beta-solamarine (BioDeep_00001028723)
代谢物信息卡片
beta-solamarine
化学式: C45H73NO15 (867.4979947999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)OC9C(C(C(C(O9)C)O)O)O)C)C)C)NC1
InChI: InChI=1S/C45H73NO15/c1-19-9-14-45(46-17-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(53)34(51)32(49)22(4)56-41)37(54)38(29(18-47)58-42)59-40-35(52)33(50)31(48)21(3)55-40/h7,19-22,24-42,46-54H,8-18H2,1-6H3/t19-,20-,21-,22-,24-,25+,26-,27-,28-,29+,30-,31-,32-,33+,34+,35+,36+,37-,38+,39+,40-,41-,42+,43-,44-,45-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qing Tang, Qichun Zhou, Jing Li, Xiaobing Yang, Rui Wang, Xi Wang, Mengfei Xu, Ling Han, Wanyin Wu, Sumei Wang. Solamargine enhanced gefitinib anti-tumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer.
Carcinogenesis.
2023 May; ?(?):. doi:
10.1093/carcin/bgad028. [PMID: 37144780] - Qiaoyan Han, Hua Bai, Yong Xu, Min Zhou, He Zhou, Xiaoqing Dong, Bing Chen. Solamargine induces autophagy-mediated apoptosis and enhances bortezomib activity in multiple myeloma.
Clinical and experimental pharmacology & physiology.
2022 06; 49(6):674-685. doi:
10.1111/1440-1681.13643. [PMID: 35294057] - Qing Tang, Xiaojuan Li, Yun Chen, Shunqin Long, Yaya Yu, Honghao Sheng, Sumei Wang, Ling Han, Wanyin Wu. Solamargine inhibits the growth of hepatocellular carcinoma and enhances the anticancer effect of sorafenib by regulating HOTTIP-TUG1/miR-4726-5p/MUC1 pathway.
Molecular carcinogenesis.
2022 04; 61(4):417-432. doi:
10.1002/mc.23389. [PMID: 35040191] - Shuangshuang Yin, Wenke Jin, Yuling Qiu, Leilei Fu, Tao Wang, Haiyang Yu. Solamargine induces hepatocellular carcinoma cell apoptosis and autophagy via inhibiting LIF/miR-192-5p/CYR61/Akt signaling pathways and eliciting immunostimulatory tumor microenvironment.
Journal of hematology & oncology.
2022 03; 15(1):32. doi:
10.1186/s13045-022-01248-w. [PMID: 35313929] - Ricardo Andrade Furtado, Saulo Duarte Ozelin, Natália Helen Ferreira, Bárbara Ayumi Miura, Silvio Almeida Junior, Geórgia Modé Magalhães, Eduardo José Nassar, Mariza Abreu Miranda, Jairo Kenupp Bastos, Denise Crispim Tavares. Antitumor activity of solamargine in mouse melanoma model: relevance to clinical safety.
Journal of toxicology and environmental health. Part A.
2022 02; 85(4):131-142. doi:
10.1080/15287394.2021.1984348. [PMID: 34612163] - Billy Cabanillas, François Chassagne, Pedro Vásquez-Ocmín, Ali Tahrioui, Sylvie Chevalier, Marieke Vansteelandt, Asih Triastuti, Carlos A Amasifuen Guerra, Nicolas Fabre, Mohamed Haddad. Pharmacological validation of Solanum mammosum L. as an anti-infective agent: Role of solamargine.
Journal of ethnopharmacology.
2021 Nov; 280(?):114473. doi:
10.1016/j.jep.2021.114473. [PMID: 34343650] - Qing Tang, Fang Zheng, Zheng Liu, JingJing Wu, XiaoSu Chai, CuenXa He, Liuning Li, Swei Sunny Hann. Novel reciprocal interaction of lncRNA HOTAIR and miR-214-3p contribute to the solamargine-inhibited PDPK1 gene expression in human lung cancer.
Journal of cellular and molecular medicine.
2019 11; 23(11):7749-7761. doi:
10.1111/jcmm.14649. [PMID: 31475459] - Chao-Chun Yang, Tak-Wah Wong, Chih-Hung Lee, Chien-Hui Hong, Chung-Hsing Chang, Feng-Jie Lai, Shang-Hung Lin, Ching-Chi Chi, Tzu-Kai Lin, Hsi Yen, Chin-Han Wu, Hamm-Ming Sheu, Cheng-Che E Lan. Efficacy and safety of topical SR-T100 gel in treating actinic keratosis in Taiwan: A Phase III randomized double-blind vehicle-controlled parallel trial.
Journal of dermatological science.
2018 Jun; 90(3):295-302. doi:
10.1016/j.jdermsci.2018.02.015. [PMID: 29530340] - Yuqing Chen, Qing Tang, Qian Xiao, LiJun Yang, Swei S Hann. Targeting EP4 downstream c-Jun through ERK1/2-mediated reduction of DNMT1 reveals novel mechanism of solamargine-inhibited growth of lung cancer cells.
Journal of cellular and molecular medicine.
2017 02; 21(2):222-233. doi:
10.1111/jcmm.12958. [PMID: 27620163] - Qing Tang, Fang Zheng, JingJing Wu, Qian Xiao, Liuning Li, Swei Sunny Hann. Combination of Solamargine and Metformin Strengthens IGFBP1 Gene Expression Through Inactivation of Stat3 and Reciprocal Interaction Between FOXO3a and SP1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 43(6):2310-2326. doi:
10.1159/000484383. [PMID: 29073599] - S S El-Hawary, R Mohammed, S F AbouZid, W Bakeer, R Ebel, A M Sayed, M E Rateb. Solamargine production by a fungal endophyte of Solanum nigrum.
Journal of applied microbiology.
2016 Apr; 120(4):900-11. doi:
10.1111/jam.13077. [PMID: 26811095] - Fatma Njeh, Houda Feki, Imed Koubaa, Nejia Hamed, Mohamed Damak, Ali Ayadi, Hayet Hammami, Raoudha Mezghani-Jarraya. Molluscicidal activity of Solanum elaeagnifolium seeds against Galba truncatula intermediate host of Fasciola hepatica: Identification of β-solamarine.
Pharmaceutical biology.
2016; 54(4):726-31. doi:
10.3109/13880209.2015.1073332. [PMID: 26429590] - YuQing Chen, Qing Tang, JingJing Wu, Fang Zheng, LiJun Yang, Swei Sunny Hann. Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells.
Journal of experimental & clinical cancer research : CR.
2015 Dec; 34(?):154. doi:
10.1186/s13046-015-0272-0. [PMID: 26689593] - Renata F J Tiossi, Juliana C Da Costa, Mariza A Miranda, Fabíola S G Praça, James D McChesney, Maria Vitória L B Bentley, Jairo K Bastos. In vitro and in vivo evaluation of the delivery of topical formulations containing glycoalkaloids of Solanum lycocarpum fruits.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2014 Sep; 88(1):28-33. doi:
10.1016/j.ejpb.2014.01.010. [PMID: 24509413] - Yan Zhou, Qing Tang, Shunyu Zhao, Fang Zhang, Liuning Li, WanYin Wu, ZhiYu Wang, Swei Hann. Targeting signal transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and -induced apoptosis of human lung cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2014 Aug; 35(8):8169-78. doi:
10.1007/s13277-014-2047-1. [PMID: 24845028] - Carla Carolina Munari, Pollyanna Francielli de Oliveira, Jacqueline Costa Lima Campos, Sabrina de Paula Lima Martins, Juliana Carvalho Da Costa, Jairo Kenupp Bastos, Denise Crispim Tavares. Antiproliferative activity of Solanum lycocarpum alkaloidic extract and their constituents, solamargine and solasonine, in tumor cell lines.
Journal of natural medicines.
2014 Jan; 68(1):236-41. doi:
10.1007/s11418-013-0757-0. [PMID: 23475509] - Mahenina Jaovita Manase, Anne-Claire Mitaine-Offer, David Pertuit, Tomofumi Miyamoto, Chiaki Tanaka, Stéphanie Delemasure, Patrick Dutartre, Jean-François Mirjolet, Olivier Duchamp, Marie-Aleth Lacaille-Dubois. Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
Fitoterapia.
2012 Sep; 83(6):1115-9. doi:
10.1016/j.fitote.2012.04.024. [PMID: 22579841] - Bill Elliot Cham, Tania Robyn Chase. Solasodine rhamnosyl glycosides cause apoptosis in cancer cells. Do they also prime the immune system resulting in long-term protection against cancer?.
Planta medica.
2012 Mar; 78(4):349-53. doi:
10.1055/s-0031-1298149. [PMID: 22399274] - Xia Ding, Fang-Shi Zhu, Min Li, Si-Guo Gao. Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L.
Journal of ethnopharmacology.
2012 Jan; 139(2):599-604. doi:
10.1016/j.jep.2011.11.058. [PMID: 22172325] - Xiao Zheng, Lianming Xu, Yan Liang, Wei Xiao, Lin Xie, Yan Zhang, Li Zhao, Liang Cao, Jun Chen, Guangji Wang. Quantitative determination and pharmacokinetic study of solamargine in rat plasma by liquid chromatography-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2011 Jul; 55(5):1157-62. doi:
10.1016/j.jpba.2011.04.007. [PMID: 21549540] - Lingmei Sun, Ying Zhao, Huiqing Yuan, Xia Li, Aixia Cheng, Hongxiang Lou. Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells.
Cancer chemotherapy and pharmacology.
2011 Apr; 67(4):813-21. doi:
10.1007/s00280-010-1387-9. [PMID: 20563579] - Waraporn Putalun. Technology of compact MAb and its application for medicinal plant breeding named as missile type molecular breeding.
Current drug discovery technologies.
2011 Mar; 8(1):24-31. doi:
10.2174/157016311794519965. [PMID: 21143130] - Karuna Shanker, Shalini Gupta, Pooja Srivastava, Santosh K Srivastava, Subash C Singh, Madan M Gupta. Simultaneous determination of three steroidal glycoalkaloids in Solanum xanthocarpum by high performance thin layer chromatography.
Journal of pharmaceutical and biomedical analysis.
2011 Feb; 54(3):497-502. doi:
10.1016/j.jpba.2010.09.025. [PMID: 20965683] - Padma Kumar, Bindu Sharma, Nidhi Bakshi. Biological activity of alkaloids from Solanum dulcamara L.
Natural product research.
2009; 23(8):719-23. doi:
10.1080/14786410802267692. [PMID: 19418354] - L Y Shiu, L C Chang, C H Liang, Y S Huang, H M Sheu, K W Kuo. Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2007 Nov; 45(11):2155-64. doi:
10.1016/j.fct.2007.05.009. [PMID: 17619073] - Aline Schwarz, Erika C G Felippe, Maria M Bernardi, Helenice S Spinosa. Impaired female sexual behavior of rat offspring exposed to Solanum lycocarpum unripe fruits during gestation and lactation: lack of hormonal and fertility alterations.
Pharmacology, biochemistry, and behavior.
2005 Aug; 81(4):928-34. doi:
10.1016/j.pbb.2005.07.003. [PMID: 16095678] - W Putalun, F Taura, W Qing, H Matsushita, H Tanaka, Y Shoyama. Anti-solasodine glycoside single-chain Fv antibody stimulates biosynthesis of solasodine glycoside in plants.
Plant cell reports.
2003 Dec; 22(5):344-9. doi:
10.1007/s00299-003-0689-3. [PMID: 14504907] - Alphonse W Wanyonyi, Sumesh C Chhabra, Gerald Mkoji, Udo Eilert, Wilson M Njue. Bioactive steroidal alkaloid glycosides from Solanum aculeastrum.
Phytochemistry.
2002 Jan; 59(1):79-84. doi:
10.1016/s0031-9422(01)00424-1. [PMID: 11754948] - J T Blankemeyer, M L McWilliams, J R Rayburn, M Weissenberg, M Friedman. Developmental toxicology of solamargine and solasonine glycoalkaloids in frog embryos.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
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FEBS letters.
1997 Mar; 404(2-3):279-82. doi:
10.1016/s0014-5793(97)00106-3. [PMID: 9119079] - K Fukuhara, I Kubo. Isolation of steroidal glycoalkaloids from Solanum incanum by two countercurrent chromatographic methods.
Phytochemistry.
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