(1R,4S,5S,6R,6S,8R,10E,12S,13S,14E,16E,20R,21E,24S)-6-cyclohexyl-24-hydroxy-21-hydroxyimino-12-[(4S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5,11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2-oxane]-2-one (BioDeep_00001029132)
代谢物信息卡片
(1R,4S,5S,6R,6S,8R,10E,12S,13S,14E,16E,20R,21E,24S)-6-cyclohexyl-24-hydroxy-21-hydroxyimino-12-[(4S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5,11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2-oxane]-2-one
化学式: C43H63NO11 (769.4400888)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2(CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)O)OC)C)OC1C7CCCCC7
InChI: InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36+/t24-,26-,28-,31+,32-,33-,34-,35?,37?,38-,39-,40+,42+,43+/m0/s1
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- José Manuel Ezquerra-Aznárez, Giulia Degiacomi, Henrich Gašparovič, Giovanni Stelitano, Josè Camilla Sammartino, Jana Korduláková, Paolo Governa, Fabrizio Manetti, Maria Rosalia Pasca, Laurent Roberto Chiarelli, Santiago Ramón-García. The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of the Mycobacterium tuberculosis DprE1 Enzyme.
International journal of molecular sciences.
2022 Jan; 23(2):. doi:
10.3390/ijms23020771. [PMID: 35054958] - Wakako Yonetake, Takeshi Fujii, Masaya Naito, Steven Maeder, Douglas Rugg. Efficacy and safety of a new topical formulation containing selamectin and sarolaner in the prevention of heartworm disease and the treatment of roundworm infection in cats presented as veterinary patients in Japan.
Veterinary parasitology.
2019 Jun; 270 Suppl 1(?):S38-S44. doi:
10.1016/j.vetpar.2019.04.001. [PMID: 31104940] - A Ray Dillon, Bryon L Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders, Sharron Barney. The progression of heartworm associated respiratory disease (HARD) in SPF cats 18 months after Dirofilaria immitis infection.
Parasites & vectors.
2017 Nov; 10(Suppl 2):533. doi:
10.1186/s13071-017-2425-9. [PMID: 29143683] - Miranda J Sadar, David Sanchez-Migallon Guzman, Asli Mete, Janet Foley, Nicole Stephenson, Krysta H Rogers, Claire Grosset, K Shawn Smallwood, Jessica Shipman, Amy Wells, Stephen D White, Douglas A Bell, Michelle G Hawkins. Mange Caused by a Novel Micnemidocoptes Mite in a Golden Eagle ( Aquila chrysaetos ).
Journal of avian medicine and surgery.
2015 Sep; 29(3):231-7. doi:
10.1647/2014-047. [PMID: 26378670] - Emilie Bouhsira, Michel Franc, Emmanuel Lienard, Corinne Bouillin, Christelle Gandoin, Thomas Geurden, Csilla Becskei, Philippe Jacquiet, Anne Thomas, Henri Jean Boulouis. The efficacy of a selamectin (Stronghold ®) spot on treatment in the prevention of Bartonella henselae transmission by Ctenocephalides felis in cats, using a new high-challenge model.
Parasitology research.
2015 Mar; 114(3):1045-50. doi:
10.1007/s00436-014-4271-4. [PMID: 25582566] - Brad Hayes, Beate Schnitzler, Scott Wiseman, Daniel E Snyder. Field evaluation of the efficacy and safety of a combination of spinosad and milbemycin oxime in the treatment and prevention of naturally acquired flea infestations and treatment of intestinal nematode infections in dogs in Europe.
Veterinary parasitology.
2015 Jan; 207(1-2):99-106. doi:
10.1016/j.vetpar.2014.11.011. [PMID: 25465736] - A Ray Dillon, D M Tillson, A Wooldridge, R Cattley, J Hathcock, W R Brawner, R Cole, B Welles, P W Christopherson, T Lee-Fowler, S Bordelon, S Barney, M Sermersheim, R Garbarino, S Z Wells, E B Diffie, E R Schachner. Effect of pre-cardiac and adult stages of Dirofilaria immitis in pulmonary disease of cats: CBC, bronchial lavage cytology, serology, radiographs, CT images, bronchial reactivity, and histopathology.
Veterinary parasitology.
2014 Nov; 206(1-2):24-37. doi:
10.1016/j.vetpar.2014.09.007. [PMID: 25288308] - Alicia Hahn, Jennifer D'Agostino, Gretchen Cole, Butch Kukanich. Pharmacokinetics of selamectin in helmeted guineafowl (Numida meleagris) after topical administration.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2014 Mar; 45(1):176-8. doi:
10.1638/2013-0112r.1. [PMID: 24712181] - James W Carpenter, Michael W Dryden, Butch Kukanich. Pharmacokinetics, efficacy, and adverse effects of selamectin following topical administration in flea-infested rabbits.
American journal of veterinary research.
2012 Apr; 73(4):562-6. doi:
10.2460/ajvr.73.4.562. [PMID: 22452505] - J Geyer, O Gavrilova, E Petzinger. Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein- and bcrp- deficient knockout mice.
Journal of veterinary pharmacology and therapeutics.
2009 Feb; 32(1):87-96. doi:
10.1111/j.1365-2885.2008.01007.x. [PMID: 19161460] - C McCoy, A B Broce, M W Dryden. Flea blood feeding patterns in cats treated with oral nitenpyram and the topical insecticides imidacloprid, fipronil and selamectin.
Veterinary parasitology.
2008 Oct; 156(3-4):293-301. doi:
10.1016/j.vetpar.2008.04.028. [PMID: 18619735] - M U Esatgil, A Gülanber, H Aydin. Use of topical selamectin for the treatment of Trichosomoides crassicauda infection in laboratory rats.
Polish journal of veterinary sciences.
2008; 11(2):143-5. doi:
NULL. [PMID: 18683544] - Jennifer J D'Agostino, Gary West, Dawn M Boothe, Prashanth K Jayanna, Timothy Snider, John P Hoover. Plasma pharmacokinetics of selamectin after a single topical administration in the American bullfrog (Rana catesbeiana).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2007 Mar; 38(1):51-4. doi:
10.1638/06-054.1. [PMID: 17469275] - J Dupuy, A L Derlon, J F Sutra, M C Cadiergues, M Franc, M Alvinerie. Pharmacokinetics of selamectin in dogs after topical application.
Veterinary research communications.
2004 Jul; 28(5):407-13. doi:
10.1023/b:verc.0000034993.87007.f8. [PMID: 15379435] - Jeffrey R Bloomquist. Chloride channels as tools for developing selective insecticides.
Archives of insect biochemistry and physiology.
2003 Dec; 54(4):145-56. doi:
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Veterinary parasitology.
2003 Aug; 116(1):45-50. doi:
10.1016/s0304-4017(03)00163-8. [PMID: 14519326] - Nadège Chailleux, Manon Paradis. Efficacy of selamectin in the treatment of naturally acquired cheyletiellosis in cats.
The Canadian veterinary journal = La revue veterinaire canadienne.
2002 Oct; 43(10):767-70. doi:
NULL. [PMID: 12395757] - P Sarasola, A D Jernigan, D K Walker, J Castledine, D G Smith, T G Rowan. Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs.
Journal of veterinary pharmacology and therapeutics.
2002 Aug; 25(4):265-72. doi:
10.1046/j.1365-2885.2002.00415.x. [PMID: 12213114] - J F Sutra, M C Cadiergues, J Dupuy, M Franc, M Alvinerie. Determination of selamectin in dog plasma by high performance liquid chromatography with automated solid phase extraction and fluorescence detection.
Veterinary research.
2001 Sep; 32(5):455-61. doi:
10.1051/vetres:2001137. [PMID: 11592615] - D K Walker, K S Fenner. A sensitive method for the measurement of the novel pet endectocide, selamectin (UK-124,114), in dog and cat plasma by chemical derivatisation and high-performance liquid chromatography with fluorescence detection.
Journal of pharmaceutical and biomedical analysis.
2000 Dec; 24(1):105-11. doi:
10.1016/s0731-7085(00)00415-5. [PMID: 11108544] - K W Kwochka, D Gram, G A Kunkle, K M Beale, C A Sousa, A Cannon, J D Plant. Clinical efficacy of selamectin for the control of fleas on dogs and cats.
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