Disipal (BioDeep_00001029114)
代谢物信息卡片
Disipal
化学式: C18H24ClNO (305.1546324)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=CC=C1C(C2=CC=CC=C2)OCC[NH+](C)C.[Cl-]
InChI: 1H
描述信息
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065686 - Cytochrome P-450 CYP2B6 Inhibitors
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anna Detzlhofer, Christian Grechhamer, Lawrence Madikizela, Markus Himmelsbach, Franz Mlynek, Wolfgang Buchberger, Christian W Klampfl. Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea.
Environmental science and pollution research international.
2024 Mar; 31(13):19649-19657. doi:
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BMC pharmacology & toxicology.
2020 06; 21(1):45. doi:
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Journal of analytical toxicology.
2015 Jan; 39(1):75-9. doi:
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Ukrainian biochemical journal.
2014 May; 86(3):98-106. doi:
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Journal of pharmaceutical and biomedical analysis.
2009 Oct; 50(3):501-6. doi:
10.1016/j.jpba.2009.05.010. [PMID: 19524386] - Mirosław Czuczwar, Jacek Cieszczyk, Katarzyna Czuczwar, Jacek Kiś, Tomasz Saran, Waldemar A Turski. Influence of orphenadrine upon the protective activity of various antiepileptics in the maximal electroshock-induced convulsions in mice.
Pharmacological reports : PR.
2009 Jul; 61(4):732-6. doi:
10.1016/s1734-1140(09)70127-6. [PMID: 19815957] - M Elghazali, I A Wasfi, A A Abdel Hadi, A M Latum. Pharmacokinetic, metabolism and withdrawal time of orphenadrine in camels (Camelus dromedarius) after intravenous administration.
Research in veterinary science.
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1986 Sep; 26(7):529-33. doi:
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Acta neurologica.
1986 Feb; 8(1):19-26. doi:
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L'Encephale.
1986 Jan; 12(1):31-6. doi:
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1985 May; 4(3):331-3. doi:
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1984 Jul; 73(7):953-6. doi:
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1984 May; 307(2):295-304. doi:
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Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1983 Oct; 21(10):595-7. doi:
10.1515/cclm.1983.21.10.595. [PMID: 6644246] - L F Wilkinson, B M Thomson, L K Pannell. A report on the analysis of orphenadrine in post mortem specimens.
Journal of analytical toxicology.
1983 Mar; 7(2):72-5. doi:
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Therapeutic drug monitoring.
1983; 5(4):401-4. doi:
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The Journal of international medical research.
1982; 10(6):447-50. doi:
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European journal of clinical pharmacology.
1982; 21(4):343-50. doi:
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1980; 6(2):109-20. doi:
10.1159/000117742. [PMID: 6101910] - J Huisman, L L Liebregt, J H Thyssen. Gas chromatographic determination of (o-methyl-alpha-phenylbenzyloxy)acetic acid levels in human serum following therapeutic doses of orphenadrin (Disipal).
Journal of chromatography.
1979 Dec; 164(4):510-4. doi:
10.1016/s0378-4347(00)81555-8. [PMID: 541428] - L B Hansen, J Elley, T R Christensen, N E Larsen, J Naestoft, E F Hvidberg. Plasma levels of perphenazine and its major metabolites during simultaneous treatment with anticholinergic drugs.
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1979 Jan; 7(1):75-80. doi:
10.1111/j.1365-2125.1979.tb00900.x. [PMID: 760745] - P M Cotes, T J Crow, E C Johnstone, W Bartlett, R C Bourne. Neuroendocrine changes in acute schizophrenia as a function of clinical state and neuroleptic medication.
Psychological medicine.
1978 Nov; 8(4):657-65. doi:
10.1017/s0033291700018869. [PMID: 364517] - J J Labout, C T Thijssen, W Hespe. Sensitive and specific gas chromatographic and extraction method for the determination of orphenadrine in human body fluids.
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1977 Dec; 144(2):201-8. doi:
10.1016/s0021-9673(00)99355-5. [PMID: 925110] - W M Wiersinga, A J Fabius, J L Touber. Orphenadrine (Disipal), serum thyroxine and thyroid function.
Acta endocrinologica.
1977 Nov; 86(3):522-32. doi:
10.1530/acta.0.0860522. [PMID: 72472] - A E Robinson, A T Holder, R D McDowall, R Powell, H Sattar. Forensic toxicology of some orphenadrine-related deaths.
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The Medical journal of Australia.
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1975 May; 23(5):212-5. doi:
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The Practitioner.
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1974 May; 22(5):805-9. doi:
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1974 Feb; 13(2):111-7. doi:
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1973 Dec; 6(4):268-70. doi:
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1972 Feb; 195(2):213-30. doi:
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1971 Dec; 23(?):222S. doi:
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1971 Feb; 176(2):284-95. doi:
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1968 Jan; 171(1):47-57. doi:
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1967 Sep; 16(9):1847-8. doi:
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