2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid (BioDeep_00001028880)
代谢物信息卡片
2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid
化学式: C24H24FNO3 (393.174)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O
InChI: InChI=1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)/t23-/m1/s1
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Journal of medicinal chemistry.
2016 Sep; 59(18):8473-94. doi:
10.1021/acs.jmedchem.6b00914. [PMID: 27559615] - Masashi Honda, Katsuya Hikita, Bunya Kawamoto, Kuniyasu Muraoka, Shogo Shimizu, Motoaki Saito, Takehiro Sejima, Michael B Chancellor, Naoki Yoshimura, Atsushi Takenaka. Spinal glycine transporter-1 inhibition influences the micturition reflex in urethane-anesthetized rats.
International urology and nephrology.
2016 Mar; 48(3):349-54. doi:
10.1007/s11255-015-1148-0. [PMID: 26843416] - Hiroko Komatsu, Yoshiaki Furuya, Kohei Sawada, Takashi Asada. Involvement of the strychnine-sensitive glycine receptor in the anxiolytic effects of GlyT1 inhibitors on maternal separation-induced ultrasonic vocalization in rat pups.
European journal of pharmacology.
2015 Jan; 746(?):252-7. doi:
10.1016/j.ejphar.2014.11.024. [PMID: 25435080] - Franziska Barthel, Andrea Urban, Lukas Schlösser, Volker Eulenburg, Robert Werdehausen, Timo Brandenburger, Carmen Aragon, Inge Bauer, Henning Hermanns. Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.
Anesthesiology.
2014 Jul; 121(1):160-9. doi:
10.1097/aln.0000000000000203. [PMID: 24598217] - Takashi Sugane, Takahiko Tobe, Wataru Hamaguchi, Itsuro Shimada, Kyoichi Maeno, Junji Miyata, Takeshi Suzuki, Tetsuya Kimizuka, Shuichi Sakamoto, Shin-ichi Tsukamoto. Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors.
Journal of medicinal chemistry.
2013 Jul; 56(14):5744-56. doi:
10.1021/jm400383w. [PMID: 23837744] - Lauren Debrouse, Benita Hurd, Carly Kiselycznyk, Aaron Plitt, Alyssa Todaro, Masayoshi Mishina, Seth G N Grant, Marguerite Camp, Ozge Gunduz-Cinar, Andrew Holmes. Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
Alcoholism, clinical and experimental research.
2013 Feb; 37(2):223-33. doi:
10.1111/j.1530-0277.2012.01922.x. [PMID: 22934986] - Deepti Lall, Anja Armbruster, Karelia Ruffert, Heinrich Betz, Volker Eulenburg. Transport activities and expression patterns of glycine transporters 1 and 2 in the developing murine brain stem and spinal cord.
Biochemical and biophysical research communications.
2012 Jul; 423(4):661-6. doi:
10.1016/j.bbrc.2012.06.007. [PMID: 22695116] - Takeshi Fuchigami, Mamoru Haratake, Yasuhiro Magata, Terushi Haradahira, Morio Nakayama. Synthesis and characterization of [¹²⁵I]2-iodo N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-trifluoromethyl-benzamide as novel imaging probe for glycine transporter 1.
Bioorganic & medicinal chemistry.
2011 Nov; 19(21):6245-53. doi:
10.1016/j.bmc.2011.09.010. [PMID: 21975065] - John T Durkin, Chrysanthe M Spais, Justin Schreiber, Karla Kopec, Sheryl L Meyer. Amino-terminal isoforms of the human glycine transporter GlyT1 exhibit similar pharmacology.
Brain research.
2011 Feb; 1374(?):1-7. doi:
10.1016/j.brainres.2010.11.083. [PMID: 21138739] - Karla Kopec, Dorothy G Flood, Maciej Gasior, Beth Ann W McKenna, Eva Zuvich, Justin Schreiber, Joseph M Salvino, John T Durkin, Mark A Ator, Michael J Marino. Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice.
Biochemical pharmacology.
2010 Nov; 80(9):1407-17. doi:
10.1016/j.bcp.2010.07.004. [PMID: 20637735] - Hyo-Jin Jeong, Robert J Vandenberg, Christopher W Vaughan. N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.
British journal of pharmacology.
2010 Oct; 161(4):925-35. doi:
10.1111/j.1476-5381.2010.00935.x. [PMID: 20860669] - Toshiharu Shimazaki, Ayaka Kaku, Shigeyuki Chaki. D-Serine and a glycine transporter-1 inhibitor enhance social memory in rats.
Psychopharmacology.
2010 Apr; 209(3):263-70. doi:
10.1007/s00213-010-1794-y. [PMID: 20198471] - Veeramuthu Balakrishnan, Sidney P Kuo, Patrick D Roberts, Laurence O Trussell. Slow glycinergic transmission mediated by transmitter pooling.
Nature neuroscience.
2009 Mar; 12(3):286-94. doi:
10.1038/nn.2265. [PMID: 19198604] - Yuichi Terui, Yi-wen Chu, Jun-ying Li, Tsutomu Ando, Takuya Fukunaga, Takeshi Aoki, Yoshihisa Toda. New cyclic tetrapeptides from Nonomuraea sp. TA-0426 that inhibit glycine transporter type 1 (GlyT1).
Bioorganic & medicinal chemistry letters.
2008 Dec; 18(24):6321-3. doi:
10.1016/j.bmcl.2008.10.104. [PMID: 19013063] - Henning Hermanns, Uta Muth-Selbach, Ruth Williams, Sabrina Krug, Peter Lipfert, Robert Werdehausen, Sebastian Braun, Inge Bauer. Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain.
Neuroscience letters.
2008 Nov; 445(3):214-9. doi:
10.1016/j.neulet.2008.09.012. [PMID: 18793697] - Kenneth W Perry, Julie F Falcone, Matthew J Fell, John W Ryder, Hong Yu, Patrick L Love, Jason Katner, Kimberly D Gordon, Mark R Wade, Teresa Man, George G Nomikos, Lee A Phebus, Annick J Cauvin, Kirk W Johnson, Carrie K Jones, Beth J Hoffmann, George E Sandusky, Magnus W Walter, Warren J Porter, Lijuan Yang, Kalpana M Merchant, Harlan E Shannon, Kjell A Svensson. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas.
Neuropharmacology.
2008 Oct; 55(5):743-54. doi:
10.1016/j.neuropharm.2008.06.016. [PMID: 18602930] - Zhi-Liang Wu, Teresa M O'Kane, Thomas J Connors, Michael J Marino, Hervé Schaffhauser. The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake.
Brain research.
2008 Aug; 1227(?):42-51. doi:
10.1016/j.brainres.2008.06.078. [PMID: 18621031] - Kenji Hashimoto, Yuko Fujita, Tamaki Ishima, Shigeyuki Chaki, Masaomi Iyo. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the glycine transporter-1 inhibitor NFPS and D-serine.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2008 Jun; 18(6):414-21. doi:
10.1016/j.euroneuro.2007.07.009. [PMID: 17804206] - Elisa Luccini, Luca Raiteri. Mechanisms of [(3)H]glycine release from mouse spinal cord synaptosomes selectively labeled through GLYT2 transporters.
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2007 Dec; 103(6):2439-48. doi:
10.1111/j.1471-4159.2007.04967.x. [PMID: 17944872] - Magnus W Walter, Beth J Hoffman, Kimberly Gordon, Kirk Johnson, Patrick Love, Matthew Jones, Teresa Man, Lee Phebus, Jon K Reel, Helene C Rudyk, Harlan Shannon, Kjell Svensson, Hong Yu, Matthew J Valli, Warren J Porter. Discovery and SAR studies of novel GlyT1 inhibitors.
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2007 Sep; 17(18):5233-8. doi:
10.1016/j.bmcl.2007.06.074. [PMID: 17629697] - Itziar Igartua, José M Solís, Julián Bustamante. Glycine-induced long-term synaptic potentiation is mediated by the glycine transporter GLYT1.
Neuropharmacology.
2007 Jun; 52(8):1586-95. doi:
10.1016/j.neuropharm.2007.03.003. [PMID: 17462677] - Lynda Allan, J Lianne Leith, Marianthi Papakosta, John A Morrow, Nicholas G Irving, Brian W McFerran, Alan G Clark. Development of a novel high-throughput assay for the investigation of GlyT-1b neurotransmitter transporter function.
Combinatorial chemistry & high throughput screening.
2006 Jan; 9(1):9-14. doi:
10.2174/138620706775213886. [PMID: 16454681] - Garrick Smith, Thomas Ruhland, Gitte Mikkelsen, Kim Andersen, Claus Tornby Christoffersen, Lene Hjorth Alifrangis, Arne Mørk, Stephen P Wren, Neil Harris, Barry M Wyman, Guillaume Brandt. The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors.
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2004 Aug; 14(15):4027-30. doi:
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