[Des-Arg9]-BRADYKININ (BioDeep_00001028751)
代谢物信息卡片
(Des-Arg9)-Bradykinin acetate salt
化学式: C44H61N11O10 (903.4602646000001)
中文名称: 血管舒缓激肽片段1-8,醋酸盐水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)O
InChI: InChI=1S/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)/t29-,30-,31-,32-,33-,34-,35-/m0/s1
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tanja Gangnus, Bjoern B Burckhardt. Targeted LC-MS/MS platform for the comprehensive determination of peptides in the kallikrein-kinin system.
Analytical and bioanalytical chemistry.
2021 May; 413(11):2971-2984. doi:
10.1007/s00216-021-03231-9. [PMID: 33693976] - Mehrdad Alikhani, Amir Javadi, Mahdi Aalikhani. Des-Arg9 bradykinin and bradykinin potentially trigger cytokine storm in patients with COVID-19.
Iranian journal of immunology : IJI.
2021 03; 18(1):93-94. doi:
10.22034/iji.2021.89684.1962. [PMID: 33787518] - Steven de Maat, Quirijn de Mast, A H Jan Danser, Frank L van de Veerdonk, Coen Maas. Impaired Breakdown of Bradykinin and Its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection.
Seminars in thrombosis and hemostasis.
2020 10; 46(7):835-837. doi:
10.1055/s-0040-1712960. [PMID: 32526773] - Joseph A Roche, Renuka Roche. A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 06; 34(6):7265-7269. doi:
10.1096/fj.202000967. [PMID: 32359101] - Xu Qian, Duc T M Nguyen, Yaojun Li, Jianxin Lyu, Edward A Graviss, Tony Y Hu. Predictive value of serum bradykinin and desArg9-bradykinin levels for chemotherapeutic responses in active tuberculosis patients: A retrospective case series.
Tuberculosis (Edinburgh, Scotland).
2016 12; 101S(?):S109-S118. doi:
10.1016/j.tube.2016.09.022. [PMID: 27720377] - Haiyan Wu, Anton J M Roks, Frank P J Leijten, Ingrid M Garrelds, Usha M Musterd-Bhaggoe, Antoon J van den Bogaerdt, Moniek P M de Maat, Maarten L Simoons, A H Jan Danser, Hisko Oeseburg. Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease.
Clinical science (London, England : 1979).
2014 Mar; 126(6):441-9. doi:
10.1042/cs20130204. [PMID: 24117346] - Kevser Erol, Basar Sirmagul, Fatma Sultan Kilic, Semra Yigitaslan, Ali Evrim Dogan. The role of inflammation and COX-derived prostanoids in the effects of bradykinin on isolated rat aorta and urinary bladder.
Inflammation.
2012 Apr; 35(2):420-8. doi:
10.1007/s10753-011-9331-7. [PMID: 21537904] - Rafael L Pereira, Bruna N Buscariollo, Matheus Corrêa-Costa, Patricia Semedo, Cassiano D Oliveira, Vanessa O Reis, Edgar Maquigussa, Ronaldo C Araújo, Tárcio T Braga, Maria F Soares, Ivan C Moura, Denise M A C Malheiros, Alvaro Pacheco-Silva Filho, Alexandre C Keller, Niels O S Câmara. Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis.
Kidney international.
2011 Jun; 79(11):1217-27. doi:
10.1038/ki.2011.14. [PMID: 21412216] - Rocio Bautista-Pérez, Abraham Arellano, Martha Franco, Horacio Osorio, Israel Coronel. Enalaprilat-mediated activation of kinin b(1) receptors and vasodilation in the rat isolated perfused kidney.
Pharmacology.
2011; 87(3-4):195-203. doi:
10.1159/000324513. [PMID: 21430409] - Fabiana N Dornelles, Diógenes S Santos, Thomas E Van Dyke, João B Calixto, Eraldo L Batista, Maria M Campos. In vivo up-regulation of kinin B1 receptors after treatment with Porphyromonas gingivalis lipopolysaccharide in rat paw.
The Journal of pharmacology and experimental therapeutics.
2009 Sep; 330(3):756-63. doi:
10.1124/jpet.109.155762. [PMID: 19561153] - W Gary Anderson, Jérôme Leprince, J Michael Conlon. Purification, structural characterization, and myotropic activity of a peptide related to des-Arg(9)-bradykinin from an elasmobranch fish, the little skate, Leucoraja erinacea.
Peptides.
2008 Aug; 29(8):1280-6. doi:
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British journal of pharmacology.
2008 May; 154(1):136-43. doi:
10.1038/bjp.2008.48. [PMID: 18311190] - Anik Désormeaux, Marie Eve Moreau, Yves Lepage, Jacques Chanard, Albert Adam. The effect of electronegativity and angiotensin-converting enzyme inhibition on the kinin-forming capacity of polyacrylonitrile dialysis membranes.
Biomaterials.
2008 Mar; 29(9):1139-46. doi:
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American journal of physiology. Heart and circulatory physiology.
2007 Dec; 293(6):H3550-7. doi:
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The Journal of pharmacology and experimental therapeutics.
2007 Aug; 322(2):619-30. doi:
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Kidney international.
2006 Nov; 70(10):1823-31. doi:
10.1038/sj.ki.5001873. [PMID: 17003818] - Ronaldo C Araújo, Marcelo A Mori, Vanessa F Merino, Jean-Loup Bascands, Joost P Schanstra, Ricardo L Zollner, Conceição A Villela, Clovis R Nakaie, Antonio C M Paiva, Jorge L Pesquero, Michael Bader, João B Pesquero. Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function.
Biological chemistry.
2006 Apr; 387(4):431-6. doi:
10.1515/bc.2006.057. [PMID: 16606341] - Ana C C Rocha, Elizabeth S Fernandes, Giselle F Passos, João B Calixto, Maria M Campos. Assessment of TNFalpha contribution to the functional up-regulation of kinin B(1) receptors in the mouse paw after treatment with LPS.
International immunopharmacology.
2005 Oct; 5(11):1593-600. doi:
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European journal of pharmacology.
2005 May; 514(1):61-7. doi:
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Transfusion.
2004 Sep; 44(9):1361-6. doi:
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The Journal of pharmacology and experimental therapeutics.
2004 Jun; 309(3):1141-7. doi:
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British journal of pharmacology.
2003 May; 139(2):271-8. doi:
10.1038/sj.bjp.0705236. [PMID: 12770932] - Aiguo Ni, Hang Yin, Jun Agata, Zhirong Yang, Lee Chao, Julie Chao. Overexpression of kinin B1 receptors induces hypertensive response to des-Arg9-bradykinin and susceptibility to inflammation.
The Journal of biological chemistry.
2003 Jan; 278(1):219-25. doi:
10.1074/jbc.m209490200. [PMID: 12411434] - Steffen Sandmann, Elena Kaschina, Annegret Blume, Marie Luise Kruse, Thomas Unger. Bradykinin B1 and B2 receptors differentially regulate cardiac Na+-H+ exchanger, Na+-Ca2+ exchanger and Na+-HCO3- symporter.
European journal of pharmacology.
2003 Jan; 458(1-2):3-16. doi:
10.1016/s0014-2999(02)02656-0. [PMID: 12498901] - Julie Christopher, Ayad A Jaffa. Diabetes modulates the expression of glomerular kinin receptors.
International immunopharmacology.
2002 Dec; 2(13-14):1771-9. doi:
10.1016/s1567-5769(02)00188-1. [PMID: 12489791] - Giuseppe Molinaro, Albert Adam, Yves Lepage, Dale Hammerschmidt, Ulrike Koenigbauer, Ted Eastlund. Hypotensive reaction during staphylococcal protein A column therapy in a patient with anomalous degradation of bradykinin and Des-Arg9-bradykinin after contact activation.
Transfusion.
2002 Nov; 42(11):1458-65. doi:
10.1046/j.1537-2995.2002.00196.x. [PMID: 12421219] - Giuseppe Molinaro, Massimo Cugno, Mélissa Perez, Yves Lepage, Nicole Gervais, Angelo Agostoni, Albert Adam. Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)-bradykinin.
The Journal of pharmacology and experimental therapeutics.
2002 Oct; 303(1):232-7. doi:
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Planta medica.
2002 Sep; 68(9):850-3. doi:
10.1055/s-2002-34409. [PMID: 12357405] - Giuseppe Molinaro, Nicole Gervais, Albert Adam. Biochemical basis of angioedema associated with recombinant tissue plasminogen activator treatment: an in vitro experimental approach.
Stroke.
2002 Jun; 33(6):1712-6. doi:
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Kidney international.
2002 Jun; 61(6):2149-56. doi:
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Life sciences.
2002 Jan; 70(8):937-49. doi:
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American journal of physiology. Heart and circulatory physiology.
2001 Jul; 281(1):H275-83. doi:
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Circulation research.
2001 Feb; 88(3):275-81. doi:
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Journal of the American Society of Nephrology : JASN.
2000 Jul; 11(7):1208-1215. doi:
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Fundamental & clinical pharmacology.
2000 Mar; 14(2):119-23. doi:
10.1111/j.1472-8206.2000.tb00399.x. [PMID: 10796058] - A Adam, C Blais, G Loute. [Kinins: their nature and their potential role in the cardiovascular effects of angiotensin-converting enzyme inhibitors].
Nephrologie.
2000; 21(4):163-72. doi:
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British journal of pharmacology.
1999 Dec; 128(8):1643-50. doi:
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Immunopharmacology.
1999 Dec; 45(1-3):35-8. doi:
10.1016/s0162-3109(99)00055-7. [PMID: 10614987] - C Blais, J L Rouleau, N J Brown, Y Lepage, D Spence, C Munoz, J Friborg, D Geadah, N Gervais, A Adam. Serum metabolism of bradykinin and des-Arg9-bradykinin in patients with angiotensin-converting enzyme inhibitor-associated angioedema.
Immunopharmacology.
1999 Sep; 43(2-3):293-302. doi:
10.1016/s0162-3109(99)00133-2. [PMID: 10596866] - C Blais, A Adam, D Massicotte, F Péronnet. Increase in blood bradykinin concentration after eccentric weight-training exercise in men.
Journal of applied physiology (Bethesda, Md. : 1985).
1999 Sep; 87(3):1197-201. doi:
10.1152/jappl.1999.87.3.1197. [PMID: 10484595] - C Mazenot, C Ribuot, P Demenge, D Godin-Ribuot. Monophosphoryl lipid A, a derivative of bacterial lipopolysaccharide, fails to induce B1-receptor-dependent responses to (des-Arg9)-bradykinin in the rabbit in vivo.
Immunopharmacology.
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Peptides.
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The American journal of physiology.
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