(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydron;dichloride;hydrate (BioDeep_00001029118)
代谢物信息卡片
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydron;dichloride;hydrate
化学式: C34H38Cl2N2O5 (624.2157638)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [H+].[H+].CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.O.[Cl-].[Cl-]
InChI: 2*1H
描述信息
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D004639 - Emetics
D002491 - Central Nervous System Agents
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Akihiko Miyauchi, Chika Watanabe, Naoya Yamada, Eriko F Jimbo, Mizuki Kobayashi, Natsumi Ohishi, Atsuko Nagayoshi, Shiho Aoki, Yoshihito Kishita, Akira Ohtake, Nobuhiko Ohno, Masafumi Takahashi, Takanori Yamagata, Hitoshi Osaka. Apomorphine is a potent inhibitor of ferroptosis independent of dopaminergic receptors.
Scientific reports.
2024 02; 14(1):4820. doi:
10.1038/s41598-024-55293-1. [PMID: 38413694] - Noura S Dosoky, Sara A Shah, Joseph T Dawson, Sushant Sharma Banjara, Ambika Poudel, Cécile Bascoul, Prabodh Satyal. Chemical Composition, Market Survey, and Safety Assessment of Blue Lotus (Nymphaea caerulea Savigny) Extracts.
Molecules (Basel, Switzerland).
2023 Oct; 28(20):. doi:
10.3390/molecules28207014. [PMID: 37894493] - S B Caine, S Plant, K Furbish, M Yerton, E Smaragdi, B Niclou, J M Lorusso, J Y Chang, C Bitter, A Basu, S Miller, C-Y Huang, R Komson, D Liu, S Behar, M Thomsen. Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs.
Psychopharmacology.
2023 Aug; ?(?):. doi:
10.1007/s00213-023-06444-1. [PMID: 37580441] - Yami Bright, Dorien A Maas, Michel M M Verheij, Maria Serena Paladini, Helene I V Amatdjais-Groenen, Raffaella Molteni, Marco A Riva, Gerard J M Martens, Judith R Homberg. The Natural Protoalkaloid Methyl-2-Amino-3-Methoxybenzoate (MAM) Alleviates Positive as well as Cognitive Symptoms in Rat and Mouse Schizophrenia Models.
Current neuropharmacology.
2023 Jul; ?(?):. doi:
10.2174/1570159x21666230720122354. [PMID: 37475559] - Joaquim Barbosa Leite Júnior, Luiz Gustavo Soares Carvalho Crespo, Richard Ian Samuels, Norberto Cysne Coimbra, Robert J Carey, Marinete Pinheiro Carrera. Morphine and dopamine: Low dose apomorphine can prevent both the induction and expression of morphine locomotor sensitization and conditioning.
Behavioural brain research.
2023 Apr; 448(?):114434. doi:
10.1016/j.bbr.2023.114434. [PMID: 37100351] - Samaresh Pal Roy, Sunil Kumar Kadiri, Vipulkumar V Karkar, Srinivasa Rao Konijeti. Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates.
Annales pharmaceutiques francaises.
2022 Nov; 80(6):853-863. doi:
10.1016/j.pharma.2022.02.007. [PMID: 35240121] - Noah A Omeiza, Adewale G Bakre, Halimat A Abdulrahim, Happy Isibor, Precious U Ezurike, Abimbola A Sowunmi, Benneth Ben-Azu, Adegbuyi O Aderibigbe. Pretreatment with Carpolobia lutea ethanol extract prevents schizophrenia-like behavior in mice models of psychosis.
Journal of ethnopharmacology.
2022 Sep; 295(?):115432. doi:
10.1016/j.jep.2022.115432. [PMID: 35659625] - Miranda Buseman, April E Blong, Rebecca A L Walton. Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2022 Sep; 32(5):675-679. doi:
10.1111/vec.13203. [PMID: 35527394] - Saurabh Bhatia, Ahmed Al-Harrasi, Arun Kumar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Md Khalid Anwer, Deepak Kaushik, Vineet Mittal, Sridevi Chigurupati, Pritam Babu Sharma, Lotfi Aleya, Celia Vargas-de-la-Cruz, Md Tanvir Kabir. Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn.
Environmental science and pollution research international.
2022 Apr; 29(18):27460-27478. doi:
10.1007/s11356-021-17810-x. [PMID: 34981370] - Eva Thijssen, Jonas den Heijer, David Puibert, Laurence Moss, Mingzu Lei, David Hasegawa, Kyo Keum, Ken Mochel, Mohammed Ezzeldin Sharaf, Tom Alfredson, Wenxiang Zeng, Emilie van Brummelen, Tatjana Naranda, Geert Jan Groeneveld. A Randomized Trial Assessing the Safety, Pharmacokinetics, and Efficacy During Morning Off of AZ-009.
Movement disorders : official journal of the Movement Disorder Society.
2022 04; 37(4):790-798. doi:
10.1002/mds.28926. [PMID: 35048423] - Farajollah Jafari, Mahdi Goudarzvand, Ramin Hajikhani, Mostafa Qorbani, Jalal Solati. Pycnogenol ameliorates motor function and gene expressions of NF-ƙB and Nrf2 in a 6-hydroxydopamine-induced experimental model of Parkinson's disease in male NMRI mice.
Naunyn-Schmiedeberg's archives of pharmacology.
2022 03; 395(3):305-313. doi:
10.1007/s00210-022-02201-x. [PMID: 35024909] - Jayoung Kim, Yongsheng Gao, Zongmin Zhao, Danika Rodrigues, Eden E L Tanner, Kelly Ibsen, Pradip K Sasmal, Rajasekhar Jaladi, Shanavas Alikunju, Samir Mitragotri. A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America.
2022 03; 119(9):. doi:
10.1073/pnas.2110450119. [PMID: 35197281] - Huan Li, Joonki Kim, Huynh Nguyen Khanh Tran, Chang Hwan Lee, Jonghyun Hur, Min Cheol Kim, Hyun Ok Yang. Extract of Polygala tenuifolia, Angelica tenuissima, and Dimocarpus longan Reduces Behavioral Defect and Enhances Autophagy in Experimental Models of Parkinson's Disease.
Neuromolecular medicine.
2021 09; 23(3):428-443. doi:
10.1007/s12017-020-08643-x. [PMID: 33432492] - Felix Agbo, Ryan L Crass, Yu-Yuan Chiu, Sunny Chapel, Gerald Galluppi, David Blum, Bradford Navia. Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson's disease.
Clinical and translational science.
2021 07; 14(4):1464-1475. doi:
10.1111/cts.13008. [PMID: 33650272] - Lennard van der Woude, Markus Piotrowski, Gruson Klaasse, Judith K Paulus, Daniel Krahn, Sabrina Ninck, Farnusch Kaschani, Markus Kaiser, Ondřej Novák, Karin Ljung, Suzanne Bulder, Marcel van Verk, Basten L Snoek, Martijn Fiers, Nathaniel I Martin, Renier A L van der Hoorn, Stéphanie Robert, Sjef Smeekens, Martijn van Zanten. The chemical compound 'Heatin' stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilases.
The Plant journal : for cell and molecular biology.
2021 06; 106(6):1523-1540. doi:
10.1111/tpj.15250. [PMID: 33768644] - Constantin Itin, Rinat Komargodski, Dinorah Barasch, Abraham J Domb, Amnon Hoffman. Prolonged Delivery of Apomorphine Through the Buccal Mucosa, Towards a Noninvasive Sustained Administration Method in Parkinson's Disease: In Vivo Investigations in Pigs.
Journal of pharmaceutical sciences.
2021 04; 110(4):1824-1833. doi:
10.1016/j.xphs.2020.12.010. [PMID: 33333142] - Hui Lei, Rutong Ren, Yi Sun, Ke Zhang, Xin Zhao, Nuramatjan Ablat, Xiaoping Pu. Neuroprotective Effects of Safflower Flavonoid Extract in 6-Hydroxydopamine-Induced Model of Parkinson's Disease May Be Related to its Anti-Inflammatory Action.
Molecules (Basel, Switzerland).
2020 Nov; 25(21):. doi:
10.3390/molecules25215206. [PMID: 33182332] - Yu-Luan Chen, Lei Shi, Felix Agbo, Shun Hui Yong, Pang-Seng Tan, Armand Gatien Ngounou Wetie. LC-MS/MS simultaneous quantification of apomorphine and its major metabolites in human plasma: Application to clinical comparative bioavailability evaluation for the apomorphine sublingual film and a subcutaneous product.
Journal of pharmaceutical and biomedical analysis.
2020 Oct; 190(?):113493. doi:
10.1016/j.jpba.2020.113493. [PMID: 32795778] - Constantin Itin, Rinat Komargodski, Abraham J Domb, Amnon Hoffman. Controlled Delivery of Apomorphine Through Buccal Mucosa, Towards a Noninvasive Administration Method in Parkinson's Disease: A Preclinical Mechanistic Study.
Journal of pharmaceutical sciences.
2020 09; 109(9):2729-2734. doi:
10.1016/j.xphs.2020.05.017. [PMID: 32497595] - Jalles Dantas de Lucena, Carlos Vinicius Jataí Gadelha-Filho, Roberta Oliveira da Costa, Dayane Pessoa de Araújo, Francisco Arnaldo Viana Lima, Kelly Rose Tavares Neves, Glauce Socorro de Barros Viana. L-linalool exerts a neuroprotective action on hemiparkinsonian rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 06; 393(6):1077-1088. doi:
10.1007/s00210-019-01793-1. [PMID: 31938809] - Rongfei Wang, Ming Shao. L-DOPA-elicited abnormal involuntary movements in the rats damaged severely in substantia nigra by 6-hydroxydopamine.
Annals of palliative medicine.
2020 May; 9(3):947-956. doi:
10.21037/apm.2020.03.32. [PMID: 32279520] - João Marcos de Mello Bastos, Joaquim Barbosa Leite, Richard Ian Samuels, Robert J Carey, Marinete Pinheiro Carrera. Post-trial low dose apomorphine prevents the development of morphine sensitization.
Behavioural brain research.
2020 02; 380(?):112398. doi:
10.1016/j.bbr.2019.112398. [PMID: 31790782] - Rodrigo Moreno Klein, Camila Rigobello, Camila Borecki Vidigal, Kawane Fabrício Moura, Décio Sabbatini Barbosa, Daniela Cristina Ceccatto Gerardin, Graziela Scalianti Ceravolo, Estefânia Gastaldello Moreira. Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny.
Neurotoxicology and teratology.
2020 Jan; 77(?):106838. doi:
10.1016/j.ntt.2019.106838. [PMID: 31644948] - Leila Hamzehloei, Mohammad Ebrahim Rezvani, Ziba Rajaei. Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson's disease.
Arquivos de neuro-psiquiatria.
2019 07; 77(7):493-500. doi:
10.1590/0004-282x20190079. [PMID: 31365641] - Mitsuharu Ueda, Masamitsu Okada, Mineyuki Mizuguchi, Barbara Kluve-Beckerman, Kyosuke Kanenawa, Aito Isoguchi, Yohei Misumi, Masayoshi Tasaki, Akihiko Ueda, Akinori Kanai, Ryoko Sasaki, Teruaki Masuda, Yasuteru Inoue, Toshiya Nomura, Satoru Shinriki, Tsuyoshi Shuto, Hirofumi Kai, Taro Yamashita, Hirotaka Matsui, Merrill D Benson, Yukio Ando. A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH.
The Journal of biological chemistry.
2019 07; 294(29):11259-11275. doi:
10.1074/jbc.ra119.007851. [PMID: 31167790] - Takehiko Ogura, Christian Goeschl, Daniele Filiault, Madalina Mirea, Radka Slovak, Bonnie Wolhrab, Santosh B Satbhai, Wolfgang Busch. Root System Depth in Arabidopsis Is Shaped by EXOCYST70A3 via the Dynamic Modulation of Auxin Transport.
Cell.
2019 07; 178(2):400-412.e16. doi:
10.1016/j.cell.2019.06.021. [PMID: 31299202] - Frederico Velasco Costa Sanguedo, Richard Ian Samuels, Robert J Carey, Marinete Pinheiro Carrera. Medial prefrontal cortex ERK and conditioning: Evidence for the association of increased medial prefrontal cortex ERK with the presence/absence of apomorphine conditioned behavior using a unique post-trial conditioning/extinction protocol.
Behavioural brain research.
2019 06; 365(?):56-65. doi:
10.1016/j.bbr.2019.02.022. [PMID: 30779974] - Andreas Coors, Marcel Brosch, Evelyn Kahl, Radwa Khalil, Birgit Michels, Annegret Laub, Katrin Franke, Bertram Gerber, Markus Fendt. Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating.
Journal of ethnopharmacology.
2019 May; 235(?):320-328. doi:
10.1016/j.jep.2019.02.031. [PMID: 30776471] - Joaquim Barbosa Leite Junior, João Marcos de Mello Bastos, Richard Ian Samuels, Robert J Carey, Marinete Pinheiro Carrera. Reversal of morphine conditioned behavior by an anti-dopaminergic post-trial drug treatment during re-consolidation.
Behavioural brain research.
2019 02; 359(?):771-782. doi:
10.1016/j.bbr.2018.08.009. [PMID: 30114434] - Akio Nakashima, Atsushi Yamauchi, Junichi Matsumoto, Shinya Dohgu, Fuyuko Takata, Mitsuhisa Koga, Jiro Fukae, Yoshio Tsuboi, Yasufumi Kataoka. Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Behavioural pharmacology.
2019 02; 30(1):89-94. doi:
10.1097/fbp.0000000000000413. [PMID: 29847340] - Diana Hengartner, Hubert H Fernandez. The next chapter in symptomatic Parkinson disease treatments.
Parkinsonism & related disorders.
2019 02; 59(?):39-48. doi:
10.1016/j.parkreldis.2019.01.002. [PMID: 30661840] - Angelo Antonini, Wolfgang H Jost. [Duodenale levodopa and apomorphine infusion for motor complications in advanced Parkinson's disease].
Fortschritte der Neurologie-Psychiatrie.
2018 09; 86(S 01):S5-S9. doi:
10.1055/a-0646-4164. [PMID: 30107620] - Ludmila A R Lima, Maria Janice P Lopes, Roberta O Costa, Francisco Arnaldo V Lima, Kelly Rose T Neves, Iana B F Calou, Geanne M Andrade, Glauce S B Viana. Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats.
Journal of neuroinflammation.
2018 Aug; 15(1):249. doi:
10.1186/s12974-018-1266-6. [PMID: 30170624] - Angelo Antonini, Bianca Nitu. Apomorphine and levodopa infusion for motor fluctuations and dyskinesia in advanced Parkinson disease.
Journal of neural transmission (Vienna, Austria : 1996).
2018 08; 125(8):1131-1135. doi:
10.1007/s00702-018-1906-0. [PMID: 30006821] - Mohammad Reza Sarukhani, Hashem Haghdoost-Yazdi, Gilda Khandan-Chelarci. Changes in the Serum Urate Level Can Predict the Development of Parkinsonism in the 6-Hydroxydopamine Animal Model.
Neurochemical research.
2018 May; 43(5):1086-1095. doi:
10.1007/s11064-018-2522-y. [PMID: 29616443] - Rui Zhang, Anders H Andersen, Peter A Hardy, Eric Forman, April Evans, Yi Ai, Jin Yue, Guihua Yue, Don M Gash, Richard Grondin, Zhiming Zhang. Objectively measuring effects of electro-acupuncture in parkinsonian rhesus monkeys.
Brain research.
2018 Jan; 1678(?):12-19. doi:
10.1016/j.brainres.2017.10.006. [PMID: 29017909] - Bao-Dong Li, Jing-Jun Cui, Jia Song, Ce Qi, Pei-Feng Ma, Ya-Rong Wang, Jing Bai. Comparison of the Efficacy of Different Drugs on Non-Motor Symptoms of Parkinson's Disease: a Network Meta-Analysis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(1):119-130. doi:
10.1159/000486252. [PMID: 29339630] - Muserref Hilal Sehitoglu, Muhammet Yayla, Asli Kiraz, Rahime Ozlem Oztopuz, Yasin Bayir, Turan Karaca, Sumbul Khalid, Erol Akpinar. The effects of apomorphine on paracetamol-induced hepatotoxicity in rats.
Cellular and molecular biology (Noisy-le-Grand, France).
2017 Dec; 63(12):40-44. doi:
10.14715/cmb/2017.63.12.10. [PMID: 29307340] - Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo, Kennedy K E Kukuia, Thomas K Karikari, Alexander K Nyarko. An ethanolic extract of Desmodium adscendens exhibits antipsychotic-like activity in mice.
Journal of basic and clinical physiology and pharmacology.
2017 Sep; 28(5):507-518. doi:
10.1515/jbcpp-2016-0115. [PMID: 28710881] - Nrupa Borkar, Daniel R Andersson, Mingshi Yang, Anette Müllertz, René Holm, Huiling Mu. Efficacy of oral lipid-based formulations of apomorphine and its diester in a Parkinson's disease rat model.
The Journal of pharmacy and pharmacology.
2017 Sep; 69(9):1110-1115. doi:
10.1111/jphp.12758. [PMID: 28620913] - Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo, Kennedy K E Kukuia, Emelia Oppong Bekoe, Thomas K Karikari, Samuel B Kombian. Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis.
BMC complementary and alternative medicine.
2017 Aug; 17(1):389. doi:
10.1186/s12906-017-1901-2. [PMID: 28784133] - Frederico Velasco Sanguedo, Amanda Machado Figueiredo, Robert J Carey, Richard Ian Samuels, Marinete Pinheiro Carrera. ERK activation in the prefrontal cortex by acute apomorphine and apomorphine conditioned contextual stimuli.
Pharmacology, biochemistry, and behavior.
2017 08; 159(?):76-83. doi:
10.1016/j.pbb.2017.07.011. [PMID: 28739380] - Justin L Poklis, Haley A Mulder, Matthew S Halquist, Carl E Wolf, Alphonse Poklis, Michelle R Peace. The Blue Lotus Flower (Nymphea caerulea) Resin Used in a New Type of Electronic Cigarette, the Re-Buildable Dripping Atomizer.
Journal of psychoactive drugs.
2017 Jul; 49(3):175-181. doi:
10.1080/02791072.2017.1290304. [PMID: 28266899] - Sharanbasappa Durg, Naveen Kumar B, Ravichandra Vandal, Shivsharan B Dhadde, B S Thippeswamy, Veeresh P Veerapur, Shrishailappa Badami. Antipsychotic activity of embelin isolated from Embelia ribes: A preliminary study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Jun; 90(?):328-331. doi:
10.1016/j.biopha.2017.03.085. [PMID: 28376400] - Alexandre Sales Barros, Rafael Yuri Gouveia Crispim, Juliana Uchoa Cavalcanti, Ricardo Basto Souza, Jonatas Cavalcante Lemos, Gerardo Cristino Filho, Mirna Marques Bezerra, Thales Fontenele Moraes Pinheiro, Silvânia Maria Mendes de Vasconcelos, Danielle Silveira Macêdo, Glauce Socorro de Barros Viana, Lissiana Magna Vasconcelos Aguiar. Impact of the Chronic Omega-3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6-Hydroxydopamine in Rats.
Basic & clinical pharmacology & toxicology.
2017 Jun; 120(6):523-531. doi:
10.1111/bcpt.12713. [PMID: 27883274] - Marisol Maya-López, Hipolito A Ruiz-Contreras, María de Jesús Negrete-Ruíz, Julián Elías Martínez-Sánchez, Juan Benítez-Valenzuela, Ana Laura Colín-González, Juana Villeda-Hernández, Laura Sánchez-Chapul, Carmen Parra-Cid, Edgar Rangel-López, Abel Santamaría. URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Apr; 88(?):745-753. doi:
10.1016/j.biopha.2017.01.116. [PMID: 28157650] - Nikolaos Pitsikas, Petros A Tarantilis. Crocins, the active constituents of Crocus sativus L., counteracted apomorphine-induced performance deficits in the novel object recognition task, but not novel object location task, in rats.
Neuroscience letters.
2017 03; 644(?):37-42. doi:
10.1016/j.neulet.2017.02.042. [PMID: 28216334] - Nrupa Borkar, René Holm, Mingshi Yang, Anette Müllertz, Huiling Mu. In vivo evaluation of lipid-based formulations for oral delivery of apomorphine and its diester prodrugs.
International journal of pharmaceutics.
2016 Nov; 513(1-2):211-217. doi:
10.1016/j.ijpharm.2016.09.024. [PMID: 27615708] - Nrupa Borkar, Zhizhong Chen, Lasse Saaby, Anette Müllertz, Anders E Håkansson, Christian Schönbeck, Mingshi Yang, René Holm, Huiling Mu. Apomorphine and its esters: Differences in Caco-2 cell permeability and chylomicron affinity.
International journal of pharmaceutics.
2016 Jul; 509(1-2):499-506. doi:
10.1016/j.ijpharm.2016.06.010. [PMID: 27282537] - Zahra Kiasalari, Tourandokht Baluchnejadmojarad, Mehrdad Roghani. Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease.
Cellular and molecular neurobiology.
2016 May; 36(4):521-30. doi:
10.1007/s10571-015-0230-6. [PMID: 26119304] - Hashem Haghdoost-Yazdi, Hossein Piri, Ayda Faraji, Negin Fraidouni, Tahereh Dargahi, Marzieh Mahmudi, Mahmud Alipour Heidari. Pretreatment with potassium channel blockers of 4-aminopyridine and tetraethylammonium attenuates behavioural symptoms of Parkinsonism induced by intrastriatal injection of 6-hydroxydopamine; the role of lipid peroxidation.
Neurological research.
2016 Apr; 38(4):294-300. doi:
10.1080/01616412.2015.1114290. [PMID: 27098232] - Shuai Zhang, Si-Yuan Shao, Xiu-Yun Song, Cong-Yuan Xia, Ya-Nan Yang, Pei-Cheng Zhang, Nai-Hong Chen. Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity.
Neurotoxicology.
2016 Jan; 52(?):72-83. doi:
10.1016/j.neuro.2015.09.009. [PMID: 26408940] - Chuang-Hsin Chiu, I-Hsun Li, Shao-Ju Weng, Yuahn-Sieh Huang, Shinn-Chih Wu, Ta-Kai Chou, Wen-Sheng Huang, Mei-Hsiu Liao, Chyng-Yann Shiue, Cheng-Yi Cheng, Kuo-Hsing Ma. PET Imaging of Serotonin Transporters With 4-[(18)F]-ADAM in a Parkinsonian Rat Model With Porcine Neural Xenografts.
Cell transplantation.
2016; 25(2):301-11. doi:
10.3727/096368915x688236. [PMID: 25994923] - Masahiro Nomoto, Shin-ichiro Kubo, Masahiro Nagai, Tatsuo Yamada, Akira Tamaoka, Yoshio Tsuboi, Nobutaka Hattori. A Randomized Controlled Trial of Subcutaneous Apomorphine for Parkinson Disease: A Repeat Dose and Pharmacokinetic Study.
Clinical neuropharmacology.
2015 Nov; 38(6):241-7. doi:
10.1097/wnf.0000000000000111. [PMID: 26536022] - Ben A Chindo, Evelyn Kahl, Doris Trzeczak, Petra Dehmel, Axel Becker, Markus Fendt. Standardized extract of Ficus platyphylla reverses apomorphine-induced changes in prepulse inhibition and locomotor activity in rats.
Behavioural brain research.
2015 Oct; 293(?):74-80. doi:
10.1016/j.bbr.2015.06.044. [PMID: 26192913] - Bo-wen Weng, Si-chuan Hou, Hai Zhu, Luo Xu, Xiao Luan, Hai-yan Qi, Wei-min Wang, Wei Liu, Li-jiang Sun. [Expression of nNOS and ultrastructural changes in the penile tissue of rats with prolactinoma-induced erectile dysfunction].
Zhonghua nan ke xue = National journal of andrology.
2015 Oct; 21(10):871-6. doi:
. [PMID: 26665672] - Mehmet Hanifi Kokacya, Sema Inanir, Umit Sertan Copoglu, Recep Dokuyucu, Oytun Erbas. The Antipsychotic Effects of Omega-3 Fatty Acids in Rats.
The American journal of the medical sciences.
2015 Sep; 350(3):212-7. doi:
10.1097/maj.0000000000000531. [PMID: 26200950] - Susan Kashanian, Ali Shams, Hossein Ghahremani, Maliheh Paknejad. Preparation and Characterization of a Monoclonal Antibody Against Morphine.
Monoclonal antibodies in immunodiagnosis and immunotherapy.
2015 Aug; 34(4):270-4. doi:
10.1089/mab.2014.0098. [PMID: 26301931] - Xiaorong Pan, Chunxia Chen, Jianping Huang, Haiming Wei, Qiuping Fan. Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats.
Neuroscience letters.
2015 Jul; 600(?):220-5. doi:
10.1016/j.neulet.2015.06.030. [PMID: 26101828] - Jian-Hua Wei, Zhen-Feng Chen, Jiao-Lan Qin, Yan-Cheng Liu, Zhu-Quan Li, Taj-Malook Khan, Meng Wang, Yan-Hua Jiang, Wen-Ying Shen, Hong Liang. Water-soluble oxoglaucine-Y(III), Dy(III) complexes: in vitro and in vivo anticancer activities by triggering DNA damage, leading to S phase arrest and apoptosis.
Dalton transactions (Cambridge, England : 2003).
2015 Jul; 44(25):11408-19. doi:
10.1039/c5dt00926j. [PMID: 26017376] - Minetaro Arita, Stefan Philipov, Angel S Galabov. Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A.
Microbiology and immunology.
2015 Jun; 59(6):338-47. doi:
10.1111/1348-0421.12261. [PMID: 25891300] - Francisco Molinet-Dronda, Belén Gago, Ana Quiroga-Varela, Carlos Juri, María Collantes, Mercedes Delgado, Elena Prieto, Margarita Ecay, Elena Iglesias, Concepció Marín, Iván Peñuelas, José A Obeso. Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study.
Neurobiology of disease.
2015 May; 77(?):165-72. doi:
10.1016/j.nbd.2015.01.007. [PMID: 25681534] - G Martino, M Capasso, M Nasuti, L Bonanni, M Onofrj, A Thomas. Dopamine transporter single-photon emission computerized tomography supports diagnosis of akinetic crisis of parkinsonism and of neuroleptic malignant syndrome.
Medicine.
2015 Apr; 94(13):e649. doi:
10.1097/md.0000000000000649. [PMID: 25837755] - Kobra Zare, Akram Eidi, Mehrdad Roghani, Ali Haeri Rohani. The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat.
Metabolic brain disease.
2015 Feb; 30(1):205-13. doi:
10.1007/s11011-014-9604-6. [PMID: 25123753] - Feng Zhang, Anyuan Li. Dual ameliorative effects of Ningdong granule on dopamine in rat models of Tourette's syndrome.
Scientific reports.
2015 Jan; 5(?):7731. doi:
10.1038/srep07731. [PMID: 25592875] - Elisa Unti, Roberto Ceravolo, Ubaldo Bonuccelli. Apomorphine hydrochloride for the treatment of Parkinson's disease.
Expert review of neurotherapeutics.
2015; 15(7):723-32. doi:
10.1586/14737175.2015.1051468. [PMID: 26037961] - Nrupa Borkar, Boyang Li, René Holm, Anders E Håkansson, Anette Müllertz, Mingshi Yang, Huiling Mu. Lipophilic prodrugs of apomorphine I: preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2015 Jan; 89(?):216-23. doi:
10.1016/j.ejpb.2014.12.014. [PMID: 25513957] - Feng Zhang, Anyuan Li. Dual regulating effects of gastrodin on extracellular dopamine concentration in rats models of Tourette's syndrome.
The International journal of neuroscience.
2015; 125(10):784-92. doi:
10.3109/00207454.2014.971455. [PMID: 25271797] - Yu-Chun Zhou, Tian-Fu Li, Zhi-Xing Sun, Qian Fan, Tao Liu, Bao-Fang Jin. [Therapeutic efficacy of Bushengzhuyang Fang (Yangjing Capsule) on phytoestrogen-induced erectile dysfunction: an experimental study].
Zhonghua nan ke xue = National journal of andrology.
2014 Dec; 20(12):1103-8. doi:
NULL. [PMID: 25597178] - Juan Carlos Martínez-Lazcano, Sergio Montes, María Alicia Sánchez-Mendoza, Lorena Rodríguez-Páez, Iván Pérez-Neri, Marie Catherine Boll, Hortensia Denise Campos-Arroyo, Camilo Ríos, Francisca Pérez-Severiano. Sub-chronic copper pretreatment reduces oxidative damage in an experimental Huntington's disease model.
Biological trace element research.
2014 Dec; 162(1-3):211-8. doi:
10.1007/s12011-014-0127-0. [PMID: 25319005] - Hyung Ho Yoon, Yong Hwan Kim, Eun Sil Shin, Sang Ryong Jeon. A rat model of striatonigral degeneration generated by simultaneous injection of 6-hydroxydopamine into the medial forebrain bundle and quinolinic acid into the striatum.
Journal of Korean medical science.
2014 Nov; 29(11):1555-61. doi:
10.3346/jkms.2014.29.11.1555. [PMID: 25408589] - David K Grandy. TAAR1 transforms thinking about a plant alkaloid that transformed the practice of medicine.
The international journal of neuropsychopharmacology.
2014 Oct; 17(10):1545-7. doi:
10.1017/s1461145714000911. [PMID: 24901712] - Lars Tatenhorst, Lars Tönges, Kim-Ann Saal, Jan C Koch, Éva M Szegő, Mathias Bähr, Paul Lingor. Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.
Journal of neuropathology and experimental neurology.
2014 Aug; 73(8):770-9. doi:
10.1097/nen.0000000000000095. [PMID: 25003236] - Debasmita Tripathy, Poonam Verma, Dominic N Nthenge-Ngumbau, Meghna Banerjee, Kochupurackal P Mohanakumar. Regenerative therapy in experimental parkinsonism: mixed population of differentiated mouse embryonic stem cells, rather than magnetically sorted and enriched dopaminergic cells provide neuroprotection.
CNS neuroscience & therapeutics.
2014 Aug; 20(8):717-27. doi:
10.1111/cns.12295. [PMID: 24954161] - M G Magaji, M Mohammed, R A Magaji, A M Musa, I Abdu-Aguye, I M Hussaini. Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice.
Metabolic brain disease.
2014 Mar; 29(1):161-5. doi:
10.1007/s11011-014-9483-x. [PMID: 24445435] - Frederico Velasco Costa Sanguedo, Flávia Regina Cruz Dias, Enrrico Bloise, Isabel Cristina Cespedes, Arthur Giraldi-Guimarães, Richard Ian Samuels, Robert J Carey, Marinete Pinheiro Carrera. Increase in medial frontal cortex ERK activation following the induction of apomorphine sensitization.
Pharmacology, biochemistry, and behavior.
2014 Mar; 118(?):60-8. doi:
10.1016/j.pbb.2013.12.020. [PMID: 24380761] - G F Ibironke, A S Umukoro, D C Ajonijebu. Central nervous system activity of the ethanol leaf extract of Sida acuta in rats.
African journal of medicine and medical sciences.
2014 Mar; 43(1):11-6. doi:
". [PMID: 25335373] - Ling Lin, Yuequn Du, Sutao Yuan, Jie Shen, Xiang Lin, Zhihong Zheng. Serum melatonin is an alternative index of Parkinson's disease severity.
Brain research.
2014 Feb; 1547(?):43-8. doi:
10.1016/j.brainres.2013.12.021. [PMID: 24384141] - Jens Volkmann, Alberto Albanese, Angelo Antonini, K Ray Chaudhuri, Carl E Clarke, Rob M A de Bie, Günther Deuschl, Karla Eggert, Jean-Luc Houeto, Jaime Kulisevsky, Dag Nyholm, Per Odin, Karen Østergaard, Werner Poewe, Pierre Pollak, Jose Martin Rabey, Olivier Rascol, Evzen Ruzicka, Michael Samuel, Hans Speelman, Olof Sydow, Francesc Valldeoriola, Chris van der Linden, Wolfgang Oertel. Selecting deep brain stimulation or infusion therapies in advanced Parkinson's disease: an evidence-based review.
Journal of neurology.
2013 Nov; 260(11):2701-14. doi:
10.1007/s00415-012-6798-6. [PMID: 23287972] - Philipp Singer, Weining Zhang, Benjamin K Yee. SSR504734 enhances basal expression of prepulse inhibition but exacerbates the disruption of prepulse inhibition by apomorphine.
Psychopharmacology.
2013 Nov; 230(2):309-17. doi:
10.1007/s00213-013-3160-3. [PMID: 23736281] - K A Grosset, N Malek, F Morgan, D G Grosset. Phase IIa randomized double-blind, placebo-controlled study of inhaled apomorphine as acute challenge for rescuing 'off' periods in patients with established Parkinson's disease.
European journal of neurology.
2013 Nov; 20(11):1445-50. doi:
10.1111/ene.12091. [PMID: 23350812] - A Bogucki. [Apomorphine in advanced Parkinson disease].
Neurologia i neurochirurgia polska.
2013 Sep; 47(5):476-83. doi:
10.5114/ninp.2013.38227. [PMID: 24166569] - Shu Yang, Hai-Mei Sun, Ji-Hong Yan, Hong Xue, Bo Wu, Fang Dong, Wen-Shuai Li, Feng-Qing Ji, De-Shan Zhou. Conditioned medium from human amniotic epithelial cells may induce the differentiation of human umbilical cord blood mesenchymal stem cells into dopaminergic neuron-like cells.
Journal of neuroscience research.
2013 Jul; 91(7):978-86. doi:
10.1002/jnr.23225. [PMID: 23633297] - Michael J Glass, Danielle C Robinson, Elizabeth Waters, Virginia M Pickel. Deletion of the NMDA-NR1 receptor subunit gene in the mouse nucleus accumbens attenuates apomorphine-induced dopamine D1 receptor trafficking and acoustic startle behavior.
Synapse (New York, N.Y.).
2013 Jun; 67(6):265-79. doi:
10.1002/syn.21637. [PMID: 23345061] - Tanel Visnapuu, Mario Plaas, Riin Reimets, Sirli Raud, Anton Terasmaa, Sulev Kõks, Silva Sütt, Hendrik Luuk, Christian Ansgar Hundahl, Kattri-Liis Eskla, Alina Altpere, Aet Alttoa, Jaanus Harro, Eero Vasar. Evidence for impaired function of dopaminergic system in Wfs1-deficient mice.
Behavioural brain research.
2013 May; 244(?):90-9. doi:
10.1016/j.bbr.2013.01.046. [PMID: 23396150] - Pallavi Shrivastava, Kumar Vaibhav, Rizwana Tabassum, Andleeb Khan, Tauheed Ishrat, Mohd Moshahid Khan, Ajmal Ahmad, Farah Islam, Mohammed M Safhi, Fakhrul Islam. Anti-apoptotic and anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's rat model.
The Journal of nutritional biochemistry.
2013 Apr; 24(4):680-7. doi:
10.1016/j.jnutbio.2012.03.018. [PMID: 22819561] - Xuefeng Tan, Lei Zhang, JianBing Qin, Meiling Tian, Huixia Zhu, Chuanming Dong, Heyan Zhao, Guohua Jin. Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of Parkinsonian rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2013 Feb; 31(1):82-7. doi:
10.1016/j.ijdevneu.2012.10.007. [PMID: 23085081] - Gao Rui, Zhang Guangjian, Wang Yong, Feng Jie, Cui Yanchao, Jia Xi, Li Fen. High frequency electro-acupuncture enhances striatum DAT and D1 receptor expression, but decreases D2 receptor level in 6-OHDA lesioned rats.
Behavioural brain research.
2013 Jan; 237(?):263-9. doi:
10.1016/j.bbr.2012.09.047. [PMID: 23036843] - Roi Treister, Dorit Pud, Richard P Ebstein, Elon Eisenberg. Dopamine transporter genotype dependent effects of apomorphine on cold pain tolerance in healthy volunteers.
PloS one.
2013; 8(5):e63808. doi:
10.1371/journal.pone.0063808. [PMID: 23704939] - Ludmila Brunerova, Jana Potockova, Jiri Horacek, Jiri Suchy, Michal Andel. Central dopaminergic activity influences metabolic parameters in healthy men.
Neuroendocrinology.
2013; 97(2):132-8. doi:
10.1159/000338405. [PMID: 22947694] - Takako Yoshino Furukawa, Hiroe Nakayama, Aya Kikuchi, Katsunori Imazumi, Hisashi Yamakuni, Hajime Sogabe, Sachiko Yamasaki, Koji Takeshita, Masahiko Matsuo, Toshitaka Manda, Wataru Uchida. Antiemetic effects of a potent and selective neurokinin-1 receptor antagonist, FK886, on cisplatin- and apomorphine-induced emesis in dogs.
Biological & pharmaceutical bulletin.
2013; 36(6):974-9. doi:
10.1248/bpb.b12-01079. [PMID: 23727919] - Bao-Qing Wang. [Efficacy of compound Xuanju Capsule combined with apomorphine hydrochloride on erectile dysfunction].
Zhonghua nan ke xue = National journal of andrology.
2012 Dec; 18(12):1108-10. doi:
". [PMID: 23405793] - Kristian Winge, Kurt K Nielsen. Bladder dysfunction in advanced Parkinson's disease.
Neurourology and urodynamics.
2012 Nov; 31(8):1279-83. doi:
10.1002/nau.22237. [PMID: 22488851] - Min Li, Fu-rong Dai, Xiao-ping Du, Qi-dong Yang, Yuxiang Chen. Neuroprotection by silencing iNOS expression in a 6-OHDA model of Parkinson's disease.
Journal of molecular neuroscience : MN.
2012 Sep; 48(1):225-33. doi:
10.1007/s12031-012-9814-5. [PMID: 22638860] - Germain Sotoing Taïwe, Elisabeth Ngo Bum, Emmanuel Talla, Amadou Dawe, Fleur Clarisse Okomolo Moto, Gwladys Temkou Ngoupaye, Neteydji Sidiki, Bernard Dabole, Paul Désiré Djomeni Dzeufiet, Théophile Dimo, Michel De Waard. Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.
Journal of ethnopharmacology.
2012 Aug; 143(1):213-20. doi:
10.1016/j.jep.2012.06.026. [PMID: 22750453] - Keisuke Shinpo, Yoshiyuki Hirai, Hitoshi Maezawa, Yasunori Totsuka, Makoto Funahashi. The role of area postrema neurons expressing H-channels in the induction mechanism of nausea and vomiting.
Physiology & behavior.
2012 Aug; 107(1):98-103. doi:
10.1016/j.physbeh.2012.06.002. [PMID: 22722099] - Hashem Haghdoost-Yazdi, Negin Fraidouni, Ayda Faraji, Hassan Jahanihashemi, Mohammad Sarookhani. High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine.
Behavioural brain research.
2012 Aug; 233(2):375-81. doi:
10.1016/j.bbr.2012.05.011. [PMID: 22610053] - Gaurav Gupta, Imran Kazmi, Muhammad Afzal, Mahfoozur Rahman, Shakir Saleem, Md Shamim Ashraf, Mohammad Javed Khusroo, Khalid Nazeer, Sayeed Ahmed, Mohd Mujeeb, Zubair Ahmed, Firoz Anwar. Sedative, antiepileptic and antipsychotic effects of Viscum album L. (Loranthaceae) in mice and rats.
Journal of ethnopharmacology.
2012 Jun; 141(3):810-6. doi:
10.1016/j.jep.2012.03.013. [PMID: 22449438] - Maarten van den Buuse, Paul Halley, Rachel Hill, Maaike Labots, Sally Martin. Altered N-methyl-D-aspartate receptor function in reelin heterozygous mice: male-female differences and comparison with dopaminergic activity.
Progress in neuro-psychopharmacology & biological psychiatry.
2012 Jun; 37(2):237-46. doi:
10.1016/j.pnpbp.2012.02.005. [PMID: 22361156]