Isoglobotrihexosylceramide (BioDeep_00001028933)
代谢物信息卡片
化学式: C62H117NO18 (1163.8270222)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O)C(C=CCCCCCCCCCCCCC)O
InChI: InChI=1S/C62H117NO18/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-28-30-32-34-36-38-40-50(68)63-45(46(67)39-37-35-33-31-29-27-16-14-12-10-8-6-4-2)44-76-60-56(74)54(72)58(49(43-66)79-60)80-62-57(75)59(52(70)48(42-65)78-62)81-61-55(73)53(71)51(69)47(41-64)77-61/h37,39,45-49,51-62,64-67,69-75H,3-36,38,40-44H2,1-2H3,(H,63,68)/b39-37+/t45-,46+,47+,48+,49+,51-,52-,53-,54+,55+,56+,57+,58+,59-,60+,61+,62-/m0/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xingguang Liu, Peng Zhang, Yunkai Zhang, Zheng Wang, Sheng Xu, Yingke Li, Wanwan Huai, Qingqing Zhou, Xiang Chen, Xi Chen, Nan Li, Peng Wang, Yunsen Li, Xuetao Cao. Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling.
Cell research.
2019 01; 29(1):42-53. doi:
10.1038/s41422-018-0122-7. [PMID: 30514903] - Garth Cameron, Daniel G Pellicci, Adam P Uldrich, Gurdyal S Besra, Petr Illarionov, Spencer J Williams, Nicole L La Gruta, Jamie Rossjohn, Dale I Godfrey. Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity.
Journal of immunology (Baltimore, Md. : 1950).
2015 Nov; 195(10):4604-14. doi:
10.4049/jimmunol.1501222. [PMID: 26423148] - Janice M H Cheng, Emma M Dangerfield, Mattie S M Timmer, Bridget L Stocker. A divergent approach to the synthesis of iGb3 sugar and lipid analogues via a lactosyl 2-azido-sphingosine intermediate.
Organic & biomolecular chemistry.
2014 May; 12(17):2729-36. doi:
10.1039/c4ob00241e. [PMID: 24652424] - Stefan Porubsky, Anneliese O Speak, Mariolina Salio, Richard Jennemann, Mahnaz Bonrouhi, Rashad Zafarulla, Yogesh Singh, Julian Dyson, Bruno Luckow, Agnes Lehuen, Ernst Malle, Johannes Müthing, Frances M Platt, Vincenzo Cerundolo, Hermann-Josef Gröne. Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells.
Journal of immunology (Baltimore, Md. : 1950).
2012 Sep; 189(6):3007-17. doi:
10.4049/jimmunol.1201483. [PMID: 22875802] - Esther Dawen Yu, Enrico Girardi, Jing Wang, Dirk M Zajonc. Cutting edge: structural basis for the recognition of β-linked glycolipid antigens by invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950).
2011 Sep; 187(5):2079-83. doi:
10.4049/jimmunol.1101636. [PMID: 21810611] - Kelley Chuang, Erica L Elford, Jill Tseng, Briana Leung, Hobart W Harris. An expanding role for apolipoprotein E in sepsis and inflammation.
American journal of surgery.
2010 Sep; 200(3):391-7. doi:
10.1016/j.amjsurg.2009.10.017. [PMID: 20409531] - Andrea Balreira, Marco Cavallari, Maria Clara Sá Miranda, Fernando A Arosa. Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness.
Immunobiology.
2010 Jun; 215(6):505-13. doi:
10.1016/j.imbio.2009.07.002. [PMID: 19651460] - Dale Christiansen, Julie Milland, Effie Mouhtouris, Hilary Vaughan, Daniel G Pellicci, Malcolm J McConville, Dale I Godfrey, Mauro S Sandrin. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation.
PLoS biology.
2008 Jul; 6(7):e172. doi:
10.1371/journal.pbio.0060172. [PMID: 18630988] - Jens Schümann, Federica Facciotti, Luigi Panza, Mario Michieletti, Federica Compostella, Anthony Collmann, Lucia Mori, Gennaro De Libero. Differential alteration of lipid antigen presentation to NKT cells due to imbalances in lipid metabolism.
European journal of immunology.
2007 Jun; 37(6):1431-41. doi:
10.1002/eji.200737160. [PMID: 17492806] - Lu Cheng, Aito Ueno, Suzanne Cho, Jin S Im, Susanne Golby, Sheng Hou, Steven A Porcelli, Yang Yang. Efficient activation of Valpha14 invariant NKT cells by foreign lipid antigen is associated with concurrent dendritic cell-specific self recognition.
Journal of immunology (Baltimore, Md. : 1950).
2007 Mar; 178(5):2755-62. doi:
10.4049/jimmunol.178.5.2755. [PMID: 17312118] - Qingjia Yao, Jing Song, Chengfeng Xia, Wenpeng Zhang, Peng George Wang. Chemoenzymatic syntheses of iGb3 and Gb3.
Organic letters.
2006 Mar; 8(5):911-4. doi:
10.1021/ol053070p. [PMID: 16494472]