2-[(2-Ethoxyphenoxy)-phenylmethyl]morpholine (BioDeep_00001028971)
代谢物信息卡片
2-[(2-Ethoxyphenoxy)-phenylmethyl]morpholine
化学式: C19H23NO3 (313.16778480000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3
InChI: InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- R Ian Storer, Paul E Brennan, Alan D Brown, Peter J Bungay, Kelly M Conlon, Matthew S Corbett, Robert P DePianta, Paul V Fish, Alexander Heifetz, Danny K H Ho, Alan S Jessiman, Gordon McMurray, Cesar Augusto F de Oliveira, Lee R Roberts, James A Root, Veerabahu Shanmugasundaram, Michael J Shapiro, Melanie Skerten, Dominique Westbrook, Simon Wheeler, Gavin A Whitlock, John Wright. Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.
Journal of medicinal chemistry.
2014 Jun; 57(12):5258-69. doi:
10.1021/jm5003292. [PMID: 24878222] - An T Vu, Stephen T Cohn, Puwen Zhang, Callain Y Kim, Paige E Mahaney, Jenifer A Bray, Grace H Johnston, Elizabeth J Koury, Scott A Cosmi, Darlene C Deecher, Valerie A Smith, James E Harrison, Liza Leventhal, Garth T Whiteside, Jeffrey D Kennedy, Eugene J Trybulski. 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
Journal of medicinal chemistry.
2010 Mar; 53(5):2051-62. doi:
10.1021/jm901559e. [PMID: 20131864] - Puwen Zhang, Eugene A Terefenko, Jenifer Bray, Darlene Deecher, Andrew Fensome, Jim Harrison, Callain Kim, Elizabeth Koury, Lilly Mark, Casey C McComas, Cheryl A Mugford, Eugene J Trybulski, An T Vu, Garth T Whiteside, Paige E Mahaney. 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
Journal of medicinal chemistry.
2009 Sep; 52(18):5703-11. doi:
10.1021/jm900888c. [PMID: 19722525] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - An T Vu, Stephen T Cohn, Eugene A Terefenko, William J Moore, Puwen Zhang, Paige E Mahaney, Eugene J Trybulski, Igor Goljer, Rebecca Dooley, Jenifer A Bray, Grace H Johnston, Jennifer Leiter, Darlene C Deecher. 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters.
2009 May; 19(9):2464-7. doi:
10.1016/j.bmcl.2009.03.054. [PMID: 19329313] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - M Jonathan Fray, Gerwyn Bish, Alan D Brown, Paul V Fish, Alan Stobie, Florian Wakenhut, Gavin A Whitlock. N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.
Bioorganic & medicinal chemistry letters.
2006 Aug; 16(16):4345-8. doi:
10.1016/j.bmcl.2006.05.051. [PMID: 16750359] - M Jonathan Fray, Gerwyn Bish, Paul V Fish, Alan Stobie, Florian Wakenhut, Gavin A Whitlock. Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.
Bioorganic & medicinal chemistry letters.
2006 Aug; 16(16):4349-53. doi:
10.1016/j.bmcl.2006.05.049. [PMID: 16750363] - Kuo-Shyan Lin, Yu-Shin Ding. Synthesis, enantiomeric resolution, and selective C-11 methylation of a highly selective radioligand for imaging the norepinephrine transporter with positron emission tomography.
Chirality.
2004 Aug; 16(7):475-81. doi:
10.1002/chir.20055. [PMID: 15236345] - Christophe Plisson, Jonathan McConathy, Laurent Martarello, Eugene J Malveaux, Vernon M Camp, Larry Williams, John R Votaw, Mark M Goodman. Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter.
Journal of medicinal chemistry.
2004 Feb; 47(5):1122-35. doi:
10.1021/jm030384e. [PMID: 14971892] - Aurelio Orjales, Ramón Mosquera, Antonio Toledo, M Carmen Pumar, Neftalí García, Lourdes Cortizo, Luis Labeaga, Ana Innerárity. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.
Journal of medicinal chemistry.
2003 Dec; 46(25):5512-32. doi:
10.1021/jm0309349. [PMID: 14640559] - Mark M Goodman, Ping Chen, Christophe Plisson, Laurent Martarello, James Galt, John R Votaw, Clinton D Kilts, Gene Malveaux, Vernon M Camp, Bing Shi, Timothy D Ely, Leonard Howell, Jon McConathy, Charles B Nemeroff. Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.
Journal of medicinal chemistry.
2003 Mar; 46(6):925-35. doi:
10.1021/jm0100180. [PMID: 12620070]