2009 Dec; 425(1):179-93. doi:
10.1042/bj20091122. [PMID: 19845506] - Sarah A Scott, Paige E Selvy, Jason R Buck, Hyekyung P Cho, Tracy L Criswell, Ashley L Thomas, Michelle D Armstrong, Carlos L Arteaga, Craig W Lindsley, H Alex Brown. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.
Nature chemical biology.
2009 Feb; 5(2):108-17. doi:
10.1038/nchembio.140. [PMID: 19136975]