Butyrolactonei (BioDeep_00001028948)
代谢物信息卡片
Butyrolactonei
化学式: C24H24O7 (424.1522)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCC1=C(C=CC(=C1)CC2(C(=C(C(=O)O2)O)C3=CC=C(C=C3)O)C(=O)OC)O)C
InChI: InChI=1S/C24H24O7/c1-14(2)4-6-17-12-15(5-11-19(17)26)13-24(23(29)30-3)20(21(27)22(28)31-24)16-7-9-18(25)10-8-16/h4-5,7-12,25-27H,6,13H2,1-3H3/t24-/m0/s1
描述信息
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Chun-Lan Xie, Hong-Xiu Xiao, Pei-Fang Song, Qing-Mei Liu, Haoxiang Wei, Liang Wu, Guang-Hao Zhu, Guang-Ming Liu, Yandong Zhang, Ping Wang, Xian-Wen Yang. Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB.
Journal of medicinal chemistry.
2024 May; 67(9):7504-7515. doi:
10.1021/acs.jmedchem.4c00354. [PMID: 38640354] - Seham S El-Hawary, Abeer S Moawad, Hebatallah S Bahr, Eman Z Attia, Mo Men H El-Katatny, Muhamad Mustafa, Ahmed A Al-Karmalawy, Mostafa E Rateb, Jian-Ye Zhang, Usama Ramadan Abdelmohsen, Rabab Mohammed. Promising Cytotoxic butenolides from the Soybean endophytic fungus Aspergillus terreus: a combined molecular docking and in-vitro studies.
Journal of applied microbiology.
2023 Jul; ?(?):. doi:
10.1093/jambio/lxad129. [PMID: 37401132] - Tanwei Gu, Weihao Chen, Jianglian She, Bin Yang, Lan Tang, Huaming Tao, Jingxia Huang, Xuefeng Zhou. Lipid metabolism regulatory activity and adverse effects of fungi-derived butyrolactone I.
Natural product research.
2022 Sep; ?(?):1-5. doi:
10.1080/14786419.2022.2122966. [PMID: 36089911] - Liang Wu, Chun-Lan Xie, Xian-Wen Yang, Gang Chen. Pharmacokinetics and Metabolism Study of Deep-Sea-Derived Butyrolactone I in Rats by UHPLC-MS/MS and UHPLC-Q-TOF-MS.
Marine drugs.
2021 Dec; 20(1):. doi:
10.3390/md20010011. [PMID: 35049869] - Bing Liu, Ning Chen, Ying Xu, Jia-Wei Zhang, Yuan Sun, Li-Zhu Zhao, Yu-Bin Ji. A new benzophenone with biological activities from metabolites of butyrolactone I in rat faeces.
Natural product research.
2021 Aug; 35(15):2489-2497. doi:
10.1080/14786419.2019.1680668. [PMID: 31674853] - Supriya Tilvi, Rajesh Parvatkar, Keisham S Singh, Prabha Devi. Chemical Investigation of Marine-Derived Fungus Aspergillus flavipes for Potential Anti-Inflammatory Agents.
Chemistry & biodiversity.
2021 Feb; 18(2):e2000956. doi:
10.1002/cbdv.202000956. [PMID: 33533162] - Rosiára Rosária Dias Maziero, Carlos Renato de Freitas Guaitolini, Daniela Martins Paschoal, André Maciel Crespilho, Danielle Andressa Oliveira Sestari, Margot Alves Nunes Dode, Fernanda da Cruz Landim-Alvarenga. Effects of the addition of oocyte meiosis-inhibiting drugs on the expression of maturation-promoting factor components and organization of cytoplasmic organelles.
Reproductive biology.
2020 Mar; 20(1):48-62. doi:
10.1016/j.repbio.2019.12.005. [PMID: 31889629] - X An, B-M Feng, G Chen, S-F Chen, J Bai, H-M Hua, H-F Wang, Y-H Pei. Isolation and identification of phase I metabolites of butyrolactone I in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Mar; 47(3):236-244. doi:
10.3109/00498254.2016.1172280. [PMID: 27604497] - Yutaka Kasuya, Yoshio Hosaka, Hisashi Matsushima, Toshitaka Goto, Tadaichi Kitamura, Akira Okuyama. Prominent induction of cyclin B1 in G2/M renal cancer cells with butyrolactone 1.
International journal of urology : official journal of the Japanese Urological Association.
2003 Jun; 10(6):323-31. doi:
10.1046/j.1442-2042.2003.00626.x. [PMID: 12757604] - Nunzia Ponderato, Gabriella Crotti, Paola Turini, Roberto Duchi, Cesare Galli, Giovanna Lazzari. Embryonic and foetal development of bovine oocytes treated with a combination of butyrolactone I and roscovitine in an enriched medium prior to IVM and IVF.
Molecular reproduction and development.
2002 Aug; 62(4):513-8. doi:
10.1002/mrd.10134. [PMID: 12112585] - Guang-Ming Wu, Qing-Yuan Sun, Jiude Mao, Liangxue Lai, Tod C McCauley, Kwang-Wook Park, Randall S Prather, Brad A Didion, Billy N Day. High developmental competence of pig oocytes after meiotic inhibition with a specific M-phase promoting factor kinase inhibitor, butyrolactone I.
Biology of reproduction.
2002 Jul; 67(1):170-7. doi:
10.1095/biolreprod67.1.170. [PMID: 12080014] - Shu Hashimoto, Naojiro Minami, Ryo Takakura, Hiroshi Imai. Bovine immature oocytes acquire developmental competence during meiotic arrest in vitro.
Biology of reproduction.
2002 Jun; 66(6):1696-701. doi:
10.1095/biolreprod66.6.1696. [PMID: 12021049] - Y Arata, M Fujita, K Ohtani, S Kijima, J Y Kato. Cdk2-dependent and -independent pathways in E2F-mediated S phase induction.
The Journal of biological chemistry.
2000 Mar; 275(9):6337-45. doi:
10.1074/jbc.275.9.6337. [PMID: 10692433] - W A Kues, M Anger, J W Carnwath, D Paul, J Motlik, H Niemann. Cell cycle synchronization of porcine fetal fibroblasts: effects of serum deprivation and reversible cell cycle inhibitors.
Biology of reproduction.
2000 Feb; 62(2):412-9. doi:
10.1095/biolreprod62.2.412. [PMID: 10642581] - J Hill, Q Winger, K Jones, D Keller, W A King, M Westhusin. The effect of donor cell serum starvation and oocyte activation compounds on the development of somatic cell cloned embryos.
Cloning.
1999 200; 1(4):201-8. doi:
10.1089/15204559950019834. [PMID: 16218820] - D Hida, K Nakata, Y Shima, K Migita, K Nakao, Y Kato, N Ishii, K Eguchi. Suppression of albumin and alpha-fetoprotein gene expression by butyrolactone I, a selective inhibitor of the cdk family, in HuH-7 human hepatoma cells.
Anticancer research.
1998 Nov; 18(6A):4317-22. doi:
NULL. [PMID: 9891485] - Y Dobashi, M Chigira, M Shoji, Y Wakata, M Kitagawa, H Tamauchi, T Akiyama, T Kameya. Cell cycle control with minimal participation of Cdk2 in a murine fibrosarcoma clone cultured in protein-free medium.
Biochemical and biophysical research communications.
1997 Mar; 232(3):622-5. doi:
10.1006/bbrc.1997.6346. [PMID: 9126324] - M Kitagawa, H Higashi, I S Takahashi, T Okabe, H Ogino, Y Taya, S Hishimura, A Okuyama. A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression.
Oncogene.
1994 Sep; 9(9):2549-57. doi:
NULL. [PMID: 8058318]
