Tofranil (BioDeep_00001029110)
代谢物信息卡片
Tofranil
化学式: C19H25ClN2 (316.170616)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[NH+](C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.[Cl-]
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nirod Kumar Sarangi, Amrutha Prabhakaran, Mark Roantree, Tia E Keyes. Evaluation of the passive permeability of antidepressants through pore-suspended lipid bilayer.
Colloids and surfaces. B, Biointerfaces.
2023 Dec; 234(?):113688. doi:
10.1016/j.colsurfb.2023.113688. [PMID: 38128360] - Jacob M Albright, Matthew J Sydor, Jonathan Shannahan, Christina R Ferreira, Andrij Holian. Imipramine Treatment Alters Sphingomyelin, Cholesterol, and Glycerophospholipid Metabolism in Isolated Macrophage Lysosomes.
Biomolecules.
2023 12; 13(12):. doi:
10.3390/biom13121732. [PMID: 38136603] - Zakaria Zitoune, Luc Kugener, Joop Jonckheer, Katrien Lanckmans, Philippe Hantson, Jacques Devriendt, Patrick M Honore. Effective Treatment of Acute Tricyclic Antidepressant Poisoning with Cardiogenic Shock and Severe Rhabdomyolysis Using ECMO and CytoSorb® Adsorber.
The American journal of case reports.
2023 Aug; 24(?):e939884. doi:
10.12659/ajcr.939884. [PMID: 37542369] - Sanchari Basu Mallik, Jayesh Mudgal, Manas Kinra, Susan Hall, Gary D Grant, Shailendra Anoopkumar-Dukie, Madhavan Nampoothiri, Yuqing Zhang, Devinder Arora. Involvement of indoleamine 2, 3-dioxygenase (IDO) and brain-derived neurotrophic factor (BDNF) in the neuroprotective mechanisms of ferulic acid against depressive-like behaviour.
Metabolic brain disease.
2023 Jul; ?(?):. doi:
10.1007/s11011-023-01267-7. [PMID: 37490224] - Teruhisa Yamamoto, Jun Kawanokuchi, Nobuyuki Nagaoka, Ken Takagi, Torao Ishida, Tomoya Hayashi, Ning Ma. Antidepressant effects of acupuncture in a murine model: regulation of neurotrophic factors.
Acupuncture in medicine : journal of the British Medical Acupuncture Society.
2023 02; 41(1):38-47. doi:
10.1177/09645284221085279. [PMID: 35579004] - Teresa Taboada, Nelson L Alvarenga, Antonia K Galeano, Wilfrido J Arrúa, Miguel A Campuzano-Bublitz, María L Kennedy. In Vivo Antidepressant-Like Effect Assessment of Two Aloysia Species in Mice and LCMS Chemical Characterization of Ethanol Extract.
Molecules (Basel, Switzerland).
2022 Nov; 27(22):. doi:
10.3390/molecules27227828. [PMID: 36431928] - Xiangyang Liu, Song Hou, Rui Xiang, Chengqing Hu, Zhenzhen Chen, Na Li, Han Yan, Xiaoxing Yu, Xin Li, Yujing Chi, Jichun Yang. Imipramine activates FAM3A-FOXA2-CPT2 pathway to ameliorate hepatic steatosis.
Metabolism: clinical and experimental.
2022 11; 136(?):155292. doi:
10.1016/j.metabol.2022.155292. [PMID: 35995281] - Ion Brinza, Mohamed A El Raey, Walaa El-Kashak, Omayma A Eldahshan, Lucian Hritcu. Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish (Danio rerio) Model: Involvement of Cholinergic System and Brain Oxidative Stress.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185901. [PMID: 36144637] - Sanchari Basu Mallik, Jayesh Mudgal, Susan Hall, Manas Kinra, Gary D Grant, Madhavan Nampoothiri, Shailendra Anoopkumar-Dukie, Devinder Arora. Remedial effects of caffeine against depressive-like behaviour in mice by modulation of neuroinflammation and BDNF.
Nutritional neuroscience.
2022 Sep; 25(9):1836-1844. doi:
10.1080/1028415x.2021.1906393. [PMID: 33814004] - Shvetank Bhatt, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sridevi Chigurupati, Amira Saber Ahmed, Sreelakshmi Bada V Gari. Investigation of Cochlospermum religiosum leaves for antidepressant and anxiolytic activities and its synergistic effect with imipramine and fluoxetine.
Environmental science and pollution research international.
2022 Apr; 29(18):27172-27181. doi:
10.1007/s11356-021-18359-5. [PMID: 34981394] - Nicklas Hasselblad Lundstrøm, Nikolaj K Holgersen, Maija Bruun Haastrup. The effect of smoking on the plasma concentration of tricyclic antidepressants: a systematic review.
Acta neuropsychiatrica.
2022 Feb; 34(1):1-9. doi:
10.1017/neu.2021.28. [PMID: 34497000] - Lijuan Zhang, Minmin Tang, Xiaofang Xie, Qiuying Zhao, Nan Hu, Hui He, Gangcai Liu, Shiqi Huang, Cheng Peng, Ying Xiao, Zili You. Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARγ activation in male mice exposed to chronic mild stress.
Journal of neuroinflammation.
2021 Aug; 18(1):171. doi:
10.1186/s12974-021-02185-0. [PMID: 34372875] - Annamalai Yamuna, Tse-Wei Chen, Shen-Ming Chen, Amal M Al-Mohaimeed, Wedad A Al-Onazi, Mohamed Soliman Elshikh. Selective electrochemical detection of antidepressant drug imipramine in blood serum and urine samples using an antimony telluride-graphite nanofiber electrode.
Mikrochimica acta.
2021 01; 188(2):60. doi:
10.1007/s00604-021-04722-3. [PMID: 33511456] - Kristina Friedland, Giacomo Silani, Anita Schuwald, Carola Stockburger, Egon Koch, Michael Nöldner, Walter E Müller. Neurotrophic Properties of Silexan, an Essential Oil from the Flowers of Lavender-Preclinical Evidence for Antidepressant-Like Properties.
Pharmacopsychiatry.
2021 Jan; 54(1):37-46. doi:
10.1055/a-1293-8585. [PMID: 33254260] - Ahmet Berk, İsmet Yılmaz, Nurettin Abacıoğlu, Mustafa Bahadır Kaymaz, Merve Gökşin Karaaslan, Ebru Kuyumcu Savan. Antidepressant effect of Gentiana olivieri Griseb. in male rats exposed to chronic mild stress.
The Libyan journal of medicine.
2020 Dec; 15(1):1725991. doi:
10.1080/19932820.2020.1725991. [PMID: 32048914] - Peter J Hamilton, Emily Y Chen, Vladimir Tolstikov, Catherine J Peña, Joseph A Picone, Punit Shah, Kiki Panagopoulos, Ana N Strat, Deena M Walker, Zachary S Lorsch, Hannah L Robinson, Nicholas L Mervosh, Drew D Kiraly, Rangaprasad Sarangarajan, Niven R Narain, Michael A Kiebish, Eric J Nestler. Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum.
Scientific reports.
2020 10; 10(1):18134. doi:
10.1038/s41598-020-75114-5. [PMID: 33093530] - Nivedita Roy, Sweta Ghosh, Subir Kumar Juin, Rishila Ghosh, Suchandra Bhattacharya Majumdar, Subrata Majumdar. Immunomodulator mediated changes in plasma membrane calcium ATPase in controlling visceral leishmaniasis.
Experimental parasitology.
2020 Oct; 217(?):107948. doi:
10.1016/j.exppara.2020.107948. [PMID: 32698076] - Anna Rafało-Ulińska, Ewa Poleszak, Aleksandra Szopa, Anna Serefko, Magdalena Rogowska, Ireneusz Sowa, Magdalena Wójciak, Bożena Muszyńska, Agata Krakowska, Joanna Gdula-Argasińska, Katarzyna Kała, Barbara Jasiewicz, Włodzimierz Opoka, Bernadeta Szewczyk, Gabriel Nowak. Imipramine Influences Body Distribution of Supplemental Zinc Which May Enhance Antidepressant Action.
Nutrients.
2020 Aug; 12(9):. doi:
10.3390/nu12092529. [PMID: 32825449] - Ghazal Rahmani, Fereshteh Farajdokht, Gisou Mohaddes, Shirin Babri, Vida Ebrahimi, Hadi Ebrahimi. Garlic (Allium sativum) improves anxiety- and depressive-related behaviors and brain oxidative stress in diabetic rats.
Archives of physiology and biochemistry.
2020 May; 126(2):95-100. doi:
10.1080/13813455.2018.1494746. [PMID: 30169970] - Fernanda Midori de Oliveira, Guilherme Luiz Scheel, Rodinei Augusti, César Ricardo Teixeira Tarley, Clésia Cristina Nascentes. Supramolecular microextraction combined with paper spray ionization mass spectrometry for sensitive determination of tricyclic antidepressants in urine.
Analytica chimica acta.
2020 Apr; 1106(?):52-60. doi:
10.1016/j.aca.2020.01.061. [PMID: 32145855] - Anderson Luiz Oenning, Letícia Birk, Sarah Eller, Tiago Franco de Oliveira, Josias Merib, Eduardo Carasek. A green and low-cost method employing switchable hydrophilicity solvent for the simultaneous determination of antidepressants in human urine by gas chromatography - mass spectrometry detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Apr; 1143(?):122069. doi:
10.1016/j.jchromb.2020.122069. [PMID: 32213465] - Danusio Pinheiro Sartori, N F Oliveira, José Tiago Valentim, D M A Silva, A S V Mallman, I C M Oliveira, R C Chaves, V C Capibaribe, A M R Carvalho, M O Rebouças, Danielle Silveira Macedo, Adriano José Maia Chaves Filho, M M F Fonteles, S J C Gutierrez, José Maria Barbosa-Filho, Melina Mottin, Carolina Horta Andrade, F C F Sousa. Involvement of monoaminergic targets in the antidepressant- and anxiolytic-like effects of the synthetic alkamide riparin IV: Elucidation of further mechanisms through pharmacological, neurochemistry and computational approaches.
Behavioural brain research.
2020 04; 383(?):112487. doi:
10.1016/j.bbr.2020.112487. [PMID: 31987932] - Per Plenge, Ara M Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J Loland. The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter.
Nature communications.
2020 03; 11(1):1491. doi:
10.1038/s41467-020-15292-y. [PMID: 32198394] - Norimichi Hattori, Asuka Takumi, Kosuke Saito, Yoshiro Saito. Effects of serial cervical or tail blood sampling on toxicity and toxicokinetic evaluation in rats.
The Journal of toxicological sciences.
2020; 45(10):599-609. doi:
10.2131/jts.45.599. [PMID: 33012728] - Lina Xiang, Yuan Feng, Qianqian Hu, Jiahui Zhu, Ren Ye, Zhengzhong Yuan. Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress.
BioMed research international.
2020; 2020(?):1507561. doi:
10.1155/2020/1507561. [PMID: 33015153] - T M S Cavalero, F O Papa, R A Schmith, V F C Scheeren, L E F Canuto, M L M Gobato, L T Rodrigues, C P Freitas-Dell'aqua. Protocols using detomidine and oxytocin induce ex copula ejaculation in stallions.
Theriogenology.
2019 Dec; 140(?):93-98. doi:
10.1016/j.theriogenology.2019.08.024. [PMID: 31454723] - Yeqing Huang, Danhong Xu, Haiqing Xiang, Shi Yan, Fangfang Sun, Zhisheng Wei. Rapid antidepressant actions of imipramine potentiated by zinc through PKA-dependented regulation of mTOR and CREB signaling.
Biochemical and biophysical research communications.
2019 10; 518(2):337-343. doi:
10.1016/j.bbrc.2019.08.059. [PMID: 31420165] - Vitor Silva Pereira, Sâmia R L Joca, Brian H Harvey, Betina Elfving, Gregers Wegener. Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression.
Acta neuropsychiatrica.
2019 Oct; 31(5):258-265. doi:
10.1017/neu.2019.25. [PMID: 31230597] - Valerie Koppen, Cis Van Looveren, Isabelle François, Filip Cuyckens. Selective drug metabolite trace analysis by very high-volume injections and heartcut two-dimensional (2D)-ultrahigh performance liquid chromatography (UHPLC).
Journal of chromatography. A.
2019 Sep; 1601(?):164-170. doi:
10.1016/j.chroma.2019.04.064. [PMID: 31047660] - Kanae Nishimura, Noboru Okamura, Tetsutaro Kimachi, Jun Haginaka. Evaluation of molecularly imprinted polymers for chlorpromazine and bromopromazine prepared by multi-step swelling and polymerization method-The application for the determination of chlorpromazine and its metabolites in rat plasma by column-switching LC.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):248-255. doi:
10.1016/j.jpba.2019.05.063. [PMID: 31181487] - Hiroshi Kawai, Reiko Iwadate, Takuya Ishibashi, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumoto. Antidepressants with different mechanisms of action show different chronopharmacological profiles in the tail suspension test in mice.
Chronobiology international.
2019 09; 36(9):1194-1207. doi:
10.1080/07420528.2019.1625360. [PMID: 31198056] - Riad Ladjohounlou, Catherine Lozza, Alexandre Pichard, Julie Constanzo, Jihad Karam, Pierre Le Fur, Emmanuel Deshayes, Vincent Boudousq, Salomé Paillas, Muriel Busson, Marion Le Blay, Marta Jarlier, Sara Marcatili, Manuel Bardiès, Frank Bruchertseifer, Alfred Morgenstern, Julien Torgue, Isabelle Navarro-Teulon, Jean-Pierre Pouget. Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019 08; 25(15):4775-4790. doi:
10.1158/1078-0432.ccr-18-3295. [PMID: 31061069] - Yalda Ravanshad, Anoush Azarfar, Mohammad Esmaeeli, Zahra Mostafavian, Elham Zahabi, Sahar Ravanshad. Effect of Low Dose Imipramine in Patients with Nocturnal Enuresis, A Randomized Clinical Trial.
Iranian journal of kidney diseases.
2019 07; 13(4):257-261. doi:
. [PMID: 31422392] - Sandra Tillmann, Denise F Happ, Per F Mikkelsen, Juergen Geisel, Gregers Wegener, Rima Obeid. Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression.
Behavioural brain research.
2019 05; 364(?):274-280. doi:
10.1016/j.bbr.2019.02.011. [PMID: 30738101] - Reyhaneh Sobhani, Behzad Rezaei, Marzieh Shahshahanipour, Ali A Ensafi, Gholamhossein Mohammadnezhad. Simple and green synthesis of carbon dots (CDs) from valerian root and application of modified mesoporous boehmite (AlOOH) with CDs as a fluorescence probe for determination of imipramine.
Analytical and bioanalytical chemistry.
2019 May; 411(14):3115-3124. doi:
10.1007/s00216-019-01779-1. [PMID: 30989266] - Víctor Navarro, Ilham Boulahfa, Amadeu Obach, Dídac Jerez, Maribel Diaz-Ricart, Cristóbal Gastó, Joana Guarch. Lithium Augmentation Versus Citalopram Combination in Imipramine-Resistant Major Depression: A 10-Week Randomized Open-Label Study.
Journal of clinical psychopharmacology.
2019 May; 39(3):254-257. doi:
10.1097/jcp.0000000000001024. [PMID: 30925498] - Gabrielle Pastenkos, Jonathan L Miller, Suzanne M Pritchard, Anthony V Nicola. Role of Sphingomyelin in Alphaherpesvirus Entry.
Journal of virology.
2019 03; 93(5):. doi:
10.1128/jvi.01547-18. [PMID: 30541840] - Gabriela Starowicz, Magdalena Jarosz, Ewelina Frąckiewicz, Natalia Grzechnik, Beata Ostachowicz, Gabriel Nowak, Katarzyna Mlyniec. Long-lasting antidepressant-like activity of the GPR39 zinc receptor agonist TC-G 1008.
Journal of affective disorders.
2019 02; 245(?):325-334. doi:
10.1016/j.jad.2018.11.003. [PMID: 30419533] - Kazunori Sasaki, Mahmoud Ben Othman, Farhana Ferdousi, Masaki Yoshida, Makoto Watanabe, Kenichi Tominaga, Hiroko Isoda. Modulation of the neurotransmitter systems through the anti-inflammatory and antidepressant-like effects of squalene from Aurantiochytrium sp.
PloS one.
2019; 14(6):e0218923. doi:
10.1371/journal.pone.0218923. [PMID: 31251788] - Víctor Navarro, Ilham Boulahfa, Amadeu Obach, Dídac Jerez, Maribel Diaz-Ricart, Cristóbal Gastó, Joana Guarch. Switching to Imipramine Versus Add-on Mirtazapine in Venlafaxine-Resistant Major Depression: A 10-Week Randomized Open Study.
Journal of clinical psychopharmacology.
2019 Jan; 39(1):63-66. doi:
10.1097/jcp.0000000000000988. [PMID: 30516574] - Simone H Schelder-Marzzani, Paula Dias, Viviane Freiberger, Letícia Ventura, Bruna B Silva, Matheus L Dutra, Franciane Bobinski, Aline D Schlindwein, Omar J Cassol, Clarissa M Comim. Neonatal Immune Activation May Provoke Long-term Depressive Attributes.
Current neurovascular research.
2019; 16(4):358-364. doi:
10.2174/1567202616666191007125502. [PMID: 31589124] - Chandana Choudhury Barua, Prakash Haloi, Beenita Saikia, Kunjbihari Sulakhiya, Debesh Chandra Pathak, Shantanu Tamuli, Hooriah Rizavi, Xinguo Ren. Zanthoxylum alatum abrogates lipopolysaccharide-induced depression-like behaviours in mice by modulating neuroinflammation and monoamine neurotransmitters in the hippocampus.
Pharmaceutical biology.
2018 Dec; 56(1):245-252. doi:
10.1080/13880209.2017.1391298. [PMID: 29569964] - Peng Zhu, Zhi Ye, Dong Guo, Zongping Xiong, Shiqiong Huang, Jun Guo, Wei Zhang, James E Polli, Honghao Zhou, Qing Li, Yan Shu. Irinotecan Alters the Disposition of Morphine Via Inhibition of Organic Cation Transporter 1 (OCT1) and 2 (OCT2).
Pharmaceutical research.
2018 Oct; 35(12):243. doi:
10.1007/s11095-018-2526-y. [PMID: 30361780] - Saeed Nojavan, Hossein Shaghaghi, Turaj Rahmani, Ali Shokri, Mahnaz Nasiri-Aghdam. Combination of electromembrane extraction and electro-assisted liquid-liquid microextraction: A tandem sample preparation method.
Journal of chromatography. A.
2018 Aug; 1563(?):20-27. doi:
10.1016/j.chroma.2018.05.068. [PMID: 29880217] - Alessia Costa, Claudia Cristiano, Tommaso Cassano, Cristina Anna Gallelli, Silvana Gaetani, Carla Ghelardini, Patrizio Blandina, Antonio Calignano, M Beatrice Passani, Gustavo Provensi. Histamine-deficient mice do not respond to the antidepressant-like effects of oleoylethanolamide.
Neuropharmacology.
2018 06; 135(?):234-241. doi:
10.1016/j.neuropharm.2018.03.033. [PMID: 29596898] - Harinder Singh, Nathan Wray, Jeffrey M Schappi, Mark M Rasenick. Disruption of lipid-raft localized Gαs/tubulin complexes by antidepressants: a unique feature of HDAC6 inhibitors, SSRI and tricyclic compounds.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2018 06; 43(7):1481-1491. doi:
10.1038/s41386-018-0016-x. [PMID: 29463911] - Nicolas Violle, Pascale Rozan, Hervé Demais, Pi Nyvall Collen, Jean-François Bisson. Evaluation of the antidepressant- and anxiolytic-like effects of a hydrophilic extract from the green seaweed Ulva sp. in rats.
Nutritional neuroscience.
2018 May; 21(4):248-256. doi:
10.1080/1028415x.2016.1276704. [PMID: 28102110] - Inge Oberholzer, Marisa Möller, Brendan Holland, Olivia M Dean, Michael Berk, Brian H Harvey. Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat.
Metabolic brain disease.
2018 04; 33(2):467-480. doi:
10.1007/s11011-017-0144-8. [PMID: 29101602] - Matthew J Justice, Irina Bronova, Kelly S Schweitzer, Christophe Poirier, Janice S Blum, Evgeny V Berdyshev, Irina Petrache. Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy.
Journal of lipid research.
2018 04; 59(4):596-606. doi:
10.1194/jlr.m080242. [PMID: 29378782] - Farhad Ahmadi, Tahereh Mahmoudi-Yamchi, Homa Azizian. Super paramagnetic core-shells anchored onto silica grafted with C8/NH2 nano-particles for ultrasound-assisted magnetic solid phase extraction of imipramine and desipramine from plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Mar; 1077-1078(?):52-59. doi:
10.1016/j.jchromb.2018.01.033. [PMID: 29413577] - Ailton Spiacci, Heloisa H Vilela-Costa, Ana Beatriz Sant'Ana, Gabriel Gripp Fernandes, Alana Tercino Frias, Glauber S Ferreira da Silva, José Antunes-Rodrigues, Hélio Zangrossi. Panic-like escape response elicited in mice by exposure to CO2, but not hypoxia.
Progress in neuro-psychopharmacology & biological psychiatry.
2018 Feb; 81(?):178-186. doi:
10.1016/j.pnpbp.2017.10.018. [PMID: 29111406] - M Kuśmider, A Faron-Górecka, P Pabian, J Solich, M Szlachta, M Kolasa, D Żurawek, J Wójcikowski, W Daniel, M Dziedzicka-Wasylewska. Effects of imipramine on cytokines panel in the rats serum during the drug treatment and discontinuation.
Neurochemistry international.
2018 02; 113(?):85-91. doi:
10.1016/j.neuint.2017.11.016. [PMID: 29196145] - Søren H Sindrup, Jakob V Holbech, Flemming W Bach, Nanna B Finnerup, Kim Brøsen, Troels S Jensen. The Impact of Serum Drug Concentration on the Efficacy of Imipramine, Pregabalin, and their Combination in Painful Polyneuropathy.
The Clinical journal of pain.
2017 12; 33(12):1047-1052. doi:
10.1097/ajp.0000000000000497. [PMID: 28272120] - Tadatoshi Tanino, Toru Bando, Akira Komada, Yukie Nojiri, Yuna Okada, Yukari Ueda, Eiichi Sakurai. Hepatic Flavin-Containing Monooxygenase 3 Enzyme Suppressed by Type 1 Allergy-Produced Nitric Oxide.
Drug metabolism and disposition: the biological fate of chemicals.
2017 11; 45(11):1189-1196. doi:
10.1124/dmd.117.076570. [PMID: 28760731] - Adaeze Adebesin, Olusegun A Adeoluwa, Anthony T Eduviere, Solomon Umukoro. Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice.
Journal of psychiatric research.
2017 11; 94(?):29-35. doi:
10.1016/j.jpsychires.2017.06.007. [PMID: 28647678] - Cong Bi, Ryan Matsuda, Chenhua Zhang, Zitha Isingizwe, William Clarke, David S Hage. Studies of drug interactions with alpha1-acid glycoprotein by using on-line immunoextraction and high-performance affinity chromatography.
Journal of chromatography. A.
2017 Oct; 1519(?):64-73. doi:
10.1016/j.chroma.2017.08.073. [PMID: 28886937] - Cuilin Chu, Hui Wei, Wanwan Zhu, Yan Shen, Qi Xu. Decreased Prostaglandin D2 Levels in Major Depressive Disorder Are Associated with Depression-Like Behaviors.
The international journal of neuropsychopharmacology.
2017 09; 20(9):731-739. doi:
10.1093/ijnp/pyx044. [PMID: 28582515] - M Vermeiden, A M Kamperman, W J G Hoogendijk, W W van den Broek, T K Birkenhäger. A randomized clinical trial comparing two two-phase treatment strategies for in-patients with severe depression.
Acta psychiatrica Scandinavica.
2017 07; 136(1):118-128. doi:
10.1111/acps.12743. [PMID: 28478653] - A Faron-Górecka, M Kuśmider, K Szafran-Pilch, M Kolasa, D Żurawek, P Gruca, M Papp, J Solich, P Pabian, M Dziedzicka-Wasylewska. Basal prolactin levels in rat plasma correlates with response to antidepressant treatment in animal model of depression.
Neuroscience letters.
2017 04; 647(?):147-152. doi:
10.1016/j.neulet.2017.03.034. [PMID: 28336340] - Sachie Sasaki-Hamada, Azusa Suzuki, Yudai Ueda, Kinzo Matsumoto, Jun-Ichiro Oka. Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice.
Journal of pharmacological sciences.
2017 Feb; 133(2):110-113. doi:
10.1016/j.jphs.2017.01.002. [PMID: 28233634] - Tomoyuki Tashiro, Yuki Murakami, Akihiro Mouri, Yukio Imamura, Toshitaka Nabeshima, Yasuko Yamamoto, Kuniaki Saito. Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Behavioural brain research.
2017 01; 317(?):279-285. doi:
10.1016/j.bbr.2016.09.050. [PMID: 27693848] - Kazunari Iwao, Rushiana Tokie Kawai, Masako Oda, Hiroshi Saitoh. Investigation on the Interactions between Various Drugs and Aojiru (Green Juice) Using a Simple Centrifugation Method.
Biological & pharmaceutical bulletin.
2017; 40(9):1566-1571. doi:
10.1248/bpb.b17-00149. [PMID: 28867740] - Jessica M Carpenter, Mary K Jourdan, Emily M Fountain, Zulfiqar Ali, Naohito Abe, Ikhlas A Khan, Kenneth J Sufka. The effects of Sceletium tortuosum (L.) N.E. Br. extract fraction in the chick anxiety-depression model.
Journal of ethnopharmacology.
2016 Dec; 193(?):329-332. doi:
10.1016/j.jep.2016.08.019. [PMID: 27553978] - Yong Wang, Xingwen Li, Liyuan Sun, Baihuan Feng, Wenjun Sun. Acid sphingomyelinase mediates 50-Hz magnetic field-induced EGF receptor clustering on lipid raft.
Journal of receptor and signal transduction research.
2016 Dec; 36(6):593-600. doi:
10.3109/10799893.2016.1147583. [PMID: 26915736] - Yun-Ui Bae, Jae-Wan Huh, Bieong-Kil Kim, Hyeon Young Park, Young-Bae Seu, Kyung-Oh Doh. Enhancement of liposome mediated gene transfer by adding cholesterol and cholesterol modulating drugs.
Biochimica et biophysica acta.
2016 12; 1858(12):3017-3023. doi:
10.1016/j.bbamem.2016.09.013. [PMID: 27664498] - Karol Ramirez, John F Sheridan. Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors.
Brain, behavior, and immunity.
2016 Oct; 57(?):293-303. doi:
10.1016/j.bbi.2016.05.008. [PMID: 27223094] - Hoa Q Nguyen, Ernesto Callegari, R Scott Obach. The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine.
Drug metabolism and disposition: the biological fate of chemicals.
2016 10; 44(10):1569-78. doi:
10.1124/dmd.116.071639. [PMID: 27440861] - Kartik T Nakhate, Sadanand U Yedke, Ashish P Bharne, Nishikant K Subhedar, Dadasaheb M Kokare. Evidence for the involvement of neuropeptide Y in the antidepressant effect of imipramine in type 2 diabetes.
Brain research.
2016 09; 1646(?):1-11. doi:
10.1016/j.brainres.2016.05.035. [PMID: 27208493] - Gayaprasad Upadhyay, Sarvesh Khoshla, Ramoji Kosuru, Sanjay Singh. Anxiolytic, antidepressant, and antistress activities of the aqueous extract of Cinnamomum tamala Nees and Eberm in rats.
Indian journal of pharmacology.
2016 Sep; 48(5):555-561. doi:
10.4103/0253-7613.190752. [PMID: 27721543] - Weronika Duda, Katarzyna Curzytek, Marta Kubera, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Anna Bilska-Wilkosz, Elżbieta Lorenc-Koci, Monika Leśkiewicz, Agnieszka Basta-Kaim, Bogusława Budziszewska, Magdalena Regulska, Joanna Ślusarczyk, Piotr Gruca, Mariusz Papp, Michael Maes, Władysław Lasoń, Lucyna Antkiewicz-Michaluk. The Effect of Chronic Mild Stress and Imipramine on the Markers of Oxidative Stress and Antioxidant System in Rat Liver.
Neurotoxicity research.
2016 08; 30(2):173-84. doi:
10.1007/s12640-016-9614-8. [PMID: 26961706] - Ahmad Nassar, Yael Sharon-Granit, Abed N Azab. Psychotropic drugs attenuate lipopolysaccharide-induced hypothermia by altering hypothalamic levels of inflammatory mediators in rats.
Neuroscience letters.
2016 07; 626(?):59-67. doi:
10.1016/j.neulet.2016.05.019. [PMID: 27181513] - Tingxu Yan, Mengjie Xu, Bo Wu, Zhengzheng Liao, Zhi Liu, Xu Zhao, Kaishun Bi, Ying Jia. The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice.
Food & function.
2016 Jun; 7(6):2811-9. doi:
10.1039/c6fo00328a. [PMID: 27225351] - Anne Brinkø, Maja T Larsen, Heidi Koldsø, Louise Besenbacher, Anders Kolind, Birgit Schiøtt, Steffen Sinning, Henrik H Jensen. Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter.
Bioorganic & medicinal chemistry.
2016 06; 24(12):2725-38. doi:
10.1016/j.bmc.2016.04.039. [PMID: 27160055] - Qin Ding, Hongxia Li, Xue Tian, Zhilei Shen, Xiaoli Wang, Fengfeng Mo, Junlong Huang, Hui Shen. Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress.
Journal of affective disorders.
2016 Jun; 197(?):100-6. doi:
10.1016/j.jad.2016.03.017. [PMID: 26985741] - Nobuyuki Tanahashi, Ken Takagi, Nozomi Amagasu, Guifeng Wang, Kaito Mizuno, Jun Kawanoguchi, Guo Yi, Torao Ishida. Effect of acupuncture stimulation on rats with depression induced by water-immersion stress.
Neuroscience letters.
2016 Apr; 618(?):99-103. doi:
10.1016/j.neulet.2016.02.051. [PMID: 26940241] - Jing Zhao, Yujin Shin, Kwang-Hoon Chun, Hye-Ran Yoon, Jeongmi Lee. A Simple, Rapid and Reliable Method to Determine Imipramine and Desipramine in Mouse Serum Using Ultra-High-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry.
Journal of chromatographic science.
2016 Apr; 54(4):561-8. doi:
10.1093/chromsci/bmv187. [PMID: 26688563] - Bai Li, Yangyang Hou, Ming Zhu, Hongkun Bao, Jun Nie, Grace Y Zhang, Liping Shan, Yao Yao, Kai Du, Hongju Yang, Meizhang Li, Bingrong Zheng, Xiufeng Xu, Chunjie Xiao, Jing Du. 3'-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway.
The international journal of neuropsychopharmacology.
2016 Apr; 19(4):. doi:
10.1093/ijnp/pyv112. [PMID: 26443809] - Valter Viana Andrade-Neto, Thaís Martins Pereira, Marilene do Canto-Cavalheiro, Eduardo Caio Torres-Santos. Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole.
Parasites & vectors.
2016 Mar; 9(?):183. doi:
10.1186/s13071-016-1467-8. [PMID: 27036654] - Priyadeep Bhutani, Devang Shah, Ninad Varkhede, Sandhya Mandlekar, Silvi Chacko, Murali Subramanian. Absolute quantification of imipramine and its metabolites in vivo utilizing calibrators from radiolabeled in vitro incubations.
Bioanalysis.
2016 Feb; 8(4):297-309. doi:
10.4155/bio.15.259. [PMID: 26847656] - Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Propiverine increases urethral wall catecholamine levels and bladder leak point pressure in rats.
International journal of urology : official journal of the Japanese Urological Association.
2016 Jan; 23(1):93-9. doi:
10.1111/iju.12991. [PMID: 26502799] - Christopher A Crutchfield, Autumn R Breaud, William A Clarke. Quantification of Tricyclic Antidepressants in Serum Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS).
Methods in molecular biology (Clifton, N.J.).
2016; 1383(?):265-70. doi:
10.1007/978-1-4939-3252-8_27. [PMID: 26660194] - Gaocai Zhang, Li Chen, Lingli Yang, Xiaodong Hua, Beiqun Zhou, Zhigang Miao, Jizhen Li, Hua Hu, Michael Namaka, Jiming Kong, Xingshun Xu. Combined use of spatial restraint stress and middle cerebral artery occlusion is a novel model of post-stroke depression in mice.
Scientific reports.
2015 Nov; 5(?):16751. doi:
10.1038/srep16751. [PMID: 26572587] - Arum Han, Hyelim Yeo, Min-Jung Park, Seung Hyun Kim, Hyun Jin Choi, Chang-Won Hong, Min-Soo Kwon. IL-4/10 prevents stress vulnerability following imipramine discontinuation.
Journal of neuroinflammation.
2015 Oct; 12(?):197. doi:
10.1186/s12974-015-0416-3. [PMID: 26521132] - Dinesh Dhingra, Sudha Bansal. Antidepressant-like activity of plumbagin in unstressed and stressed mice.
Pharmacological reports : PR.
2015 Oct; 67(5):1024-32. doi:
10.1016/j.pharep.2015.03.001. [PMID: 26398399] - Cong Pang, Liang Cao, Fan Wu, Li Wang, Gang Wang, Yingcong Yu, Meixi Zhang, Lichao Chen, Weijie Wang, Weihong Lv, Ling Chen, Jiejin Zhu, Jianchun Pan, Hanting Zhang, Ying Xu, Lianshu Ding. The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis.
Neuropharmacology.
2015 Oct; 97(?):447-56. doi:
10.1016/j.neuropharm.2015.04.017. [PMID: 25937213] - Abdul Mannan, Ariful Basher Abir, Rashidur Rahman. Antidepressant-like effects of methanolic extract of Bacopa monniera in mice.
BMC complementary and alternative medicine.
2015 Sep; 15(?):337. doi:
10.1186/s12906-015-0866-2. [PMID: 26407565] - Oliver Ambrée, Veerle Bergink, Laura Grosse, Judith Alferink, Hemmo A Drexhage, Matthias Rothermundt, Volker Arolt, Tom K Birkenhäger. S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression.
The international journal of neuropsychopharmacology.
2015 Sep; 19(3):pyv103. doi:
10.1093/ijnp/pyv103. [PMID: 26364276] - Mao Nagasawa, Tsuyoshi Otsuka, Shinobu Yasuo, Mitsuhiro Furuse. Chronic imipramine treatment differentially alters the brain and plasma amino acid metabolism in Wistar and Wistar Kyoto rats.
European journal of pharmacology.
2015 Sep; 762(?):127-35. doi:
10.1016/j.ejphar.2015.05.043. [PMID: 26004533] - Tsvetan Serchov, Hans-Willi Clement, Martin K Schwarz, Felice Iasevoli, Dilip K Tosh, Marco Idzko, Kenneth A Jacobson, Andrea de Bartolomeis, Claus Normann, Knut Biber, Dietrich van Calker. Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a.
Neuron.
2015 Aug; 87(3):549-62. doi:
10.1016/j.neuron.2015.07.010. [PMID: 26247862] - Basma Fatima Anwar Husain, Ishira N Nanavaty, Swananda V Marathe, Rajeev Rajendran, Vidita A Vaidya. Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment.
Progress in neuro-psychopharmacology & biological psychiatry.
2015 Aug; 61(?):1-9. doi:
10.1016/j.pnpbp.2015.03.004. [PMID: 25784603] - A Bai, E Kokkotou, Y Zheng, S C Robson. Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses.
Cell death & disease.
2015 Jul; 6(?):e1828. doi:
10.1038/cddis.2015.178. [PMID: 26203857] - T Ghasemi, K Abnous, F Vahdati, S Mehri, B M Razavi, H Hosseinzadeh. Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus.
Drug research.
2015 Jul; 65(7):337-43. doi:
10.1055/s-0034-1371876. [PMID: 24696423] - Caroline Bylda, Vanya Velichkova, Jens Bolle, Roland Thiele, Uwe Kobold, Dietrich A Volmer. Magnetic beads as an extraction medium for simultaneous quantification of acetaminophen and structurally related compounds in human serum.
Drug testing and analysis.
2015 Jun; 7(6):457-66. doi:
10.1002/dta.1708. [PMID: 25231125] - Chandra Shaker Sriram, Ashok Jangra, Satendra Singh Gurjar, Md Iftikar Hussain, Probodh Borah, Mangala Lahkar, Pritam Mohan, Babul Kumar Bezbaruah. Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice.
Pharmacology, biochemistry, and behavior.
2015 Jun; 133(?):83-91. doi:
10.1016/j.pbb.2015.03.022. [PMID: 25863272] - Ajaykumar N Sharma, Sagar S Ligade, Jay N Sharma, Praveen Shukla, Khalid M Elased, James B Lucot. GLP-1 receptor agonist liraglutide reverses long-term atypical antipsychotic treatment associated behavioral depression and metabolic abnormalities in rats.
Metabolic brain disease.
2015 Apr; 30(2):519-27. doi:
10.1007/s11011-014-9591-7. [PMID: 25023888] - E J J Berm, J Paardekooper, E Brummel-Mulder, E Hak, B Wilffert, J G Maring. A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine, clomipramine, and their active metabolites using LC-MS/MS.
Talanta.
2015 Mar; 134(?):165-172. doi:
10.1016/j.talanta.2014.10.041. [PMID: 25618654] - Luísa K Pilz, Yasmine Trojan, Caroline L Quiles, Radharani Benvenutti, Gabriela Melo, Rosa Levandovski, Maria Paz L Hidalgo, Elaine Elisabetsky. Effects of N-acetylcysteine and imipramine in a model of acute rhythm disruption in BALB/c mice.
Chronobiology international.
2015 Mar; 32(2):248-54. doi:
10.3109/07420528.2014.965315. [PMID: 25286136] - Kazuaki Kawaura, Hiroyuki Koike, Kohnosuke Kinoshita, Daiji Kambe, Ayaka Kaku, Jun-ichi Karasawa, Shigeyuki Chaki, Hirohiko Hikichi. Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
Behavioural brain research.
2015 Feb; 278(?):186-92. doi:
10.1016/j.bbr.2014.09.046. [PMID: 25300471] - Brandon H Cline, Daniel C Anthony, Alexander Lysko, Oleg Dolgov, Konstantin Anokhin, Careen Schroeter, Dmitry Malin, Aslan Kubatiev, Harry W Steinbusch, Klaus-Peter Lesch, Tatyana Strekalova. Lasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedonia.
Behavioural brain research.
2015 Jan; 276(?):118-29. doi:
10.1016/j.bbr.2014.04.037. [PMID: 24786329]